Page last updated: 2024-09-28

Tricuspid Valve Stenosis

The pathologic narrowing of the orifice of the TRICUSPID VALVE. This hinders the emptying of RIGHT ATRIUM leading to elevated right atrial pressure and systemic venous congestion. Tricuspid valve stenosis is almost always due to RHEUMATIC FEVER.

Synonyms(1)

Synonym
Tricuspid Valve Stenosis

Research Excerpts

Research

Studies (49)

TimeframeStudies, This Condition (%)All Conditions %
pre-199034 (69.39)23.3326
1990's3 (6.12)12.5806
2000's5 (10.20)18.1394
2010's7 (14.29)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
hydrogen carbonate0low10
dalteparin0low10
indoleacetic acid0low10
hydroxyindoleacetic acid0low10
furosemide0low10
isoproterenol0low30
propranolol0low10
krypton0low10
spironolactone0low10
prednisone0low20
chloramphenicol0low10
tromethamine0low10
n-vinyl-2-pyrrolidinone0low10
methysergide0low20
n-pentyl nitrite0low10
technetium0low40
captopril0low10
xenon radioisotopes0low10
atropine0low10
lanatosides0low10
kava0low10
4-hydroxy-2-nonenal0low10
sulfur0low10
indocyanine green0low10
cardiovascular agents0low10
colistin0low10
natriuretic peptide, brain0low10
ascorbic acid0low10
salicylates0low10
warfarin0low30
exudates0low10
trypan blue0low10

Protein Targets (429)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Microtubule-associated protein tau3003
vitamin D3 receptor isoform VDRA5005
Transient receptor potential cation channel subfamily A member 10011
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase3003
RAR-related orphan receptor gamma5005
GLI family zinc finger 3100010
AR protein8008
thioredoxin glutathione reductase3003
cytochrome P450 family 3 subfamily A polypeptide 45005
glucocorticoid receptor [Homo sapiens]6006
retinoic acid nuclear receptor alpha variant 18008
estrogen-related nuclear receptor alpha8008
estrogen nuclear receptor alpha100010
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
IDH14004
euchromatic histone-lysine N-methyltransferase 26006
chromobox protein homolog 15005
nuclear factor erythroid 2-related factor 2 isoform 23003
thyroid hormone receptor beta isoform 28008
nuclear factor erythroid 2-related factor 2 isoform 16006
lethal(3)malignant brain tumor-like protein 1 isoform I1001
geminin7007
lethal factor (plasmid)2002
lamin isoform A-delta104004
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0225
Spike glycoprotein4004
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Atrial natriuretic peptide receptor 10112
Atrial natriuretic peptide receptor 1 0011
Chain A, 2-oxoglutarate Oxygenase3003
nuclear receptor subfamily 1, group I, member 36006
retinoid X nuclear receptor alpha3003
pregnane X nuclear receptor9009
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta1001
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 0202
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
5-hydroxytryptamine receptor 40606
Bile salt export pump0808
Muscarinic acetylcholine receptor M20328
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M10215
Muscarinic acetylcholine receptor M30215
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M20216
Muscarinic acetylcholine receptor M10328
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M30327
Alpha-1D adrenergic receptor0225
5-hydroxytryptamine receptor 2C0617
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor1013
5-hydroxytryptamine receptor 70202
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0112
Canalicular multispecific organic anion transporter 10505
Chain A, angiotensin converting enzyme0101
Chain A, angiotensin converting enzyme0101
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
15-lipoxygenase, partial1001
phosphopantetheinyl transferase2002
Thrombopoietin1001
Metallo-beta-lactamase type 20112
peripheral myelin protein 22 isoform 12002
M-phase phosphoprotein 82002
transient receptor potential cation channel subfamily V member 11001
Prothrombin0101
Renin0101
Neprilysin0101
Neprilysin0101
Leukotriene A-4 hydrolase0213
EEF1AKMT4-ECE2 readthrough transcript protein0101
Angiotensin-converting enzyme 0213
Angiotensin-converting enzyme0203
Leukotriene A-4 hydrolase0101
Thymidine phosphorylase0011
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 20101
Endothelin-converting enzyme 10101
Succinyl-diaminopimelate desuccinylase0202
Angiotensin-converting enzyme0202
Solute carrier family 15 member 10101
Beta-lactamase TEM0101
Mu-type opioid receptor0011
TAR DNA-binding protein 431001
Beta-lactamase 0203
Beta-lactamase 0202
Angiotensin-converting enzyme 2 0101
Beta-lactamase class B VIM-2 0112
ATP-dependent phosphofructokinase2002
interleukin 81001
TDP1 protein6006
aldehyde dehydrogenase 1 family, member A16006
EWS/FLI fusion protein4004
farnesoid X nuclear receptor4004
G2002
cytochrome P450 2D63003
peroxisome proliferator activated receptor gamma4004
aryl hydrocarbon receptor6006
activating transcription factor 64004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
heat shock protein beta-11001
DNA polymerase iota isoform a (long)1001
streptokinase A precursor0011
Dihydroxyacetone phosphate acyltransferase0001
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Cellular tumor antigen p535005
Cytochrome P450 3A40202
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Inositol hexakisphosphate kinase 12002
Methionine--tRNA ligase, mitochondrial0011
cytochrome P450 2C9, partial2002
estrogen receptor 2 (ER beta)4004
thyrotropin-releasing hormone receptor1001
Solute carrier family 22 member 60101
Carbonic anhydrase 120102
Bile salt export pump0303
Carbonic anhydrase 10203
Carbonic anhydrase 20203
Albumin0123
Carbonic anhydrase 30101
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0303
Carbonic anhydrase 40203
Carbonic anhydrase 60102
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 70102
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20202
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0202
Carbonic anhydrase 90102
Multidrug and toxin extrusion protein 10202
Carbonic anhydrase 130102
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140102
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Carbonic anhydrase 5B, mitochondrial0102
Carbonic anhydrase0101
Carbonic anhydrase 150101
endonuclease IV2002
thioredoxin reductase4004
Fumarate hydratase1001
USP1 protein, partial2002
NFKB1 protein, partial1001
GLS protein3003
Smad33003
thyroid stimulating hormone receptor1001
hypothetical protein, conserved1001
regulator of G-protein signaling 43003
polyprotein1001
alpha-galactosidase2002
cytochrome P450 2C9 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
neuropeptide S receptor isoform A1001
Uracil nucleotide/cysteinyl leukotriene receptor0101
Peptide deformylase 1A, chloroplastic/mitochondrial0101
Peptide deformylase 0101
Luciferase3003
pregnane X receptor3003
progesterone receptor4004
thyroid stimulating hormone receptor2002
glp-1 receptor, partial2002
NPYLR7B0011
Beta-1 adrenergic receptor 0125
Histone H2A.x2002
beta-2 adrenergic receptor1001
hexokinase-4 isoform 12002
glucokinase regulatory protein2002
serine/threonine-protein kinase mTOR isoform 11001
peripheral myelin protein 221001
Beta-2 adrenergic receptor0438
Beta-1 adrenergic receptor0426
Beta-2 adrenergic receptor0416
Polyunsaturated fatty acid lipoxygenase ALOX150101
Beta-3 adrenergic receptor0325
D(2) dopamine receptor0415
Alpha-1B adrenergic receptor0314
Beta-1 adrenergic receptor0428
Beta-2 adrenergic receptor0011
Alpha-2B adrenergic receptor0213
D(1A) dopamine receptor0415
D(4) dopamine receptor0101
Alpha-2C adrenergic receptor0213
Alpha-2A adrenergic receptor0213
Alpha-1D adrenergic receptor0314
Beta-adrenergic receptor kinase 10011
Beta-3 adrenergic receptor0011
Beta-3 adrenergic receptor0314
Vasopressin V1a receptor0011
Beta-1 adrenergic receptor0213
Alpha-1A adrenergic receptor0135
Alpha-1B adrenergic receptor0023
Glutamate receptor ionotropic, NMDA 1 0011
D(3) dopamine receptor0303
Alpha-1A adrenergic receptor0314
D(1A) dopamine receptor1001
Beta-2 adrenergic receptor0202
Taste receptor type 2 member 380011
Taste receptor type 2 member 390011
Taste receptor type 2 member 400011
Taste receptor type 2 member 410011
Taste receptor type 2 member 430011
Taste receptor type 2 member 310011
Taste receptor type 2 member 450011
Taste receptor type 2 member 460011
Taste receptor type 2 member 300011
Taste receptor type 2 member 190011
Taste receptor type 2 member 200011
Taste receptor type 2 member 500011
Taste receptor type 2 member 600011
Oxytocin receptor0011
Glutamate receptor ionotropic, NMDA 2A 0011
Glutamate receptor ionotropic, NMDA 2B0011
Glutamate receptor ionotropic, NMDA 2C0011
Beta-2 adrenergic receptor 0112
Glutamate receptor ionotropic, NMDA 2D0011
Taste receptor type 2 member 420011
Beta-2 adrenergic receptor0135
Glutamate receptor ionotropic, NMDA 3B0011
Taste receptor type 2 member 160011
Taste receptor type 2 member 140011
Taste receptor type 2 member 130011
Taste receptor type 2 member 100011
Taste receptor type 2 member 90011
Taste receptor type 2 member 80011
Taste receptor type 2 member 70011
Taste receptor type 2 member 50011
Taste receptor type 2 member 40011
Taste receptor type 2 member 30011
Taste receptor type 2 member 10011
Glutamate receptor ionotropic, NMDA 3A0011
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
PAX80001
67.9K protein2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
dopamine D1 receptor1001
DNA polymerase III, partial1001
arylsulfatase A2002
D(1A) dopamine receptor2002
flap endonuclease 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
histone acetyltransferase KAT2A isoform 11001
Alpha-2A adrenergic receptor0326
5-hydroxytryptamine receptor 1A0416
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 1B0404
5-hydroxytryptamine receptor 2B0415
5-hydroxytryptamine receptor 60415
DNA polymerase kappa isoform 12002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)1001
nuclear receptor ROR-gamma isoform 11001
Glucocorticoid receptor0426
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Nuclear receptor ROR-gamma1001
Gamma-aminobutyric acid receptor subunit pi0112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Cytochrome P450 1A20101
ATP-dependent translocase ABCB10303
5-hydroxytryptamine receptor 1A0101
Adenosine receptor A30112
Cytochrome P450 2C80101
Cytochrome P450 2D60101
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit delta0112
Gamma-aminobutyric acid receptor subunit gamma-20112
Alpha-2C adrenergic receptor0124
D(3) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit alpha-30112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Gamma-aminobutyric acid receptor subunit gamma-10112
Gamma-aminobutyric acid receptor subunit alpha-20112
Endothelin-1 receptor0112
5-hydroxytryptamine receptor 1B0213
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit gamma-30112
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Gamma-aminobutyric acid receptor subunit alpha-60112
Type-1 angiotensin II receptor0112
Sodium-dependent serotonin transporter0202
Cholecystokinin receptor type A0112
Cytochrome P450 2C190202
5-hydroxytryptamine receptor 70112
Mu-type opioid receptor0112
Vasopressin V1a receptor0112
Delta-type opioid receptor0112
Kappa-type opioid receptor0112
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit beta-20112
Potassium voltage-gated channel subfamily H member 20101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
GABA theta subunit0112
Ataxin-22002
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit epsilon0112
Nuclear receptor subfamily 2 group E member 10022
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
SMAD family member 21001
SMAD family member 31001
peroxisome proliferator-activated receptor delta1001
thyroid hormone receptor beta isoform a2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Vpr1001
Voltage-dependent calcium channel gamma-2 subunit1001
Estrogen receptor0213
Progesterone receptor0213
Mineralocorticoid receptor 0203
Androgen receptor0213
Androgen receptor0203
Glutamate receptor 21001
Sodium-dependent serotonin transporter0101
Estrogen receptor beta0112
ATPase family AAA domain-containing protein 51001
Chain A, CARBONIC ANHYDRASE II0101
Chain A, Beta-lactamase1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
PPM1D protein1001
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]