Roles > EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor
Page last updated: 2024-08-05 15:43:25
EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor
An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29).
ChEBI ID: 102248
Members (2)
| Member | Definition | Class |
|---|
| dimethyloxalylglycine | A glycine derivative that is the diester obtained by formal condensation of the carboxy groups of N-oxalylglycine with two molecules of methanol. | dimethyloxalylglycine |
| fg-4592 | An N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid. It is an inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH). | roxadustat |
Research
Studies (210)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.48) | 18.2507 |
| 2000's | 1 (0.48) | 29.6817 |
| 2010's | 74 (35.24) | 24.3611 |
| 2020's | 134 (63.81) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 30 (14.02%) | 5.53% |
| Reviews | 24 (11.21%) | 6.00% |
| Case Studies | 10 (4.67%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 150 (70.09%) | 84.16% |
Protein Targets (10)
Potency Measurements
Inhibition Measurements
Activation Measurements