Page last updated: 2024-08-05 15:27:09
cathartic
Any substance that accelerates defecation. Compare with laxatives, which are substances that ease defecation (usually by softening faeces). A substance can be both a laxative and a cathartic.
ChEBI ID: 75325
Members (3)
| Member | Definition | Class |
|---|
| lactitol | A glycosyl alditol consisting of beta-D-galactopyranose and D-glucitol joined by a 1->4 glycosidic bond. It is used as a laxative, as an excipient, and as replacement bulk sweetener in some low-calorie foods. | lactitol |
| naloxegol | An organic heteropentacyclic compound that is naloxone in which the keto group is replaced by a PEG moiety. Used for treatment of opioid-induced constipation. | naloxegol |
| sorbitol | The D-enantiomer of glucitol (also known as D-sorbitol). | D-glucitol |
Research
Studies (6,360)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 3,042 (47.83) | 18.7374 |
| 1990's | 1,091 (17.15) | 18.2507 |
| 2000's | 1,091 (17.15) | 29.6817 |
| 2010's | 870 (13.68) | 24.3611 |
| 2020's | 266 (4.18) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 428 (6.29%) | 5.53% |
| Reviews | 349 (5.13%) | 6.00% |
| Case Studies | 168 (2.47%) | 4.05% |
| Observational | 4 (0.06%) | 0.25% |
| Other | 5,856 (86.05%) | 84.16% |
Protein Targets (11)
Potency Measurements
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Trans-sialidase | Trypanosoma cruzi | Km | 260.0000 | 1 | 1 |