An inhibitor of any of the glioma-associated oncogene (GLI) proteins.
ChEBI ID: 140922
| Member | Definition | Class |
|---|---|---|
| cyclopamine | Cyclopamine | |
| gant 61 | An aminal that is hexahydropyrimidine which is substituted on each nitrogen by a 2-(dimethylamino)benzyl group, and at the aminal carbon by a pyridin-4-yl group. A Hedgehog signaling pathway and Gli protein inhibitor. | 2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline; GANT61 |
| resveratrol | A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups. | resveratrol |
| zerumbone | A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia. | zerumbone |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (0.41) | 18.7374 |
| 1990's | 9 (0.93) | 18.2507 |
| 2000's | 274 (28.28) | 29.6817 |
| 2010's | 575 (59.34) | 24.3611 |
| 2020's | 107 (11.04) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 58 (5.69%) | 6.00% |
| Case Studies | 1 (0.10%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 961 (94.22%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 15.6034 | 6 | 7 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 18.5839 | 4 | 8 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 13.1808 | 2 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 11.7704 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.2236 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 5.3538 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 3.1623 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 26.2123 | 1 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 13.3332 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| polyprotein | Zika virus | Potency | 11.7704 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 26.2123 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 8.4127 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 3.0107 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 10.4155 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 2.1800 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 8.1300 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 8.2500 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 1.9500 | 1 | 1 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 2.5700 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 1.7500 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 6.7500 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 4.0100 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 2.8600 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 3.2400 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 8.6300 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 8.9800 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 9.5300 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 21.8000 | 1 | 1 |
| Integrin alpha-4 | Homo sapiens (human) | IC50 | 1.3120 | 1 | 1 |
| Integrin beta-1 | Homo sapiens (human) | IC50 | 1.3120 | 1 | 1 |
| Smoothened homolog | Homo sapiens (human) | IC50 | 0.2147 | 3 | 3 |
| Smoothened homolog | Mus musculus (house mouse) | IC50 | 1.2710 | 4 | 4 |
| Smoothened homolog | Homo sapiens (human) | Ki | 0.0986 | 3 | 3 |
| Sonic hedgehog protein | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| Sonic hedgehog protein | Mus musculus (house mouse) | IC50 | 1.8030 | 4 | 4 |
| Zinc finger protein GLI1 | Homo sapiens (human) | IC50 | 23.5500 | 2 | 2 |
| Zinc finger protein GLI1 | Mus musculus (house mouse) | IC50 | 5.0000 | 1 | 1 |
| Zinc finger protein GLI2 | Homo sapiens (human) | IC50 | 0.9100 | 1 | 1 |
| Zinc finger protein GLI2 | Mus musculus (house mouse) | IC50 | 5.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Smoothened homolog | Homo sapiens (human) | Kd | 0.0642 | 2 | 2 |
| Sonic hedgehog protein | Mus musculus (house mouse) | EC50 | 0.5000 | 1 | 1 |