An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Member | Definition | Class |
|---|
| benzonatate | The ester obtained by formal condensation of 4-butylaminobenzoic acid with nonaethylene glycol monomethyl ether. Structurally related to procaine and benzocaine, it has an anaesthetic effect on the stretch sensors in the lungs, and is used as a non-narcotic cough suppressant. | benzonatate |
| butorphanol | Levorphanol in which a hydrogen at position 14 of the morphinan skeleton is substituted by hydroxy and one of the hydrogens of the N-methyl group is substituted by cyclopropyl. A semi-synthetic opioid agonist-antagonist analgesic, it is used as its (S,S)-tartaric acid salt for relief or moderate to severe pain. | butorphanol |
| clofedanol | A diarylmethane that is 2-chlorophenyl(phenyl)methane substituted on the methane carbon by a 2-(dimethylamino)ethyl group. Used in the treatment of dry cough, it suppresses the cough reflex by a direct effect on the cough centre in the medulla of the brain. | clofedanol |
| codeine | A morphinane alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties. | codeine |
| dextromethorphan | A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough. | dextromethorphan |
| diphenhydramine | An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug. | diphenhydramine |
| doxofylline | An oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. | doxofylline |
| doxylamine | | doxylamine |
| germacrone | A germacrane sesquiterpenoid that has formula C15H22O. It is a natural product found in traditional medicinal plants of the family Zingiberaceae. The compound exhibits a range of pharmacological activities including anti-inflammatory, anticancer, antiviral, anti-androgenic, antioxidant, antimicrobial, antifungal, neuroprotective and insecticidal activities. | (E,E)-germacrone |
| glaucine | An aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups. | (S)-glaucine |
| hydrocodone | A morphinane-like compound that is a semi-synthetic opioid synthesized from codeine. | hydrocodone |
| levomethadone | A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (R)-configuration. It is the active enantiomer of methadone and its hydrochloride salt is used to treat adults who are addicted to drugs such as heroin and morphine. | levomethadone |
| menthol | A p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer. | (-)-menthol |
| noscapine | A benzylisoquinoline alkaloid that is 1,2,3,4-tetrahydroisoquinoline which is substituted by a 4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl group at position 1, a methylenedioxy group at positions 6-7 and a methoxy group at position 8. Obtained from plants of the Papaveraceae family, it lacks significant painkilling properties and is primarily used for its antitussive (cough-suppressing) effects. | (-)-noscapine |
| oxycodone | A semisynthetic opioid of formula C18H21NO4 that is derived from thebaine. It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain. | oxycodone |
| pholcodine | A morphinane alkaloid that is a derivative of morphine with a 2-morpholinoethyl group at the 3-position. | pholcodine |
| picrinine | A natural product with formula C20H22N2O3 that is the member of the akuammiline family of alkaloids, first isolated in 1965 from the leaves of Alstonia scholaris. | picrinine |
| tramadol | A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. | (R,R)-tramadol |
| tramadol hydrochloride | A hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride; the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. | (R,R)-tramadol hydrochloride |
| u-50488 | A monocarboxylic acid amide obtained by formal condensation between the carboxy group of 3,4-dichlorophenylacetic acid and the secondary amino group of (1R,2R)-N-methyl-2-(pyrrolidin-1-yl)cyclohexanamine | U50488 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 67.9K protein | Vaccinia virus | Potency | 8.9125 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 71.9654 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 23.9860 | 6 | 8 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 61.9396 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 30.1313 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 16.3535 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 4.7755 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 16.4816 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 69.4974 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 69.4974 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 23.4712 | 2 | 4 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 16.1862 | 2 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 19.2119 | 2 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 7.9433 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0501 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.4424 | 2 | 3 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 0.1585 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 0.1259 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 2.9217 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 4.6312 | 1 | 2 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 4.8645 | 1 | 5 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 4.5822 | 2 | 8 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 4.9918 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 18.0829 | 7 | 11 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 18.8680 | 5 | 7 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.4828 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 29.0189 | 3 | 3 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 29.8470 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 0.1889 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 2.9217 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 4.5822 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 13.0246 | 2 | 5 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 23.7700 | 2 | 10 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 8.1548 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 24.2425 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 13.2154 | 1 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 19.1310 | 1 | 2 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 0.1259 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 2.9217 | 1 | 3 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 50.1187 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 2.1314 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 2.9217 | 1 | 6 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 5.6114 | 2 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 12.5893 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 12.5893 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 2.9217 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 22.1969 | 1 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 12.5893 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 14.3818 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 10.9839 | 2 | 8 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 29.8506 | 2 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 10.3225 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 21.2155 | 2 | 3 |
| Parkin | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 12.8178 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 100.6636 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 14.1254 | 1 | 1 |
| polyprotein | Zika virus | Potency | 35.4813 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 15.6730 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 20.2906 | 2 | 4 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 28.2262 | 2 | 2 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 115.8210 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.1889 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 52.7862 | 2 | 5 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 27.9169 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.5809 | 2 | 7 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 89.1251 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.3981 | 1 | 1 |
| Thrombopoietin | Homo sapiens (human) | Potency | 0.0631 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 18.9063 | 2 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 8.0722 | 2 | 6 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 14.1254 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 14.1254 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 28.7358 | 2 | 3 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 19.1310 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.1710 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 1.2950 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.7673 | 3 | 3 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 1.1180 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.4150 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.4205 | 2 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.9800 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.5130 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.0430 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 76.2000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 3.5420 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 1.3643 | 2 | 3 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 31.8590 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 26.1013 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 282.6000 | 3 | 5 |
| Calcium release-activated calcium channel protein 1 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.4003 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 36.0591 | 2 | 3 |
| Cytochrome P450 2D1 | Rattus norvegicus (Norway rat) | IC50 | 792.0000 | 1 | 2 |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | IC50 | 121.8000 | 1 | 2 |
| Cytochrome P450 2D3 | Rattus norvegicus (Norway rat) | IC50 | 2,053.8000 | 1 | 2 |
| Cytochrome P450 2D4 | Rattus norvegicus (Norway rat) | IC50 | 1,176.0000 | 1 | 2 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 50.4120 | 5 | 7 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 2 |
| D | Rattus norvegicus (Norway rat) | Ki | 2.9000 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 2.8000 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 9.3000 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 10.0000 | 1 | 3 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 8.7167 | 2 | 3 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 8.8372 | 10 | 13 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 3.2500 | 4 | 4 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 3.0435 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | Ki | 1.6800 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 2.2460 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | Ki | 1.6800 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 2.2460 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | Ki | 1.6800 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 2.2460 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | Ki | 1.6800 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 2.2460 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | Ki | 1.6800 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 2.2460 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | Ki | 1.6800 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 2.2460 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | Ki | 1.6800 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 2.2460 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.1710 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0174 | 2 | 2 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 42.6579 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 25.4638 | 3 | 3 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 1.0501 | 14 | 15 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | IC50 | 5.0014 | 3 | 6 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 5.2303 | 4 | 5 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0191 | 13 | 16 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 1.1215 | 31 | 32 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | Ki | 0.0081 | 1 | 1 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.8864 | 3 | 3 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 0.0595 | 2 | 2 |
| Mu-type opioid receptor | Mus musculus (house mouse) | IC50 | 10.0000 | 1 | 3 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 8.7167 | 2 | 3 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.5226 | 6 | 13 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.8876 | 11 | 11 |
| Mu-type opioid receptor | Mus musculus (house mouse) | Ki | 0.5050 | 3 | 4 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 1.3416 | 5 | 6 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 34.5000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.3460 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.0830 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.0500 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.3730 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.6470 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.1370 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.3720 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.0520 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.1620 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.1160 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 11.0500 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | IC50 | 11.0500 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 31.8590 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 26.1013 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 54.0463 | 7 | 8 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 26.1013 | 1 | 1 |
| Protein orai-2 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Protein orai-3 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | IC50 | 0.1236 | 2 | 2 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0365 | 2 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 7.5870 | 4 | 4 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | Ki | 5.0700 | 1 | 1 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 | 285.0000 | 2 | 4 |
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 5.6500 | 2 | 2 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 3.5420 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 3.5130 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.0027 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.0014 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 24.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 481.7417 | 2 | 6 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 2.6000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 32.0000 | 1 | 1 |
| Tubulin beta-2B chain | Bos taurus (cattle) | IC50 | 285.0000 | 2 | 2 |