| Excerpt | Reference |
|---|
| "Cushing's syndrome is the common clinical presentation of three unique disorders that give rise to hypercortisolism." | ( Gold, EM, 1979) |
| "Cushing's syndrome is characterized by protein wasting secondary to hypergluconeogenesis, which produces thin skin, poor muscle tone, osteoporosis and capillary fragility." | ( Greenblatt, RB; Rincón, J; Schwartz, RP, 1979) |
| "The etiology of Cushing's syndrome is best determined by combining measurements of basal state plasma adrenocorticotropin (ACTH) levels with the 8-mg high-dose dexamethasone suppression test." | ( Crapo, L, 1979) |
| "Cushing's syndrome is rarely an admitting diagnosis to critical care but is a disorder that can seriously affect recovery from coexisting illnesses if not treated." | ( Gumowski, J; Kessler, CA; Proch, M, 1992) |
| "Two patients with Cushing's syndrome are reported." | ( Arriagada, V; González, G; Michaud, P; Reyes, C; Téllez, R, 1991) |
| "We conclude that hypercortisolism is responsible for the abnormalities in anterior pituitary function in Cushing's syndrome." | ( Astigarraga, B; Bernabeu, I; Cuerda, C; Diez, S; Estrada, J; Marazuela, M; Salto, L; Vicente, A, 1991) |
| "Cushing's syndrome is a rarely observed disease with a poor prognosis when not treated appropriately." | ( Holdener, EE; Rolf, N; Surmann, R; Tenschert, W; Vetter, H; Vetter, W; Winterberg, B; Zumkley, H, 1989) |
| "Cushing's syndrome is caused by hypercortisolism that can be due to (1) medicinal use of steroids, (2) excess pituitary secretion of adrenocorticotropin (ACTH) (Cushing's disease), (3) adrenocortical tumor, benign or malignant, and (4) the ectopic ACTH syndrome." | ( Abumrad, NN; Orth, DN; Scott, HW, 1985) |
| "Cushing's syndrome is the consequence of a sustained overproduction of cortisol (hydrocortisone) by the adrenal cortex." | ( Gabrilove, JL; Krakoff, LR, 1986) |
| "Factitious Cushing's syndrome is a variant of the Münchausen syndrome and should be considered if tests used to establish the diagnosis of Cushing's syndrome appear incongruous particularly in subjects with access to medical intelligence and drugs." | ( Corrall, RJ; O'Hare, JP; Vale, JA; Wood, S, 1986) |
| "Cyclic Cushing's syndrome is a rare but increasingly recognized disorder of periodic fluctuations of adrenal steroid production." | ( Ashcraft, MW; Sakiyama, R; Van Herle, AJ, 1984) |
| "Cushing's syndrome is usually caused by the secretion of corticotropin or cortisol by a pituitary or adrenal tumor, respectively, or by ectopic secretion of corticotropin." | ( Orth, DN, 1995) |
| "Cushing's syndrome is considered to be a risk factor dissecting aneurysm, and in this case the metabolic changes in Cushing's disease may have influenced the development of the dissecting aneurysm." | ( Murakami, O; Nagura, H; Sasano, H; Suzuki, T, 1993) |
| "Cushing's syndrome is rare in children and adolescents." | ( Chrousos, GP; Cutler, GB; Doppman, JL; Gomez, MT; Magiakou, MA; Mastorakos, G; Nieman, LK; Oldfield, EH, 1994) |
| "In conclusion, Cushing's syndrome is associated with a decrease of mean 24-hour plasma TSH, related to a decrease of TSH pulse amplitude (not of TSH pulse frequency)." | ( Adriaanse, R; Brabant, G; Endert, E; Wiersinga, WM, 1994) |
| "A case of Cushing's syndrome is described in a woman who self-treated psoriasis with a variety of potent topical glucocorticoids over 15 years." | ( Bahall, M; Bartholomew, C; Coomansingh, D; Suite, M; Teelucksingh, S, 1993) |
| "Familial Cushing's syndrome is rare, and when it occurs, it is usually associated with primary micronodular dysplasia." | ( Aron, DC; Engeland, WC; Findlay, JC; Sheeler, LR, 1993) |
| "Cushing's syndrome is characterized by central obesity and muscle wasting." | ( Bowes, SB; Carroll, PV; Cummings, MH; Jackson, NC; Lowy, C; Russell-Jones, DL; Sönksen, PH; Umpleby, M, 1997) |
| "Cushing's syndrome is a disease state usually associated with weight gain due to the accumulation of adipose tissue." | ( Astorga, R; Casanueva, FF; Considine, RV; Dieguez, C; Leal-Cerro, A; Peino, R; Venegas, E, 1996) |
| "Cushing's syndrome is associated with psychiatric and psychological disturbances." | ( Faragher, B; Kelly, MJ; Kelly, WF, 1996) |
| "Chronic hypercortisolism is associated with decreased GH responsiveness to GHRH." | ( Borges, MH; DiNinno, FB; Lengyel, AM, 1997) |
| "Cushing's syndrome is characterized by chronic excessive glucocorticoid production, which results in muscle wasting." | ( Attaix, D; Boiteux, JP; Giraud, B; Guy, L; Rallière, C; Taillandier, D; Tauveron, I; Thiéblot, P, 1997) |
| "Cushing's syndrome is a rare disorder." | ( Abs, RE; Berwaerts, JJ; Verhaegen, AA; Verhaert, GC; Verhelst, JA, 1998) |
| "Because Cushing's syndrome is characterized by an endogenous increase in glucocorticoids, we studied levels of FVIII and vWF in 20 patients with Cushing's syndrome." | ( Boscaro, M; Casonato, A; Ferasin, S; Girolami, A; Pontara, E; Sartorello, F; Sonino, N, 1999) |
| "Cushing's syndrome is infrequently associated with adenocarcinomas of the lung." | ( Chaouat, A; Kessler, R; Schott, R; Tavernier, M; Weitzenblum, E, 1999) |
| "Cushing's syndrome is defined as the symptoms and signs of glucocorticoid excess, but the precise diagnosis may be difficult to establish and harder to localise." | ( Grossman, A; Jorgensen, JO; Newell-Price, J, 1999) |
| "Cushing's syndrome is also characterized by central obesity and insulin resistance." | ( Chung, YE; Hong, SK; Kim, GS; Kim, JY; Koh, JM; Lee, KU; Park, JY; Shong, YK, 2000) |
| "Patients with Cushing's syndrome are relatively insensitive to glucocorticoid feedback and exhibit an oversecretion of cortisol devoid of a circadian cycle." | ( Grossman, AB; Newell-Price, J, 2001) |
| "Cushing's syndrome is an uncommon but important disease." | ( Charles, CF; Fletcher, P; Hanchard, B; Kelly, D; Richards, R; Wright-Pascoe, R, 2001) |
| "Chronic severe hypercortisolism is associated with life-threatening infections, diabetes and a high surgical mortality rate." | ( Alexander, RH; Calis, KA; Koch, CA; Krakoff, J; Nieman, LK, 2001) |
| "Cushing's syndrome is associated with hypertension in approximately 80% of cases." | ( Ilias, I; Mullen, N; Nieman, LK; Torpy, DJ, 2002) |
| "Cushing's syndrome is an uncommon disorder, but one that often presents diagnostic challenges to the managing physician." | ( Grossman, AB; Morris, DG, 2003) |
| "The diagnosis of Cushing's syndrome is one of the most difficult and yet one of the most important ones a primary care physician can make." | ( Schuff, KG, 2003) |
| "Cushing's syndrome is accompanied by a reversible decrease in GR affinity, possibly related to an increased GR-beta expression, which may be a compensatory mechanism to GC excess." | ( Brinkmann, AO; de Jong, FH; Feelders, RA; Hagendorf, A; Koper, JW; Lamberts, SW, 2005) |
| "Cushing's syndrome is associated with typical central redistribution of adipose tissue." | ( Haluzík, M; Hána, V; Krsek, M; Kvasnicková, H; Lai, EW; Marek, J; Nedvídková, J; Pacák, K; Rosická, M, 2006) |
| "Iatrogenic Cushing's syndrome is a well-known adverse effect of glucocorticoids." | ( Díez, JJ; González, J; Iglesias, P, 2005) |
| "Endogenous Cushing's syndrome is caused by elevated cortisol levels." | ( Aanderud, S; Bakke, SJ; Bollerslev, J; Carlsen, SM; Evang, JA; Johannesen, Ø; Lund-Johansen, M; Ramm-Pettersen, J; Schreiner, T; Svartberg, J, 2006) |
| "Cushing's syndrome is a rare disease in childhood." | ( Bocca, G; de Delemarre-van Wall, HA; Voorhoeve, PG, 2006) |
| "Cushing's syndrome is a consequence of primary or, more commonly, secondary oversecretion of cortisol." | ( Kelly, JJ; Mangos, G; Whitworth, JA; Williamson, PM, 2005) |
| "Central Cushing's syndrome is not always curable by surgery or radiation of the pituitary." | ( Becker, C; Bierhaus, A; Bode, H; Fohr, B; Hamann, A; Hammes, HP; Humpert, P; Kasperk, C; Morcos, M; Nawroth, PP; Pfisterer, F; Schilling, T; Schwenger, V; Tafel, J; Zeier, M, 2007) |
| "Cyclical Cushing's syndrome is a pattern of hypercortisolism in which the biochemistry of cortisol production fluctuates rhythmically." | ( Atkinson, AB; Mullan, KR; Sheridan, B, 2007) |
| "Cushing's syndrome is a rare but frequently considered disease." | ( Bertagna, X; Fierrard, H; Raffin-Sanson, ML; Rosales, C, 2008) |
| "The incidence of Cushing's syndrome is only 1/100000 per year." | ( Bertagna, X; Fierrard, H; Raffin-Sanson, ML; Rosales, C, 2008) |
| "Cushing's syndrome is a rare endocrine disease characterized by cortisol hypersecretion, induced mainly by a pituitary tumor (Cushing's disease) or, rarely, by an adrenal or an ectopic neuroendocine tumor." | ( Colao, A; De Leo, M; De Martino, MC; Lombardi, G; Pivonello, R, 2008) |
| "ACTH-dependent Cushing's syndrome is a heterogeneous disorder requiring a multidisciplinary and individualized approach to patient management." | ( Bertagna, X; Bertherat, J; Biller, BM; Boscaro, M; Buchfelder, M; Colao, A; Grossman, AB; Hermus, AR; Hofland, LJ; Klibanski, A; Lacroix, A; Lindsay, JR; Melmed, S; Newell-Price, J; Nieman, LK; Petersenn, S; Sonino, N; Stalla, GK; Stewart, PM; Swearingen, B; Vance, ML; Wass, JA, 2008) |
| "Cushing's syndrome is involved in refractory hypertension." | ( Sakihara, S, 2008) |
| "Ectopic Cushing's syndrome is a rare disease with varied manifestations and associated with increased morbidity and mortality." | ( Bhadada, SK; Bhansali, A; Dutta, P; Khandelwal, N; Radotra, BD; Rana, SS; Walia, R, 2009) |
| "Cushing's syndrome is frequently complicated by osteoporosis, which results in an increased tendency for the development of vertebral compression fractures." | ( Heran, MK; Malfair, D; Munk, PL; Rashid, F; Riccio, SA, 2009) |
| "Cushing's syndrome is being recognized with greater frequency and in patients with milder disease." | ( Carroll, TB; Findling, JW, 2009) |
| "Endogenous Cushing's syndrome is a very rare entity, with an incidence of 2-4 cases per million inhabitants per year." | ( da Costa, CV; Lahera Vargas, M, 2009) |
| "Cushing's syndrome is uncommon in children and adolescents." | ( Goñi Iriarte, MJ, 2009) |
| "Cushing's syndrome is an unusual condition which shares phenotypic features with much more common states such as the metabolic syndrome." | ( Ibsen, H; Poulsen, PL, 2009) |
| "Cushing's syndrome is a complex endocrine condition with potential serious complications if untreated or inadequately treated." | ( Schteingart, DE, 2009) |
| "Endogenous Cushing's syndrome is an uncommon endocrine disorder that can often prove challenging, for both initial diagnosis and subsequent differential diagnosis of the underlying cause." | ( Newell-Price, J, 2009) |
| "Cushing's syndrome is commonly complicated with an impairment of glucose metabolism, which is often clinically manifested as diabetes mellitus." | ( Colao, A; Cozzolino, A; De Leo, M; De Martino, MC; Lombardi, G; Pivonello, R; Simeoli, C; Vitale, P, 2010) |
| "Active Cushing's syndrome is associated with insulin resistance induced by the high and prolonged circulating level of glucocorticoids." | ( Munir, A; Newell-Price, J, 2010) |
| "Cushing's syndrome is associated with serious morbidity and increased mortality." | ( de Herder, WW; Feelders, RA; Hofland, LJ, 2010) |
| "Non-iatrogenic Cushing's syndromes are due in 70% of the cases to a pituitary adrenocorticotropic hormone (ACTH)-producing adenoma, and, less frequently, to an adrenal adenoma or an ectopic ACTH secretion by a neuroendocrine tumor." | ( Beckers, A; Petrossians, P; Thonnard, AS, 2010) |
| "Cushing's syndrome is a condition caused by high levels of glucocorticoids, or most commonly as a result of prolonged exposure to exogenous steroids." | ( Biswas, M; Gibby, O; Harding, K; Ivanova-Stoilova, T, 2011) |
| "Subclinical hypercortisolism is significantly more prevalent in bilateral incidentaloma patients, posing great dilemmas for its optimum management." | ( Ntali, G; Tsagarakis, S; Vassiliadi, DA; Vicha, E, 2011) |
| "Cushing's syndrome is associated with increased cardiovascular morbidity and mortality." | ( Deepak, KK; Gupta, N; Jyotsna, VP; Naseer, A; Sreenivas, V, 2011) |
| "Hypercortisolism is a state of chronically elevated cortisol levels due to a failure to return to, or maintain baseline levels." | ( Reini, SA, 2010) |
| "Cyclical Cushing's syndrome is a pattern of hypercortisolism in which the biochemistry of cortisol production fluctuates rhythmically." | ( Atkinson, B; Mullan, KR, 2011) |
| "Cushing's syndrome is associated with excessive cortisol secretion by the adrenal gland or ectopic tumours and may result in diabetes, hypertension, and life-threatening infections with high mortality rates especially in the case of surgical resection." | ( Briegel, J; Geiger, C; Heyn, J; Hinske, CL; Weis, F, 2012) |
| "Pregnancy-induced Cushing's syndrome is exceptionally rare with fewer than ten cases reported in the world literature and none in Australia or New Zealand." | ( Achong, N; D'Emden, M; Fagermo, N; Mortimer, R, 2012) |
| "Cushing's syndrome is a rare condition in the general population (1/1000000) and is even less common during pregnancy." | ( Gayet, FX; Homer, L; Kerlan, V; Laurent, Y; Viatge, M, 2012) |
| "Subclinical hypercortisolism is a secondary cause of hypertension that had never been evaluated in resistant hypertensive patients, a subgroup of general hypertensive individuals with an expected high prevalence of secondary hypertension." | ( Conceição, FL; Martins, LC; Muxfeldt, ES; Salles, GF, 2012) |
| "Cushing's syndrome is a rare disease, responsible for increased morbidity and mortality." | ( Brue, T; Castinetti, F; Conte-Devolx, B, 2012) |
| "Cyclical Cushing's syndrome is detected in our center by collecting sequential early morning urine (EMU) samples for cortisol to creatinine ratio over 28 d." | ( Atkinson, AB; Graham, UM; Hunter, SJ; McDonnell, M; Mullan, KR, 2013) |
| "Endogenous Cushing's syndrome is associated with a higher risk of cardiovascular morbidity and mortality." | ( Ali, N; Chandran, DS; Deepak, KK; Jaryal, AK; Jyotsna, VP, 2013) |
| "Cushing's syndrome is a debilitating endocrine disorder caused by elevated circulating glucocorticoid levels." | ( Laufgraben, MJ; Morgan, FH, 2013) |
| "Hypercortisolism is one of the possible causes of secondary hypertension, but its low prevalence and atypical clinical symptoms can lead to a delayed diagnosis." | ( Canu, L; Corsini, E; Leone, A; Mannelli, M; Montereggi, A; Montereggi, F; Pisaneschi, S, 2013) |
| "Iatrogenic Cushing's syndrome is an undesirable outcome of glucocorticoids treatment." | ( Coignard-Biehler, H; Hermine, O; Jullien, V; Lecuit, M; Lortholary, O; Pilmis, B; Touraine, P, 2013) |
| "Clinically relevant hypercortisolism is a new prognostic factor in patients with completely resected ACC." | ( Allolio, B; Ardito, A; Baudin, E; Berruti, A; Deutschbein, T; Else, T; Fassnacht, M; Feelders, R; Gelderblom, H; Grisanti, S; Haak, H; Hammer, GD; Kerkhofs, T; Kroiss, M; Leboulleux, S; Papotti, M; Porpiglia, F; Ronchi, C; Sperone, P; Terzolo, M; Volante, M; Williams, AR, 2014) |
| "Hypercortisolism is known to cause osteoporosis." | ( Atteritano, M; Basile, G; Catalano, A; Lasco, A; Mallamace, A; Pilato, A, 2014) |
| "The endogenous Cushing's syndrome is rare, but its prevalence, although difficult to define, is much higher in populations at risk." | ( Bertherat, J; Guignat, L, 2014) |
| "Adrenal Cushing's syndrome is caused by excess production of glucocorticoid from adrenocortical tumors and hyperplasias, which leads to metabolic disorders." | ( Cao, Y; Gao, Z; He, J; He, M; Jiang, X; Jiang, Y; Lei, Y; Li, L; Li, X; Li, Y; Liu, L; Ning, G; Peng, Y; Su, T; Wang, H; Wang, J; Wang, W; Wei, Q; Wei, W; Yang, L; Yang, X; Ye, J; Zhong, X; Zhou, W, 2014) |
| "While endogenous Cushing's syndrome is an uncommon cause of both obesity and hypertension, the recent recognition of other hypercortisolemic states has raised the profile of hypercortisolism as an important contributor in obesity hypertension." | ( Nimkevych, O; Uwaifo, GI; Varughese, AG, 2014) |
| "Endogenous Cushing's syndrome is a rare endocrine disorder that incurs significant cardiovascular morbidity and mortality, due to glucocorticoid excess." | ( Duan, K; Gomez Hernandez, K; Mete, O, 2015) |
| "Cushing's syndrome is a complex metabolic disorder that is a result of excess glucocorticoids." | ( Arafah, BM; Bansal, V; El Asmar, N; Selman, WR, 2015) |
| "When hypercortisolism is severe, its signs and symptoms are unmistakable." | ( Nieman, LK, 2015) |
| "Cushing's syndrome is a clinical condition resulting from chronic exposure to excess glucocorticoid." | ( Ba, J; Chen, K; Cui, J; Dou, J; Du, J; Gu, W; Jin, N; Li, J; Lu, J; Lyu, Z; Mu, Y; Pan, C; Wang, X; Yang, G; Yang, L; Zang, L, 2015) |
| "Hypercortisolism is associated with mood disorders such as depression and bipolar disorder." | ( Bartel, M; de Witte, LD; Kleijweg, M; Smits, RB; Valk, GD; Vergeer, M; Vinkers, CH, 2015) |
| "Chronic hypercortisolism is accompanied by a deleterious impact on aspects of cognitive function." | ( Bourdeau, I; Cohen, H; Forget, H; Lacroix, A, 2016) |
| "Cyclic Cushing's syndrome is a type of Cushing's disease which is characterized by alternating periods of increasing and decreasing levels of cortisol in the blood." | ( Doroszewska, K; Kiałka, M; Milewicz, T; Mrozińska, S; Stochmal, E, 2015) |
| "Hypercortisolism is prevalent in type 2 diabetes (T2D), but analytical and functional uncertainties prevail." | ( Christiansen, JS; Dekkers, OM; Jørgensen, JO; Rungby, J; Steffensen, C; Thomsen, HH, 2016) |
| "The hypercortisolism is a rare endocrine disease characterized by an autonomous steroid secretion or excessive adrenal stimulation by ACTH." | ( Stigliano, A; Toscano, V, 2016) |
| "Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing's syndrome, abnormal findings relative to age (e." | ( Araújo, LA; Boguszewski, CL; Bronstein, MD; Czepielewski, MA; Fragoso, MC; Gadelha, MR; Machado, MC; Miranda, PA; Moreira, AC; Musolino, NR; Naves, LA; Ribeiro-Oliveira, A; Vieira, L; Vilar, L, 2016) |
| "Subclinical Cushing's syndrome is discussed as the paradigm." | ( Notarianni, E, 2017) |
| "Cushing's syndrome is associated with hypertrophy of PR adipocytes and a higher percentage of macrophage infiltration in PR adipose tissue." | ( Ballak, DB; d'Ancona, FC; Hermus, ARMM; Langenhuijsen, JF; Netea-Maier, RT; Plantinga, TS; Roerink, SHPP; Rooijackers, HMM; Smit, JWA; van Dielen, FM; Wagenmakers, MAEM, 2017) |
| "ACTH-independent Cushing's syndrome is an uncommon disorder in children." | ( Nourbakhsh, M; Razzaghy Azar, M; Shemshaki, H; Simforoosh, N; Soltani, MH, 2017) |
| "Hypercortisolism is one of the most commonly diagnosed endocrinopathies in dogs, and new targeted medical treatment options are desirable." | ( Galac, S; Kooistra, HS; Mol, JA; Sanders, K; Slob, A, 2018) |
| "Although endogenous Cushing's syndrome is rare in older people, it should always be considered among the differential diagnosis of behavioural disorders." | ( Abbate, C; Belloni, G; Cesari, M; Chiodini, I; Damanti, S; Lucchi, T; Mandelli, C; Mari, D; Nestola, T, 2018) |
| "Cushing's syndrome is associated with multisystem morbidity and, when suboptimally treated, increased mortality." | ( Feelders, RA; Hofland, LJ; Lacroix, A; Newell-Price, J; Nieman, LK; Pivonello, R, 2019) |
| "Cushing's syndrome is defined as chronic excess free cortisol in circulation." | ( Lin, DC; Lin, YC; Tsai, PS, 2019) |
| "Cushing's syndrome is known to present with a characteristic set of clinical manifestations and complications, well described in literature." | ( Alexander, V; Carey, RA; Dasgupta, R; Koshy, M, 2019) |
| "Endogenous Cushing's syndrome is a chronic disease associated with increased morbidity and mortality if not appropriately treated." | ( Cuevas-Ramos, D; Fleseriu, M; Hinojosa-Amaya, JM, 2019) |
| "Cushing's syndrome is caused by increased exposure to cortisol." | ( Hána, V; Hill, M; Ježková, J; Kosák, M; Kršek, M, 2019) |
| "Infantile Cushing's syndrome is potentially found as part of McCune-Albright syndrome (MAS) which is caused by postzygotic somatic mutations of the GNAS gene." | ( Dejkhamron, P; Ittiwut, C; Natesirinilkul, R; Shotelersuk, V; Sunkonkit, K; Suphapeetiporn, K; TangNgam, H, 2019) |
| "However, endogenous Cushing's syndrome is less frequently associated with nocardiosis." | ( Asimakopoulou, A; Gomatou, G; Kopelia, M; Kyriakopoulos, G; Masaoutis, C; Mylonas, CC; Poulakou, G; Syrigos, K, 2019) |
| "Hypercortisolism is a rare endocrine disorder in cats." | ( Chirayath, D; Shaheena, S, 2020) |
| "Severe hypercortisolism is characterized as a life-threatening endocrine condition in patients with Cushing syndrome, usually related to the concomitant onset of one or more comorbidities, requiring rapid normalization of cortisol concentrations and aggressive treatment of associated complications." | ( Boguszewski, CL; Marques, JVO, 2021) |
| "Thus, severe hypercortisolism is a warning sign that CS affected by COVID-19 could require emergency care despite a lack of clinical presentations and low inflammation biomarkers." | ( Belaya, Z; Dedov, I; Dzeranova, L; Fadeev, V; Golounina, O; Gorokhov, M; Kalashnikov, V; Melnichenko, G; Pashkova, E; Tarbaeva, N; Volchkov, P, 2021) |
| "Diagnosis of cyclic Cushing's syndrome is based on at least three periods of confirmed hypercortisolemia interspersed by two periods of normocortisolemia." | ( Berlińska, A; Kłosowski, P; Stefańska, K; Świątkowska-Stodulska, R; Sworczak, K, 2021) |
| "However, endogenous hypercortisolism is a rare, but relevant, cause of bone avascular necrosis." | ( Carvalho, D; Esteves, C; Ferreira, MJ; Pedro, J; Pimenta, T; Portugal, R; Salazar, D, 2021) |
| "Adrenal Cushing's syndrome is characterized by ACTH-independent hypercortisolism." | ( Broekhuis, JM; James, BC; Raje, P; Sacks, BA, 2021) |
| "Cushing's syndrome is associated with high morbidity, with significant inter-individual variability." | ( Allassonnière, S; Amar, L; Armignacco, R; Assié, G; Bertherat, J; Beuschlein, F; Blanchard, A; Bonnet-Serrano, F; Bouys, L; Braun, L; Ceccato, F; Gaspar, C; Jouinot, A; Larsen, CK; Lartigue, T; Neou, M; Perlemoine, K; Reincke, M; Riester, A; Rossi, GP; Scaroni, C; Septier, A; Williams, TA; Zennaro, MC, 2022) |
| "Endogenous Cushing's syndrome is a rare endocrine disorder that is fatal if left untreated." | ( Braun, L; Reincke, M; Vogel, F, 2022) |
| "Severe hypercortisolism is frequently treated by a block and replace approach during which a substitutive treatment is given after the induction of adrenal insufficiency." | ( Castinetti, F, 2022) |
| "Cushing's syndrome is defined by an endogenous or exogenous hypercortisolism." | ( Brue, T; Castinetti, F, 2022) |
| "Hypercortisolism is one of the most common endocrine diseases in dogs." | ( Sousa, MG; Vanhoni, MS; Vila, BCP, 2023) |
| "Endogenous Cushing's syndrome is characterized by unique clinical features and comorbidities, and progress in the analysis of its genetic pathogenesis has been achieved." | ( Iwasaki, Y; Makino, S; Nishiyama, M, 2022) |
| "Cushing's syndrome is associated with metabolic dysregulation, but the significance of adipokines in this entity and related complications is largely unknown." | ( Dadej, D; Ruchała, M; Szczepanek-Parulska, E; Wrotkowska, E, 2022) |
| "Cyclic Cushing's syndrome is a pathological condition characterized by alternating periods of excessive cortisol secretion with corresponding clinical manifestations and periods of spontaneous remission of the disease." | ( Azizyan, VN; Dorovskikh, AV; Dzeranova, LK; Grigoriev, AY; Lapshina, AM; Perepelova, MA; Pigarova, EA; Shutova, AS; Vorotnikova, SY, 2023) |
| "Cushing's syndrome is known as an important cause of secondary osteoporosis, characterized by reduction of bone mineral density and potential occurrence of fragility fractures before diagnosis in young population." | ( Cheng, J; Ju, S; Zhang, Z, 2023) |
| "Cushing's syndrome is one of the most common endocrinopathies in dogs." | ( Holtdirk, A; Klein, R; Kottmann, T; Müller, E; Rehbein, S; Schäfer, I; Thoren-Tolling, K, 2023) |
| "The diagnosis of Cushing's syndrome is challenging; however, through the clinical picture and the search for secondary causes of osteoporosis, it was possible to reach the diagnosis of the case reported." | ( da Silva, LM; de Macedo Veloso, FL; De Oliveira Souza, GZ; Dos Santos Ribeiro Simões Juliano, AC; Ezequiel, DGA; Ferreira, LV; Ferreira, M; Leal, CTS; Reis, BO, 2023) |
| Excerpt | Reference |
|---|
| "In 7 patients with untreated Cushing's syndrome, bilateral uptake was found in 4 patients with bilateral hyperplasia whereas unilateral visualization was obtained in three cases of cortisol producing adenomas." | ( Blichert-Toft, M; Dige-Petersen, H; Fogh, J; Lund, JO; Munkner, T, 1975) |
| "A 52-year-old woman developed recurrent hypercortisolism 3 yr after successful surgical treatment of Cushing's disease." | ( Belding, P; Moore, SA; Schlechte, JA; Tonner, D, 1992) |
| "She underwent conservative treatment for Cushing's syndrome and delivered a normal infant by Caesarean section." | ( Abe, Y; Ito, M; Izumi, Y; Kubo, A; Matsuoka, M; Nakayama, T; Soma, M; Watanabe, M; Watanabe, Y; Yasugi, T, 1992) |
| "Ketoconazole treatment of Cushing's syndrome has been reported in single cases and a few small groups of 5-8 patients." | ( Boscaro, M; Mantero, F; Paoletta, A; Sonino, N; Ziliotto, D, 1991) |
| "A 48-year-old man was admitted for treatment of Cushing's syndrome due to right adrenal adenoma, associated with chronic renal failure (CRF) with a blood urea nitrogen level of 64." | ( Fujiwara, T; Kato, M; Oriso, S; Otokida, K, 1989) |
| "After treatment of the Cushing's syndrome by trans-sphenoidal adenomectomy or adrenalectomy, these defects in cellular sodium balance were corrected." | ( Burke, CW; Evans, DJ; Ng, LL, 1988) |
| "The cause of hypercortisolism was identified by low- and high-dose dexamethasone suppression tests, the ovine corticotropin-releasing hormone (CRH) stimulation test, imaging studies, and bilateral sampling of the inferior petrosal sinuses combined with administration of CRH." | ( Chrousos, GP; Cutler, GB; Doppman, JL; Gomez, MT; Magiakou, MA; Mastorakos, G; Nieman, LK; Oldfield, EH, 1994) |
| "Exploration of mifepristone in the treatment of Cushing's syndrome is in its infancy." | ( Cutler, GB; Sartor, O, 1996) |
| "Prompt evaluation of the cause of the hypercortisolism, initiation of cortisol lowering therapy, primary prophylaxis for Pneumocystis carinii infection when plasma cortisol exceeds 2500 nmol L-1 and a search for concomitant infectious disease is recommended." | ( Bakker, RC; Gallas, PR; Romijn, JA; Wiersinga, WM, 1998) |
| "To control hypercortisolism, the patient was treated with metyrapone." | ( Dokoupilová, M; Hána, V; Marek, J; Plavka, R, 2001) |
| "Medical treatment of hypercortisolism improves muscle strength and resolves the respiratory insufficiency." | ( Alvarez, J; Blanco, C; Flores, J; Marazuela, M, 2001) |
| "This is a very rare case of successful treatment of Cushing's syndrome arising from an ovarian adenocarcinoma secreting multiple endocrine substances." | ( Ino, K; Kajiyama, H; Kikkawa, F; Mizutani, S; Morita, T; Nagasaka, T; Shibata, K; Suzuki, T, 2003) |
| "Thus, we should treat Cushing's syndrome as soon as possible, since many complications, including cardiovascular diseases and infections, will soon occur when the definite diagnosis is delayed." | ( Nishikawa, T; Omura, M; Saito, J, 2008) |
| "Only few adult patients with hypercortisolism were treated to date by this drug." | ( Allolio, B; Bouchard, P; Brue, T; Castinetti, F; Chanson, P; Conte-Devolx, B; Do Cao, C; Fassnacht, M; Hahner, S; Johanssen, S; Morange, I; Ouzounian, S; Picó, A; Terzolo, M; Young, J, 2009) |
| "The effect of clinical treatment of hypercortisolism with ketoconazole on ACTH secretion in CD is controversial." | ( Correa-Silva, SR; Lengyel, AM; Molica, P; Nascif, SO; Sá, LB; Vieira, JG, 2010) |
| "Bilateral adrenalectomy is the standard treatment for Cushing's syndrome (CS) related to ACTH-independent bilateral macronodular hyperplasia (AIMAH), although it imposes life-long adrenal insufficiency." | ( Chabre, O; Chaffanjon, P; Martinie, M; Mazzuco, TL; Sturm, N, 2009) |
| "First-line treatment in Cushing's syndrome consists of the surgical removal of the secreting tumor." | ( Beckers, A; Petrossians, P; Thonnard, AS, 2010) |
| "Medical treatment of hypercortisolism was successful in six of the eight patients with whom it was attempted, and bilateral adrenalectomy had to be performed in only two cases." | ( Baudin, E; Borson-Chazot, F; Coutant, R; More, J; Raverot, G; Reznik, Y; Rohmer, V; Tabarin, A; Young, J, 2011) |
| "Both spontaneous hypercortisolism and chronic glucocorticoid treatment are associated with osteoporosis and low circulating concentrations of 1,25-dihydroxy-vitamin D in humans." | ( Corbee, RJ; Hazewinkel, HA; Kooistra, HS; Meij, BP; Tryfonidou, MA, 2012) |
| "Adrenalectomy during pregnancy for the treatment of Cushing's syndrome caused by adrenocortical adenoma has been reported in 23 patients in the English-language medical literature to date and seems safe and beneficial." | ( Cohen, M; Dickstein, G; Gonen, R; Matter, I; Ohel, G; Saiegh, L; Sammour, RN; Shechner, C, 2012) |
| "Patients with endogenous hypercortisolism, Cushing's syndrome, have significant morbidity and increased mortality when inadequately treated." | ( Carroll, T; Findling, JW, 2012) |
| "Because hypercortisolism symptoms are wide ranging, it is important to assess a variety of outcomes including both clinical factors, such as cortisol levels, and health-related quality of life (HR-QOL), to better understand the severity and impact of CD on patients and the potential efficacy of CD treatment." | ( Badia, X; Coles, T; Forsythe, A; Maldonado, M; McLeod, L; Nelson, LM; Pulgar, S; Webb, SM; Zhang, Y, 2013) |
| "Despite biochemical "cure" of hypercortisolism and clinical improvement after effective treatment, these complications are only partially reversible." | ( Aulinas, A; Valassi, E; Webb, SM, 2014) |
| "Changes in signs and symptoms of hypercortisolism over 12 months' treatment in patients still enroled in the study and with evaluable measurements were assessed in relation to degree of UFC control." | ( Biller, BM; Findling, JW; Gu, F; Hughes, G; Lacroix, A; Maldonado, M; Newell-Price, J; Petersenn, S; Pivonello, R; Salgado, LR; Schopohl, J; Trovato, A, 2014) |
| "The treatment of subclinical hypercortisolism in patients with bilateral adrenal incidentalomas (AI) is debatable." | ( Botoula, E; Karapanou, O; Perogamvros, I; Tsagarakis, S; Tzanela, M; Vassiliadi, DA, 2015) |
| "The baby girl underwent medical treatment of Cushing's syndrome with metyrapone which was followed by a rapid recovery." | ( Dias, P; Gouveia, R; Lourenço, R; Oliveira, G; Sousa, AB, 2015) |
| "Untreated dogs with hypercortisolism had significantly higher epinephrine, norepinephrine, and normetanephrine:creatinine ratios compared to healthy dogs." | ( Boretti, F; Hofmann-Lehmann, R; Quante, S; Rentsch, K; Reusch, C; Riond, B; Salesov, E; Sieber-Ruckstuhl, N, 2017) |
| "Surgery is the definitive treatment of Cushing's syndrome (CS) but medications may also be used as a first-line therapy." | ( Bolanowski, M; Brue, T; Chabre, O; Chanson, P; Droste, M; Fajardo, C; Feelders, RA; Franz, H; Kastelan, D; Komerdus, I; Krsek, M; Maiter, D; Netea-Maier, R; Pfeifer, M; Reincke, M; Santos, A; Strasburger, CJ; Tabarin, A; Tóth, M; Trainer, PJ; Tsagarakis, S; Valassi, E; Wass, JAH; Webb, SM; Yaneva, M, 2018) |
| "Control of both hypercortisolism and the tumor requires multiple treatment modalities, and multidisciplinary management is recommended." | ( Aller Pardo, J; Araujo Castro, M; Armengod Grao, L; Estrada García, J; Izquierdo Alvarez, C; Palacios García, N, 2018) |
| "In the hypercortisolism female mouse model, body weight and food intake were much higher than in the control, and corticosterone, estradiol, cholesterol (CHO) and triglycerides (TG) in the plasma of CORT-treated mice was significantly increased." | ( Hou, G; Hou, Y; Li, L; Li, QN; Liu, ZH; Schatten, H; Sun, QY; Wang, ZB, 2018) |
| "Patients with hypercortisolism did not differ as regards age, BMI, HbA1c, T-score or blood pressure, but a higher proportion of them received antihypertensive treatment (100% vs." | ( Dekkers, OM; Jørgensen, JOL; Lyhne, J; Pedersen, BG; Poulsen, PL; Rasmussen, F; Rungby, J; Steffensen, C, 2019) |
| "Medical therapy to control hypercortisolism in adrenal Cushing's syndrome is currently not the first-line therapy." | ( Braun, LT; Reincke, M, 2020) |
| "We used a noninvasive mouse model of hypercortisolism to compare GC-induced effects on adipose tissue with diet-induced obesity [high-fat diet (HFD) 45%] and control mice after 10 wk of treatment." | ( García-Eguren, G; Giró, O; Hanzu, FA; Sala-Vila, A; Vega-Beyhart, A, 2020) |
| "Changes in clinical signs of hypercortisolism and HRQoL were assessed over 12 months of treatment and were stratified by degree of mUFC control for each patient." | ( Barkan, A; Bronstein, MD; Delibasi, T; Lacroix, A; Li, Y; Ortmann, CE; Petersenn, S; Pivonello, R; Ravichandran, S; Salvatori, R; Schopohl, J; Suzaki, N; Tauchmanova, L, 2020) |
| "Subclinical hypercortisolism may influence patients' mental health and cognitive performances, requiring an integrated treatment." | ( Aresta, C; Arosio, M; Buoli, M; Caldiroli, A; Caletti, E; Chiodini, I; Corbetta, S; Di Giorgio, A; Ghielmetti, A; Grassi, S; Morelli, V; Mucci, F; Passeri, E; Pugliese, F; Scillitani, A; Siri, FM, 2021) |
| "Severe hypercortisolism is characterized as a life-threatening endocrine condition in patients with Cushing syndrome, usually related to the concomitant onset of one or more comorbidities, requiring rapid normalization of cortisol concentrations and aggressive treatment of associated complications." | ( Boguszewski, CL; Marques, JVO, 2021) |
| "Despite adequate treatment, Cushing's syndrome is associated with increased long-term morbidity and mortality." | ( Braun, L; Reincke, M; Vogel, F, 2022) |
| "This is especially the case in severe hypercortisolism for which medical treatment will be given for a short period of time to prepare the patient for surgery, or on a long-term basis after failed transsphenoidal surgery, or when waiting for the maximal beneficial effect of radiation techniques." | ( Castinetti, F, 2022) |
| "In patients with active hypercortisolism, GH secretion is completely suppressed, but it may spontaneously and progressively recover over the years following successful therapy, meaning that GH testing may be performed at an appropriate time after remission for the correct diagnosis." | ( Boguszewski, CL, 2022) |
| "After successful treatment for Cushing's syndrome (CS), secondary adrenal insufficiency develops as a result of the prior suppression of the hypothalamic-pituitary-adrenal (HPA) axis by excess cortisol in the body." | ( Balasko, A; Dusek, T; Kastelan, D; Zibar Tomsic, K, 2022) |
| "Canine pituitary-dependent hypercortisolism (PDH) management with trilostane usually demands lifelong therapy." | ( da Silva Mello, FP; da Silva, CC; de Carvalho, GLC; de Faria Valle, S; de Moura Martins, FS; Furtado, PV; Machado, L; Meirelles, L; Neto, WS; Pöppl, ÁG, 2022) |
| "Ketoconazole effectively controlled hypercortisolism in 66% of Cushing's disease patients, being a relatively safe drug for those without remission after transsphenoidal surgery or whose symptoms must be controlled until a new definitive therapy is carried out." | ( Costa, MCB; Czepielewski, MA; de Melo, RB; Mattos, ACV; Rodrigues, TDC; Viecceli, C, 2022) |