ascorbic-acid and Rectal-Diseases

Over a 4-year period in a chemoprevention trial on large bowel neoplasia, 58 patients with familial adenomatous polyposis were treated with 4 g of ascorbic acid (vitamin C)/day plus 400 mg of alpha-tocopherol (vitamin E)/day alone or with a grain fiber supplement (22.5 g/day). In this randomized, double-blind, placebo-controlled study, we determined the effects of these supplements on rectal polyps in these patients. Analysis by intent to treat suggested that the high-fiber supplement had a limited effect. Analysis adjusted for patient compliance showed a stronger benefit from the high-fiber supplement during the middle 2 years of the trial. The results provide evidence for inhibition of benign large bowel neoplasia by grain fiber supplements in excess of 11 g/day in this study population. The findings are consistent with the hypothesis that dietary grain fiber and total dietary fat act as competing variables in the genesis of large bowel neoplasia.

Topics: Adenomatous Polyposis Coli; Adult; Ascorbic Acid; Clinical Trials as Topic; Diet; Dietary Fiber; Double-Blind Method; Humans; Patient Compliance; Placebos; Polyps; Random Allocation; Rectal Diseases; Triticum; Vitamin E

Topics: Anti-Bacterial Agents; Ascorbic Acid; Child; Colonic Diseases; Female; Humans; Kidney Diseases; Malacoplakia; Nutrition Disorders; Parenteral Nutrition; Rectal Diseases

Of one hundred and twenty-six patients with Gardner's syndrome, 60% showed soft tissue tumors, 32% showed osteomatosis, 67% polyposis, and 20% the complete triad. Bowel cancer developed in 32% of the patients. The frequency of other diseases in these patients showed fibrous tumors in 8%, and two patients with cancer of the ampulla of Vater; otherwise the diseases seen did not show any major variation from what might be expected for the group at risk. Laboratory evaluation has included the demonstration of increased fecal cholesterol and primary bile acids in these patients. The recommended surgical treatment is colectomy and ileorectal anastomosis at a measured 12 cm level. This level of ileorectal anastomosis may be vital in giving a regression of rectal polyps, which was seen in 15 to 17 patients so treated. The conversion of an ileosigmoid to an ileorectal anastomosis resulted in polyp regression in one patient. The oral administration of ascorbic acid gave polyp regression in seven of 10 patients. There may be a possible relationship of fecal coprostanol and cholesterol levels and polyp regression.

Topics: Adolescent; Adult; Ascorbic Acid; Bone Neoplasms; Child; Colectomy; Colon, Sigmoid; Female; Follow-Up Studies; Humans; Ileum; Intestinal Polyps; Male; Rectal Diseases; Rectum; Soft Tissue Neoplasms; Syndrome

Topics: Adult; Aged; Anus Diseases; Ascorbic Acid; Coumarins; Female; Flavonoids; Hemorrhoids; Humans; Male; Middle Aged; Plant Extracts; Rectal Diseases; Thrombosis