A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.
| Member | Definition | Class |
|---|
| 1-(4-bromoacetamidobenzyl)edta | A tetracarboxylic acid consisting of ethylenediaminetetraacetic acid having a 4-bromoacetamidobenzyl group at the C1-position and (S)-configuration. | (S)-1-(4-bromoacetamidobenzyl)EDTA |
| 1,2-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid | A polyamino carboxylic acid in which bis(carboxymethyl)nitrilo groups are bonded to C-2 and C-2' of 1,1'-[ethane-1,2-diylbis(oxy)]dibenzene. | BAPTA |
| 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid | An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group. | DOTA |
| 2,2'-dipyridyl | A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'. | 2,2'-bipyridine |
| 2,2',2''-terpyridine | A tridentate heterocyclic ligand that binds metals at three meridional sites giving two adjacent 5-membered MN2C2 chelate rings. | 2,2':6',2''-terpyridine |
| 2,3-dimethylsuccinic acid | An alpha,omega-dicarboxylic acid that is succinic acid substituted by two methyl groups at positions 2 and 3 respectively. | 2,3-dimethylsuccinic acid |
| 5,5'-dibromo-1,2-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid | A polyamino carboxylic acid, the structure of which is that of BAPTA carrying bromine substituents at C-5 and C-5'. | 5,5'-dibromo-BAPTA |
| 5,5'-dimethyl-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetate | A polyamino carboxylic acid, the structure of which is that of BAPTA carrying methyl substituents at C-5 and C-5'. | 5,5'-dimethyl-BAPTA |
| acetopyrrothine | A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and acetamido groups, respectively. It is a potent inhibitor of RNA polymerases, inhibits the angiogenesis of human umbilical vein endothelial cells, and also inhibits JAMM metalloproteases. | thiolutin |
| bathocuproine disulfonate | A phenanthroline that consists of 1,10-phenanthroline bearing two methyl groups at position 2 and 9 as well as two 4-sulfophenyl groups at positions 4 and 7. | bathocuproine disulfonic acid |
| bathophenanthroline | A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two phenyl substituents at positions 4 and 7. | 4,7-diphenyl-1,10-phenanthroline |
| calcium acetate | The calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces. | calcium acetate |
| citric acid, anhydrous | A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms. | citric acid |
| clioquinol | A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease. | 5-chloro-7-iodoquinolin-8-ol |
| dexrazoxane | | (+)-dexrazoxane |
| dimercaprol | A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury. | dimercaprol |
| dithiothreitol | The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol. | 1,4-dimercaptobutane-2,3-diol; 1,4-dithiothreitol |
| ditiocarb | A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur. | diethyldithiocarbamic acid |
| edda | An ethylenediamine derivative in which two of the four amine protons of ethylenediamine are replaced by carboxymethyl groups. | ethylenediaminediacetic acid |
| edetic acid | | ethylenediaminetetraacetic acid |
| egtazic acid | A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively. | ethylene glycol bis(2-aminoethyl)tetraacetic acid |
| ergothioneine | A L-histidine derivative that is N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine in which the hydrogen at position 2 on the imdazole ring is replaced by a mercapto group. A naturally occurring metabolite of histidine synthesized by bacteria and fungi with antioxidant properties. It is found ubiquitously in plants and animals and is present in many human foodstuffs. | ergothioneine thione form; ergothioneine |
| etidronate | A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces. | etidronic acid |
| etidronate disodium | An organic sodium salt resulting from the replacement of two protons from etidronic acid (one from from each of the phosphonic acid groups) by sodium ions. | etidronate disodium |
| gluconic acid | A gluconic acid having D-configuration. | D-gluconic acid |
| glycyl-histidyl-lysine | A tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence. | Gly-His-Lys |
| hexaconazole | A member of the class of triazoles that is 1-hexyl-1H-1,2,4-triazole in which the hydrogens at position 2 of the hexyl chain are replaced by hydroxy and 2,4-dichlorophenyl groups. | 2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol |
| holomycin | A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. | holomycin |
| iminodiacetic acid | An amino dicarboxylic acid that is glycine in which one of the hydrogens attached to the nitrogen is substituted by a carboxymethyl group. | iminodiacetic acid |
| methylene diphosphonate | A 1,1-bis(phosphonic acid) consisting of methane substituted by two phosphonic acid groups. | medronic acid |
| n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine | An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups. | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine |
| n,n,n',n'-tetramethylethylenediamine | An ethylenediamine derivative in which each nitrogen carries two methyl substituents. It is widely employed both as a ligand for metal ions and as a catalyst in organic polymerisation. | N,N,N',N'-tetramethylethylenediamine |
| neocuproine | A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two methyl substituents at positions 2 and 9. | neocuproine |
| nicotianamine | The (S,S,S)-stereoisomer of nicotianamine. | (S,S,S)-nicotianamine trizwitterion; (S,S,S)-nicotianamine |
| penicillamine | An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning. | D-penicillamine |
| quercetin | A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine. | quercetin |
| sodium pyrophosphate | An inorganic sodium salt comprised of a diphosphate(4-) anion and four sodium(1+) cations. More commonly known as tetrasodium pyrophosphate, it finds much use in the food industry as an emulsifier and in dental hygiene as a calcium-chelating salt. | sodium diphosphate |
| succimer | A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning. | succimer |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 20.7188 | 1 | 4 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 12.4518 | 1 | 4 |
| 67.9K protein | Vaccinia virus | Potency | 25.5154 | 1 | 2 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 15.5990 | 2 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 27.8165 | 1 | 11 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 14.4987 | 1 | 3 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 8.1941 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 29.1676 | 10 | 36 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 33.0807 | 3 | 12 |
| arylsulfatase A | Homo sapiens (human) | Potency | 11.5616 | 1 | 3 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 23.2514 | 3 | 5 |
| Ataxin-2 | Homo sapiens (human) | Potency | 25.3835 | 1 | 4 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 12.7957 | 2 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 25.3835 | 1 | 4 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 40.0076 | 2 | 8 |
| BRCA1 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 46.7862 | 1 | 4 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 61.0684 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 76.9588 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 61.0684 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 76.9588 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 37.0861 | 2 | 11 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 9.8338 | 2 | 7 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 20.0549 | 1 | 11 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 1.6182 | 2 | 7 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 100.0000 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 23.9944 | 2 | 7 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 2.5405 | 2 | 7 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 66.2078 | 1 | 5 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 2.7125 | 2 | 10 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 23.1413 | 2 | 9 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 7.1173 | 1 | 10 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 2.5405 | 2 | 7 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 81.5561 | 2 | 3 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 15.8489 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 11.9464 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 2.6837 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 16.9330 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 35.7168 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 21.4975 | 2 | 5 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 21.2146 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 29.2676 | 1 | 5 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 3.0521 | 2 | 3 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 11.7343 | 1 | 3 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 19.9595 | 3 | 3 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 44.6623 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 10.6213 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 43.8206 | 1 | 8 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 0.8592 | 1 | 7 |
| endonuclease IV | Escherichia coli | Potency | 63.0957 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 30.1810 | 12 | 49 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 37.3489 | 2 | 7 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 31.5114 | 9 | 40 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 10.5824 | 1 | 15 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 12.7667 | 4 | 7 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 44.4024 | 4 | 6 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 20.4870 | 2 | 5 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 22.7406 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 2.6837 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| galactokinase | Homo sapiens (human) | Potency | 42.1285 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 23.1851 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 9.5732 | 2 | 11 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 20.1676 | 3 | 15 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 7.3133 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 0.4467 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 22.9287 | 1 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 22.2180 | 4 | 20 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 34.4081 | 1 | 7 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 40.8708 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 25.6086 | 2 | 5 |
| hepatitis C virus polyprotein | | Potency | 3.5312 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 10.3832 | 2 | 17 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 37.6460 | 1 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 24.5163 | 2 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 61.9378 | 2 | 11 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 2.6837 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 9.2810 | 1 | 4 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 19.1428 | 1 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 6.0990 | 3 | 7 |
| IDH1 | Homo sapiens (human) | Potency | 8.8512 | 1 | 4 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 141.2540 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 2.6837 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 9.5691 | 1 | 4 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 18.0291 | 1 | 3 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 18.0291 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 2.6837 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.6408 | 1 | 8 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 10.0000 | 1 | 1 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 44.4908 | 2 | 4 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 14.5168 | 2 | 15 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 25.4763 | 2 | 5 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 11.5574 | 2 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 0.1585 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 5.6234 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 5.0800 | 1 | 3 |
| Nrf2 | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 32.7680 | 4 | 13 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 12.6744 | 1 | 3 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 5.4184 | 1 | 2 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 23.7101 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 2.0769 | 2 | 13 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 33.3121 | 3 | 17 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 11.9201 | 3 | 3 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 2.6855 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 16.0560 | 2 | 6 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 71.5191 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 38.2648 | 5 | 13 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 41.0779 | 5 | 8 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 7.5686 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 45.8749 | 1 | 9 |
| PINK1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 0.0141 | 1 | 1 |
| polyprotein | Zika virus | Potency | 22.7406 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 0.9433 | 1 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 8.6246 | 1 | 4 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 27.8506 | 1 | 3 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 40.2139 | 2 | 8 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 17.8714 | 2 | 10 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 36.6137 | 2 | 16 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.2239 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 41.3560 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 35.5817 | 3 | 18 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 15.2191 | 3 | 10 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| signal transducer and activator of transcription 6, interleukin-4 induced | Homo sapiens (human) | Potency | 2.5119 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 27.1613 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 27.1613 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 25.1682 | 1 | 5 |
| snurportin-1 | Homo sapiens (human) | Potency | 141.2540 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 16.8828 | 1 | 5 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 10.1578 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 15.4622 | 2 | 27 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 50.1187 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 22.2526 | 1 | 5 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 37.4843 | 2 | 11 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 28.7312 | 4 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 33.9470 | 6 | 11 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 15.4103 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 13.4239 | 2 | 4 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 0.0141 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 0.0141 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 50.4512 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 22.8464 | 2 | 9 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 36.8849 | 3 | 3 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 46.3454 | 1 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 34.4081 | 1 | 7 |
| Vpr | Human immunodeficiency virus 1 | Potency | 51.4532 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 4.5885 | 2 | 2 |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli K-12 | IC50 | 1.9000 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | IC50 | 1.5400 | 2 | 2 |
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 5.4000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 4.0000 | 1 | 1 |
| 5'-nucleotidase | Rattus norvegicus (Norway rat) | Ki | 0.0453 | 1 | 1 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 27.8400 | 2 | 2 |
| 90-kda heat shock protein beta HSP90 beta, partial | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 38.3000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 8.9000 | 3 | 3 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 5.1250 | 2 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 30.0000 | 1 | 1 |
| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | Homo sapiens (human) | IC50 | 37.9000 | 1 | 1 |
| Aldo-keto reductase family 1 member A1 | Rattus norvegicus (Norway rat) | IC50 | 2.3200 | 1 | 1 |
| Aldo-keto reductase family 1 member A1 | Sus scrofa (pig) | IC50 | 38.4000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | IC50 | 17.7540 | 5 | 5 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 2.2141 | 6 | 6 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 6.6417 | 5 | 6 |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | IC50 | 50.1000 | 1 | 1 |
| Aldo-keto reductase family 1 member C21 | Mus musculus (house mouse) | IC50 | 6.9000 | 1 | 1 |
| Aldo-keto reductase family 1 member C21 | Mus musculus (house mouse) | Ki | 11.0000 | 1 | 1 |
| ALK tyrosine kinase receptor | Homo sapiens (human) | IC50 | 3.3200 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 39.9000 | 1 | 2 |
| Alpha-amylase 1A | Homo sapiens (human) | IC50 | 21.4000 | 2 | 2 |
| Alpha-ketoglutarate-dependent dioxygenase FTO | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 2.6200 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Bos taurus (cattle) | IC50 | 0.0100 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Bos taurus (cattle) | IC50 | 20.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 64.3300 | 2 | 2 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 35.4267 | 9 | 9 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 16.3500 | 2 | 2 |
| Anthrax toxin receptor 2 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Arginase | Leishmania amazonensis | IC50 | 4.0000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 6.0060 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 52.5000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 2.4350 | 2 | 2 |
| B2 bradykinin receptor | Cavia porcellus (domestic guinea pig) | IC50 | 4.0000 | 2 | 2 |
| Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1.5000 | 1 | 1 |
| Beta-lactamase | Enterobacter cloacae | IC50 | 269.6667 | 3 | 3 |
| Beta-lactamase | Escherichia coli K-12 | IC50 | 58.0000 | 4 | 4 |
| Beta-lactamase | Bacillus licheniformis | Ki | 490.0000 | 1 | 1 |
| Beta-lactamase | Bacillus anthracis | IC50 | 1,060.0000 | 1 | 1 |
| Beta-lactamase | Pseudomonas aeruginosa | IC50 | 27.9000 | 1 | 1 |
| Beta-lactamase VIM-1 | Pseudomonas aeruginosa | IC50 | 9.3000 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 7.6400 | 3 | 3 |
| Beta-secretase 1 | Homo sapiens (human) | Ki | 14.0000 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 20.2700 | 2 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 342.0325 | 4 | 8 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Botulinum neurotoxin type A | Clostridium botulinum | IC50 | 20.3000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 7.2500 | 2 | 2 |
| Butyrophilin subfamily 3 member A1 | Homo sapiens (human) | IC50 | 1,140.0000 | 1 | 1 |
| C-C chemokine receptor type 1 | Homo sapiens (human) | IC50 | 562.9732 | 1 | 4 |
| C-C chemokine receptor type 4 | Homo sapiens (human) | IC50 | 47.2409 | 3 | 6 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | IC50 | 45.8624 | 1 | 6 |
| C-X-C chemokine receptor type 1 | Homo sapiens (human) | IC50 | 35.3780 | 2 | 4 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Rattus norvegicus (Norway rat) | IC50 | 275.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Rattus norvegicus (Norway rat) | IC50 | 275.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Calmodulin-1 | Homo sapiens (human) | IC50 | 12.9700 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Carbonic anhydrase | Astrosclera willeyana | Ki | 57,700.0000 | 1 | 1 |
| Carbonic anhydrase | Pseudomonas aeruginosa PAO1 | Ki | 8,200.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 11,554.4061 | 14 | 18 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 9.3900 | 1 | 1 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 369.5150 | 2 | 2 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 5.4100 | 1 | 1 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 2.3300 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 1,250.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 28,803.0748 | 25 | 29 |
| Carbonic anhydrase 3 | Bos taurus (cattle) | Ki | 6.5260 | 2 | 5 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 8.1000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 798.8150 | 5 | 8 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 368.4050 | 2 | 2 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 11.9000 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 4.9500 | 2 | 2 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 437.4200 | 2 | 2 |
| Carbonic anhydrase 9 | Homo sapiens (human) | IC50 | 860.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 433.5000 | 2 | 2 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 1.6500 | 5 | 5 |
| Casein kinase II subunit alpha | Homo sapiens (human) | Ki | 1.1800 | 4 | 4 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 0.5500 | 1 | 1 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | Ki | 1.1800 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 1.6500 | 5 | 5 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | Ki | 1.1800 | 1 | 1 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 1.6500 | 5 | 5 |
| Casein kinase II subunit beta | Homo sapiens (human) | Ki | 1.1800 | 1 | 1 |
| Catechol O-methyltransferase | Rattus norvegicus (Norway rat) | IC50 | 4.7863 | 1 | 1 |
| Cationic trypsin | Bos taurus (cattle) | IC50 | 24.4200 | 2 | 5 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Rattus norvegicus (Norway rat) | IC50 | 81.3000 | 1 | 1 |
| Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase | Helicobacter pylori | Ki | 12.7000 | 1 | 3 |
| Chain A, APH(2')-Id | Enterococcus casseliflavus | Ki | 25.1000 | 1 | 1 |
| Chain A, Proto-oncogene Tyrosine-protein Kinase Src | Homo sapiens (human) | IC50 | 40,000.0000 | 1 | 26 |
| Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase | Helicobacter pylori | Ki | 12.7000 | 1 | 3 |
| Chymotrypsin-C | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Chymotrypsin-like elastase family member 1 | Sus scrofa (pig) | IC50 | 28.7500 | 1 | 4 |
| Chymotrypsinogen A | Bos taurus (cattle) | IC50 | 292.5000 | 2 | 2 |
| Chymotrypsinogen B | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Collagenase 3 | Homo sapiens (human) | IC50 | 8.4600 | 1 | 1 |
| Cyclin homolog | Herpesvirus saimiri (strain 11) | IC50 | 31.2750 | 1 | 4 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 28.8625 | 4 | 4 |
| Cyclin-dependent kinase 1 | Oryzias latipes (Japanese medaka) | IC50 | 31.2750 | 1 | 4 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Cyclin-dependent kinase 4 | Homo sapiens (human) | IC50 | 61.0000 | 1 | 1 |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | IC50 | 29.6200 | 2 | 5 |
| Cyclin-dependent kinase 6 | Homo sapiens (human) | IC50 | 30.0200 | 2 | 5 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | IC50 | 29.6200 | 2 | 5 |
| Cystathionine gamma-lyase | Homo sapiens (human) | IC50 | 270.0000 | 1 | 1 |
| Cytochrome P450 11B1, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 8.4364 | 5 | 5 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 0.6600 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 14.6990 | 3 | 3 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 1.1108 | 5 | 5 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0230 | 2 | 2 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 13.5000 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 27.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 20.0000 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 15.6667 | 3 | 3 |
| Cytosol aminopeptidase | Sus scrofa (pig) | IC50 | 34.3000 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 7.8460 | 1 | 1 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 8.9000 | 1 | 1 |
| delta-type opioid receptor | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Deoxyhypusine hydroxylase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Dipeptidyl peptidase 3 | Homo sapiens (human) | IC50 | 74.1000 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 66.4600 | 2 | 2 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| ELAV-like protein 1 | Homo sapiens (human) | IC50 | 1.4000 | 1 | 1 |
| ELAV-like protein 3 | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] FabI | Escherichia coli K-12 | IC50 | 20.0000 | 1 | 1 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1.8333 | 3 | 3 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.5283 | 3 | 3 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 68.6000 | 3 | 3 |
| Epoxide hydrolase 1 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Eyes absent homolog 2 | Homo sapiens (human) | IC50 | 386.2500 | 4 | 4 |
| Fe(3+)-Zn(2+) purple acid phosphatase | Phaseolus vulgaris | Ki | 140.0000 | 1 | 1 |
| Focal adhesion kinase 1 | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 15.4000 | 1 | 1 |
| G1/S-specific cyclin-D1 | Homo sapiens (human) | IC50 | 61.0000 | 1 | 1 |
| G2/mitotic-specific cyclin-B | Marthasterias glacialis (spiny starfish) | IC50 | 31.2750 | 1 | 4 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 | 38.3333 | 3 | 3 |
| G2/mitotic-specific cyclin-B2 | Homo sapiens (human) | IC50 | 75.0000 | 1 | 1 |
| G2/mitotic-specific cyclin-B3 | Homo sapiens (human) | IC50 | 75.0000 | 1 | 1 |
| Gasdermin-D | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Gasdermin-D | Mus musculus (house mouse) | IC50 | 0.4000 | 1 | 1 |
| glucose-6-phosphate dehydrogenase | Leuconostoc mesenteroides | IC50 | 25.0000 | 1 | 1 |
| Glutathione reductase | Saccharomyces cerevisiae S288C | IC50 | 48.8000 | 1 | 1 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | IC50 | 218.0000 | 1 | 1 |
| Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | Trypanosoma cruzi | IC50 | 142.0000 | 1 | 1 |
| Glycogen phosphorylase, liver form | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | IC50 | 2.1000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 2.1000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Rattus norvegicus (Norway rat) | IC50 | 31.2750 | 1 | 4 |
| Heat shock factor protein 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Hepatocyte growth factor receptor | Homo sapiens (human) | IC50 | 0.5800 | 1 | 1 |
| hepatocyte nuclear factor 4-alpha isoform 2 | Homo sapiens (human) | IC50 | 39.8690 | 1 | 1 |
| hexokinase | Trypanosoma brucei brucei TREU927 | IC50 | 22.3780 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Hypoxia-inducible factor 1-alpha inhibitor | Homo sapiens (human) | IC50 | 10.2000 | 1 | 1 |
| Inositol hexakisphosphate kinase 2 | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| Inositol polyphosphate multikinase | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Insulin-like growth factor 1 receptor | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 13.1600 | 5 | 5 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 1.4900 | 1 | 1 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 1.0000 | 1 | 1 |
| kappa-type opioid receptor isoform 1 | Homo sapiens (human) | IC50 | 18.8950 | 2 | 2 |
| Lactoperoxidase | Bos taurus (cattle) | IC50 | 6.1000 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 15.1356 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 1.2600 | 1 | 1 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| Macrophage metalloelastase | Homo sapiens (human) | IC50 | 10.2300 | 1 | 1 |
| Malate dehydrogenase | Thermus thermophilus | IC50 | 6.0000 | 1 | 1 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | IC50 | 9.3000 | 2 | 2 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 0.8919 | 2 | 2 |
| Metallo-beta-lactamase VIM-13 | Pseudomonas aeruginosa | IC50 | 252.6000 | 1 | 1 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 2.8800 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 2.8800 | 1 | 2 |
| Monocarboxylate transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 14.0000 | 1 | 1 |
| Monocarboxylate transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 48,500.0000 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | Ki | 5.2500 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 95.6000 | 1 | 3 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 1.6975 | 4 | 4 |
| NADPH oxidase 4 | Homo sapiens (human) | IC50 | 0.6800 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 7.7500 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 53.9250 | 4 | 4 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | Ki | 3.8000 | 1 | 1 |
| Neutrophil elastase | Homo sapiens (human) | IC50 | 18.3390 | 2 | 2 |
| Neutrophil elastase | Homo sapiens (human) | Ki | 11.9000 | 1 | 1 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 16.4000 | 1 | 1 |
| Nociceptin receptor | Mus musculus (house mouse) | Ki | 20,000.0000 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/California/07/2009(H1N1)) | IC50 | 1.8370 | 1 | 1 |
| NUAK family SNF1-like kinase 1 | Homo sapiens (human) | IC50 | 5.0900 | 1 | 1 |
| Oligo-1,6-glucosidase IMA1 | Saccharomyces cerevisiae S288C | IC50 | 530.0000 | 1 | 1 |
| Ornithine transcarbamylase, mitochondrial | Homo sapiens (human) | Ki | 16,333.3333 | 3 | 3 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 3.7080 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 4.5885 | 2 | 2 |
| Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens (human) | IC50 | 3.8000 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Homo sapiens (human) | IC50 | 8.7950 | 2 | 2 |
| Phosphodiesterase | Rattus norvegicus (Norway rat) | IC50 | 275.0000 | 1 | 1 |
| Phospholipase A2 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 71.0857 | 1 | 14 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 135.5000 | 2 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 6.9580 | 5 | 5 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 1.9500 | 6 | 6 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | IC50 | 0.4400 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 18.7150 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Probable maltase-glucoamylase 2 | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| Prolyl 4-hydroxylase | Paramecium bursaria Chlorella virus 1 | IC50 | 212.6000 | 1 | 1 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 2 | 2 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 28.6000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 2 | 2 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 2.7500 | 2 | 2 |
| Protein E6 | Human papillomavirus 16 | IC50 | 20.0000 | 1 | 1 |
| Protein farnesyltransferase subunit beta | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Prothrombin | Homo sapiens (human) | IC50 | 15.7500 | 2 | 2 |
| Prothrombin | Bos taurus (cattle) | IC50 | 28.7500 | 1 | 4 |
| Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (human) | IC50 | 78.1000 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 20,003.7800 | 4 | 4 |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 5.3900 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 12.7600 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 26.4250 | 4 | 4 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 7.4000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 7.4000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 9.0000 | 1 | 1 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | Ki | 106.7000 | 1 | 1 |
| Serine/threonine-protein kinase B-raf | Homo sapiens (human) | IC50 | 7.5890 | 1 | 1 |
| Serine/threonine-protein kinase N1 | Homo sapiens (human) | IC50 | 5.8000 | 1 | 1 |
| Serine/threonine-protein kinase Nek2 | Homo sapiens (human) | IC50 | 5.7300 | 1 | 1 |
| Serine/threonine-protein kinase Nek6 | Homo sapiens (human) | IC50 | 4.2300 | 1 | 1 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 | 0.7686 | 5 | 5 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 34.8750 | 2 | 2 |
| Short transient receptor potential channel 5 | Homo sapiens (human) | IC50 | 6.5000 | 1 | 1 |
| Sialidase | Clostridium perfringens | IC50 | 9.9200 | 5 | 5 |
| Sialidase-2 | Homo sapiens (human) | IC50 | 160.0000 | 1 | 1 |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Solute carrier family 15 member 2 | Homo sapiens (human) | Ki | 3,095.1500 | 1 | 2 |
| Solute carrier family 2, facilitated glucose transporter member 2 | Homo sapiens (human) | IC50 | 12.0000 | 2 | 2 |
| Solute carrier family 2, facilitated glucose transporter member 4 | Rattus norvegicus (Norway rat) | Ki | 16.0000 | 1 | 1 |
| Solute carrier family 22 member 4 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Sorbitol dehydrogenase | Homo sapiens (human) | IC50 | 106.3000 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 | IC50 | 5.6000 | 1 | 1 |
| Stromelysin-1 | Homo sapiens (human) | IC50 | 5.5700 | 1 | 1 |
| Substance-K receptor | Cavia porcellus (domestic guinea pig) | IC50 | 58.4000 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 58.4000 | 1 | 1 |
| Succinyl-diaminopimelate desuccinylase | Haemophilus influenzae Rd KW20 | IC50 | 50.0000 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| Transmembrane prolyl 4-hydroxylase | Homo sapiens (human) | IC50 | 34.2000 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 15.4000 | 1 | 1 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 15.4000 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 15.4000 | 1 | 1 |
| Type IV secretion-like conjugative transfer relaxase protein TraI | Escherichia coli SMS-3-5 | Ki | 0.0030 | 1 | 2 |
| Tyrosinase | Homo sapiens (human) | IC50 | 44.3800 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 13.0000 | 2 | 2 |
| Tyrosine-protein kinase receptor UFO | Homo sapiens (human) | IC50 | 0.9600 | 1 | 1 |
| Tyrosine-protein kinase SYK | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Tyrosine-protein kinase Yes | Homo sapiens (human) | Ki | 0.4720 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 23.3000 | 2 | 2 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 11.1333 | 3 | 3 |
| Urease subunit alpha | Helicobacter pylori 26695 | Ki | 9.3400 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 11.1333 | 3 | 3 |
| Urease subunit beta | Helicobacter pylori 26695 | Ki | 9.3400 | 1 | 1 |
| Urokinase-type plasminogen activator | Homo sapiens (human) | IC50 | 25.4200 | 2 | 5 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 0.9700 | 2 | 2 |
| Vasopressin V2 receptor | Homo sapiens (human) | IC50 | 20.3282 | 3 | 6 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 31.9000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 3.0400 | 3 | 3 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | Ki | 1.2000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | Ki | 0.2800 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 3-dehydroquinate dehydratase | Helicobacter pylori 26695 | Kd | 2.5000 | 1 | 1 |
| 3-dehydroquinate dehydratase | Streptomyces coelicolor A3(2) | Kd | 7.3000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, germ cell type preproprotein | Homo sapiens (human) | EC50 | 27.1000 | 1 | 1 |
| alkaline phosphatase, intestinal | Homo sapiens (human) | EC50 | 21.0500 | 2 | 2 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | EC50 | 27.5000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 31.5000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 31.5000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 31.5000 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 83.4000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Kd | 7.0795 | 1 | 1 |
| Beta-galactosidase | Escherichia coli | EC50 | 31.5000 | 1 | 1 |
| botulinum neurotoxin type A | Clostridium botulinum A str. ATCC 3502 | EC50 | 20.0000 | 1 | 1 |
| botulinum neurotoxin type F, BoNT/F | Clostridium botulinum Bf | EC50 | 20.0000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | EC50 | 0.1953 | 3 | 3 |
| C-C chemokine receptor type 1 | Homo sapiens (human) | EC50 | 32.6506 | 1 | 6 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | EC50 | 38.2785 | 1 | 6 |
| C-C chemokine receptor type 8 | Homo sapiens (human) | EC50 | 348.6204 | 1 | 6 |
| calcineurin A1, putative | Candida dubliniensis CD36 | EC50 | 180.0000 | 1 | 1 |
| Chain A, N5-carboxyaminoimidazole ribonucleotide mutase | Acetobacter aceti | Kd | 1,200.0000 | 1 | 4 |
| Chain B, N5-carboxyaminoimidazole ribonucleotide mutase | Acetobacter aceti | Kd | 1,200.0000 | 1 | 4 |
| Cystic fibrosis transmembrane conductance regulator | Homo sapiens (human) | Kd | 25.6000 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | EC50 | 8.8000 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | EC50 | 1.1000 | 1 | 1 |
| delta-type opioid receptor | Homo sapiens (human) | EC50 | 32.0000 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | EC50 | 6.9750 | 2 | 2 |
| heat shock protein 90 | Candida albicans | EC50 | 75.3800 | 3 | 4 |
| Heterogeneous nuclear ribonucleoprotein A1 | Homo sapiens (human) | Kd | 5.3000 | 1 | 2 |
| Interstitial collagenase | Homo sapiens (human) | Kd | 51.8000 | 1 | 1 |
| LAP4 | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 2.4415 | 1 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | EC50 | 20.0000 | 1 | 1 |
| MEP2 | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 337,300.0000 | 1 | 1 |
| Methionine aminopeptidase 1 | Homo sapiens (human) | EC50 | 66.7733 | 3 | 3 |
| mu opioid receptor, partial | Homo sapiens (human) | EC50 | 32.0000 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 27.5500 | 2 | 2 |
| Procathepsin L | Homo sapiens (human) | EC50 | 83.4000 | 1 | 1 |
| Prothrombin | Homo sapiens (human) | Kd | 0.0387 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 83.4000 | 2 | 2 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 83.4000 | 1 | 1 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 83.4000 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 83.4000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 83.4000 | 2 | 2 |
| RPL19A | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 49.9300 | 1 | 1 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | Kd | 0.0250 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 83.4000 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 83.4000 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 83.4000 | 1 | 1 |
| Tyrosine-protein kinase SYK | Homo sapiens (human) | EC50 | 35.0000 | 1 | 1 |