Hsp90 inhibitor

An EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor that blocks the action of heat shock protein 90.

ChEBI ID: 63962

Members (19)

Member	Definition	Class
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.	alvespimycin
8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amine	A member of the class of 6-aminopurines that is 2-fluoroadenine carrying additional 2-chloro-3,4,5-trimethoxybenzyl and pent-4-yn-1-yl substituents at positions 8 and 9 respectively.	8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amine
at 13387	A member of the class of isoindoles that is isoindole in which the amino group has been acylated by a 2,4-dihydroxy-5-isopropylbenzoyl group and in which position 5 of the isoidole moiety has been substituted by a (4-methylpiperazin-1-yl)methyl group. A second-generation Hsp90 inhibitor.	onalespib
cct018159	A member of the class of pyrazoles that is 1H-pyrazole carrying 1,4-benzodioxane-6-yl and 5-ethyl-2,4-dihydroxyphenyl substituents at positions 4 and 5 respectively.	CCT-018159
celastrol	A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).	celastrol
cnf 2024	A member of the class of 2-aminopurines that is 2-aminopurine which is substituted by a chlorine at position 6 and by a (4-methoxy-3,5-dimethylpyridin-2-yl)methyl group at position 9.	BIIB021
coumermycin	A hydroxycoumarin antibiotic that is obtained from Streptomyces rishiriensis and exhibits potent antibacterial and anticancer activity.	coumermycin A1
dicumarol	A hydroxycoumarin that is methane in which two hydrogens have each been substituted by a 4-hydroxycoumarin-3-yl group. Related to warfarin, it has been used as an anticoagulant.	dicoumarol
epigallocatechin gallate	A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	(-)-epigallocatechin 3-gallate
ethoxyquin	A quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6.	ethoxyquin
gamendazole	A member of the class of indazoles that is 3-(indazol-3-yl}prop-2-enoic acid carrying additional 2,4-dichlorobenzyl and trifluoromethyl substituents at positions 1 and 6 respectively. An orally active antispermatogenic compound with antifertility effects that is a potential male contraceptive drug.	gamendazole
gedunin	A pentacyclic triterpenoid natural product found particularly in Azadirachta indica and Cedrela odorata.	gedunin
geldanamycin	An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.	geldanamycin
herbimycin	A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.	herbimycin
monascorubrin		monascorubrin
sb 203580	A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.	SB 203580
tanespimycin	A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects.	tanespimycin
ver 52296	A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(2,4-dihydroxy-5-isopropylphenyl)-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxylic acid with the amino group of ethylamine.	luminespib
ver-49009	An aromatic amide obtained by formal condensation of the carboxy group of 5-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)pyrazole-3-carboxylic acid with the amino group of ethylamine.	5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)pyrazole-3-carboxamide

Research

Studies (14,256)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	1,938 (13.59)	18.7374
1990's	1,261 (8.85)	18.2507
2000's	4,308 (30.22)	29.6817
2010's	5,327 (37.37)	24.3611
2020's	1,422 (9.97)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	264 (1.77%)	5.53%
Reviews	707 (4.73%)	6.00%
Case Studies	80 (0.53%)	4.05%
Observational	2 (0.01%)	0.25%
Other	13,904 (92.96%)	84.16%

Protein Targets (706)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	21.5927	1	5
15-lipoxygenase, partial	Homo sapiens (human)	Potency	19.2203	1	3
67.9K protein	Vaccinia virus	Potency	8.9716	2	2
acetylcholinesterase	Homo sapiens (human)	Potency	79.9007	1	1
acid sphingomyelinase	Homo sapiens (human)	Potency	25.1189	1	1
activating transcription factor 6	Homo sapiens (human)	Potency	47.8419	2	5
Adenosine receptor A1	Rattus norvegicus (Norway rat)	Potency	10.0000	1	1
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	25.1647	1	7
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	22.3872	1	1
AR protein	Homo sapiens (human)	Potency	32.2751	10	26
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	17.3583	2	5
ATAD5 protein, partial	Homo sapiens (human)	Potency	10.1269	6	6
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	29.5156	1	2
caspase-3	Cricetulus griseus (Chinese hamster)	Potency	68.4153	1	2
Caspase-7	Cricetulus griseus (Chinese hamster)	Potency	68.4153	1	2
Cellular tumor antigen p53	Homo sapiens (human)	Potency	26.0844	3	10
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	11.2947	2	2
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	21.4442	1	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	3.1623	1	1
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	25.1189	1	1
Chain A, HADH2 protein	Homo sapiens (human)	Potency	26.4013	2	8
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	44.6684	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	17.7638	1	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	11.7908	1	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	19.9754	1	4
Chain B, HADH2 protein	Homo sapiens (human)	Potency	26.4013	2	8
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	3.3633	1	3
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	1.3386	1	3
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	7.5515	1	7
cytochrome P450 2D6	Homo sapiens (human)	Potency	7.8024	1	5
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	21.1613	1	2
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	7.0420	2	10
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	8.7216	2	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	14.2999	1	1
DNA polymerase beta	Homo sapiens (human)	Potency	0.4467	1	1
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	23.8770	1	2
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	23.1478	10	24
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	11.8832	1	1
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	31.7179	5	11
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	10.1663	1	4
EWS/FLI fusion protein	Homo sapiens (human)	Potency	9.0057	4	24
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	24.2130	2	2
flap endonuclease 1	Homo sapiens (human)	Potency	35.4813	1	1
Fumarate hydratase	Homo sapiens (human)	Potency	32.8968	1	4
G	Vesicular stomatitis virus	Potency	7.5515	1	7
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
galactokinase	Homo sapiens (human)	Potency	10.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	7.0420	1	5
geminin	Homo sapiens (human)	Potency	8.8022	2	5
GLI family zinc finger 3	Homo sapiens (human)	Potency	37.5126	2	8
glp-1 receptor, partial	Homo sapiens (human)	Potency	5.6234	1	1
glucocerebrosidase	Homo sapiens (human)	Potency	0.7943	1	1
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	21.3202	2	3
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	33.4915	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	35.4813	1	1
heat shock protein beta-1	Homo sapiens (human)	Potency	47.5275	2	5
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	7.1642	2	15
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	39.1180	2	6
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	7.5515	1	7
hypothetical protein, conserved	Trypanosoma brucei	Potency	31.6228	1	1
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	37.7491	2	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	1.2589	2	2
IDH1	Homo sapiens (human)	Potency	10.3225	1	1
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	7.5515	1	14
Integrin alpha-IIb	Homo sapiens (human)	Potency	10.0000	1	1
Integrin beta-3	Homo sapiens (human)	Potency	10.0000	1	1
Interferon beta	Homo sapiens (human)	Potency	4.0512	3	29
lamin isoform A-delta10	Homo sapiens (human)	Potency	10.8942	1	5
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	22.1060	1	2
Luciferase	Photinus pyralis (common eastern firefly)	Potency	39.8537	2	6
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	3.9811	1	1
Microtubule-associated protein tau	Homo sapiens (human)	Potency	14.8214	2	5
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	18.8541	1	2
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	12.5893	1	1
Nrf2	Homo sapiens (human)	Potency	19.9526	1	1
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	36.2154	4	13
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	29.0929	1	1
nuclear factor NF-kappa-B p105 subunit isoform 1	Homo sapiens (human)	Potency	12.5893	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	52.9707	1	1
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	42.1632	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	18.8657	2	5
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	23.4314	3	11
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	44.6684	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	0.0721	1	1
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	37.4382	5	12
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	42.0971	4	6
phosphopantetheinyl transferase	Bacillus subtilis	Potency	30.6694	1	2
plasminogen precursor	Mus musculus (house mouse)	Potency	31.6228	1	1
polyprotein	Zika virus	Potency	32.8968	1	4
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	12.5893	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	15.9027	1	3
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	21.2804	1	2
PPM1D protein	Homo sapiens (human)	Potency	1.8181	1	14
pregnane X nuclear receptor	Homo sapiens (human)	Potency	38.3088	3	4
pregnane X receptor	Rattus norvegicus (Norway rat)	Potency	45.8577	1	2
progesterone receptor	Homo sapiens (human)	Potency	30.7538	1	2
pyruvate kinase PKM isoform a	Homo sapiens (human)	Potency	3.9811	2	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	19.6559	2	3
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	1.5912	1	2
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	54.8276	3	6
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	26.6729	3	5
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	2.4172	3	3
SMAD family member 2	Homo sapiens (human)	Potency	38.7317	2	4
SMAD family member 3	Homo sapiens (human)	Potency	38.7317	2	4
Smad3	Homo sapiens (human)	Potency	1.2450	1	2
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	5.3972	1	2
TDP1 protein	Homo sapiens (human)	Potency	19.0065	2	10
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	50.1727	1	2
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	89.1251	1	1
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	30.2658	3	14
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	39.1512	1	2
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	33.9558	5	6
tyrosine-protein kinase Yes	Homo sapiens (human)	Potency	17.9872	1	3
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	31.6228	1	1
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	31.6228	1	1
USP1 protein, partial	Homo sapiens (human)	Potency	48.2242	2	5
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	29.4962	2	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	51.2080	4	7
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	55.3275	1	5
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	33.4915	1	1
Vpr	Human immunodeficiency virus 1	Potency	0.7943	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
10 kDa chaperonin	Escherichia coli	IC50	0.4700	2	2
10 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	2.3000	1	1
3-oxoacyl-[acyl-carrier-protein] reductase	Plasmodium falciparum 3D7	IC50	0.3200	1	1
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	0.3000	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	Homo sapiens (human)	IC50	7.2833	1	6
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	IC50	0.0036	1	1
6-phosphogluconate dehydrogenase, decarboxylating	Homo sapiens (human)	IC50	0.7200	1	1
60 kDa chaperonin	Escherichia coli K-12	IC50	250.0000	1	1
60 kDa chaperonin	Escherichia coli	IC50	0.4700	2	2
60 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	2.3000	1	1
72 kDa type IV collagenase	Homo sapiens (human)	IC50	7.6143	2	7
Adenosine receptor A1	Homo sapiens (human)	IC50	2.9500	1	1
Adenosine receptor A1	Homo sapiens (human)	Ki	1.7210	1	1
Adenosine receptor A2a	Homo sapiens (human)	IC50	6.0680	1	1
Adenosine receptor A2a	Homo sapiens (human)	Ki	3.4070	1	1
Alpha-(1,3)-fucosyltransferase 7	Homo sapiens (human)	IC50	7.2833	1	6
Alpha-amylase 1A	Homo sapiens (human)	IC50	1,400.0000	1	1
Amine oxidase [flavin-containing] B	Rattus norvegicus (Norway rat)	IC50	0.3600	1	2
Amyloid-beta precursor protein	Homo sapiens (human)	IC50	27.0250	4	4
Angiopoietin-1 receptor	Homo sapiens (human)	IC50	20.0000	1	1
Apoptosis regulator Bcl-2	Homo sapiens (human)	IC50	0.4500	1	1
Apoptosis regulator Bcl-2	Homo sapiens (human)	Ki	0.3622	2	2
ATP phosphoribosyltransferase	Mycobacterium tuberculosis H37Rv	Ki	60.0000	1	1
ATP-dependent molecular chaperone HSC82	Saccharomyces cerevisiae S288C	IC50	6.4133	1	3
ATP-dependent molecular chaperone HSP82	Saccharomyces cerevisiae S288C	IC50	9.1222	4	9
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	0.1234	2	2
Bcl-2-like protein 1	Homo sapiens (human)	IC50	0.5900	1	1
Bcl-2-like protein 10	Homo sapiens (human)	IC50	0.3600	1	1
Bcl-2-like protein 2	Homo sapiens (human)	IC50	2.3300	1	1
Bcl-2-related protein A1	Homo sapiens (human)	IC50	1.7900	1	1
Bcl2-associated agonist of cell death	Homo sapiens (human)	Ki	0.4900	1	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	0.2150	2	2
Beta-secretase 1	Homo sapiens (human)	IC50	1.1785	2	2
BH3-interacting domain death agonist	Homo sapiens (human)	IC50	1.0733	6	6
Bile salt export pump	Homo sapiens (human)	IC50	126.9650	2	2
Breakpoint cluster region protein	Homo sapiens (human)	IC50	3.0000	2	4
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	IC50	50.0000	1	1
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	IC50	50.0000	1	1
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	IC50	50.0000	1	1
Cannabinoid receptor 1	Homo sapiens (human)	Ki	33.6000	2	2
Cannabinoid receptor 2	Homo sapiens (human)	Ki	42.8000	1	1
Casein kinase I isoform delta	Homo sapiens (human)	IC50	0.4147	3	3
Casein kinase I isoform epsilon	Homo sapiens (human)	IC50	1.0000	1	1
cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	IC50	11.4760	1	1
Chain A, Erk2	Homo sapiens (human)	Ki	0.0004	1	1
Chain A, Heat shock protein HSP 90-alpha	Homo sapiens (human)	IC50	0.0190	1	3
Chain A, Heat shock protein HSP 90-alpha	Homo sapiens (human)	Ki	0.0017	1	1
Chain A, POLYMERASE PA	Influenza A virus	IC50	1.9000	1	1
Chain A, Polymerase Pa	Influenza A virus (A/California/04/2009(H1N1))	IC50	1.9000	1	4
Cholesteryl ester transfer protein	Homo sapiens (human)	IC50	0.0400	1	1
Cholinesterase	Homo sapiens (human)	IC50	0.0026	1	1
Citron Rho-interacting kinase	Homo sapiens (human)	IC50	1.0000	1	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	Homo sapiens (human)	IC50	7.2833	1	6
Corticotropin releasing hormone receptor 2	Sus scrofa (pig)	IC50	0.0040	1	1
CPG DNA methylase	Spiroplasma monobiae	Ki	0.0280	1	1
CREB-binding protein	Homo sapiens (human)	IC50	50.0000	2	2
Cyclin-G-associated kinase	Homo sapiens (human)	IC50	0.4133	3	3
Cytochrome P450 1A2	Homo sapiens (human)	IC50	1.0070	2	2
Cytochrome P450 2C19	Homo sapiens (human)	IC50	0.2940	2	3
Cytochrome P450 2C9	Homo sapiens (human)	IC50	0.3455	2	4
Cytochrome P450 2C9	Homo sapiens (human)	Ki	1.2500	2	2
Cytochrome P450 2D6	Homo sapiens (human)	IC50	1.0070	2	2
Cytochrome P450 3A4	Homo sapiens (human)	IC50	0.0380	2	2
Cytochrome P450 3A43	Homo sapiens (human)	IC50	0.0140	1	1
Cytochrome P450 3A5	Homo sapiens (human)	IC50	0.0140	1	1
Cytochrome P450 3A7	Homo sapiens (human)	IC50	0.0140	1	1
Delta-type opioid receptor	Mus musculus (house mouse)	IC50	0.0200	1	1
Dipeptidyl peptidase 4	Homo sapiens (human)	IC50	10.2100	1	1
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)	IC50	21.0000	1	1
DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)	IC50	0.5000	1	1
DNA repair protein RAD52 homolog	Homo sapiens (human)	IC50	2.5108	5	5
DNA-dependent protein kinase catalytic subunit	Homo sapiens (human)	IC50	40.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	IC50	61.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	IC50	61.0000	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	IC50	2.9324	5	5
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Rattus norvegicus (Norway rat)	IC50	0.3300	1	1
Endoplasmin	Canis lupus familiaris (dog)	IC50	0.0380	2	5
Endoplasmin	Homo sapiens (human)	IC50	0.0535	2	2
Endoplasmin	Homo sapiens (human)	Ki	0.0900	1	2
Endothelial PAS domain-containing protein 1	Homo sapiens (human)	IC50	7.5252	4	4
Enoyl-[acyl-carrier-protein] reductase [NADH]	Francisella tularensis subsp. tularensis SCHU S4	IC50	47.0000	1	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	Escherichia coli K-12	IC50	10.0000	2	2
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	0.2250	2	2
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum (malaria parasite P. falciparum)	Ki	0.0910	3	3
Ephrin type-B receptor 2	Homo sapiens (human)	IC50	7.8000	1	1
Epidermal growth factor receptor	Homo sapiens (human)	IC50	64.5000	2	2
Fatty acid synthase	Gallus gallus (chicken)	IC50	68.0000	3	3
Fatty acid synthase	Homo sapiens (human)	IC50	51.9700	1	1
G-protein coupled receptor 35	Homo sapiens (human)	Ki	0.0390	1	1
Genome polyprotein	Zika virus	IC50	87.0000	1	1
Glucose-6-phosphate 1-dehydrogenase	Saccharomyces cerevisiae S288C	IC50	0.2500	1	1
Heat shock protein 75 kDa, mitochondrial	Homo sapiens (human)	IC50	0.5507	4	7
Heat shock protein 75 kDa, mitochondrial	Homo sapiens (human)	Ki	0.0390	1	2
Heat shock protein HSP 90	Oryctolagus cuniculus (rabbit)	IC50	1.1410	2	2
Heat shock protein HSP 90-alpha	Homo sapiens (human)	GI50	0.0320	1	1
Heat shock protein HSP 90-alpha	Homo sapiens (human)	IC50	6.5061	72	100
Heat shock protein HSP 90-alpha	Homo sapiens (human)	Ki	0.0813	7	9
Heat shock protein HSP 90-beta	Homo sapiens (human)	IC50	7.3081	53	82
Heat shock protein HSP 90-beta	Homo sapiens (human)	Ki	0.0542	6	11
Heat-shock protein	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	20.1000	1	1
Heme oxygenase 1	Rattus norvegicus (Norway rat)	IC50	18.0000	1	1
Heme oxygenase 2	Rattus norvegicus (Norway rat)	IC50	18.0000	1	1
Hepatocyte growth factor receptor	Homo sapiens (human)	IC50	10.0000	1	1
Hepatocyte growth factor receptor	Homo sapiens (human)	Ki	3.3000	1	1
Histidine kinase	Caulobacter vibrioides	IC50	17.6500	1	2
Histone acetyltransferase KAT2B	Homo sapiens (human)	IC50	60.0000	2	2
Histone acetyltransferase KAT5	Homo sapiens (human)	IC50	70.0000	2	2
Histone acetyltransferase p300	Homo sapiens (human)	IC50	30.0000	2	2
Histone deacetylase 1	Homo sapiens (human)	IC50	334.0000	3	3
Histone deacetylase 11	Homo sapiens (human)	IC50	334.0000	3	3
Histone deacetylase 2	Homo sapiens (human)	IC50	334.0000	3	3
Histone deacetylase 3	Homo sapiens (human)	IC50	334.0000	3	3
Histone deacetylase 4	Homo sapiens (human)	IC50	334.0000	3	3
Histone deacetylase 5	Homo sapiens (human)	IC50	334.0000	3	3
Histone deacetylase 6	Homo sapiens (human)	IC50	334.0000	3	3
Histone deacetylase 7	Homo sapiens (human)	IC50	334.0000	3	3
Histone deacetylase 8	Homo sapiens (human)	IC50	334.0000	3	3
Histone deacetylase 9	Homo sapiens (human)	IC50	334.0000	3	3
Hypoxia-inducible factor 1-alpha	Homo sapiens (human)	IC50	4.3521	7	7
Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)	IC50	8.4100	1	1
Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens (human)	IC50	0.9200	1	1
Integrase	Human immunodeficiency virus 1	IC50	166.6667	2	3
L-ornithine N(5)-monooxygenase	Aspergillus fumigatus Af293	IC50	11.0000	2	2
Lethal factor	Bacillus anthracis	IC50	0.0970	1	1
Lysine-specific demethylase 4B	Homo sapiens (human)	IC50	0.7000	1	3
Lysine-specific demethylase 4C	Homo sapiens (human)	IC50	0.7000	1	3
Lysine-specific demethylase 5A	Homo sapiens (human)	IC50	0.1300	1	3
Lysine-specific demethylase 6B	Homo sapiens (human)	IC50	0.4000	1	3
MAP kinase-activated protein kinase 5	Homo sapiens (human)	IC50	1.0000	1	1
Matrilysin	Homo sapiens (human)	IC50	9.3143	2	7
Matrix metalloproteinase-14	Homo sapiens (human)	IC50	6.8000	1	1
Microtubule-associated protein tau	Homo sapiens (human)	IC50	1.8000	1	1
Mitogen-activated protein kinase 1	Homo sapiens (human)	IC50	4.4260	1	1
Mitogen-activated protein kinase 1	Rattus norvegicus (Norway rat)	IC50	500.0240	1	2
Mitogen-activated protein kinase 10	Homo sapiens (human)	IC50	0.6933	3	3
Mitogen-activated protein kinase 10	Homo sapiens (human)	Ki	0.0900	1	1
Mitogen-activated protein kinase 11	Homo sapiens (human)	IC50	0.2646	26	27
Mitogen-activated protein kinase 12	Homo sapiens (human)	IC50	0.2329	21	22
Mitogen-activated protein kinase 13	Homo sapiens (human)	IC50	0.2329	21	22
Mitogen-activated protein kinase 14	Homo sapiens (human)	IC50	15.1567	74	77
Mitogen-activated protein kinase 14	Homo sapiens (human)	Ki	0.0375	2	2
Mitogen-activated protein kinase 14	Mus musculus (house mouse)	IC50	0.0560	1	3
Mitogen-activated protein kinase 2	Pneumocystis carinii	IC50	0.1050	1	1
Mitogen-activated protein kinase 9	Homo sapiens (human)	IC50	2.3871	7	7
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	IC50	10.6660	1	1
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	Ki	2.5690	1	1
Myeloperoxidase	Homo sapiens (human)	Ki	0.0900	1	1
Myotonin-protein kinase	Homo sapiens (human)	IC50	1.0000	1	1
NAD	Homo sapiens (human)	IC50	0.2585	7	8
NAD	Rattus norvegicus (Norway rat)	Ki	0.0010	1	1
NAD kinase	Homo sapiens (human)	IC50	0.9600	1	1
NAD kinase	Homo sapiens (human)	Ki	3.2800	1	1
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Ki	0.0900	1	1
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	Ki	0.0900	1	1
Neutrophil elastase	Homo sapiens (human)	IC50	6.4125	2	2
P2X purinoceptor 7	Homo sapiens (human)	IC50	5.0000	1	1
P2X purinoceptor 7	Rattus norvegicus (Norway rat)	IC50	30.0000	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	IC50	20.0000	1	1
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	Homo sapiens (human)	IC50	13.3000	1	1
Phosphoglycerate mutase 1	Homo sapiens (human)	IC50	0.4900	2	2
Plasminogen activator inhibitor 1	Homo sapiens (human)	IC50	0.0910	1	1
Polyamine deacetylase HDAC10	Homo sapiens (human)	IC50	334.0000	3	3
Polymerase acidic protein	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	IC50	5.8600	1	1
Proprotein convertase subtilisin/kexin type 7	Homo sapiens (human)	IC50	1.3000	1	1
Prostaglandin E synthase	Homo sapiens (human)	IC50	1.8000	1	1
Prostaglandin G/H synthase 1	Homo sapiens (human)	IC50	3.5000	2	2
Proteasome subunit beta type-5	Homo sapiens (human)	IC50	6.3620	3	3
Protein kinase C alpha type	Homo sapiens (human)	IC50	75.0000	1	1
Protein kinase C beta type	Homo sapiens (human)	IC50	75.0000	1	1
Protein kinase C delta type	Homo sapiens (human)	IC50	75.0000	1	1
Protein kinase C epsilon type	Homo sapiens (human)	IC50	75.0000	1	1
Protein kinase C eta type	Homo sapiens (human)	IC50	75.0000	1	1
Protein kinase C gamma type	Homo sapiens (human)	IC50	75.0000	1	1
Protein kinase C iota type	Homo sapiens (human)	IC50	75.0000	1	1
Protein kinase C theta type	Homo sapiens (human)	IC50	75.0000	1	1
Protein kinase C zeta type	Homo sapiens (human)	IC50	75.0000	1	1
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	IC50	5.0000	1	1
Putative heat shock protein HSP 90-alpha A4	Homo sapiens (human)	IC50	0.4600	1	2
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	IC50	0.7575	4	4
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50	9.4635	2	2
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	IC50	1.0359	7	8
Receptor-type tyrosine-protein phosphatase epsilon	Homo sapiens (human)	IC50	500.0000	1	1
Receptor-type tyrosine-protein phosphatase eta	Homo sapiens (human)	IC50	111.5000	1	1
Regulator of G-protein signaling 17	Homo sapiens (human)	IC50	27.9338	5	5
Replicase polyprotein 1ab	Betacoronavirus England 1	IC50	10.0000	1	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	4.2000	2	3
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	10.3000	2	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Ki	4.2000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	Ki	4.2000	2	2
Reverse transcriptase/RNaseH	Human immunodeficiency virus 1	IC50	0.7300	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus (rabbit)	IC50	12.0000	1	1
Serine/threonine-protein kinase 36	Homo sapiens (human)	IC50	1.0000	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	IC50	1.0000	1	1
Serine/threonine-protein kinase D1	Homo sapiens (human)	IC50	75.0000	1	1
Serine/threonine-protein kinase D3	Homo sapiens (human)	IC50	75.0000	1	1
Serine/threonine-protein kinase NLK	Homo sapiens (human)	IC50	1.0000	1	1
Sigma non-opioid intracellular receptor 1	Cavia porcellus (domestic guinea pig)	IC50	10.0000	1	1
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	IC50	0.0100	1	1
Squalene monooxygenase	Rattus norvegicus (Norway rat)	IC50	0.6900	2	2
Telomerase reverse transcriptase	Homo sapiens (human)	IC50	1.0100	4	4
TGF-beta receptor type-1	Homo sapiens (human)	IC50	18.0000	2	2
Thiosulfate sulfurtransferase	Homo sapiens (human)	IC50	7.3000	1	1
Thromboxane-A synthase	Homo sapiens (human)	IC50	0.4940	1	1
Tissue-type plasminogen activator	Homo sapiens (human)	IC50	0.0910	1	1
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	IC50	1.0000	1	1
Tryptophan 2,3-dioxygenase	Homo sapiens (human)	IC50	100.0000	1	1
Tyrosinase	Mus musculus (house mouse)	IC50	0.0340	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	IC50	3.0000	2	4
Tyrosine-protein kinase Lck	Homo sapiens (human)	IC50	3.4500	1	1
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	IC50	6.7000	3	3
Tyrosine-protein phosphatase non-receptor type 11	Homo sapiens (human)	IC50	3.5667	3	3
Tyrosine-protein phosphatase non-receptor type 2	Homo sapiens (human)	IC50	20.9000	2	2
Tyrosine-protein phosphatase non-receptor type 6	Homo sapiens (human)	IC50	15.4500	2	2
Tyrosine-protein phosphatase non-receptor type 7	Homo sapiens (human)	IC50	75.7000	1	1
Ubiquitin carboxyl-terminal hydrolase 15	Homo sapiens (human)	IC50	31.4000	1	5
Ubiquitin carboxyl-terminal hydrolase 2	Homo sapiens (human)	IC50	31.4000	1	5
Ubiquitin carboxyl-terminal hydrolase isozyme L1	Homo sapiens (human)	IC50	31.4000	1	5
Ubiquitin carboxyl-terminal hydrolase isozyme L3	Homo sapiens (human)	IC50	31.4000	1	5
Ubiquitin carboxyl-terminal hydrolase isozyme L5	Homo sapiens (human)	IC50	31.4000	1	5
Urease	Canavalia ensiformis (jack bean)	IC50	15.0728	2	2
Urokinase-type plasminogen activator	Homo sapiens (human)	IC50	0.0910	1	1
Urokinase-type plasminogen activator	Mus musculus (house mouse)	IC50	0.0910	1	1
Virulence sensor histidine kinase PhoQ	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	IC50	261.0000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	10.0000	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (human)	Kd	10.0000	2	2
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Activin receptor type-1	Homo sapiens (human)	Kd	10.0000	2	2
Activin receptor type-1B	Homo sapiens (human)	Kd	3.0000	2	2
Activin receptor type-2A	Homo sapiens (human)	Kd	10.0000	2	2
Activin receptor type-2B	Homo sapiens (human)	Kd	10.0000	2	2
ALK tyrosine kinase receptor	Homo sapiens (human)	Kd	10.0000	2	2
Angiopoietin-1 receptor	Homo sapiens (human)	Kd	10.0000	2	2
Ankyrin repeat and protein kinase domain-containing protein 1	Homo sapiens (human)	Kd	10.0000	2	2
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
ATP-dependent molecular chaperone HSP82	Saccharomyces cerevisiae S288C	Kd	1.2000	1	1
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	10.0000	2	2
Atypical kinase COQ8B, mitochondrial	Homo sapiens (human)	Kd	3.1000	2	2
Aurora kinase A	Homo sapiens (human)	Kd	10.0000	2	2
Aurora kinase B	Homo sapiens (human)	Kd	10.0000	2	2
Aurora kinase C	Homo sapiens (human)	Kd	10.0000	2	2
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	Kd	10.0000	2	2
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	10.0000	2	2
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	3.3000	1	1
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	10.0000	2	2
Calcium-dependent protein kinase 1	Plasmodium falciparum 3D7	Kd	0.8500	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	10.0000	2	2
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	10.0000	2	2
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	10.0000	2	2
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	Kd	10.0000	2	2
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	0.0750	1	1
Casein kinase I isoform alpha-like	Homo sapiens (human)	Kd	1.7000	2	2
Casein kinase I isoform delta	Homo sapiens (human)	Kd	0.0370	2	2
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	0.1400	3	3
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	10.0000	2	2
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	10.0000	2	2
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	10.0000	2	2
Casein kinase II subunit alpha	Homo sapiens (human)	Kd	10.0000	2	2
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	10.0000	2	2
Cell division control protein 2 homolog	Plasmodium falciparum 3D7	Kd	10.0000	1	1
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
cGMP-dependent protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Kd	21.6000	1	1
Chain A, Troponin C, slow skeletal and cardiac muscles	Homo sapiens (human)	Kd	1,100.0000	1	1
Cholesteryl ester transfer protein	Homo sapiens (human)	Kd	0.1235	1	4
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	0.4200	2	2
Cyclin-dependent kinase 11A	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 11B	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 14	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 15	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 18	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 19	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 8	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase-like 1	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase-like 2	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase-like 3	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	0.0257	3	3
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	Kd	10.0000	2	2
Death-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Death-associated protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Death-associated protein kinase 3	Homo sapiens (human)	Kd	10.0000	3	3
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	5.0000	2	2
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	9.6000	2	2
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	1.4000	1	1
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	1
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	2.5000	2	2
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	10.0000	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
eIF-2-alpha kinase GCN2	Homo sapiens (human)	Kd	10.0000	2	2
Endoplasmin	Canis lupus familiaris (dog)	EC50	0.0945	1	2
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-A receptor 6	Homo sapiens (human)	Kd	1.2000	2	2
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-A receptor 8	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-B receptor 1	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	8.9333	3	3
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	3.1000	1	1
Epidermal growth factor receptor	Homo sapiens (human)	Kd	1.6783	23	23
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	1.0000	2	2
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	10.0000	2	2
Fibroblast growth factor receptor 2	Homo sapiens (human)	Kd	10.0000	2	2
Fibroblast growth factor receptor 3	Homo sapiens (human)	Kd	10.0000	4	4
Fibroblast growth factor receptor 4	Homo sapiens (human)	Kd	10.0000	2	2
Focal adhesion kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
G protein-coupled receptor kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	EC50	4.1267	3	3
GABA theta subunit	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	EC50	0.0325	1	2
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	10.0000	2	2
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	1.7000	2	2
Heat shock factor protein 1	Homo sapiens (human)	EC50	1.8500	2	2
Heat shock protein 90, putative	Plasmodium falciparum 3D7	Kd	0.2435	2	2
Heat shock protein HSP 90-alpha	Homo sapiens (human)	EC50	0.1674	17	28
Heat shock protein HSP 90-alpha	Homo sapiens (human)	Kd	0.4963	17	20
Heat shock protein HSP 90-beta	Homo sapiens (human)	EC50	0.2809	12	18
Heat shock protein HSP 90-beta	Homo sapiens (human)	Kd	0.5639	10	13
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	9.4750	4	4
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	10.0000	2	2
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	1
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
Hormonally up-regulated neu tumor-associated kinase	Homo sapiens (human)	Kd	10.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	Kd	10.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	Kd	10.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	10.0000	2	2
Insulin receptor	Homo sapiens (human)	Kd	10.0000	2	2
Insulin receptor-related protein	Homo sapiens (human)	Kd	10.0000	2	2
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	10.0000	2	2
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	10.0000	2	2
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
L-ornithine N(5)-monooxygenase	Aspergillus fumigatus Af293	Kd	1.4000	2	2
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	Kd	10.0000	2	2
Leukotriene C4 synthase	Cavia porcellus (domestic guinea pig)	Kd	10.0000	1	1
LIM domain kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
LIM domain kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Kd	10.0000	2	2
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	10.0000	1	1
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	10.0000	2	2
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	10.0000	2	2
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	10.0000	2	2
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	Kd	10.0000	15	15
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	10.0000	2	2
Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	10.0000	2	2
Microtubule-associated serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Misshapen-like kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	0.0383	3	3
Mitogen-activated protein kinase 11	Homo sapiens (human)	EC50	0.0600	1	1
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	0.1000	4	4
Mitogen-activated protein kinase 12	Homo sapiens (human)	EC50	0.0600	1	1
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	1.1775	4	4
Mitogen-activated protein kinase 13	Homo sapiens (human)	EC50	0.0600	1	1
Mitogen-activated protein kinase 13	Homo sapiens (human)	Kd	5.0050	2	2
Mitogen-activated protein kinase 14	Homo sapiens (human)	EC50	0.0600	2	2
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	0.0128	6	6
Mitogen-activated protein kinase 14	Mus musculus (house mouse)	Kd	0.0200	2	2
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase 4	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase 6	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	1.1333	3	3
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	0.1183	3	3
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase kinase kinase 12	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 13	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 15	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 19	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	4.4000	2	2
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	3.7000	2	2
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	10.0000	2	2
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	Kd	10.0000	2	2
Myosin light chain kinase 3	Homo sapiens (human)	Kd	10.0000	1	1
Myosin light chain kinase family member 4	Homo sapiens (human)	Kd	10.0000	2	2
Myosin light chain kinase, smooth muscle	Gallus gallus (chicken)	Kd	10.0000	1	1
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	10.0000	2	2
Myosin-IIIa	Homo sapiens (human)	Kd	10.0000	2	2
Myosin-IIIb	Homo sapiens (human)	Kd	10.0000	2	2
Myotonin-protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
NAD kinase	Homo sapiens (human)	Kd	1.7800	1	1
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	10.0000	2	2
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	7.3333	3	3
NT-3 growth factor receptor	Homo sapiens (human)	Kd	10.0000	2	2
NUAK family SNF1-like kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)	Kd	0.3000	3	3
Peripheral plasma membrane protein CASK	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (human)	Kd	10.0000	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	Homo sapiens (human)	Kd	2.6000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Kd	10.0000	12	12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (human)	Kd	10.0000	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	10.0000	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	10.0000	2	2
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	Kd	10.0000	2	2
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Kd	10.0000	2	2
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	10.0000	2	2
Polycomb protein EED	Homo sapiens (human)	Kd	15.1000	1	1
POsterior Segregation	Caenorhabditis elegans	EC50	5.8920	1	1
Prostaglandin G/H synthase 2	Homo sapiens (human)	Kd	10.0000	1	1
Protein kinase C delta type	Homo sapiens (human)	Kd	10.0000	2	2
Protein kinase C epsilon type	Homo sapiens (human)	Kd	10.0000	2	2
Protein kinase C eta type	Homo sapiens (human)	Kd	10.0000	2	2
Protein kinase C iota type	Homo sapiens (human)	Kd	10.0000	1	1
Protein kinase C theta type	Homo sapiens (human)	Kd	10.0000	2	2
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	10.0000	2	2
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	5.6000	3	3
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	10.0000	6	6
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	Kd	10.0000	2	2
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	5.3000	2	2
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Kd	0.9800	2	2
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Kd	10.0000	2	2
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	Kd	10.0000	1	1
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	Kd	4.8000	1	1
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	0.7160	3	3
Receptor-interacting serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	10.0000	12	12
recombinase A	Mycobacterium tuberculosis H37Rv	EC50	87.1000	2	2
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Rhodopsin kinase GRK1	Homo sapiens (human)	Kd	10.0000	1	1
Rhodopsin kinase GRK7	Homo sapiens (human)	Kd	10.0000	1	1
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	5.1600	4	4
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	10.0000	4	4
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	10.0000	2	2
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	10.0000	4	4
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	10.0000	4	4
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	5.1250	4	4
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 17B	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 24	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 25	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 32A	Homo sapiens (human)	Kd	1.3000	1	1
Serine/threonine-protein kinase 32B	Homo sapiens (human)	Kd	2.1000	2	2
Serine/threonine-protein kinase 32C	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 33	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 35	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 36	Homo sapiens (human)	Kd	1.1533	3	3
Serine/threonine-protein kinase 38	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	0.6200	4	4
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase Chk2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase D1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase DCLK3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase MAK	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	6.2000	2	2
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	2.7000	2	2
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	0.4000	2	2
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase Nek11	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek4	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase Nek6	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase NIM1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	0.0250	2	2
Serine/threonine-protein kinase OSR1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PknB	Mycobacterium tuberculosis H37Rv	Kd	10.0000	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PRP4 homolog	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase RIO1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase RIO2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase RIO3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase SBK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Sgk3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	3.9000	1	1
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	Kd	3.5000	2	2
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase ULK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase VRK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	10.0000	1	1
Signal transducer and activator of transcription 1-alpha/beta	Homo sapiens (human)	Kd	0.7000	1	1
SNF-related serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	EC50	0.7270	1	1
SRSF protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
SRSF protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
SRSF protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	1
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	4.0000	3	3
STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Testis-specific serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
TGF-beta receptor type-1	Homo sapiens (human)	Kd	7.1000	2	2
TGF-beta receptor type-2	Homo sapiens (human)	Kd	1.8000	2	2
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	1.0467	3	3
Transient receptor potential cation channel subfamily M member 6	Homo sapiens (human)	Kd	10.0000	1	1
Transthyretin	Homo sapiens (human)	Kd	0.4000	2	2
Tubulin alpha-1A chain	Rattus norvegicus (Norway rat)	Kd	10.0000	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	9.3864	22	22
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase Blk	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	2.6667	3	3
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	10.0000	3	3
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	2.8000	2	2
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase Mer	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase receptor Tie-1	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase Srms	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase TXK	Homo sapiens (human)	Kd	4.5000	2	2
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	Kd	6.0800	1	1
Uncharacterized serine/threonine-protein kinase SBK3	Homo sapiens (human)	Kd	10.0000	1	1
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Kd	10.0000	2	2
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Kd	10.0000	2	2
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Kd	10.0000	2	2
Wee1-like protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
Wee1-like protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Zinc finger protein mex-5	Caenorhabditis elegans	EC50	0.7270	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Dihydrofolate reductase	Homo sapiens (human)	Activity	0.9200	1	1
Heat shock protein HSP 90-alpha	Homo sapiens (human)	Concentration	5.0000	1	1
Heat shock protein HSP 90-beta	Homo sapiens (human)	Activity	0.5337	2	3
Heat shock protein HSP 90-beta	Homo sapiens (human)	K	0.0610	1	1
Lactoperoxidase	Bos taurus (cattle)	Km	0.3200	1	1
NAD	Homo sapiens (human)	Activity	11.0000	1	1
replicative DNA helicase	Mycobacterium tuberculosis H37Rv	AC50	24.5480	2	2
Tissue factor	Homo sapiens (human)	Concentration	5.0000	1	1

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Hsp90 inhibitor

Members (19)

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Studies (14,256)

Study Types

Protein Targets (706)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements