An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of methionine adenosyltransferase (EC 2.5.1.6).
ChEBI ID: 78756
| Member | Definition | Class |
|---|---|---|
| cycloleucine | A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups. | 1-aminocyclopentanecarboxylic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 203 (16.79) | 18.7374 |
| 1990's | 743 (61.46) | 18.2507 |
| 2000's | 200 (16.54) | 29.6817 |
| 2010's | 51 (4.22) | 24.3611 |
| 2020's | 12 (0.99) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 4 (0.32%) | 5.53% |
| Reviews | 18 (1.45%) | 6.00% |
| Case Studies | 1 (0.08%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,215 (98.14%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Glutamate [NMDA] receptor subunit zeta 1 | Rattus norvegicus (Norway rat) | Ki | 15,300.0000 | 1 | 3 |
| S-adenosylmethionine synthase isoform type-1 | Rattus norvegicus (Norway rat) | Ki | 516.0000 | 1 | 1 |
| S-adenosylmethionine synthase isoform type-2 | Homo sapiens (human) | IC50 | 3,450.0000 | 2 | 2 |