A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell.
| Member | Definition | Class |
|---|
| 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone | A differentiation-inducing factor that is hexaphenone bearing two chloro substituents at positions 3 and 5, two hydroxy substituents at positions 2 and 6 as well as a single methoxy substituent at position 4. A secreted, chlorinated molecule that controls cell fate during development of Dictyostelium cells. | 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one |
| 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl-)-1-pentanone | A differentiation-inducing factor that is pentaphenone bearing two chloro substituents at positions 3 and 5, two hydroxy substituents at positions 2 and 6 as well as a single methoxy substituent at position 4. A secreted, chlorinated molecule that controls cell fate during development of Dictyostelium cells. | 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one |
| 2-heptyl-3-hydroxy-4-quinolone | A quinolone consisting of quinolin-4(1H)-one carrying a heptyl substituent at position 2 and a hydroxy group at position 3. | 2-heptyl-3-hydroxy-4-quinolone |
| 8-nitroguanosine 3',5'-cyclic monophosphate | A 3',5'-cyclic purine nucleotide that is guanosine 3',5'-cyclic monophosphate in which the hydrogen at position 8 on the purine fragment has been replaced by a nitro group. | 8-nitroguanosine 3',5'-cyclic monophosphate |
| arachidonoylserotonin | An N-acylserotonin obtained by formal condensation of the carboxy group of arachidonic acid with the primary amino group of serotonin. | N-arachidonoylserotonin |
| bis(3',5')-cyclic diguanylic acid | A cyclic purine dinucleotide that is the 3',5'-cyclic dimer of MP. | c-di-GMP |
| carbon monoxide | A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas. | carbon monoxide |
| cyclic 3',5'-uridine monophosphate | A 3',5'-cyclic pyrimidine nucleotide having uridine as the nucleobase. | 3',5'-cyclic UMP |
| gamma-aminobutyric acid | A gamma-amino acid that is butanoic acid with the amino substituent located at C-4. | gamma-aminobutyric acid zwitterion; gamma-aminobutyric acid |
| hydrogen sulfide | A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen. | hydrogen sulfide |
| my 12-62c | A quinolone consisting of quinolin-4(1H)-one carrying a heptyl substituent at position 2. | 2-heptyl-4-hydroxyquinoline; 2-heptyl-4-quinolone |
| my 12-62c | A monohydroxyquinoline that is 4-hydroxyquinoline bearing an additional heptyl substituent at position 2. | 2-heptyl-4-hydroxyquinoline; 2-heptyl-4-quinolone |
| naadp | A nicotinic acid dinucleotide that is NADP(+) in which the carboxamide group on the pyridine ring is replaced by a carboxy group. | nicotinic acid-adenine dinucleotide phosphate |
| s-nitrosoglutathione | A glutathione derivative that is glutathione in which the hydrogen attached to the sulfur has been replaced by a nitroso group. | S-nitrosoglutathione |
| sphingosine 1-phosphate | A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1 | sphingosine 1-phosphate |
| tretinoin | A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. | all-trans-retinoic acid |
| tropodithietic acid | A monocarboxylic acid that is 8,9-dithiabicyclo[5.2.0]nona-1,3,6-triene substituted by a carboxy group at position 2 and an oxo group at position 3. It is a broad spectrum antibiotic produced by the marine bacterium Phaeobacter inhibens that also acts as a signalling molecule at lower concentrations. | tropodithietic acid |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 58.2993 | 1 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 35.5182 | 1 | 4 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 1.7783 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 12.4064 | 7 | 15 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 39.1150 | 2 | 3 |
| arylsulfatase A | Homo sapiens (human) | Potency | 8.4921 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 1.4575 | 1 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 27.4122 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 26.4096 | 2 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 31.1448 | 2 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0130 | 2 | 4 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 41.5774 | 1 | 3 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 68.5199 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 68.5199 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 55.9470 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 8.9125 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 35.7168 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 14.2500 | 2 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 31.0990 | 2 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 19.4971 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 4.1092 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 7.4771 | 11 | 29 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 31.1877 | 2 | 6 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 11.9970 | 10 | 22 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 21.1728 | 1 | 7 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 28.3860 | 4 | 9 |
| G | Vesicular stomatitis virus | Potency | 27.5404 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 16.9264 | 3 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 9.0323 | 3 | 7 |
| GLS protein | Homo sapiens (human) | Potency | 0.2512 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 58.3079 | 1 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.2188 | 1 | 3 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 1.0323 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 49.6428 | 2 | 6 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 35.7168 | 1 | 2 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 0.0794 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 56.0456 | 2 | 4 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 0.2512 | 2 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 1.0323 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 27.5404 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 2.8157 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 47.2810 | 2 | 4 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 28.1274 | 2 | 6 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 7.0795 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 41.3145 | 4 | 8 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 3.2643 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 6.3903 | 1 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 24.0778 | 3 | 9 |
| Parkin | Homo sapiens (human) | Potency | 3.6626 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.1284 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 13.8468 | 4 | 10 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 22.1439 | 3 | 5 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 79.4328 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 42.8055 | 2 | 5 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 37.6188 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 3.9743 | 2 | 6 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 19.2954 | 1 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 11.0429 | 3 | 10 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 0.4110 | 3 | 8 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 21.1923 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 1.0323 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 15.3236 | 2 | 6 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 35.4813 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 22.9600 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 30.6776 | 3 | 8 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 9.9777 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 23.8924 | 4 | 4 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 37.9117 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 67.8334 | 1 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 47.3936 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 0.2188 | 1 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 13.8500 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 5.3000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.3580 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.2280 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 13.8500 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 5.3000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 5.2750 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 2.9820 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.2750 | 1 | 1 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.0004 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.7458 | 2 | 4 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.2750 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.7458 | 2 | 4 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 3 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 0.1800 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 71.5000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Carbonic anhydrase | Methanosarcina thermophila | Ki | 50.0000 | 1 | 1 |
| Carbonic anhydrase | Methanothermobacter thermautotrophicus str. Delta H | Ki | 700.0000 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 3,940.0000 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 580.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 0.6000 | 8 | 8 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 5,200.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 35.8667 | 9 | 9 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 3,900.0000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 710.0000 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 1,240.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 7.0000 | 1 | 1 |
| Carbonic anhydrase, alpha family | Hydrogenovibrio crunogenus XCL-2 | Ki | 1.1000 | 1 | 1 |
| Cellular retinoic acid-binding protein 1 | Gallus gallus (chicken) | IC50 | 0.5233 | 3 | 3 |
| Chain A, Nuclear Receptor ROR-beta | Rattus norvegicus (Norway rat) | Ki | 0.2800 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 11.2000 | 3 | 3 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 | 4.3675 | 3 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0323 | 9 | 12 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0332 | 10 | 12 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 0.0333 | 9 | 11 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 700.0247 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 0.1165 | 2 | 2 |
| Gamma-aminobutyric acid type B receptor subunit 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0292 | 4 | 4 |
| Gamma-aminobutyric acid type B receptor subunit 2 | Rattus norvegicus (Norway rat) | IC50 | 0.0292 | 4 | 4 |
| Histone deacetylase 1 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | IC50 | 301.3000 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 2 | Mus musculus (house mouse) | IC50 | 28.7000 | 1 | 1 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 0.5760 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Nuclear receptor ROR-alpha | Homo sapiens (human) | IC50 | 0.1995 | 1 | 1 |
| Nuclear receptor ROR-beta | Homo sapiens (human) | IC50 | 12.6224 | 2 | 2 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | IC50 | 0.1995 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | IC50 | 0.8200 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Ki | 0.8200 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 4,000.0000 | 1 | 1 |
| Retinoic acid receptor alpha | Homo sapiens (human) | IC50 | 2.2542 | 4 | 4 |
| Retinoic acid receptor alpha | Mus musculus (house mouse) | IC50 | 0.0057 | 3 | 3 |
| Retinoic acid receptor alpha | Homo sapiens (human) | Ki | 0.0688 | 3 | 3 |
| Retinoic acid receptor beta | Homo sapiens (human) | IC50 | 0.7537 | 4 | 4 |
| Retinoic acid receptor beta | Mus musculus (house mouse) | IC50 | 0.0050 | 2 | 2 |
| Retinoic acid receptor beta | Homo sapiens (human) | Ki | 0.0095 | 3 | 3 |
| Retinoic acid receptor gamma | Mus musculus (house mouse) | IC50 | 0.0040 | 2 | 2 |
| Retinoic acid receptor gamma | Homo sapiens (human) | IC50 | 0.0064 | 3 | 3 |
| Retinoic acid receptor gamma | Homo sapiens (human) | Ki | 0.0056 | 4 | 4 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Retinoic acid receptor RXR-alpha | Mus musculus (house mouse) | IC50 | 18.0000 | 3 | 3 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | Ki | 0.2268 | 3 | 3 |
| Retinoic acid receptor RXR-beta | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Retinoic acid receptor RXR-beta | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| Retinoic acid receptor RXR-beta | Homo sapiens (human) | Ki | 0.3118 | 3 | 3 |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | IC50 | 0.3500 | 1 | 1 |
| Retinoic acid receptor RXR-gamma | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | Ki | 0.1365 | 3 | 3 |
| RocR | Pseudomonas aeruginosa PAO1 | IC50 | 0.0200 | 1 | 1 |
| Sodium- and chloride-dependent betaine transporter | Homo sapiens (human) | IC50 | 15.8771 | 30 | 57 |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 | Homo sapiens (human) | IC50 | 5.2623 | 4 | 5 |
| Sodium- and chloride-dependent GABA transporter 1 | Mus musculus (house mouse) | IC50 | 10.3241 | 5 | 6 |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 2.1520 | 5 | 15 |
| Sodium- and chloride-dependent GABA transporter 2 | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 2 | Mus musculus (house mouse) | IC50 | 20.7214 | 3 | 3 |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 2.5100 | 2 | 2 |
| Sodium- and chloride-dependent GABA transporter 3 | Homo sapiens (human) | IC50 | 5.3962 | 4 | 5 |
| Sodium- and chloride-dependent GABA transporter 3 | Mus musculus (house mouse) | IC50 | 17.5743 | 3 | 3 |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| Sodium- and chloride-dependent taurine transporter | Homo sapiens (human) | IC50 | 354.0000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.0230 | 1 | 1 |
| Sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | IC50 | 0.0008 | 6 | 6 |
| Sphingosine 1-phosphate receptor 2 | Homo sapiens (human) | IC50 | 0.0019 | 4 | 4 |
| Sphingosine 1-phosphate receptor 3 | Homo sapiens (human) | IC50 | 0.0004 | 6 | 6 |
| Sphingosine 1-phosphate receptor 4 | Homo sapiens (human) | IC50 | 0.0522 | 7 | 7 |
| Sphingosine 1-phosphate receptor 5 | Homo sapiens (human) | IC50 | 0.0020 | 5 | 5 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 91.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | IC50 | 4.6350 | 3 | 4 |