An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
ChEBI ID: 37890
| Member | Definition | Class |
|---|---|---|
| (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzodioxan hydrochloride | A hydrochloride salt that is obtained by reaction of N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine with one equivalent of hydrogen chloride. An alpha1A-adrenergic selective antagonist. | N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine hydrochloride |
| alfuzosin | alfuzosin | |
| carvedilol | A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure. | carvedilol |
| cleistanthin | A member of the class of cleistanthins that is the 4-O-3,4-di-O-methyl-beta-D-xylopyranoside of 1,3-dihydronaphtho[2,3-c]furan-4-ol which is substituted by an oxo group at position 1, methoxy groups at positions 6 and 7, and a 1,3-benzodioxol-5-yl group at position 9. It is one of the toxic principles in Cleistanthus collinus. | cleistanthin A |
| cleistanthin b | A member of the class of cleistanthins that is cleistanthin A in which the 3,4-di-O-methyl-D-xylopyranosyl group is replaced by a beta-D-glucopyranosyl group. | cleistanthin B |
| clopenthixol | A thioxanthene derivative having a chloro substituent at the 2-position and an alkylidene group at the 10-position with undefined double bond stereochemistry. | clopenthixol |
| dapiprazole | dapiprazole | |
| demethylmirtazapine | A benzazepine metabolite resulting from demethylation of the antidpressant, mirtazapine. | N-demethylmirtazapine |
| desipramine | A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group. | desipramine |
| dihydroergocristine monomesylate | The methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia. | dihydroergocristine mesylate |
| doxazosin | A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure. | doxazosin |
| idazoxan | A benzodioxine that is 2,3-dihydro-1,4-benzodioxine in which one of the hydrogens at position 2 has been replaced by a 4,5-dihydro-1H-imidazol-2-yl group. | idazoxan |
| ketanserin | A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group. | ketanserin |
| mianserin | A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere. | mianserin |
| mirtazapine | mirtazapine | |
| nefazodone | nefazodone | |
| phentolamine | A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension. | phentolamine |
| prazosin | A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively. | prazosin |
| prochlorperazine | A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. | prochlorperazine |
| quinidine | A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. | quinidine |
| raubasine | A monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure. | ajmalicine |
| risperidone | A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2. | risperidone |
| roxindole | roxindole | |
| rx 821002 | A benzodioxine that is idazoxan substituted at position 2 by a methoxy group. | 2-methoxyidazoxan |
| sertindole | A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-oxoimidazolidin-1-yl)ethyl group. | sertindole |
| setiptiline | A tetracyclic antidepressant that is 2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine carrying a methyl group at position 2. Its maleate salt is used for the treatment of depression in Japan. | setiptiline |
| spiperone | An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively. | spiperone |
| tamsulosin | A 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (R)-configuration. A specific alpha1 adrenoceptor antagonist used (generally as its hydrochloride salt, tamsulosin hydrochloride) in the treatment of prostatic hyperplasia, chronic prostatitis, urinary retention, and help with the passage of kidney stones. | tamsulosin |
| tamsulosin hydrochloride | A hydrochloride resulting from the reaction of equimolar amounts of tamulosin and hydrogen chloride. | tamsulosin hydrochloride |
| terazosin | terazosin | |
| thioridazine | A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position. | thioridazine |
| tolazoline | A member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group. | tolazoline |
| wb 4101 | A benzodioxine that is 2,3-dihydro-1,4-benzodioxine bearing a [(2',6'-dimethoxyphenoxy)ethylamino]methyl group at position 2. An alpha1A-adrenergic selective antagonist. | N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine |
| yohimbine | An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina. | yohimbine |
| zuclopenthixol | The (Z)-isomer of clopenthixol. | zuclopenthixol |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 24,117 (43.15) | 18.7374 |
| 1990's | 11,967 (21.41) | 18.2507 |
| 2000's | 10,575 (18.92) | 29.6817 |
| 2010's | 7,483 (13.39) | 24.3611 |
| 2020's | 1,753 (3.14) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 7,541 (11.12%) | 5.53% |
| Reviews | 3,898 (5.75%) | 6.00% |
| Case Studies | 4,457 (6.57%) | 4.05% |
| Observational | 141 (0.21%) | 0.25% |
| Other | 51,768 (76.35%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 25.2049 | 1 | 7 |
| 67.9K protein | Vaccinia virus | Potency | 25.7715 | 2 | 8 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 26.0655 | 3 | 16 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 25.1189 | 1 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 10.9001 | 2 | 6 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 24.9373 | 1 | 12 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 35.8747 | 2 | 12 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 15.8489 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 21.5994 | 9 | 50 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 22.0982 | 2 | 6 |
| arylsulfatase A | Homo sapiens (human) | Potency | 10.4366 | 1 | 8 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 25.2637 | 3 | 13 |
| Ataxin-2 | Homo sapiens (human) | Potency | 25.1036 | 2 | 12 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 20.1921 | 1 | 9 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 27.6881 | 2 | 5 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 5.7701 | 1 | 2 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 19.4184 | 1 | 3 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 9.4360 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 47.5599 | 1 | 6 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 2 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 30.0474 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 2 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 30.0474 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 22.7301 | 2 | 13 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 14.0140 | 2 | 6 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 20.8594 | 1 | 9 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 20.9848 | 2 | 6 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 24.8379 | 2 | 6 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 63.6354 | 1 | 4 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 16.4191 | 1 | 4 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 11.8378 | 1 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 36.5159 | 1 | 4 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 24.8379 | 2 | 6 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 38.2348 | 2 | 10 |
| ClpP | Bacillus subtilis | Potency | 18.2563 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 7.6053 | 1 | 8 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 11.6487 | 1 | 5 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 19.0597 | 1 | 4 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 3.9252 | 1 | 14 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 4.5464 | 1 | 14 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 12.3138 | 2 | 29 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 18.2811 | 2 | 11 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 27.0071 | 1 | 7 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 5.8672 | 3 | 22 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 15.6076 | 1 | 6 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 61.3396 | 1 | 5 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.0496 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 20.1754 | 9 | 50 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 21.5248 | 2 | 5 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 24.1292 | 8 | 52 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 19.1163 | 2 | 25 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 18.5451 | 4 | 22 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 27.6299 | 2 | 6 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 43.9022 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 23.7711 | 1 | 10 |
| G | Vesicular stomatitis virus | Potency | 19.0597 | 1 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| GALC protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 12.4317 | 1 | 15 |
| geminin | Homo sapiens (human) | Potency | 15.5305 | 2 | 17 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 14.0148 | 2 | 21 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 15.2970 | 1 | 5 |
| GLS protein | Homo sapiens (human) | Potency | 14.2901 | 2 | 9 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 21.8311 | 1 | 8 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 22.2878 | 3 | 14 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 17.8622 | 1 | 4 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 20.8959 | 2 | 4 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 21.4302 | 2 | 5 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 14.3027 | 2 | 31 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 13.1567 | 2 | 3 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 43.5776 | 2 | 9 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 19.0597 | 1 | 4 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 26.1727 | 2 | 5 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 13.4657 | 2 | 12 |
| IDH1 | Homo sapiens (human) | Potency | 23.3551 | 1 | 5 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 19.0597 | 1 | 8 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 2.2536 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 17.4945 | 1 | 3 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 17.4945 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 23.2706 | 2 | 8 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 4.7235 | 1 | 12 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 16.5311 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 39.6666 | 2 | 3 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 28.4488 | 3 | 10 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 20.8413 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 24.7140 | 2 | 11 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 18.1068 | 2 | 6 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 7.2877 | 2 | 8 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 23.9401 | 1 | 3 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 23.9401 | 1 | 3 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 11.1857 | 5 | 6 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 17.5594 | 2 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 11.2202 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 70.2298 | 1 | 6 |
| Nrf2 | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 17.5680 | 3 | 12 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 23.7246 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 26.1030 | 2 | 4 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 17.1390 | 2 | 12 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 13.2303 | 3 | 16 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 64.0255 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 42.9542 | 2 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 16.8145 | 2 | 8 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 85.4848 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 23.6879 | 3 | 8 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 23.6423 | 3 | 8 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 61.6840 | 3 | 9 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.1218 | 1 | 5 |
| polyprotein | Zika virus | Potency | 23.7711 | 1 | 10 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 16.7909 | 1 | 8 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 7.4771 | 1 | 13 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 19.7661 | 3 | 11 |
| progesterone receptor | Homo sapiens (human) | Potency | 24.9825 | 2 | 5 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 19.9912 | 2 | 12 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 55.6176 | 1 | 6 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 6.5578 | 1 | 6 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 23.2833 | 3 | 14 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 11.5728 | 2 | 7 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 16.0940 | 4 | 20 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 36.9872 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 36.9872 | 2 | 3 |
| Smad3 | Homo sapiens (human) | Potency | 15.9023 | 1 | 4 |
| snurportin-1 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 19.2764 | 1 | 12 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 2.4118 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 0.3548 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 16.3634 | 2 | 50 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 22.7167 | 4 | 20 |
| Thrombopoietin | Homo sapiens (human) | Potency | 18.8541 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 18.1308 | 3 | 27 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 21.2638 | 6 | 20 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 9.9878 | 2 | 2 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.1218 | 1 | 5 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.1218 | 1 | 5 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 43.3716 | 1 | 9 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 14.5253 | 2 | 10 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 17.8012 | 2 | 6 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 17.8622 | 1 | 4 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | Ki | 0.0170 | 1 | 2 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Homo sapiens (human) | Ki | 0.0006 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.2657 | 3 | 3 |
| 5-hydroxytryptamine receptor 1A | Mus musculus (house mouse) | IC50 | 0.4300 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.9403 | 5 | 13 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.2899 | 22 | 24 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.3267 | 18 | 26 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | IC50 | 8.2500 | 2 | 2 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 1.0224 | 2 | 10 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Ki | 6.9390 | 3 | 4 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 1.0684 | 5 | 15 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | IC50 | 2.2581 | 5 | 5 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 2.6750 | 1 | 2 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | Ki | 6.6668 | 3 | 3 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.4603 | 3 | 4 |
| 5-hydroxytryptamine receptor 1E | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 2.6750 | 1 | 2 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.4603 | 3 | 4 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0598 | 21 | 29 |
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | IC50 | 0.0015 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 2.2873 | 17 | 21 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0145 | 47 | 59 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0258 | 37 | 43 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.8337 | 2 | 12 |
| 5-hydroxytryptamine receptor 2B | Mus musculus (house mouse) | IC50 | 0.0015 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 2.9653 | 13 | 16 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.4909 | 3 | 13 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.0661 | 12 | 16 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.1304 | 8 | 16 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 2.9653 | 13 | 16 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0757 | 21 | 38 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.3074 | 21 | 26 |
| 5-hydroxytryptamine receptor 2C | Mus musculus (house mouse) | IC50 | 0.0015 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | IC50 | 1.4125 | 2 | 2 |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | IC50 | 1.4125 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | IC50 | 2.6750 | 1 | 2 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 2.9000 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | Ki | 0.2520 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.0700 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | IC50 | 1.4125 | 2 | 2 |
| 5-hydroxytryptamine receptor 3B | Mus musculus (house mouse) | IC50 | 1.4125 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | IC50 | 2.6750 | 1 | 2 |
| 5-hydroxytryptamine receptor 3B | Mus musculus (house mouse) | Ki | 0.2520 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.0700 | 1 | 1 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | IC50 | 1.4125 | 2 | 2 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | IC50 | 1.4125 | 2 | 2 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | IC50 | 1.4125 | 2 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.2286 | 1 | 9 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.1167 | 2 | 10 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 13.4500 | 2 | 3 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | IC50 | 2.6750 | 1 | 2 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | Ki | 34.3333 | 2 | 3 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | IC50 | 2.6750 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.6122 | 1 | 6 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | IC50 | 2.6750 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.8426 | 13 | 21 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 50.7600 | 1 | 10 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 0.1148 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | Ki | 0.0035 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.6928 | 12 | 17 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | IC50 | 2.6750 | 1 | 2 |
| 5-hydroxytryptamine receptor 7 | Mus musculus (house mouse) | Ki | 0.0630 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0323 | 5 | 8 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 0.5275 | 1 | 2 |
| Albumin | Homo sapiens (human) | IC50 | 3.5000 | 1 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.6630 | 1 | 4 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 0.6570 | 1 | 4 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | IC50 | 0.3475 | 18 | 20 |
| Alpha-1A adrenergic receptor | Mus musculus (house mouse) | IC50 | 0.0018 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1407 | 22 | 32 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.7985 | 9 | 33 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0297 | 48 | 77 |
| Alpha-1A adrenergic receptor | Oryctolagus cuniculus (rabbit) | Ki | 0.0082 | 1 | 7 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1160 | 39 | 58 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | IC50 | 0.0056 | 8 | 9 |
| Alpha-1B adrenergic receptor | Mus musculus (house mouse) | IC50 | 0.0018 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1453 | 22 | 31 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0287 | 47 | 75 |
| Alpha-1B adrenergic receptor | Mesocricetus auratus (golden hamster) | Ki | 0.0318 | 4 | 7 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1287 | 38 | 52 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.0569 | 10 | 22 |
| Alpha-1D adrenergic receptor | Mus musculus (house mouse) | IC50 | 0.0018 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1607 | 19 | 28 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0208 | 45 | 79 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0879 | 38 | 81 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.8632 | 9 | 20 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0729 | 9 | 11 |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | Ki | 0.1060 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.4286 | 48 | 69 |
| Alpha-2A adrenergic receptor | Mus musculus (house mouse) | Ki | 0.1706 | 8 | 14 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5323 | 37 | 59 |
| Alpha-2A adrenergic receptor | Sus scrofa (pig) | Ki | 2.0522 | 2 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.1535 | 7 | 19 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0729 | 9 | 11 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.3366 | 41 | 62 |
| Alpha-2B adrenergic receptor | Mus musculus (house mouse) | Ki | 0.1706 | 8 | 14 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5044 | 37 | 59 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.3956 | 9 | 20 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0729 | 9 | 11 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.2452 | 44 | 65 |
| Alpha-2C adrenergic receptor | Mus musculus (house mouse) | Ki | 0.1706 | 8 | 14 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5393 | 34 | 55 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 0.0190 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 0.0190 | 2 | 2 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 10.7706 | 1 | 8 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 6.1882 | 2 | 12 |
| Angiotensin-converting enzyme | Rattus norvegicus (Norway rat) | Ki | 0.2590 | 1 | 6 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 12 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 33.6786 | 11 | 14 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 11.5000 | 4 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 3.6240 | 5 | 5 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 0.0002 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 22.0000 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | IC50 | 1.3741 | 1 | 2 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 0.9446 | 1 | 2 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | IC50 | 1.6561 | 1 | 2 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Ki | 1.2421 | 1 | 2 |
| Beta-casein | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 173.5917 | 7 | 35 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 17.4000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 6.6000 | 1 | 1 |
| Bromodomain-containing protein 2 | Homo sapiens (human) | IC50 | 0.0009 | 1 | 1 |
| Bromodomain-containing protein 2 | Homo sapiens (human) | Ki | 0.0006 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 11 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Cathepsin D | Bos taurus (cattle) | IC50 | 0.0600 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 7.3700 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 1.2300 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 5.6662 | 1 | 2 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 4.6889 | 1 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 26.5000 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 32.0000 | 1 | 1 |
| Cytochrome P450 2D1 | Rattus norvegicus (Norway rat) | IC50 | 19.9000 | 1 | 1 |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | IC50 | 2.8000 | 1 | 1 |
| Cytochrome P450 2D3 | Rattus norvegicus (Norway rat) | IC50 | 26.9000 | 1 | 1 |
| Cytochrome P450 2D4 | Rattus norvegicus (Norway rat) | IC50 | 47.2000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 2.3131 | 46 | 51 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 0.1065 | 5 | 8 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 27.0000 | 3 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.4323 | 3 | 8 |
| D | Mus musculus (house mouse) | IC50 | 35.0000 | 1 | 1 |
| D | Rattus norvegicus (Norway rat) | IC50 | 0.3046 | 4 | 5 |
| D | Rattus norvegicus (Norway rat) | Ki | 1.9215 | 8 | 17 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.6747 | 1 | 6 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.2773 | 6 | 13 |
| D(1B) dopamine receptor | Mus musculus (house mouse) | IC50 | 35.0000 | 1 | 1 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0850 | 1 | 2 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 1.3340 | 2 | 3 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 1.3720 | 7 | 12 |
| D(2) dopamine receptor | Mus musculus (house mouse) | IC50 | 11.6820 | 2 | 3 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9255 | 17 | 24 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.2011 | 35 | 44 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.5757 | 24 | 38 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.8598 | 6 | 10 |
| D(3) dopamine receptor | Mus musculus (house mouse) | IC50 | 35.0000 | 1 | 1 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0850 | 1 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.4864 | 24 | 33 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 1.1564 | 4 | 7 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 2.0804 | 4 | 5 |
| D(4) dopamine receptor | Mus musculus (house mouse) | IC50 | 35.0000 | 1 | 1 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0850 | 1 | 2 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.5145 | 15 | 19 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 1.3340 | 2 | 3 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 700.0000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Endothelin receptor type B | Homo sapiens (human) | Ki | 0.0415 | 2 | 4 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Ki | 0.0415 | 1 | 2 |
| Endothelin-1 receptor | Homo sapiens (human) | IC50 | 0.1148 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 2.9470 | 1 | 1 |
| Estrogen receptor | Mus musculus (house mouse) | Ki | 0.0840 | 1 | 2 |
| Estrogen receptor beta | Mus musculus (house mouse) | Ki | 0.0840 | 1 | 2 |
| estrogen receptor beta isoform 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| G-protein coupled receptor | Apis mellifera (honey bee) | IC50 | 73.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Glycogen phosphorylase, brain form | Homo sapiens (human) | Ki | 49.6000 | 1 | 1 |
| Glycogen phosphorylase, muscle form | Homo sapiens (human) | Ki | 49.6000 | 1 | 1 |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0970 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 29.0034 | 8 | 11 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0201 | 2 | 5 |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0284 | 3 | 3 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0522 | 10 | 16 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 2.3400 | 1 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 1.1470 | 1 | 3 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 1.1280 | 1 | 3 |
| Histamine H3 receptor | Homo sapiens (human) | Ki | 3.0528 | 2 | 2 |
| Histamine H3 receptor | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| Histidine-rich protein PFHRP-II | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 325.0000 | 1 | 1 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 4.8925 | 1 | 2 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 2.4900 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 0.9960 | 1 | 1 |
| Lanosterol 14-alpha demethylase | Rattus norvegicus (Norway rat) | Ki | 0.0057 | 1 | 1 |
| Lysosomal alpha-glucosidase | Bos taurus (cattle) | Ki | 0.0087 | 1 | 1 |
| Lysosomal alpha-glucosidase | Rattus norvegicus (Norway rat) | Ki | 0.0087 | 1 | 1 |
| M-phase inducer phosphatase 1 | Homo sapiens (human) | IC50 | 22.3000 | 1 | 1 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 6.9630 | 1 | 1 |
| Mcl-1 | Homo sapiens (human) | IC50 | 3.7733 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 0.8500 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.3450 | 1 | 1 |
| Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Homo sapiens (human) | IC50 | 3.7650 | 2 | 2 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 26.7000 | 1 | 4 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 164.7000 | 1 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 102.5083 | 1 | 12 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.8143 | 1 | 3 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.1060 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 8.4986 | 5 | 8 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 49.6000 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.4320 | 1 | 3 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 0.1060 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 10.1880 | 3 | 6 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 49.6000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 22.6018 | 3 | 5 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 0.1060 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 10.0397 | 3 | 6 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 49.6000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 1.1697 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.1060 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 10.0148 | 3 | 6 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 49.6000 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.1831 | 1 | 3 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 1.0030 | 2 | 2 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 9.9991 | 3 | 6 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 49.6000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0148 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.0148 | 1 | 1 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Nischarin | Homo sapiens (human) | Ki | 0.7056 | 2 | 4 |
| Nischarin | Rattus norvegicus (Norway rat) | Ki | 1.2589 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 10.7706 | 1 | 8 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 8.8241 | 1 | 8 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | IC50 | 1.5000 | 1 | 2 |
| Potassium channel subfamily K member 10 | Homo sapiens (human) | IC50 | 15.8000 | 2 | 2 |
| Potassium channel subfamily K member 2 | Homo sapiens (human) | IC50 | 10.9500 | 2 | 2 |
| Potassium voltage-gated channel subfamily A member 5 | Homo sapiens (human) | IC50 | 4.6500 | 2 | 2 |
| Potassium voltage-gated channel subfamily D member 2 | Rattus norvegicus (Norway rat) | IC50 | 2.2000 | 1 | 1 |
| Potassium voltage-gated channel subfamily D member 3 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily E member 1 | Homo sapiens (human) | IC50 | 125.8930 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 4.3896 | 34 | 76 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 7.2382 | 3 | 10 |
| Potassium voltage-gated channel subfamily KQT member 1 | Homo sapiens (human) | IC50 | 125.8930 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | Ki | 0.1600 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 6.6900 | 1 | 1 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | IC50 | 0.0078 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 0.3845 | 2 | 5 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.7500 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.0880 | 1 | 2 |
| Sodium channel protein type 1 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 10 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 11 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 3 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 239.4458 | 8 | 8 |
| Sodium channel protein type 7 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 8 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 1.8118 | 3 | 6 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 1.9673 | 6 | 8 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 23.6827 | 6 | 9 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.7878 | 4 | 9 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 0.1351 | 17 | 20 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.6618 | 16 | 20 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.8535 | 5 | 9 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 3 | 5 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 1.7082 | 5 | 9 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.1630 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 15.1000 | 1 | 2 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 7.8000 | 3 | 3 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 30.6490 | 4 | 10 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Ki | 11.4300 | 1 | 2 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 33.0250 | 2 | 4 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 12.3000 | 1 | 2 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | Ki | 16.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | Ki | 19.1000 | 1 | 1 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | IC50 | 12.6000 | 1 | 1 |
| Solute carrier family 22 member 3 | Rattus norvegicus (Norway rat) | IC50 | 68.0000 | 1 | 1 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | Ki | 14.0000 | 1 | 1 |
| Solute carrier family 22 member 4 | Rattus norvegicus (Norway rat) | IC50 | 80.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 9.2700 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A4 | Rattus norvegicus (Norway rat) | Ki | 120.0000 | 1 | 1 |
| sphingosine 1-phosphate receptor 3 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Synaptic vesicular amine transporter | Homo sapiens (human) | IC50 | 0.1800 | 1 | 1 |
| Synaptic vesicular amine transporter | Homo sapiens (human) | Ki | 0.5400 | 3 | 3 |
| Toll-like receptor 4 | Homo sapiens (human) | IC50 | 32.2200 | 1 | 1 |
| Trace amine-associated receptor 1 | Homo sapiens (human) | Ki | 1.6400 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 3.2663 | 4 | 7 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 5.0310 | 4 | 7 |
| Tryptophan 5-hydroxylase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0600 | 1 | 1 |
| Tryptophan 5-hydroxylase 1 | Rattus norvegicus (Norway rat) | Ki | 0.0067 | 2 | 2 |
| Type-1 angiotensin II receptor | Oryctolagus cuniculus (rabbit) | Ki | 0.0020 | 2 | 3 |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | Ki | 0.2590 | 1 | 2 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 5.3670 | 1 | 2 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | IC50 | 273.2000 | 1 | 5 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 200.7143 | 3 | 7 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | IC50 | 273.2000 | 1 | 5 |
| UDP-glucuronosyltransferase 2B10 | Homo sapiens (human) | IC50 | 273.2000 | 1 | 5 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | IC50 | 273.2000 | 1 | 5 |
| Vesicular acetylcholine transporter | Rattus norvegicus (Norway rat) | Ki | 5.5165 | 1 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Cavia porcellus (domestic guinea pig) | IC50 | 5.8920 | 3 | 5 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 44.9962 | 9 | 9 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 11.8600 | 5 | 5 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 11.8600 | 5 | 5 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 11.8600 | 5 | 5 |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Kd | 0.9715 | 2 | 7 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | EC50 | 0.0010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | EC50 | 33.6080 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Kd | 0.0010 | 3 | 3 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Kd | 0.0015 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Kd | 0.0015 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Kd | 0.0001 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Kd | 0.0060 | 1 | 1 |
| Albumin | Homo sapiens (human) | Kd | 851.1380 | 1 | 1 |
| Albumin | Rattus norvegicus (Norway rat) | Kd | 25.2450 | 1 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | EC50 | 0.0343 | 2 | 3 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 1.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Kd | 0.1213 | 3 | 5 |
| Alpha-1A adrenergic receptor | Oryctolagus cuniculus (rabbit) | Kd | 0.0079 | 1 | 4 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.3665 | 23 | 49 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | EC50 | 0.0008 | 2 | 3 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 1.0000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Kd | 0.0515 | 4 | 13 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.3676 | 21 | 46 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 1.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Kd | 0.1213 | 3 | 5 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.3838 | 21 | 44 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | EC50 | 43.6042 | 2 | 2 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 1.0000 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Kd | 0.2896 | 2 | 2 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5971 | 12 | 26 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | EC50 | 87.2000 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 1.0000 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Kd | 0.2896 | 2 | 2 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5971 | 12 | 26 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | EC50 | 87.2000 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 1.0000 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Kd | 0.2896 | 2 | 2 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5971 | 12 | 26 |
| Alpha-mannosidase 2C1 | Rattus norvegicus (Norway rat) | Kd | 3.7154 | 1 | 1 |
| alternatively spliced Trp4 | Mus musculus (house mouse) | EC50 | 6.6827 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Kd | 0.0024 | 1 | 3 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Kd | 0.0018 | 2 | 4 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Kd | 0.0024 | 1 | 3 |
| D(2) dopamine receptor | Homo sapiens (human) | EC50 | 0.0004 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Kd | 0.0001 | 2 | 2 |
| Glycine receptor subunit alpha-1 | Homo sapiens (human) | EC50 | 0.3200 | 1 | 1 |
| glycogen synthase kinase-3 beta isoform 1 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 1 |
| HLA class I histocompatibility antigen, A alpha chain | Homo sapiens (human) | Kd | 2.5000 | 1 | 1 |
| Hsf1 protein | Mus musculus (house mouse) | EC50 | 227.5000 | 2 | 2 |
| mu-type opioid receptor isoform MOR-1 | Homo sapiens (human) | EC50 | 92.4700 | 1 | 1 |
| POsterior Segregation | Caenorhabditis elegans | EC50 | 300.0000 | 1 | 1 |
| Proteasome subunit alpha type-6 | Homo sapiens (human) | EC50 | 12.0000 | 1 | 1 |
| short transient receptor potential channel 6 isoform 1 | Mus musculus (house mouse) | EC50 | 44.6700 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Kd | 0.3600 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | EC50 | 103.4860 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Kd | 0.1804 | 2 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Kd | 0.2000 | 1 | 1 |
| Zinc finger protein mex-5 | Caenorhabditis elegans | EC50 | 103.4860 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Log Ki | 0.0087 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Log Ki | 0.0094 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Log Ki | 0.0094 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Log Ki | 0.0094 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Log Ki | 0.0094 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Kb | 0.0020 | 3 | 3 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ke | 0.0320 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Log Ki | 0.0060 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Kb | 1.9800 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Kb | 0.1120 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Kb | 0.0300 | 1 | 1 |
| Aldehyde oxidase | Homo sapiens (human) | Kii | 1.3000 | 1 | 1 |
| Aldehyde oxidase | Homo sapiens (human) | Kis | 1.3000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Activity | 0.0010 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | EC40 | 0.0164 | 2 | 7 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Kb | 0.0002 | 2 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ke | 0.0011 | 2 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ke(app) | 0.0011 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Log Ki | 0.0094 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Activity | 0.0032 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | EC40 | 0.0164 | 2 | 7 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Kb | 0.0000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Log Ki | 0.0080 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Activity | 0.0090 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | EC40 | 0.0164 | 2 | 7 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Kb | 0.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kb | 0.0118 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Log Ki | 0.0093 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Log Ki | 0.0093 | 1 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | EC40 | 1.3000 | 2 | 3 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Kb | 0.0070 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Log Ki | 0.0089 | 2 | 3 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | EC40 | 1.3000 | 2 | 3 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Kb | 0.0070 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Log Ki | 0.0089 | 2 | 3 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | EC40 | 1.3000 | 2 | 3 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Kb | 0.0070 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Log Ki | 0.0089 | 2 | 3 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 14.0050 | 4 | 4 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | Kact | 1.0000 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | K 0.5 | 0.0002 | 2 | 2 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | K 0.5 | 0.0004 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | K0.5 | 0.0486 | 2 | 18 |
| interferon gamma precursor | Homo sapiens (human) | AC50 | 18.7000 | 2 | 2 |
| Multidrug resistance protein 1a | Rattus norvegicus (Norway rat) | Km | 5.0000 | 1 | 1 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | INH | 12.1000 | 1 | 2 |
| Snq2p | Saccharomyces cerevisiae EC1118 | INH | 13.0000 | 1 | 2 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Km | 2.2000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Activity | 5.4000 | 1 | 1 |