Page last updated: 2024-08-05 11:19:10
N-sulfonyldiazepane
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ChEBI ID: 46946
Members (3)
| Member | Definition | Role |
|---|---|---|
| fasudil | An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia. | fasudil |
| h 1152 | A member of the class of isoquinolines that is the sulfonamide formed by the formal condensation of the sulfo group of 4-methylisoquinoline-5-sulfonic acid with the 1-amino group of (S)-2-methyl-1,4-diazepane. | (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane |
| ml 7 | An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18). | ML-7 |
Research
Studies (1,193)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 6 (0.50) | 18.7374 |
| 1990's | 80 (6.71) | 18.2507 |
| 2000's | 411 (34.45) | 29.6817 |
| 2010's | 577 (48.37) | 24.3611 |
| 2020's | 119 (9.97) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 40 (3.24%) | 5.53% |
| Reviews | 73 (5.92%) | 6.00% |
| Case Studies | 9 (0.73%) | 4.05% |
| Observational | 1 (0.08%) | 0.25% |
| Other | 1,110 (90.02%) | 84.16% |