A proteinogenic amino acid derivative resulting from reaction of L-lysine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-lysine by a heteroatom.
ChEBI ID: 25095
| Member | Definition | Role |
|---|---|---|
| 2-formyl-5-(hydroxymethyl)pyrrole-1-norleucine | An N-substituted pyrraline formed via Maillard reaction of L-lysine with glucose. | 1-(L-norleucin-6-yl)pyrraline |
| aerobactin | aerobactin | |
| alpha-acetyllysine methyl ester | An alpha-amino acid ester obtained by formal condensation of the carboxy group of N(alpha)-acetyl-L-lysine with the hydroxy group of methanol. | N(alpha)-acetyl-L-lysine methyl ester |
| biocytin | A monocarboxylic acid amide that results from the formal condensation of the carboxylic acid group of biotin with the N(6)-amino group of L-lysine. | biocytin zwitterion; biocytin |
| dansyllysine | An L-lysine derivative with a dansyl group at the N(6)-position. | N(6)-dansyl-L-lysine |
| deoxyhypusine | An L-lysine derivative in which the N(6) of the lysine is substituted with a 4-aminobutyl group. | deoxyhypusine |
| epsilon n-dimethyllysine | An L-lysine derivative comprising L-lysine having two methyl substituents attached to the side-chain amino group. | N(6),N(6)-dimethyl-L-lysine |
| epsilon-n-methyllysine | An L-lysine derivative that is L-lysine in which one of the hydrogens attached to N(6) is substituted by a methyl group. | N(6)-methyl-L-lysine |
| homoarginine | An L-lysine derivative that is the L-enantiomer of homoarginine. | L-homoarginine |
| homocitrulline | A L-lysine derivative that is L-lysine having a carbamoyl group at the N(6)-position. It is found in individuals with urea cycle disorders. | L-homocitrulline zwitterion; L-homocitrulline |
| l796778 | A methyl ester resulting from the formal condensation of the carboxy group of N-{[(2S)-1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-D-norleucyl-L-lysine with methanol. It is a partial agonist of somatostatin subtype receptor 3 (Ki = 24 nM) that exhibits anticonvulsant effects. | L-796,778 |
| lysine tyrosylquinone | An L-lysine derivative in which one of the amino hydrogens at N(6)-amino is substituted by a 6-[(2S)-2-amino-2-carboxyethyl]-3,4-dioxocyclohexa-1,5-dien-1-yl group. | 5'-(N(6)-L-lysine)-L-tyrosylquinone |
| n(6)-(1-carboxyethyl)lysine | A L-lysine derivative formed during the reaction between methylglyoxal and protein. CEL is a homologue of N(epsilon)-(carboxymethyl)lysine (CML), an advanced glycation end-product that is formed on reaction of glyoxal or glycolaldehyde with protein and on oxidative cleavage of fructoselysine, the Amadori adduct formed on glycation of protein by glucose. | N(6)-(1-carboxyethyl)-L-lysine |
| n(6)-(1-iminoethyl)lysine | An L-lysine derivative that is L-lysine in which one of the hydrogens attached to N(6) is substituted by an acetimidoyl group | N(6)-acetimidoyl-L-lysine |
| n(6)-carboxymethyllysine | An L-lysine derivative with a carboxymethyl substituent at the N(6)-position. | N(6)-carboxymethyl-L-lysine |
| saccharopine | The N(6)-(1,3-dicarboxypropan-1-yl) derivative of L-lysine. | L-saccharopine |
| thiobenzyl benzyloxycarbonyl-l-lysinate | An L-lysine derivative that is L-lysine in which the amino group is replaced by a [(benzyloxy)carbonyl]amino group and the carboxy group is replaced by a (benzylsulfanyl)carbonyl group. It is a substrate for a sensitive colorimetric assay for trypsin-like enzymes. | thiobenzyl benzyloxycarbonyl-L-lysinate |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 265 (9.34) | 18.7374 |
| 1990's | 769 (27.10) | 18.2507 |
| 2000's | 861 (30.34) | 29.6817 |
| 2010's | 775 (27.31) | 24.3611 |
| 2020's | 168 (5.92) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 69 (2.31%) | 5.53% |
| Reviews | 100 (3.35%) | 6.00% |
| Case Studies | 37 (1.24%) | 4.05% |
| Observational | 17 (0.57%) | 0.25% |
| Other | 2,764 (92.53%) | 84.16% |