ascorbic-acid and Syndrome

Fibromyalgia (FM) is a multifactorial syndrome of unknown etiology, characterized by widespread chronic pain and various somatic and psychological manifestations. The management of FM requires a multidisciplinary approach combining both pharmacological and nonpharmacological strategies. Among nonpharmacological strategies, growing evidence suggests a potential beneficial role for nutrition. This review summarizes the possible relationship between FM and nutrition, exploring the available evidence on the effect of dietary supplements and dietary interventions in these patients. Analysis of the literature has shown that the role of dietary supplements remains controversial, although clinical trials with vitamin D, magnesium, iron and probiotics' supplementation show promising results. With regard to dietary interventions, the administration of olive oil, the replacement diet with ancient grains, low-calorie diets, the low FODMAPs diet, the gluten-free diet, the monosodium glutamate and aspartame-free diet, vegetarian diets as well as the Mediterranean diet all appear to be effective in reducing the FM symptoms. These results may suggest that weight loss, together with the psychosomatic component of the disease, should be taken into account. Therefore, although dietary aspects appear to be a promising complementary approach to the treatment of FM, further research is needed to provide the most effective strategies for the management of FM.

Topics: Acetylcarnitine; Ascorbic Acid; Chlorella; Diet, Vegan; Dietary Supplements; Fibromyalgia; Nutrition Therapy; Nutritional Physiological Phenomena; Syndrome; Ubiquinone; Vitamin E

Arterial Tortuosity Syndrome (ATS) is a heritable disease characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. ATS is caused by mutations in SLC2A10, encoding Glucose Transporter 10 (GLUT10). The current model of ATS holds that loss of GLUT10 at the nuclear periphery induces a glucose-dependent increase in Transforming Growth Factor-beta (TGFbeta) that stimulates vessel wall cell proliferation. Instead, we propose that GLUT10 transports ascorbate, a cofactor for collagen and elastin hydroxylases, into the secretory pathway. In ATS, loss of GLUT10 results in defective collagen and/or elastin. TGFbeta activation represents a secondary response to a defective extracellular matrix.

Topics: Animals; Arteries; Ascorbic Acid; Collagen; Elastin; Glucose; Glucose Transport Proteins, Facilitative; Mice; Models, Biological; Mutation; Skin; Syndrome; Transforming Growth Factor beta; Vitamins

Topics: Anemia; Ascorbic Acid; Blood Coagulation Disorders; Chronic Disease; Folic Acid; Hematologic Diseases; Hemolysis; Humans; Leukocytosis; Mononuclear Phagocyte System; Serum Albumin; Stress, Physiological; Syndrome; Thrombocytosis; Zinc

Topics: Ascorbic Acid; Blood Transfusion; Chelating Agents; Deferoxamine; Diet; Gentisates; Hemochromatosis; Hemosiderosis; Hydroxamic Acids; Hydroxybenzoates; Iron; Piperazines; Syndrome

It is apparent that significant progress has been made in our understanding of the biosynthesis, modifications, and maturation of collagen and elastin. We now recognize and partially understand special reactions involved in hydroxylations within the cell and complex cross-linking processes occurring outside the cell. Recent experiments (191) have shown that in human diploid fibroblast cultures of limited doubling potential (191) the hydroxylation of collagen prolyl residues appears to be "age" or passage-level dependent. With increasing passage level of these cultures, both the ascorbate requirements and the extent of collagen hydroxylation decrease. "Young" cell cultures have a strong requirement for complete hydroxylation and without ascorbate there is only about 50% of the normal level. "Middle-aged" cultures show higher hydroxylation without and full hydroxylation with ascorbate, whereas "old" (or cultures close to "senescence") are incapable of full hydroxylation with or without ascorbic acid. Although the overall system may show some deterioration with increasing passage levels, it appears that with increasing passage levels other components in the cell replace the ascorbate dependence of the hydroxylase system to a greater exten. In some ways, aging WI-38 cultures begin to resemble some transformed cells in their biochemical reactions, although they continue to remain diploid and eventually lose the ability to replicate. It is not yet known whether old animals can produce collagen, which may now be underhydroxylated, perhaps contributing to certain senescent changes. Careful examination of the hydroxylation index of collagen produced in organoid cultures of tissue biopsies as a function of donor age might be informative, particularly if one looks at the quality of collagen by employing collagenase and other proteolytic digests with collagen (191). One could comare the levels of frequent and characteristic peptide triplet sequences such as Gly-Pro-Hyp to Gly-Pro-Pro, Gly-Ala-Hyp to Gly-Ala-Pro, or Gly-Pro-Hyl to Gly-Pro-Lys and others for evaluation of hydroxylation throughout the entire molecule or at selected sequences.

Topics: Amino Acid Sequence; Animals; Antibody Specificity; Ascorbic Acid; Collagen; Connective Tissue; Copper; Ehlers-Danlos Syndrome; Elastin; Epitopes; Homocystinuria; Humans; Hydralazine; Lathyrism; Marfan Syndrome; Molecular Conformation; Platelet Aggregation; Procollagen-Proline Dioxygenase; Skin Diseases; Syndrome

The public health cost impact of complex regional pain syndrome type I (CRPS I) is considerable in both emergency and scheduled orthopaedic surgery. We proposed to assess the effectiveness of vitamin C in prevention of CRPS I in foot and ankle surgery.. We carried out a "before-after" quasi-experimental study comparing two chronologically successive groups without (Group I: July 2002-June 2003) and with (Group II: July 2003-June 2004) preventive 1g daily vitamin C treatment. All patients having surgery on the foot or ankle were enrolled, with the exception of diabetic foot cases. Several factors were analysed: sex, age, type of pathology, history of CRPS I, psychological context, tourniquet time, and cast immobilisation time.. 420 feet (392 patients) were included in the study: 185 in Group I, 235 in Group II. CRPS I occurred in 18 cases in Group I (9.6%) and 4 cases in Group II (1.7%) (p<10(-4)), with history of CRPS I as a significantly correlated factor (relative risk=10.4). The psychological context (anxio-depressive state) showed a (sub-significant) tendency to increase the risk of CRPS I (relative risk=2.6).. Vitamin C has been shown to be effective in preventing CRPS I secondary to wrist fracture, but few data are available with respect to foot and ankle cases. The present study demonstrates the effectiveness of vitamin C in preventing CRPS I of the foot and ankle-a frequent complication in our control group (9.6%). The authors recommend preventive management by vitamin C.

Topics: Adolescent; Adult; Aged; Ankle Injuries; Antioxidants; Ascorbic Acid; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Foot Injuries; Humans; Male; Middle Aged; Orthopedic Procedures; Pain, Postoperative; Prospective Studies; Reflex Sympathetic Dystrophy; Syndrome; Treatment Outcome; Young Adult

The glucose transporter protein syndrome (GTPS) is caused by defective transport of glucose across the blood-brain barrier via the glucose transporter GLUT1, resulting in hypoglycorrhachia, infantile seizures, and developmental delay. Recent reports indicated that GLUT1 is a multifunctional transporter. We investigated the transport of vitamin C in its oxidized form (dehydroascorbic acid) via GLUT1 into erythrocytes of 2 patients with GTPS. In both patients, uptake of oxidized vitamin C was 61% of the mothers' values. Our findings are consistent with recent observations that vitamin C is transported in its oxidized form via GLUT1. We speculate that impaired transport of this substrate and perhaps other substrates in GTPS might contribute to the pathophysiology of this condition.

Topics: Adult; Ascorbic Acid; Blood-Brain Barrier; Child; Dehydroascorbic Acid; Erythrocytes; Female; Humans; Male; Middle Aged; Monosaccharide Transport Proteins; Oxidation-Reduction; Syndrome

The relevance, to general practice, of the various views on the idiopathic tetany syndrome is discussed. The effect of a drug (Frubiase Calcium forte), which largely metts the requirements stemming from the above, on all important symptome and diagnostic signs was found to be statistically superior to placebo on the basis of a randomised double blind trial in 80 patients.

Topics: Adolescent; Adult; Ascorbic Acid; Calcium; Child; Clinical Trials as Topic; Drug Combinations; Ergocalciferols; Female; Humans; Male; Middle Aged; Phosphorus; Placebos; Syndrome; Tetany

Topics: Ascorbic Acid; Humans; Syndrome; Thiamine; Thiamine Deficiency; Vitamins

Topics: Adolescent; Antioxidants; Ascorbic Acid; Child; Chromosome Disorders; Dipeptidases; Forehead; Humans; Male; Nose Deformities, Acquired; Plastic Surgery Procedures; Postoperative Complications; Skin Transplantation; Skin Ulcer; Surgical Flaps; Syndrome; Wound Healing

Infantile Tremor Syndrome is a distinct clinical entity most commonly seen in Indian Subcontinent. Syndrome consists of tremors, mental and developmental retardation, abnormal skin pigmentation and anemia in children between 6 months to 2 years. The etiology is still elusive. Amongst various theories, nutritional theory is the most accepted. So far there are no cases reported of vitamin C deficiency in ITS. In this article, three cases of ITS associated with vitamin C deficiency are reported.

Topics: Age Factors; Ascorbic Acid; Ascorbic Acid Deficiency; Folic Acid; Humans; Infant; Iron; Male; Malnutrition; Propranolol; Scurvy; Socioeconomic Factors; Syndrome; Treatment Outcome; Tremor

1. Single comb White Leghorn hens of an inbred line highly susceptible to fatty liver haemorrhagic syndrome (FLHS) were fed supplemented dietary ascorbic acid (200 mg/kg), alpha-tocopherol (75 mg/kg), or L-cysteine (3 g/kg, and 6 g/kg) for 28 d in order to evaluate the potential therapeutic effect of these compounds against the disease. 2. Supplementation of ascorbic acid, alpha-tocopherol, or a low level of L-cysteine (3 g/kg) did not significantly affect any of the hepatic variables evaluated. Hepatic glutathione was not increased by the supplementation of dietary L-cysteine. 3. L-cysteine supplemented at a level of 6 g/kg decreased hepatic dry matter and fat contents without affecting the hepatic malondialdehyde or the liver haemorrhagic score. 4. Because one of the predisposing factors of FLHS is a high hepatic fat content it was concluded that dietary supplementation of L-cysteine (6 g/kg) may be useful in the prevention of the disease.

Topics: Animals; Antioxidants; Ascorbic Acid; Chickens; Cysteine; Fatty Liver; Female; Food, Fortified; Glutathione; Hemorrhage; Liver; Oviposition; Poultry Diseases; Syndrome; Vitamin E

A deafferentation syndrome, produced in rats by dorsal root ganglionectomies, is expressed as scratching of partially deafferented limb areas and/or biting of anesthetic limb areas. This self-mutilation may be objective evidence of dysesthesias, thus serving as an experimental model to study chronic dysesthesias and/or pain from deafferentation in man. This study included behavioral observations of the syndrome and the effects of intraventricular apomorphine, a dopamine agonist, on its expression. Thirty-eight female Sprague-Dawley rats underwent unilateral C5-T2 dorsal root ganglionectomies followed immediately by stereotactically guided cannulation of the right lateral ventricle in 20 of the rats. For 2 weeks continuously via an osmotic minipump, 10 rats received apomorphine (5 micrograms/h) and 10 others received L-ascorbate (the vehicle). Rats with ganglionectomies only, as well as those receiving L-ascorbate, demonstrated early onset, more severe and later onset, less severe biting groups (P less than 0.05 Mann-Whitney U). Animals receiving apomorphine exhibited low autotomy scores irrespective of time of bite onset. Among the control groups, but not the experimental animals, the earlier the onset of biting, the more severe was the autotomy. The rats receiving vehicle via the minipump had earlier bite onsets than the rats in the ganglionectomy only group. This may indicate that the presence of the minipump is a stress which can accelerate the onset of biting. Intraventricular apomorphine can affect the deafferentation syndrome in the rat; it seems to decrease the level of autotomy and disrupt the relationship of bite onset with degree of biting.

Topics: Afferent Pathways; Animals; Apomorphine; Ascorbic Acid; Behavior, Animal; Denervation; Female; Forelimb; Hindlimb; Nervous System Diseases; Pain; Rats; Rats, Inbred Strains; Syndrome

Preliminary data of a postmortem brain study in a single case with Rett syndrome compared to a single control case showed a severe reduction of ascorbic acid and reduced glutathione in most brain regions studied. These findings suggest a secondary disturbance of ascorbic acid and glutathione metabolism in the Rett syndrome.

Topics: Ascorbic Acid; Brain Chemistry; Brain Diseases; Child; Female; Glutathione; Humans; Intellectual Disability; Syndrome

Chronic refractory anemia associated with congenital hypoplastic anemia (CHA, Blackfan-Diamond syndrome) and with the 5q-syndrome may require chronic transfusion therapy to sustain life. Hemosiderosis and death from chronic iron overload may result from such a program. The effect of subcutaneous (SC) deferoxamine (DF) and supplemental oral vitamin C (vit. C) on urinary iron excretion was studied in two patients with congenital hypoplastic anemia and one patient with 5q-syndrome. In the two patients with CHA, urinary iron excretion in response to DF given SC over 24 hours was comparable to the results following intravenous (I.V.) administration. Both of these cases had low levels of plasma ascorbate on initial evaluation and excreted more iron in response to two different doses of DF after they had received supplemental vit C and their stores were repleted. Significant iron excretion occurred in all three patients for 12 hours during the SC infusion of DF and for 12 hours after the end of the infusion. In all three patients, increasing the dose of DF up to 3-4 g given SC over 12 hours resulted in a linear increase in iron excretion. Once normal body stores of ascorbate were achieved by oral supplementation, increasing doses of vit C did not appear to cause a further increment in iron excretion. DF administered by a slow SC infusion appears to be an effective approach to iron overload in patients with refractory anemia and hemosiderosis secondary to chronic transfusions. Only small amounts of supplemental vit. C necessary to sustain adequate body stores are required for optimal iron excretion.

Topics: Administration, Oral; Anemia, Aplastic; Ascorbic Acid; Blood Transfusion; Child; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 4-5; Deferoxamine; Female; Hemosiderosis; Humans; Injections, Subcutaneous; Iron; Male; Middle Aged; Syndrome

Topics: Ascorbic Acid; Fatty Acids, Essential; Humans; Lacrimal Apparatus Diseases; Pyridoxine; Salivary Gland Diseases; Sjogren's Syndrome; Syndrome

Lack of adequate synthesis of prostaglandin (PG) E1 may be the key factor in Sjogren's syndrome. PGE1 is important for lacrimal and salivary gland secretion and for T lymphocyte function: a deficiency could therefore account for the main features of Sjogren's syndrome and the sicca syndrome. PGE1 could also account for many of the other features often associated with these syndromes. These include the Raynaud's phenomenon, the abnormalities of renal function and the precipitation of the syndrome by vitamin C deficiency. Vitamin C is important in PGE1 biosynthesis. PGE1 treatment has been shown to correct the immunological abnormalities in the NZB/W mouse, the animal model of Sjogren's syndrome. An attempt to treat humans with Sjogren's syndrome by raising endogenous PGE1 production by administration of essential fatty acid PGE1 precursors, of pyridoxine and of vitamin C was successful in raising the rates of tear and saliva production.

Topics: Arthritis, Rheumatoid; Ascorbic Acid; Fatty Acids, Essential; Female; Humans; Lacrimal Apparatus Diseases; Middle Aged; Prostaglandins E; Pyridoxine; Salivary Gland Diseases; Sjogren's Syndrome; Syndrome

Topics: Amino Acids; Anemia, Hypochromic; Ascorbic Acid; Diet; Humans; Nutritional Physiological Phenomena; Pyridoxine; Riboflavin; Riboflavin Deficiency; Seizures; Syndrome; Thiamine; Thiamine Deficiency; Vitamin B 6 Deficiency; Vitamin B Complex; Vitamin B Deficiency; Vitamins

Topics: Adult; Ascorbic Acid; Blood Bactericidal Activity; Cell Movement; Chemotaxis, Leukocyte; Granulocytes; Humans; Hypergammaglobulinemia; Immunoglobulin E; Lymphocyte Activation; Male; Rosette Formation; Syndrome; Transfer Factor

A Candida albicans corneal ulcer developed in a 24-year-old man with a history of eczema, asthma, and multiple bacterial infections since childhood. The infection responded well to oral flucytosine (12 g/day for 15 days) and topical amphotericin B. Positive laboratory findings included eosinophilla, hyperimmunoglobulinemia E, and impaired neutrophil and monocyte spontaneous migration and chemotactic responses. Ascorbic acid corrected the monocyte defect in vitro and in vivo, but had no effect on neutrophil function.

Topics: Adult; Ascorbic Acid; Bacterial Infections; Candidiasis; Chemotaxis, Leukocyte; Corneal Ulcer; Humans; Hypergammaglobulinemia; Hypersensitivity, Immediate; Immunoglobulin E; Infections; Male; Monocytes; Neutrophils; Recurrence; Syndrome

Leukocyte peroxidase deficiency has been demonstrated in a confirmed case of neuronal ceroid-lipofuscinosis with guaiacol, o-dianisidine, and p-phenylenediamine used as hydrogen donors in the peroxidase assay system. Nitroblue tetrazolium (NBT) reduction values in the leukocytes of the patient were also found to be significantly higher than those of normal controls, indicating the impaired hydrogen peroxide catabolism. When the patient was given a daily dose of vitamin E (400 I.U.), vitamin C (1 gm), and methionine (1 gm.) along with a weekly intramuscular injection of vitamin B12, the leukocyte peroxidase values of the patient returned to normal levels in about 7 weeks. NBT reductions values also decreased to normal levels. The regenerated enzyme in the patient's leukocytes was shown to have similar chromatographic and electrophoretic properties as the leukocyte peroxidase of normal controls. After about 28 weeks of therapy, the peroxidase levels in the leukocytes of the patient returned to original low levels, with concomitant increase in the NBT reduction values. The effect of vitamin therapy on normal control subjects was, at least in some cases, an increase of leukocyte peroxidase. A significant increase in the peroxidase levels of the patient's leukocytes during vitamin therapy remains unexplained, and the possibility of peroxidase deficiency being a secondary manifestation rather than the primary defect in Batten's disease cannot be ruled out.

Topics: Ascorbic Acid; Child, Preschool; Humans; In Vitro Techniques; Leukocytes; Lipidoses; Methionine; Peroxidases; Syndrome; Vitamin B 12; Vitamin E

The author conducted a study of the tyrosine balance and the urine excretion of its metabolites: paraoxyphenylpyruvic and homogentistic acid in 39 oligophrenic patients of a nontypical and of 90 with an exogenous genesis. In exogenic forms of oligophrenia the oxidation of tyrosine was characterized by hypertyrosinemia, hypertyrosinuria, a drop of paraoxyphenylpyruvic acid excretion. In genotypical oligophrenia the most typical were high indices of tyrosinemia, tyrosinuria, excretion of paraphenylpyruvic acid and homogentistic acid.

Topics: Adolescent; Ascorbic Acid; Child; Female; Homogentisic Acid; Humans; Intellectual Disability; Male; Phenylpyruvic Acids; Syndrome; Tyrosine

Of one hundred and twenty-six patients with Gardner's syndrome, 60% showed soft tissue tumors, 32% showed osteomatosis, 67% polyposis, and 20% the complete triad. Bowel cancer developed in 32% of the patients. The frequency of other diseases in these patients showed fibrous tumors in 8%, and two patients with cancer of the ampulla of Vater; otherwise the diseases seen did not show any major variation from what might be expected for the group at risk. Laboratory evaluation has included the demonstration of increased fecal cholesterol and primary bile acids in these patients. The recommended surgical treatment is colectomy and ileorectal anastomosis at a measured 12 cm level. This level of ileorectal anastomosis may be vital in giving a regression of rectal polyps, which was seen in 15 to 17 patients so treated. The conversion of an ileosigmoid to an ileorectal anastomosis resulted in polyp regression in one patient. The oral administration of ascorbic acid gave polyp regression in seven of 10 patients. There may be a possible relationship of fecal coprostanol and cholesterol levels and polyp regression.

Topics: Adolescent; Adult; Ascorbic Acid; Bone Neoplasms; Child; Colectomy; Colon, Sigmoid; Female; Follow-Up Studies; Humans; Ileum; Intestinal Polyps; Male; Rectal Diseases; Rectum; Soft Tissue Neoplasms; Syndrome

An infant with a combination of clinical and biochemical features resembling those found in hereditary tyrosinemia ("inborn hepatorenal dysfunction with tyrosyluria") but with spontaneous recovery is described briefly. The child also had severe congenital hydrocephalus, and was being given chloral hydrate. She was not treated by restriction of dietary phenylalanine and tyrosine. The abnormal aromatic aciduria was unaltered by ascorbic acid administration. The results of loading tests with phenylalanine, tyrosine, and sodium 4-hydroxyphenylpyruvate are compatible with the existence of a partial block in the oxidation of 4-hydroxyphenylpyruvate to homogentisate which was exacerbated by administering chloral hydrate.

Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Ascorbic Acid; Chloral Hydrate; Female; Humans; Hydrocephalus; Infant; Lactates; Methionine; Oxygenases; Phenylacetates; Phenylalanine; Phenylpyruvic Acids; Syndrome; Tyrosine

Topics: Adult; Amino Acids; Anemia, Hemolytic; Ascorbic Acid; Cerebellar Diseases; Cyanides; Electroencephalography; Electromyography; Erythrocytes; Female; Glutathione; Humans; Leukocytes; Male; Metabolism, Inborn Errors; Muscles; Neural Conduction; Peptide Synthases; Potassium; Renal Aminoacidurias; Spinal Cord Diseases; Syndrome

Topics: Adolescent; Anemia; Ascorbic Acid; Child; Corrinoids; Folic Acid; Geriatrics; Humans; Injections, Intravenous; Liver Diseases; Niacinamide; Syndrome; Vitamin B 12; Vitamin B Complex; Vitamins

Topics: Ascorbic Acid; Humans; Pseudoxanthoma Elasticum; Steroids; Syndrome; Vitamin E

Topics: Adenine Nucleotides; Ascorbic Acid; Humans; Osteoporosis; Polyphosphates; Syndrome; Testosterone; Vitamins

Topics: Ascorbic Acid; Blood; Child; Female; Humans; Infant; Pregnancy; Schizophrenia; Syndrome; Vitamins

Topics: Ascorbic Acid; Hemorrhage; Humans; Pectins; Solutions; Syndrome; Vitamins

Topics: Ascorbic Acid; Autonomic Nervous System; Calcium; Calcium, Dietary; Humans; Migraine Disorders; Phosphorus; Phosphorus Compounds; Phosphorus, Dietary; Syndrome

Topics: Ascorbic Acid; Biliary Tract; Calcium; Calcium, Dietary; Humans; Migraine Disorders; Phosphorus; Phosphorus, Dietary; Syndrome; Vitamins

Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Avitaminosis; Glossitis; Humans; Sweat; Syndrome