An EC 4.3.1.* (ammonia-lyase) inhibitor that interferes with the action of diaminopropionate ammonia-lyase (EC 4.3.1.15).
ChEBI ID: 77881
| Member | Definition | Class |
|---|---|---|
| 2-iodosobenzoic acid | A benzoic acid compound having an iodosyl substituent at the ortho-position. | ortho-iodosylbenzoic acid |
| alanine | The L-enantiomer of alanine. | L-alanine zwitterion; L-alanine |
| D-alanine | The D-enantiomer of alanine. | D-alanine zwitterion; D-alanine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 8,428 (35.34) | 18.7374 |
| 1990's | 3,653 (15.32) | 18.2507 |
| 2000's | 5,789 (24.28) | 29.6817 |
| 2010's | 3,711 (15.56) | 24.3611 |
| 2020's | 2,264 (9.49) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 512 (2.09%) | 5.53% |
| Reviews | 807 (3.29%) | 6.00% |
| Case Studies | 441 (1.80%) | 4.05% |
| Observational | 72 (0.29%) | 0.25% |
| Other | 22,706 (92.53%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 26.8325 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.3548 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 6.9178 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 18.0459 | 2 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 33.4889 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 17.7828 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 21.1923 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 30.0474 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 33.4915 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 23.9145 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 126.6000 | 2 | 3 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 90.9000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 90.9000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 90.9000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 90.9000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 90.9000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 90.9000 | 1 | 1 |
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 10,900.0000 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | KA | 150.0000 | 1 | 1 |
| Adenosine deaminase | Rattus norvegicus (Norway rat) | Km | 1,300.0000 | 1 | 1 |
| Alanine racemase, biosynthetic | Escherichia coli K-12 | Km | 7,750.0000 | 2 | 2 |
| Carbonic anhydrase 1 | Homo sapiens (human) | KA | 54.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | KA | 150.0000 | 1 | 1 |
| Carbonic anhydrase 4 | Bos taurus (cattle) | KA | 66.0000 | 1 | 1 |