Page last updated: 2024-12-08

1,2-diamino-4,5-dimethoxybenzene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,2-diamino-4,5-dimethoxybenzene, also known as **3,4-dimethoxy-o-phenylenediamine** (DMOPD), is an organic compound with the molecular formula C8H12N2O2.

**Structure and Properties:**

* **Structure:** DMOPD is a benzene ring with two amino groups (–NH2) at positions 1 and 2, and two methoxy groups (–OCH3) at positions 4 and 5.
* **Appearance:** It is a white to pale yellow solid at room temperature.
* **Solubility:** It is soluble in organic solvents like ethanol and acetone, but sparingly soluble in water.

**Importance in Research:**

DMOPD is a versatile compound with various research applications, particularly in the fields of:

**1. Organic Synthesis:**

* **Precursor for Pharmaceuticals:** DMOPD serves as a key precursor for the synthesis of various pharmaceuticals, including antihistamines, analgesics, and antipsychotics.
* **Synthesis of Polymers:** It can be used as a monomer in the synthesis of polyamides and other polymers with specific properties.
* **Dye Synthesis:** DMOPD is a valuable intermediate in the production of dyes and pigments.

**2. Materials Science:**

* **Organic Electronics:** Its electron-donating properties make it suitable for use in organic light-emitting diodes (OLEDs) and other organic electronic devices.
* **Sensors:** DMOPD-based materials can be used in the development of chemical and biological sensors due to their sensitivity to specific analytes.

**3. Biochemistry and Pharmacology:**

* **Biological Activity:** DMOPD exhibits biological activity, acting as a dopamine receptor agonist and exhibiting antioxidant properties.
* **Pharmacological Studies:** Research on DMOPD explores its potential therapeutic applications in neurological disorders and other conditions.

**4. Analytical Chemistry:**

* **Chromatography:** DMOPD is used as a standard in chromatographic analysis, particularly in high-performance liquid chromatography (HPLC).

**Note:**

It's important to handle DMOPD with caution as it may be a skin and eye irritant.

**Overall, 1,2-diamino-4,5-dimethoxybenzene is a significant compound in various research fields due to its versatility in synthesis, its potential applications in materials science and biochemistry, and its contribution to the development of pharmaceuticals and analytical tools.**

1,2-diamino-4,5-dimethoxybenzene: used for determination of ascorbic acid in human serum [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID152939
CHEMBL ID1896702
SCHEMBL ID209984
MeSH IDM0137914

Synonyms (31)

Synonym
BB 0246075
4,5-dimethoxy-benzene-1,2-diamine
dadmb
AKOS000111002
4,5-dimethoxybenzene-1,2-diamine
FT-0690816
NCGC00188141-01
4,5-dimethoxy-1,2-diaminobenzene
1,2-diamino-4,5-dimethoxybenzene
1,2-benzenediamine, 4,5-dimethoxy-
27841-33-4
EN300-51468
F3308-2814
SCHEMBL209984
SKIUVOVOIJBJPN-UHFFFAOYSA-N
4,5-dimethoxy-1,2-phenylenediamine
CHEMBL1896702
DTXSID80182156
mfcd00462577
4,5-dimethoxy-1,2-phenylenediamine hydrochloride, for hplc derivatization, >=98.0% (gc)
1,2-diamino-4,5-dimethoxybenzene, aldrichcpr
J-016894
BS-13668
AMY24259
1,2-diamino-4,5-dimethoxybenzene;1,2-benzenediamine, 4,5-dimethoxy-
BCP30099
C74439
CS-0006999
PD045665
HY-77873
Z382723632
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
TDP1 proteinHomo sapiens (human)Potency8.97160.000811.382244.6684AID686978; AID686979
flap endonuclease 1Homo sapiens (human)Potency3.98110.133725.412989.1251AID588795
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency22.38720.050127.073689.1251AID588590
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (30.00)18.7374
1990's4 (40.00)18.2507
2000's2 (20.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.94 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.34 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.94)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]