An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC 1.14.13.70 (sterol 14alpha-demethylase).
| Member | Definition | Class |
|---|
| azaconazole | A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2,4-dichlorophenyl and 1,2,4-triazol-1-ylmethyl groups. A fungicide used mainly in ornamental crops to control canker and other diseases. Azaconazole is moderately toxic to mammals but is not expected to bioaccumulate. It is moderately toxic to birds, fish and aquatic invertebrates. | azaconazole |
| difenoconazole | A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms. | difenoconazole |
| efinaconazole | A member of the class of triazoles that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,4-difluorophenyl, and 4-methylenepiperidin-1-yl groups, respectively (the 2R,3R stereoisomer). It is an antifungal drug used for the topical treatment of onychomycosis (a nail infection caused mainly by dermatophytes). | efinaconazole |
| fluquinconazole | A member of the class of quinazolines that is 6-fluoroquinazolin-4-one carrying additional 1,2,4-triazol-1-yl and 2,4-dichlorophenyl substituents at positions 2 and 3 respectively. A fungicide used to control Ascomycetes, Deuteromycetes and Basidiomycetes spp. on cereals, beets and fruit. | fluquinconazole |
| flusilazole | An organosilicon compound that is dimethylsilane in which the hydrogens attached to the silicon are replaced by p-fluorophenyl groups and a hydrogen attached to one of the methyl groups is replaced by a 1H-1,2,4-triazol-1-yl group. It is a broad-sepctrum fungicide used to protect a variety of crops. | flusilazole |
| flutrimazole | An imidazole antifungal agent that is imidazole in which the hydrogen attached to the nitrogen is replaced by a 2,4'-difluorotrityl group. A topical antifungal agent which displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts. | flutrimazole |
| isavuconazole | A 1,3-thiazole that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,5-difluorophenyl, and 4-(p-cyanophenyl)-1,3-thiazol-2-yl groups, respectively. It is an antifungal drug used for the treatment of invasive aspergillosis and invasive mucormycosis. | isavuconazole |
| liquid crystal polymer | A member of the class of oxolanes carrying 1,2,4-triazol-ylmethyl and 2,4-dichlorophenyl substituents at position 2 as well as a bromo substituent at position 4. A foliar applied conazole fungicide for a range of crops including cereals, fruit, vegetables and vines. | bromuconazole |
| metconazole | A member of the class of cyclopentanols carrying 1,2,4-triazol-1-ylmethyl and 4-chlorobenzyl and geminal dimethyl substituents at positions 1, 2 and 5 respectively. Used to control a range of fungal infections including alternaria, rusts, fusarium and septoria diseases. | metconazole |
| neticonazole | An enamine that is ethene which is substituted at positions 1, 1, and 2 by o-pentoxyphenyl, 1H-imidazol-1-yl, and methylthio groups, respectively (the E isomer). An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan (generally as the corresponding hydrochloride salt) as an antifungal drug for the treatment of superficial skin infections. | neticonazole |
| prochloraz | A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables. | prochloraz |
| propiconazole | The cyclic ketal obtained by formal condensation of 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone with pentane-1,2-diol. A triazole fungicide, it is used commercially as a diastereoisomeric mixture on soft fruit (including apricots, peaches, nectarines, plums and prunes), nuts (including peanuts, pecans and almonds), mushrooms, and grasses grown for seeds. | propiconazole |
| triadimenol | A member of the class of triazoles that is 3,3-dimethyl-1-(1,2,4-triazol-1-yl)butane-1,2-diol substituted at position O1 by a 4-chlorophenyl group. A fungicide for cereals, beet and brassicas used to control a range of diseases including powdery mildew, rusts, bunts and smuts. | triadimenol |
| triforine | A member of the class of N-alkylpiperazines in which the two amino groups of piperazine are replaced by 1-formamido-2,2,2-trichloroethyl groups. A fungicide active against a range of diseases including powdery mildew, scab and rust. | triforine |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 64.9652 | 2 | 5 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 48.1245 | 2 | 7 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 0.3548 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 38.1379 | 10 | 72 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 27.3879 | 3 | 15 |
| Ataxin-2 | Homo sapiens (human) | Potency | 37.1518 | 1 | 4 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 37.1518 | 1 | 4 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 50.8474 | 3 | 13 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 28.1838 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 31.6228 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 7.5951 | 1 | 4 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 20.9524 | 1 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.8958 | 1 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 17.0060 | 1 | 11 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 0.1413 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 47.5801 | 11 | 79 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 49.2180 | 1 | 10 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 30.7159 | 7 | 68 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 24.5382 | 4 | 12 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 7.5951 | 1 | 4 |
| GALC protein | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 18.6533 | 2 | 20 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 47.3584 | 4 | 13 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 47.9675 | 1 | 11 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 40.5356 | 2 | 5 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 31.6228 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 87.2716 | 1 | 3 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 7.5951 | 1 | 4 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 14.5372 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 7.5951 | 1 | 8 |
| Interferon beta | Homo sapiens (human) | Potency | 7.5951 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 89.3584 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 15.9695 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 35.3861 | 3 | 22 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 40.3160 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 21.4509 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 33.8966 | 3 | 31 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 36.1254 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 40.6458 | 5 | 13 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 42.9419 | 5 | 11 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 17.7828 | 1 | 1 |
| polyprotein | Zika virus | Potency | 35.4813 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 19.2209 | 2 | 22 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 26.0664 | 1 | 9 |
| progesterone receptor | Homo sapiens (human) | Potency | 24.5179 | 2 | 14 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 34.4522 | 2 | 21 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 52.0165 | 3 | 16 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 25.9128 | 4 | 20 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 29.1722 | 2 | 5 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 29.1722 | 2 | 5 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 27.2475 | 2 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 18.9966 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 48.8412 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 45.4195 | 3 | 22 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.1548 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 51.7450 | 4 | 10 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 34.5465 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 22.2236 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 38.7238 | 4 | 8 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 47.9675 | 1 | 11 |