Page last updated: 2024-10-24

dehydroascorbic acid transmembrane transporter activity

Definition

Target type: molecularfunction

Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other. [GOC:go_curators]

Dehydroascorbic acid transmembrane transporter activity involves the facilitated movement of dehydroascorbic acid (DHA), the oxidized form of vitamin C, across cellular membranes. This transport is essential for maintaining intracellular levels of vitamin C, a critical antioxidant and cofactor for various enzymatic reactions.

The transporter protein binds DHA on one side of the membrane and facilitates its passage to the other side. This process is typically driven by the concentration gradient of DHA across the membrane.

The transporter's primary function is to ensure adequate vitamin C supply within cells. This is crucial for several reasons:

* **Antioxidant defense:** Vitamin C protects cells from oxidative stress caused by reactive oxygen species (ROS), which can damage cellular components and contribute to aging and diseases.
* **Collagen synthesis:** Vitamin C is a cofactor for enzymes involved in collagen synthesis, essential for connective tissue integrity, wound healing, and blood vessel formation.
* **Immune function:** Vitamin C supports immune function by enhancing the activity of immune cells like lymphocytes and neutrophils.
* **Other metabolic processes:** Vitamin C participates in various metabolic processes, including the synthesis of neurotransmitters and the metabolism of amino acids.

Dysregulation of dehydroascorbic acid transmembrane transporter activity can lead to vitamin C deficiency, also known as scurvy. This condition manifests with symptoms like fatigue, bleeding gums, and impaired wound healing.

In summary, dehydroascorbic acid transmembrane transporter activity is crucial for maintaining intracellular vitamin C levels, which are essential for various physiological functions and preventing vitamin C deficiency.'
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Proteins (6)

ProteinDefinitionTaxonomy
Solute carrier family 2, facilitated glucose transporter member 3A solute carrier family 2, facilitated glucose transporter member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11169]Homo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 1A solute carrier family 2, facilitated glucose transporter member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11166]Homo sapiens (human)
Solute carrier family 23 member 1A solute carrier family 23 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHI7]Homo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 3A solute carrier family 2, facilitated glucose transporter member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11169]Homo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 2A solute carrier family 2, facilitated glucose transporter member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11168]Homo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 1A solute carrier family 2, facilitated glucose transporter member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11166]Homo sapiens (human)

Compounds (27)

CompoundDefinitionClassesRoles
gossypolGossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
phloretindihydrochalconesantineoplastic agent;
plant metabolite
cytidinecytidinesEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cycloheximidecycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.

Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol
anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
emetineemetine : A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.

Emetine: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.
isoquinoline alkaloid;
pyridoisoquinoline
antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor
c 137C 137: RN given refers to parent cpd
imidocarbImidocarb: One of ANTIPROTOZOAL AGENTS used especially against BABESIA in livestock. Toxicity has been reported.ureasantiprotozoal drug
colforsinColforsin: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol
adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist
1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylenediarylmethane
mmv665852MMV665852: an antischistosomal agent
1,3,4,10-Tetrahydro-9(2H)-acridinoneacridines
anisomycin(-)-anisomycin : An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.

Anisomycin: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
monohydroxypyrrolidine;
organonitrogen heterocyclic antibiotic
anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
antiparasitic agent;
bacterial metabolite;
DNA synthesis inhibitor;
protein synthesis inhibitor
jp-1302
1,4,8-trimethyl-12-quinolino[2,3-b]quinolinamineaminoquinoline
polysulfide rubber
2-[2-methoxyethyl-(1-oxo-2-thiophen-2-ylethyl)amino]-N-[(4-methoxyphenyl)methyl]-2-(4-propan-2-ylphenyl)acetamidemonoterpenoid
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
kaempferol7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone
antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
genistein7-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
myricetin7-hydroxyflavonol;
hexahydroxyflavone
antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
cytochalasin bcytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.

Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.
cytochalasin;
lactam;
lactone;
organic heterotricyclic compound
actin polymerisation inhibitor;
metabolite;
mycotoxin;
platelet aggregation inhibitor
pd 166285
pd-173952
glucopiericidin aglucopiericidin A: from Streptomyces pactum S48727 as co-metabolite of piericidin A(1); structure given in first source; glycoside antibiotic
wzb117WZB117: structure in first source
ascorbic acidAscorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.

L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.

vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.
ascorbic acid;
vitamin C
coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
hesperadin