An agent that inhibits the passage of cations through the transient receptor potential (TRP) channels.
ChEBI ID: 139361
| Member | Definition | Class |
|---|---|---|
| 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole | An ether that is 2-(1H-imidazol-1-yl)-1-(4-methoxyphenyl)ethanol in which the hydrogen of the hydroxy group has been substituted by a 3-(4-methoxyphenyl)propyl group. | SKF-96365 free base |
| 4-amylcinnamoylanthranilic acid | An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 4-pentylcinnamoyl group. It is a transient receptor potential (TRP) channel blocker and phospholipase A2 (PLA2) inhibitor. | N-(p-amylcinnamoyl)anthranilic acid |
| gadolinium chloride | gadolinium trichloride | |
| scalaradial | A scalarane sesterterpenoid with formula C27H40O4. It is a natural product found in the marine sponges Spongia officinalis and Cacospongia mollior, and exhibits anti-inflammatory activity. | scalaradial |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 13 (1.15) | 18.7374 |
| 1990's | 349 (30.78) | 18.2507 |
| 2000's | 452 (39.86) | 29.6817 |
| 2010's | 292 (25.75) | 24.3611 |
| 2020's | 28 (2.47) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.09%) | 5.53% |
| Reviews | 13 (1.11%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,157 (98.80%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 26.9680 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 31.8326 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 31.6568 | 1 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 18.2563 | 1 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 11.7504 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 33.5875 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 12.5426 | 2 | 4 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 84.2790 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 0.1617 | 2 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.1033 | 2 | 3 |
| Phosphatidylcholine 2-acylhydrolase | Apis mellifera (honey bee) | IC50 | 0.0700 | 1 | 1 |
| Phospholipase A2 | Apis mellifera (honey bee) | IC50 | 0.0700 | 1 | 1 |
| Phospholipase A2 | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| Short transient receptor potential channel 6 | Mus musculus (house mouse) | IC50 | 4.9000 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 2 | Homo sapiens (human) | IC50 | 1.5050 | 7 | 8 |
| Transient receptor potential cation channel subfamily M member 2 | Rattus norvegicus (Norway rat) | IC50 | 0.3300 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 7 | Mus musculus (house mouse) | IC50 | 0.7600 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 8 | Homo sapiens (human) | IC50 | 3.9000 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 28.0919 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 2C9 | Homo sapiens (human) | Activity | 0.4350 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Activity | 0.4310 | 1 | 1 |