An agonist that binds to and activates aryl hydrocarbon receptors (AhRs).
| Member | Definition | Class |
|---|
| 1,2-naphthoquinone | The parent structure of the family of 1,2-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 2 of the naphthalene ring. It is a metabolite of naphthalene and is found in diesel exhaust particles. | 1,2-naphthoquinone |
| 2-(methylthio)benzothiazole | An organic sulfide that is the methyl thioether of 1,3-benzothiazole-2-thiol. | 2-methylthio-1,3-benzothiazole |
| 3-methylcholanthrene | A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position. | 3-methylcholanthrene |
| alpha-naphthoflavone | An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14). | alpha-naphthoflavone |
| beta-naphthoflavone | An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone. | beta-naphthoflavone |
| cyprodinil | A member of the class of aminopyrimidine that is N-phenylpyrimidin-2-amine carrying additional cyclopropyl and methyl substituents at positions 4 and 6 respectively. A broad spectrum fungicide used to control a range of pathogens including Tapesia yallundae, Botrytis spp., Alternaria spp. and Rhynchospium secalis. Whilst it is a recognised irritant no serious human health concerns have been identified. It is moderately toxic to birds as well as most aquatic organisms and earthworms, but it is not considered toxic to honeybees. | cyprodinil |
| mepanipyrim | A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying additional methyl and 1-propynyl substituents at positions 4 and 6 respectively. A fungicide used to control a wide range of diseases including grey mould on strawberries, tomatoes and cucumabers, and scab on apples and pears. | mepanipyrim |
| pyrimethanil | A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying two additional methyl substituents at positions 4 and 6. A fungicide used to control grey mould on fruit, vegetables and ornamentals as well as leaf scab on pome fruit. Also commonly employed to control Botrytis cinerea throughout the winemaking process in grapes, must, fermenting must and wine. | pyrimethanil |
| tranilast | An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group. | tranilast |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 12.0647 | 1 | 3 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 8.9125 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 21.4708 | 2 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 31.3424 | 1 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 27.7146 | 9 | 30 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 24.6741 | 3 | 14 |
| arylsulfatase A | Homo sapiens (human) | Potency | 6.7456 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 6.2002 | 4 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 1.3612 | 2 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 21.7738 | 3 | 5 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 0.5676 | 2 | 4 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 9.5283 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 3.6898 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 64.4679 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 11.6773 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 11.6773 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 18.0069 | 2 | 4 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 18.0707 | 2 | 3 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.9703 | 1 | 5 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 14.4074 | 2 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 26.7594 | 2 | 4 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 23.8770 | 2 | 2 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 3.5397 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 26.7594 | 2 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 0.0060 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 11.2947 | 2 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 9.8615 | 1 | 6 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 10.6359 | 9 | 36 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 2.7306 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 8.6711 | 9 | 29 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 7.3481 | 1 | 6 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 34.6312 | 2 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 29.7136 | 1 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 32.2503 | 3 | 8 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 42.1160 | 3 | 5 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 13.1698 | 1 | 7 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 2.0749 | 2 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 37.0143 | 2 | 4 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.9433 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 25.5875 | 2 | 7 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 73.6328 | 2 | 3 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 15.6498 | 1 | 2 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 31.6228 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 7.9433 | 2 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0224 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 25.1189 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 13.4753 | 4 | 9 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 13.7588 | 2 | 5 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 12.0570 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.1259 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 17.6476 | 1 | 4 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 28.1838 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 5.0119 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 0.5349 | 1 | 3 |
| Nrf2 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 24.5086 | 4 | 14 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 24.6007 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 3.3981 | 2 | 6 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 18.5961 | 3 | 14 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 13.0816 | 2 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 7.5686 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 23.5718 | 2 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 49.8976 | 3 | 3 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 32.5352 | 1 | 3 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.0795 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 30.4167 | 2 | 7 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 27.8298 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 27.4748 | 1 | 2 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 12.5893 | 2 | 2 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 19.9526 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 5.2643 | 2 | 9 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.3611 | 1 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 11.5541 | 3 | 15 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 38.4067 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 17.1854 | 1 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 17.1854 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 0.4929 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 16.5795 | 2 | 6 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 11.2202 | 1 | 1 |
| Thrombopoietin | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 26.2074 | 2 | 7 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 42.5198 | 4 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 28.3037 | 4 | 4 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.0795 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.0795 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 76.1104 | 1 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 38.4792 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 61.6448 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 13.1698 | 1 | 7 |