Any substance that inhibits the action of sodium-dependent Pi-transporters.
ChEBI ID: 63330
| Member | Definition | Class |
|---|---|---|
| foscarnet | Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity. | phosphonoformic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 224 (14.17) | 18.7374 |
| 1990's | 726 (45.92) | 18.2507 |
| 2000's | 348 (22.01) | 29.6817 |
| 2010's | 225 (14.23) | 24.3611 |
| 2020's | 58 (3.67) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 116 (6.90%) | 5.53% |
| Reviews | 229 (13.61%) | 6.00% |
| Case Studies | 433 (25.74%) | 4.05% |
| Observational | 4 (0.24%) | 0.25% |
| Other | 900 (53.51%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 14,200.0000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 820.0000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 41,700.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 2,210.0000 | 1 | 1 |
| DNA polymerase alpha catalytic subunit | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| DNA polymerase catalytic subunit | Human herpesvirus 3 strain Dumas | IC50 | 0.2800 | 1 | 1 |
| DNA polymerase catalytic subunit | Human herpesvirus 5 strain AD169 | IC50 | 2.5000 | 2 | 2 |
| DNA polymerase delta catalytic subunit | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 11.3444 | 9 | 9 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, probable fosfomycin resistance protein | Pseudomonas aeruginosa PAO1 | Kd | 0.2000 | 1 | 1 |
| Chain B, probable fosfomycin resistance protein | Pseudomonas aeruginosa PAO1 | Kd | 0.2000 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | Kd | 7.1500 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carbonic anhydrase 1 | Homo sapiens (human) | KA | 12.0000 | 1 | 1 |