An agonist at the estrogen receptor.
| Member | Definition | Class |
|---|
| 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1h-pyrazole | A pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERalpha over ERbeta. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. | 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol |
| 2,3-bis(4-hydroxyphenyl)-propionitrile | A nitrile that is acetonitrile in which one of the hydrogens is replaced by a 4-hydroxyphenyl group while a second hydrogen is replaced by a 4-hydroxybenzyl group. It is a specific agonist for estrogen receptor beta (ERbeta). | 2,3-bis(4-hydroxyphenyl)propionitrile |
| 5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol | A carbotetracyclic compound that is 5,6,11,12-tetrahydrochrysene substituted by hydroxy groups at positions 2 and 8 and by ethyl groups at positions 5 and 11 (the 5R,11R-stereoisomer). It is an agonist of ER-alpha and antagonist of ER-beta receptors. | (R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol |
| estetrol | A 3-hydroxy steroid that is 17beta-estradiol which has been substituted at the 15alpha and 16alpha positions by two additional hydroxy groups. It is a natural estrogen produced exclusively during pregnancy by the fetal liver. | estetrol |
| estradiol 3-benzoate | A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol. | 17beta-estradiol 3-benzoate |
| fludioxonil | A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria. | fludioxonil |
| lasofoxifene | A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women. | lasofoxifene |
| psoralidin | A member of the class of coumestans that is coumestan substituted by hydroxy groups at positions 3 and 9 and a prenyl group at position 2 respectively. | psoralidin |
| resolvin d2 | A member of the class of resolvins that is (4Z,8E,10Z,12E,14E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 7, 16 and 17 (the 7S,16R,17S-stereoisomer). | resolvin D2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 29.9033 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 10.0000 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 11.2202 | 1 | 1 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 2 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 32.8152 | 3 | 5 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 9.8633 | 11 | 13 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 21.0726 | 3 | 3 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 30.1638 | 3 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 27.8298 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 37.9330 | 1 | 1 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 10.6910 | 1 | 1 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 34.0620 | 2 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 18.8677 | 2 | 4 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 59.6218 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 12.1972 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 12.1972 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 28.2057 | 3 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 21.2950 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 31.9503 | 1 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 58.3344 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 31.9394 | 2 | 4 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 31.6228 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 15.8498 | 2 | 5 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0028 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 15.8498 | 2 | 5 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 52.0764 | 2 | 3 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 11.2947 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 3.1623 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 33.7858 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 30.7369 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 9.1804 | 2 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 27.3060 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 6.2378 | 2 | 3 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 50.1187 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 18.4270 | 10 | 15 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 17.2289 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 20.1439 | 10 | 13 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 22.5438 | 1 | 5 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 27.3084 | 2 | 4 |
| G | Vesicular stomatitis virus | Potency | 33.7858 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 9.1804 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 20.9236 | 4 | 7 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 13.4587 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 15.2379 | 2 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 12.3566 | 2 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 25.1106 | 1 | 5 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 24.6693 | 3 | 6 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 24.3365 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 4.1957 | 2 | 10 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 44.7164 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 33.7858 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 43.6412 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 14.1406 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 33.7858 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 33.7858 | 1 | 1 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 10.0422 | 2 | 5 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 15.8489 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 16.9441 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 37.6460 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 25.1254 | 2 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 29.1056 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 13.4574 | 2 | 3 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 11.2947 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 19.0919 | 2 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 22.7406 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 58.0479 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 47.8693 | 2 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 48.9662 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 16.5311 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 27.4268 | 3 | 3 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 13.9943 | 2 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 3.6125 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 40.2472 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 31.4254 | 3 | 6 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 25.6651 | 2 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 19.1180 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 5.7457 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 14.1406 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 21.5774 | 2 | 2 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 64.7758 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 17.2475 | 2 | 2 |
| putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | Potency | 39.8107 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 18.6582 | 2 | 2 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 58.0479 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 25.2288 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 24.9846 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 19.4432 | 4 | 7 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 16.4816 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 22.7406 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.4358 | 2 | 5 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 39.0713 | 4 | 9 |
| Thrombopoietin | Homo sapiens (human) | Potency | 6.4776 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 12.6837 | 2 | 2 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 24.8033 | 1 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 16.4139 | 3 | 6 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 27.6211 | 2 | 3 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 19.2841 | 2 | 3 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 60.3740 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 24.3365 | 1 | 1 |
| Vpr | Human immunodeficiency virus 1 | Potency | 35.4813 | 1 | 1 |