| Excerpt | Reference |
|---|
| "Aplastic anemia is a rare but usually fatal complication of gold salt therapy for rheumatoid arthritis." | ( Baldwin, JL; Mannik, M; Storb, R; Thomas, ED, 1977) |
| "Prognosis in aplastic anemia is usually linked to the degree of hypoplasia in the bone marrow and pancytopenia in the blood." | ( Ahn, YH; Biswas, N; Goldman, JM; Schwartz, JM, 1991) |
| "Aplastic anaemia is recognised to occur following the use of some non-steroidal anti-inflammatory drugs." | ( Eustace, S; McHale, S; Molony, J; O'Neill, T, 1989) |
| "A case of aplastic anemia is described, in which bacterial and fungal infections were coincidental with a sudden development of an almost complete myeloperoxidase deficiency of neutrophils." | ( Bizzaro, N; Boccato, P; Briani, G, 1988) |
| "Aplastic anemia is very rare but can occur after either oral or intravenous administration." | ( Feder, HM, 1986) |
| "Aplastic anemia is an idiosyncratic, non-dose-related side effect that is most likely to occur within the first 3 or 4 months of initiating therapy." | ( Porter, RJ, 1987) |
| "Aplastic anaemia is rare as a primary feature of systemic lupus erythematosus and is more commonly a complication of treatment with cytotoxic drugs." | ( Hubbard, WN; Hughes, GR; Walport, MJ, 1982) |
| "Aplastic anemia is a disease characterized by pancytopenia with hypocellular bone marrow." | ( Casale, TB, 1982) |
| "A case of fatal aplastic anemia is described in which no drugs other than allopurinol and indomethacin were given." | ( Berrebi, A; Levy, R; Schattner, A; Shtalrid, M, 1981) |
| "Aplastic anaemia is characterized by multilineage bone marrow failure resulting in pancytopenia." | ( Görg, C; Havemann, K; Köppler, H; Lyttelton, M; Pflüger, KH; Samson, D; Weide, R, 1993) |
| "Aplastic anemia is an uncommon adverse hematologic effect in patients treated with dapsone, the pathogenesis of which remains unknown." | ( Cohen, PR; Meyerson, MA, 1994) |
| "Aplastic anaemia is a recognized, but extremely rare, complication of exposure to NSAIDs of any chemical subtype." | ( Fitzsimons, E; Holyoake, T; Muir, KW, 1994) |
| "Secondary hypoplastic anemia is common in FAP, but treatment of anemia in this disease using erythropoietin is promising." | ( Ando, M; Ando, Y; Asahara, K; Tanaka, Y; Yamashita, T; Yi, S, 1993) |
| "Aplastic anemia is rare." | ( Hwang, JJ; Lee, YT; Su, CC; Tien, HF; Tseng, CD, 1995) |
| "Aplastic anemia is a disorder characterized by pancytopenia and bone marrow hypocellularity." | ( Doolittle, G; Dorr, V; Woodroof, J, 1996) |
| "Aplastic anemia is a rare but severe complication of thionamide therapy." | ( Bravo, P; de la Calle, H; Escobar-Morreale, HF; García-Laraña, J; García-Robles, R; Sancho, JM, 1997) |
| "Aplastic anaemia is both frequent and difficult to manage in patients with dyskeratosis congenita (DC)." | ( Alter, BP; Gardner, FH; Hall, RE, 1997) |
| "Aplastic anaemia is a severe blood dyscrasia that is more common in Thailand than in Western countries." | ( Anderson, T; Chansung, K; Issaragrisil, S; Kaufman, DW; Leaverton, PE; Piankijagum, A; Porapakkham, Y; Shapiro, S; Sirijirachai, J; Thamprasit, T; Vannasaeng, S; Young, NS, 1997) |
| "Aplastic anemia is the rare hematologic complication of the antithyroid medication." | ( Grzywa, M; Swider, G; Zuzak, Z, 1996) |
| "Severe aplastic anemia is a hematological disease with a high mortality rate, for which bone marrow transplantation is the treatment of choice, specially in children and young adults." | ( Bonduel, M; Bullorsky, EO; Ceresetto, J; Del Pozo, A; Delfino, S; Figueroa, C; Muriel, FS; Puppo, M; Shanley, C; Stemmelin, G, 1998) |
| "Aplastic anemia is a rare side-effect associated with ticlopidine therapy." | ( Ahn, JH; Bahng, H; Chi, HS; Kim, SB; Kim, SH; Kim, SW; Kim, WK; Lee, JH; Lee, JS; Lee, KH; Park, CJ; Suh, C, 1998) |
| "These data indicate aplastic anaemia is associated with a decreased TGF-beta1 expression in peripheral blood circulation, which may be a direct consequence of thrombocytopenia." | ( Ball, SE; Dilger, P; Gibson, FM; Gordon-Smith, EC; Killick, SB; Patel, S; Rizzo, S; Wadhwa, M, 1999) |
| "Severe aplastic anaemia is uniformly fatal unless treated with immunosuppressive therapy or bone marrow transplantation." | ( Charles, W; Daisley, H; Jones-Lecointe, A; Murphy, A; Pitt-Miller, P, 1999) |
| "Severe aplastic anemia is a well-recognized complication of ticlopidine therapy that carries a high mortality." | ( Liebman, HA; Murata-Collins, JL; Pullarkat, VA; Rho, H, 2000) |
| "Aplastic anaemia is a rare disease which is more prevalent in the Far East." | ( Goh, AS; Menon, J; Purushothaman, V; Rahman, M; Yong, AS, 1998) |
| "Severe aplastic anemia is a life-threatening bone marrow failure disorder." | ( Brodsky, I; Brodsky, RA; Dorr, D; Jones, RJ; Karp, JE; Lee, SM; Seaman, PJ; Sensenbrenner, LL; Smith, BD, 2001) |
| "Aplastic anemia is a very unusual feature of systemic lupus erythematosus (SLE)." | ( Pavithran, K; Raji, NL; Thomas, M, 2002) |
| "Aplastic anemia is a rare complication of thymoma and is extremely infrequent after thymectomy." | ( Kim, CC; Kim, HJ; Kim, YJ; Lee, JW; Min, WS; Park, CY; Park, YH, 2003) |
| "Aplastic anemia is rare in SLE and the response to immunosuppressants is variable, but here is a success story." | ( Agarwal, SK; Garg, D; Kubba, S; Makhija, A; Pathania, A; Prakash, A; Prakash, N; Singh, NP, 2004) |
| "Aplastic anemia is a bone marrow failure disorder characterized by pancytopenia and a hypocellular marrow." | ( Chen, H; Chen, J; Liu, W; Wang, X; Wu, J; Wu, L; Yang, D; Yang, Y, 2003) |
| "Pregnancy induced aplastic anemia is a rare entity and the association is not well explained." | ( Choudhry, VP; Gupta, M; Gupta, S; Kashyap, R; Saxena, R, 2002) |
| "Aplastic anemia is a rare but severe complication of methimazole (MMI) treatment for Graves' disease." | ( Fujita, K; Hirata, F; Hosoai, H; Katayama, Y; Kimura, F; Tomiyama, K; Yamamoto, A; Yasuda, H, 2004) |
| "Aplastic anemia is a rare but potentially serious adverse drug effect of cyanamide treatment." | ( Ballarín, E; Force, L; Hernández, JA; Ibáñez, L; Laporte, JR, 2005) |
| "Aplastic anemia is a relatively uncommon disease and conventional management options include immunosuppressive drugs and/or haematopoeitic stem cell transplantation." | ( Cheong, SK; Gan, GG; Goh, KY; Leong, CF; Sangkar, JV; Teh, A, 2005) |
| "Severe aplastic anemia is a well-recognized complication of fulminant non-A, non-B, and non-C hepatitis requiring orthotopic liver transplantation." | ( Goldsby, R; Rosenthal, P; Sanchez, R, 2007) |
| "Aplastic anemia is extremely rare." | ( Jakucs, J; Pocsay, G, 2006) |
| "Aplastic anemia is characterized by bone marrow failure and marked reduction of white blood cells, red blood cells and platelets in peripheral blood." | ( Chen, C; Fang, JP; Huang, SL; Zhong, FY, 2006) |
| "Aplastic anemia is a rare complication of allopurinol use." | ( Kang, SW; Kim, YH; Kim, YW; Park, BS; Park, SJ; Ryu, CH; Shon, JH; Song, IS, 2009) |
| "Aplastic anemia is a medullary insufficiency secondary to the complete or partial disappearance of hematopoietic tissue without abnormal cellular proliferation." | ( Albuquerque, PL; Diógenes, SS; Silva Júnior, GB; Silva, HF, 2009) |
| "Aplastic anaemia is a major hematological problem among the children of northern districts of West Bengal." | ( Chakrabarti, S; Das, S; Goswami, BK; Paul, PC; Pramanik, R; Raha, K, 2009) |
| "Aplastic anemia is a hematological disorder of unknown etiology with a high lethality rate." | ( Ahamed, M; Akhtar, MJ; Kumar, A; Siddiqui, MK; Verma, S, 2011) |
| "Acquired aplastic anemia is a potentially fatal bone marrow failure disorder that is characterized by pancytopenia and a hypocellular bone marrow." | ( Brodsky, RA; Dezern, AE, 2011) |
| "Aplastic anaemia is a condition characterized by pancytopenia and unexplained bone marrow hypocellularity." | ( Akinola, NO; Arewa, OP, 2009) |
| "The incidence of aplastic anemia is reported to be higher in Asia than elsewhere." | ( Dhaliwal, JS; Kamaluddin, MA; Murad, S; Wong, L; Yin, LY, 2011) |
| "Acquired aplastic anemia is an organ-specific auto-immune disease characterized by pancytopenia and hypoplastic bone marrow." | ( Chen, C; Fang, JP; Guo, HX; Huang, K; Huang, SL; Li, Y; Xu, HG; Xue, HM; Zhou, DH, 2012) |
| "Aplastic anaemia is rear disease caused by destruction of pluripotent stem cells in bone marrow." | ( Bozhinov, P; Bozhinova, S; Kirovakov, Z; Kostova, S; Porozhanova, K, 2012) |
| "Aplastic anaemia is a rare haematological disorder characterized by pancytopenia with a hypocellular bone marrow." | ( Gupta, V; Kumar, A; Saini, I; Saxena, AK, 2013) |
| "Acquired severe aplastic anemia is a rare and potentially fatal disease, which is characterized by hypocellular bone marrow and pancytopenia." | ( Bartel, C; Grouven, U; Peinemann, F, 2013) |
| "Aplastic anemia is an abnormal immune reaction disease in which T lymphocytes destroy hematopoietic stem and progenitor cells because of immune hyperactivity." | ( Jiang, ZJ; Li, L; Li, YH; Pang, Y; Song, JY; Wang, Y; Xiao, Y, 2014) |
| "The treatment of aplastic anemia is currently with immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG) and cyclosporine, to which two thirds of patients respond." | ( Desmond, R; Dunbar, C; Townsley, DM; Young, NS, 2015) |
| "Severe aplastic anemia is a rare autoimmune disease characterized by severe pancytopenia and bone marrow failure, which is caused by activated T lymphocytes." | ( Fu, R; Guan, J; Li, L; Liu, C; Liu, H; Qi, W; Shao, Z; Wang, H; Wang, T; Yan, L, 2015) |
| "Aplastic anemia is a rare but life-threatening disorder characterized by cytopenia in at least two of the three blood lineages." | ( Bär, C; Beier, F; Blasco, MA; Huber, N, 2015) |
| "Acquired aplastic anemia is an immune-mediated disease, in which T cells target hematopoietic cells; at presentation, the bone marrow is replaced by fat." | ( Chen, J; Desierto, MJ; Feng, X; Kajigaya, S; Keyvanfar, K; Li, J; Malide, D; Muranski, P; Sato, K; Young, NS, 2016) |
| "Aplastic anemia is the bone marrow failure condition characterized by the development of hypocellularity in both marrow and peripheral blood compartments." | ( Chatterjee, R; Law, S, 2019) |
| "Aplastic anemia is a rare disease that manifests as bone marrow failure." | ( Frączkiewicz, J; Gajek, K; Jarmoliński, T; Mielcarek-Siedziuk, M; Olejnik, I; Rosa, M; Salamonowicz-Bodzioch, M; Ussowicz, M, 2020) |
| "Aplastic anemia is a syndrome characterized by the decrease in hematopoietic stem cells along with bone marrow hypoplasia and pancytopenia, which is likely to be a T cell-mediated autoimmune disease." | ( Obara, N, 2020) |
| "Aplastic anemia is an uncommon adverse event of tyrosine kinase inhibitors but it can be a fatal complication." | ( Ben Said, F; Elloumi, M; Kallel, F; Kassar, O; Khabir, A; Ksouda, K; Mallek, R, 2022) |
| "Idiopathic aplastic anemia is a potentially lethal disease, characterized by T cell-mediated autoimmune attack of bone marrow hematopoietic stem cells." | ( Austin-Tse, C; Bryson, B; Chen, YB; Fortune, SM; Hughes, T; Lareau, CA; Ludwig, LS; Massoth, LR; Peters, JM; Regev, A; Rehm, HL; Rosenberg, JM; Shalek, AK; Sykes, DB, 2022) |
| "Relapsed severe aplastic anaemia is a marrow failure disorder with high morbidity and mortality." | ( Antin, JH; Arai, S; Brodsky, RA; Dávila Saldaña, BJ; Deeg, HJ; DeZern, AE; Eapen, M; Farhadfar, N; Hexner, E; Horowitz, MM; Horwitz, ME; Jones, RJ; Karanes, C; Leifer, E; Logan, BR; Mallhi, K; Pulsipher, MA; Solh, M; Talano, JA; Westervelt, P; Wu, J, 2022) |
| "Aplastic anemia is treated with either hematopoietic stem cell transplantation in patients with a sibling donor or anti-thymocyte globulins and cyclosporine." | ( Gonnot, M; Huet, F; Lacaille, F; Leblanc, T; Maudinas, R; Neumann, F, 2022) |
| "Aplastic anemia is a rare and serious adverse reaction of antithyroid drugs, which is more common in women." | ( Cheng, Y; Liu, D; Ren, L; Tian, CF; Xia, XY; Xue, G; Zhang, W, 2023) |
| "Non-severe aplastic anemia is a rare bone marrow failure disorder characterized by variable degrees and combination of cytopenias, with limited data on management and outcome." | ( Awada, H; Barcellini, W; Bortolotti, M; Cassanello, G; Consonni, D; Fattizzo, B; Gandhi, S; Giammarco, S; Gurnari, C; Kulasekararaj, AG; Large, J; Maciejewski, JP; Salter, S; Sica, S; Trikha, R, 2023) |
| Excerpt | Reference |
|---|
| "Fifteen patients with aplastic anemia and 13 with acute leukemia were studied 36 to 1547 days after treatment with high-dose cyclophosphamide and/or total-body irradiation and marrow transplantation from HLA identical siblings." | ( Storb, R; Thomas, ED; Tsoi, MS; Weiden, PL, 1977) |
| "A 51-year-old patient with aplastic anaemia in whom a successful allogeneic bone-marrow transplantation had been performed developed acute graft-versus-host disease in spite of prophylactic administration of methotrexate." | ( Gahrton, G; Groth, CG; Lundgren, G; Möller, E; Pihlstedt, P; Ringdén, O; Sundelin, P, 1979) |
| "9 patients with severe aplastic anemia (SAA) were treated with bone marrow transplantation (BMT)." | ( Adami, R; Avanzi, G; Bacigalupo, A; Barbanti, M; Carella, A; Cerri, R; Giordano, D; Grazi, G; Librace, E; Marmont, AM; Mingari, MC; Pedullá, D; Piaggio, G; Raffo, MR; Reali, G; Risso, M; Rossi, E; Santini, G; Soldá, A; Soro, O; Strada, P; Van Lint, MT; Vimercati, R; Vitale, V, 1979) |
| "In a patient with aplastic anaemia pretreatment of the patient's bone-marrow with horse anti-human-thymocyte globulin and complement (A." | ( Ascensão, J; Good, R; Hansen, J; Kagan, W; Moore, M; Pahwa, R, 1976) |
| "Three patients with aplastic anaemia following chloroquine therapy are described." | ( Chetiyawardana, AD; Nagaratnam, N; Rajiyah, S, 1978) |
| "Bone marrow culture in a patient with aplastic anaemia responding to anabolic steroid (methandienone) therapy, showed an unusually high degree of growth in unstimulated cultures." | ( Bateman, SM; Berney, JJ; Francis, GE; Hoffbrand, AV, 1977) |
| "Our observations suggest that aplastic anemia in this patient is immunologically mediated and that prednisone therapy enhanced hemopoiesis in vivo by inhibiting the "suppressor" T lymphocytes." | ( Bagby, GC; Goodnight, SH; Mooney, WM; Richert-Boe, K, 1979) |
| "23 patients with severe aplastic anemia have been treated." | ( Burri, HP; Cornu, P; Groff, P; Jeannet, M; Nissen, C; Sartorius, J; Speck, B, 1977) |
| "A 26-year-old man with severe aplastic anemia was treated with high-dose Cyclophosphamide followed by the infusion of bone marrow cells from his HLA-identical sister." | ( Frick, PG; Gmür, J; von Felten, A, 1979) |
| "18 patients with severe aplastic anemia (SAA) but without an HLA-identical sibling were treated by antilymphocyte globulin (ALG) followed by infusion of marrow cells from a semi-compatible family donor." | ( Cornu, P; Gratwohl, A; Jeannet, M; Nissen, C; Sartorius, J; Speck, B, 1979) |
| "The effect of conservative treatment of aplastic anaemia was evaluated retrospectively in 40 patients." | ( Eernisse, JG; Guiot, HF; Haak, HL; Hartgrink-Groeneveld, CA; Speck, B; von Rood, JJ, 1977) |
| "Treatment of drug-induced aplastic anemia requires transfusions." | ( Girdwood, RH, 1976) |
| "Relationships between aplastic anemia, long-term treatment with androgens and tumour of the liver are discussed." | ( Corberand, J; Dutau, G; Pris, J; Regnier, C; Rumeau, JL, 1975) |
| "It was felt that the aplastic anemia was related to therapy with chloramphenicol or acetazolamide or both." | ( Chang, J; Lipton, JH; McWhae, JA, 1992) |
| "Three consecutive cases of severe aplastic anemia undergoing immunosuppressive therapy with cyclosporin A (CyA) and high-dose methylprednisolone (HDMP) developed grand mal seizures after receiving ketoconazole treatment." | ( Chia, LG; Gau, JP; Hwang, WL; Young, JH, 1992) |
| "Two children with severe and moderate aplastic anemia received combination treatment with methylprednisolone, antilymphocyte globulin and cyclosporine." | ( Arioka, H; Ishikawa, Y; Kobayashi, R; Naito, H, 1992) |
| "Six patients with acquired aplastic anaemia were treated with cyclosporine (5 mg/kg/day) either alone or in combination with corticosteroids." | ( Goudsmit, R; Leeksma, OC; Thomas, LL; van der Lelie, J; van Oers, MH; von dem Borne, AE, 1992) |
| "However, patients with aplastic anemia and those with chemotherapy-induced neutropenia had a normal lactoferrin:neutrophil ratio." | ( Bezwoda, WR; Dajee, D, 1992) |
| "A 22 year-old patient with severe aplastic anaemia responded to antilymphocytic globulin but developed recurrent fever despite treatment with steroids and then antibacterial, antifungal, and antituberculous drugs." | ( Allard, S; Laurie, A; O'Driscoll, J, 1992) |
| "Twenty-seven patients with aplastic anemia (20 severe: 7 moderate) were treated with combined immunosuppression consisting of antilymphocyte globulin (ALG: Ahlbulin, Green Cross Co." | ( Akatsuka, M; Fukuda, M; Kojima, S; Maeda, H; Matsuyama, T; Minami, S; Miyajima, Y; Sugihara, T; Tsuzuki, S; Yamamoto, K, 1992) |
| "This aplastic anemia failed to respond first to an antithymocyte globulin and steroid treatment and then to cyclosporine A." | ( Bergerat, JP; Dufour, P; Herbrecht, R; Koenig, H; Liu, KL; Maloisel, F; Marcellin, L; Oberling, F; Waller, J; Weber, JC, 1991) |
| "The treatment of severe aplastic anemia has been modified recently by the demonstration that Cyclosporine A is active alone or in combination leading to more than 50% response rate." | ( Espérou-Bourdeau, H; Gluckman, E, 1991) |
| "The prognosis of acquired aplastic anaemia remains poor for most children and new approaches to treatment are urgently required." | ( Chessells, JM; Hann, IM; Webb, DK, 1991) |
| "For treatment of his aplastic anemia, he received a successful marrow transplant from his 9-year-old genotypically HLA-identical sister following conditioning with cyclophosphamide 200 mg/kg and anti-thymocyte globulin 90 mg/kg." | ( Kawahara, K; Petersen, FB; Sanders, J; Storb, R, 1991) |
| "Immunosuppressive treatment of aplastic anemia with antilymphocyte globulin, methylprednisolone, and cyclosporine appears to be more effective than a regimen of antilymphocyte globulin and methylprednisolone without cyclosporine and may thus represent a treatment of choice for patients who are not eligible for bone marrow transplantation." | ( Freund, M; Frickhofen, N; Heimpel, H; Herrmann, F; Kaltwasser, JP; Meusers, P; Raghavachar, A; Salama, A; Schrezenmeier, H; Vogt, HG, 1991) |
| "Treatment of aplastic anemia may raise considerable problems in some patients." | ( Austgulen, R; Jørstad, S; Moe, PJ; Widerøe, TE, 1990) |
| "A retrospective study of acquired aplastic anemia in 100 Thai children treated with testosterone and prednisolone during 1969 to 1987 is reported." | ( Chuansumrit, A; Hathirat, P; Isarangkura, P, 1990) |
| "Twenty-nine patients with severe aplastic anemia were entered into a study of pre- and posttransplant immunosuppressive therapy for bone marrow transplantation." | ( Burnison, M; Champlin, RE; Gajewski, JG; Ho, WG; Holley, G; Nimer, SD; Petz, L; Selch, M; Winston, DJ; Yam, P, 1990) |
| "Therefore, a diagnosis of aplastic anemia was made, and bolus methylprednisolone therapy (1,000 mg/day x 3 days) was performed, which brought the patient to complete remission." | ( Horiuchi, H; Kimura, S; Kobayashi, Y; Kondo, M; Maruo, N; Morita, Y; Ozawa, M; Wada, K; Yokoh, K, 1990) |
| "Immunosuppressive treatment of aplastic anemia has been increasingly used as an alternative treatment to bone marrow transplantation." | ( Han, CH; Kim, CC; Kim, DJ; Kim, HK; Park, CW, 1989) |
| "In severe aplastic anaemia resistant to conventional immunosuppression, the response rate is lower, but a small proportion (around 15%) of patients may benefit from CS therapy." | ( Almqvist, D; Bengtsson, M; Höglund, M; Killander, A; Simonsson, B; Tötterman, TH, 1989) |
| "Twenty patients with severe aplastic anemia (SAA) were treated with low doses (1-5 mg/kg/day) of a high-potency antithymocyte globulin (ATG) produced in Mexico, shown to have at least a 10-fold potency as compared with other globulins of commercial sources." | ( Delgado-Lamas, JL; Elena Zarzosa, M; López-Karpovitch, X; Marín-López, A; Romero-García, F; Ruiz-Argüelles, GJ; Ruiz-Gonzalez, DS; Taboada, C; Vázquez-Villegas, V, 1989) |
| "We treated 22 patients with severe aplastic anaemia refractory to antithymocyte globulin (ATG) with cyclosporine, alone or in combination with prednisone." | ( Griffith, P; Kimball, J; Leonard, EM; Nienhuis, AW; Raefsky, E; Young, NS, 1989) |
| "We report a case of fatal aplastic anaemia following prolonged administration of diclofenac in a 77 year old lady with rheumatoid arthritis." | ( Eustace, S; McHale, S; Molony, J; O'Neill, T, 1989) |
| "Severe aplastic anemia should be treated with bone marrow transplantation if possible." | ( Gamillscheg, A; Hauer, C; Kaulfersch, W; Lackner, H; Slavc, I; Urban, C, 1989) |
| "Sixteen-years-old female with severe aplastic anemia received a therapy combined with antilymphocyte globulin (ALG), high-dose methylprednisolone (m-PSL) and danazol." | ( Kodera, Y; Kojima, S; Matsushita, T; Minami, S; Miyamura, K; Takeyama, K, 1989) |
| "A patient with aplastic anemia, who had been unresponsive to androgens, antithymocyte globulin, high-dose methylprednisolone, and cyclosporine, responded to treatment with 3-beta-etiocholanolone, nandrolone decanoate, and prednisolone acetate." | ( Gardner, FH; Seewald, TR; Zeigler, ZR, 1989) |
| "Ten leukemia and four aplastic anemia cases were clinicopathologically studied in autopsies from patients who had been administered the contrast medium, Thorotrast, three to five decades previously." | ( Hatakeyama, S; Ishikawa, Y; Kamiyama, R; Mori, T; Sugiyama, H, 1988) |
| "Eight patients with idiopathic severe aplastic anemia received acyclovir as the initial treatment to ascertain if this antiviral therapy could be effective." | ( Gómez-Almaguer, D; Kudish-Wersh, A; Marfil-Rivera, J, 1988) |
| "20 patients with aplastic anaemia were treated with methylprednisolone 1 g/d for 3 d followed by prednisolone 60 mg on alternate days." | ( Chinprasertsuk, S; Issaragrisil, S; Piankijagum, A; Sarasombath, S; Siriseriwan, T; Tangnai-Trisorana, Y, 1988) |
| "Twenty-two patients with aplastic anemia were treated with antilymphocyte serum or antithymocyte globulin at Vanderbilt University and affiliated hospitals from 1980 to 1986." | ( Dessypris, EN; Flexner, JM; Greer, JP; Krantz, SB; Lukens, JN; Means, RT; Niblack, GD; Stein, RS, 1988) |
| "Twenty-two of 35 patients with aplastic anaemia who received fetal liver infusion (FLI), responded to this treatment." | ( Bhargava, M; Karak, AK; Kochupillai, V; Sharma, S, 1987) |
| "One hundred patients with severe aplastic anemia were treated and evaluated in a prospective study at our hospital between January 1976 and October 1983." | ( Gratwohl, A; Jeannet, M; Lori, A; Nissen, C; Osterwalder, B; Reusser, P; Signer, E; Speck, B; Tichelli, A; Würsch, A, 1987) |
| "A 22-yr-old man with aplastic anaemia was treated with high dose methylprednisolone." | ( Coonar, HS; Durrant, ST; Gordon-Smith, EC; Lee, KW; Rahemtulla, A, 1988) |
| "It is suggested that in aplastic anaemia there are different populations of lymphocytes with differing DNA-repair capacity; ALG treatment seems to favour expansion of the normal population, which is associated with improvement of haemopoietic function." | ( Kovacs, E; Nissen, C; Signer, E; Speck, B, 1988) |
| "Of 53 consecutive patients with aplastic anaemia who were re-examined at various intervals after treatment with antilymphocyte globulin, 30 had sufficient bone marrow colony forming capacity to permit evaluation of androgen effects in vitro." | ( dalle Carbonare, V; de Planque, MM; Moser, Y; Nissen, C; Speck, B; Würsch, A, 1988) |
| "Four patients with severe aplastic anemia were treated with a combination of cyclosporin (5 mg/kg/day) and steroids (prednisone 0." | ( Beris, P; Miescher, PA, 1987) |
| "184 cases of aplastic anemia were treated by various immunosuppressive agents." | ( Takaku, F, 1986) |
| "Twenty-three patients with aplastic anemia (18/23 with severe aplastic anemia) were treated with an immunosuppressive regimen consisting of cyclosporin A (CsA) and methylprednisolone (MP) (n = 7) or CsA, MP, and antithymocyte globulin (ATG; n = 16)." | ( Frickhofen, N; Heimpel, H; Heit, W; Porzsolt, F; Raghavachar, A, 1986) |
| "A total of 46 patients with aplastic anemia (34 severe; 12 moderate) were treated with antihuman thymocyte globulin (ATG), high-dose methylprednisolone, and oxymetholone." | ( Appelbaum, FR; Buckner, CD; Deeg, HJ; Doney, K; McGuffin, R; Storb, R; Sullivan, KM; Thomas, ED; Witherspoon, R, 1987) |
| "Forty-six patients with severe aplastic anemia (median age, 23 years) were treated with high-dose cyclophosphamide followed by infusion of marrow from an HLA-identical family member." | ( Appelbaum, F; Beatty, P; Bensinger, W; Buckner, CD; Clift, R; Deeg, HJ; Doney, K; Farewell, V; Hansen, J; Storb, R, 1986) |
| "Twenty patients with aplastic anaemia were treated with a short term bolus of methylprednisolone." | ( Issaragrisil, S; Piankijagum, A, 1986) |
| "In contrast, serum from a patient with aplastic anemia gave a result equivalent to 327 mU erythropoietin/ml after heat treatment, but after antibody treatment equivalent to 1,520 mU erythropoietin/ml." | ( Bridges, JM; Elder, GE; Lappin, TR; Shannon, JS; Taylor, T, 1986) |
| "In the recovery phase of the aplastic anemia patients treated with immune suppression or androstanes the peripheral blood reflects an altered proliferation of the marrow stem cell." | ( Gardner, FH, 1985) |
| "Two patients with aplastic anemia were treated with high-dose cyclophosphamide and marrow transplantation from their normal, genetically identical twin." | ( Appelbaum, FR; Cheever, MA; Fefer, A; Storb, R; Thomas, ED, 1985) |
| "Three young patients with severe aplastic anemia undergoing intensive immunosuppressive therapy developed fever and pulmonary infiltrates during longlasting severe granulocytopenia, despite multiple broad spectrum antibiotic combinations and granulocyte transfusions." | ( Dalquen, P; Grädel, E; Gratwohl, A; Hasse, J; Nissen, C; Osterwalder, B; Signer, E; Speck, B, 1985) |
| "During an episode of aplastic anaemia she was treated with prednisolone, with a subsequent dramatic fall of serum calcium despite 1 alpha D3 treatment and serum 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in the high-normal range." | ( Benderly, A; Etzioni, A; Hochberg, Z; Levy, J; Vardi, P, 1985) |
| "3 cases of aplastic anaemia occurring in association with anti-tuberculosis chemotherapy are reported." | ( Adenle, AD; Aderoju, EA; Esan, GJ; Sekoni, G; Williams, CK, 1982) |
| "In 86 successive patients with severe aplastic anemia (SAA) the following important advances were made: (1) it was shown that the majority of patients have sufficient hemopoietic stem cells and that after treatment with antilymphocyte globulin (ALG) over 70% have long-lasting remissions, (2) the combined treatment with ALG and high dose prednisone increases the remission rates to 90% and in addition shortens the supportive care period significantly." | ( Gratwohl, A; Jeannet, M; Nissen, C; Osterwalder, B; Signer, E; Speck, B, 1983) |
| "Forty-two patients with severe aplastic anemia (SAA) were treated with immunosuppressive therapy (IS) consisting of one or more courses of the following regimens: a) high dose bolus 6 methylprednisolone (BMPr); b) horse antilymphocytic globulin (HALG); c) rabbit ALG (RALG); d) ALG followed by the infusion of haploidentical marrow (ALG +/- BM); e) BMPr in combination with HALG; f) ALG in combination with androgens." | ( Bacigalupo, A; Carella, M; Cerri, R; Damasio, EE; Frassoni, F; Marmont, AM; Risso, M; Rossi, E; Santini, G; Van Lint, MT, 1983) |
| "Fifty-four patients with severe aplastic anemia were treated with horse anti-human thymocyte globulin (ATG) and androgens." | ( Buckner, CD; Dahlberg, SJ; Doney, K; Monroe, D; Storb, R; Thomas, ED, 1984) |
| "Five patients with severe aplastic anaemia were given antilymphocytic (2) or antithymocytic (3) (ATG) gammaglobulins; two of those treated with ATG responded after two and five months respectively and there was no response in the other three." | ( Javier, G; Ortega, JJ; Tusell, J; Vilalta, R, 1984) |
| "Fifty patients with severe aplastic anemia (SAA) were treated with immunosuppressive regimens consisting of high-dose 6-methylprednisolone (HD-6MPr) followed by or given in combination with anti-lymphocyte globulin (ALG)." | ( Bacigalupo, A; Frassoni, F; Marmont, AM; Piaggio, G; Podesta, M; Reali, G; Van Lint, MT, 1984) |
| "31 children with acute acquired aplastic anaemia were treated with very high doses of i." | ( Coşkun, T; Minassazi, S; Ozsoylu, S, 1984) |
| "We surveyed cases of severe aplastic anemia treated by bone marrow transplantation from HLA-identical siblings according to information collected from 21 medical facilities throughout Japan." | ( Kanamaru, A; Nagai, K, 1984) |
| "A girl, born in 1975, developed severe aplastic anemia in November 1982 while on ethosuximide monotherapy for petit mal epilepsy, about 3 months after starting the ethosuximide medication." | ( Seip, M, 1983) |
| "Nineteen patients with severe aplastic anaemia were treated with antithymocyte globulin." | ( Branda, RF; Condie, RM; Flynn, PJ; Howe, RB; Jacob, HS; Miller, WJ; Ramsay, NK, 1983) |
| "A 16-year-old girl with severe aplastic anaemia was successfully treated with retransplantation of bone marrow from an HLA-identical sibling after rejection of the first transplantation from the same donor." | ( Fujita, S; Hara, H; Ifuku, H; Kai, S; Kanamuru, A; Nagai, K; Noguchi, K; Ohe, Y; Okamoto, T; Uchino, H; Yamagishi, S; Yoshida, Y, 1982) |
| "A 12-year-old boy with aplastic anemia developed severe but reversible cardiac failure after treatment with 200 mg/kg cyclophosphamide (4 x 50 mg/kg on four consecutive days) given as preparation for bone marrow grafting." | ( Adam, D; Hofstetter, R; Kohne, E; Lang, D; Mohr, W; Niethammer, D; von Bernuth, G, 1980) |
| "Treatment of acquired aplastic anemia with androgens has been occasionally associated with the development of hepatic tumors." | ( August, CS; Ducore, JM; Githens, JH; Johnson, ML; Montgomery, RR, 1980) |
| "A 73-year-old woman died of aplastic anemia less than two months after undergoing cataract extraction and beginning topical therapy with chloramphenicol." | ( Bagby, GC; Fraunfelder, FT; Kelly, DJ, 1982) |
| "Ten patients with aplastic anemia (AA) and seven patients with refractory anemia (RA) were treated with recombinant human granulocyte colony-stimulating factor (rhG-CSF) and erythropoietin (rhEpo) in combination." | ( Bessho, M; Fukuda, M; Hirashima, K; Ino, H; Jinnai, I; Kusumoto, S; Maruyama, M; Murohashi, I; Saito, M; Tsuji, M, 1994) |
| "In some patients with aplastic anemia (AA), hematopoietic function is dependent on continuous administration of cyclosporine A (CyA)." | ( Itoh, T; Matsuda, T; Nakao, S; Shiobara, S; Takamatsu, H; Ueda, M; Yachie, A; Yamaguchi, M, 1995) |
| "All patients with acquired aplastic anaemia were refractory to immunosuppressive treatment or had relapsed after immunosuppressive therapy and were not bone marrow transplantation candidates." | ( Gordon-Smith, EC; Heimpel, H; Marsh, JC; Müller, H; Raghavachar, A; Schrezenmeier, H; Stromeyer, P, 1995) |
| "To report a case of aplastic anemia that developed during ticlopidine treatment." | ( Mallet, J; Mallet, L, 1994) |
| "We describe a case of aplastic anemia in an 8-year-old girl which was diagnosed 8 months after initiation of ethosuximide as treatment for absence seizures." | ( Dunn, NL; Heckel, JL; Massey, GV; Myer, EC; Russell, EC, 1994) |
| "Hematopoietic function of some aplastic anemia (AA) patients is dependent on the administration of cyclosporine (CyA)." | ( Chuhjo, T; Kaneshige, T; Matsuda, T; Mizoguchi, H; Nakao, S; Shiobara, S; Takamatsu, H; Ueda, M, 1994) |
| "Thirty five patients with acquired aplastic anaemia (AAA) were treated with anti-lymphocyte globulin (ALG)." | ( Agarwal, MB; Agarwal, UM; Bhave, AB; Vishwanathan, C, 1993) |
| "Fifty patients with aplastic anemia (AA) were treated with BMT or immunosuppressive therapy (IST)." | ( Arranz, R; de la Cámara, R; Fernádez-Rañada, JM; Figuera, A; Lamana, ML; Otero, MJ; Ramos, R; Steegmann, JL; Tomás, JF; Vázquez, L, 1994) |
| "We report a patient who developed aplastic anemia after three courses of cyclohexylchloroethylnitrousurea (CCNU), procarbazine and oncovine administered after craniotomy and irradiation for brain astrocytoma." | ( Elis, A; Lishner, M; Ravid, M; Savin, H, 1994) |
| "A 75-year-old man suffering from severe aplastic anemia was treated first with cyclosporin A, then with steroid pulse therapy, and subsequently with metenolone acetate." | ( Nakazato, Y; Naruse, T; Sato, S; Takeuchi, T; Tsukamoto, N; Uchiyama, T, 1993) |
| "BMT was used to treat severe aplastic anemia which was caused by gold in one case and D-penicillamine in the other." | ( Atkinson, K; Biggs, JC; Cohen, ML; Lowenthal, RM, 1993) |
| "Treatment of severe aplastic anemia with antithymocyte globulin (ATG) and cyclosporin leads to clinical remission in a large proportion of patients." | ( Brodsky, RA; Medof, ME; Nagarajan, S; Young, NS, 1995) |
| "Severe aplastic anemia (SAA) can be successfully treated with allogeneic bone marrow transplantation (BMT) or immunosuppressive therapy." | ( Brodsky, RA; Jones, RJ; Sensenbrenner, LL, 1996) |
| "Two patients with severe aplastic anemia received combination therapy consisting of granulocyte colony-stimulating factor (G-CSF) and erythropoietin (EPO) by subcutaneous injection." | ( Hanamura, A; Hotta, T; Ichikawa, A; Utsumi, M, 1995) |
| "Improved survival of patients with aplastic anaemia (AA) has been reported over the last 20 years with immunosuppressive (IS) therapy using antilymphocyte globulin (ALG), and more recently cyclosporin (CSA)." | ( Gordon-Smith, EC; Marsh, JC, 1995) |
| "Predicting the treatment response of aplastic anaemia (AA) is essential when considering cyclosporine (CyA) therapy among several treatment options, because it requires at least 2 months determine whether the therapy is beneficial to a patient with AA." | ( Chuhjo, T; Matsuda, T; Nakao, S; Shiobara, S; Takamatsu, H; Takami, A; Ueda, M; Yamaguchi, M, 1996) |
| "Consequently, when aplastic anaemia (AA) occurs in patients with a history of PNH, allogeneic bone marrow transplantation is considered as the only effective treatment." | ( Arnoulet, C; Camerlo, J; Cappiello, MA; Gastaut, JA; Maraninchi, D; Sainty, D; Stoppa, AM; Vey, N, 1996) |
| "Forty-three cases of aplastic anemia were treated with fetal blood transfusion, Chinese medicinal herbs and Vit." | ( Fan, R; Shi, BJ; Zhang, ZM, 1995) |
| "Severe aplastic anemia (SAA) in children has been previously treated with high dose methyl prednisolone (HDMP) with favorable results." | ( Agarwal, BR; Bhalla, K; Currimbhoy, ZE; Dalvi, R; Gulvady, A, 1995) |
| "Children with severe aplastic anemia (SAA) are treated with bone marrow transplantation (BMT) if a human leukocyte antigen (HLA) compatible sibling donor is available, or alternatively with immunosuppressive therapy (IST)." | ( Boulad, F; Brochstein, JA; Castro-Malaspina, H; Childs, BH; Gillio, AP; Kernan, NA; Laver, J; O'Reilly, RJ; Reyes, B; Small, TN, 1997) |
| "For treatment of his aplastic anemia, the patient underwent an allogeneic bone marrow transplantation from his HLA-identical sister after conditioning with cyclophosphamide at 200 mg/kg and antithymocyte globulin at 3 mg/kg for 5 days." | ( Ericzon, BG; Hägglund, H; Ringdén, O; Sparrelid, E; Winiarski, J, 1997) |
| "We report a case of severe aplastic anemia (SAA) treated with granulocyte colony-stimulating factor (G-CSF), cyclosporin A and danazole, in which myelodysplastic syndrome (MDS) with monosomy 7 developed eight months later." | ( Ezaki, K; Hirano, M; Ino, T; Okamoto, M; Tsuzuki, M; Yamaguchi, T, 1997) |
| "Treatment for ticlopidine-induced aplastic anemia with colony-stimulating factors seemed to have little effect." | ( Chen, YC; Hung, CC; Kao, TW; Tien, HF, 1997) |
| "The patient had aplastic anemia with prolonged neutropenia and was treated with immunosuppressive therapy." | ( Kwon-Chung, KJ; Liu, JM; Segal, BH; Walsh, TJ; Wilson, JD, 1998) |
| "Severe aplastic anemia is a hematological disease with a high mortality rate, for which bone marrow transplantation is the treatment of choice, specially in children and young adults." | ( Bonduel, M; Bullorsky, EO; Ceresetto, J; Del Pozo, A; Delfino, S; Figueroa, C; Muriel, FS; Puppo, M; Shanley, C; Stemmelin, G, 1998) |
| "The patient developed aplastic anemia four months after the start of mesalazine therapy." | ( Hosoya, T; Kaito, K; Kobayashi, M; Otsubo, H; Sekita, T; Shimada, T, 1998) |
| "Response to immunosuppression in aplastic anemia is independent of age, but treatment is associated with increased mortality in older patients." | ( Bacigalupo, A; Gratwohl, A; Henry-Amar, M; Hows, J; Ljungman, P; Locasciulli, A; Marin, P; Marsh, J; McCann, S; Passweg, J; Raghavachar, A; Schrezenmeier, H; Socié, G; Tichelli, A, 1999) |
| "Posthepatitis aplastic anemias ran a severe and treatment-resistant course in most cases." | ( Iadrikhinskaia, VN; Mikhaĭlova, EA; Savchenko, VG, 1999) |
| "A 53-year-old woman with moderate aplastic anemia (AA) was treated with antithymocyte globulin (ATG)." | ( Akifuji, Y; Hatake, K; Miura, Y; Mori, M; Nakamoto, S; Ozawa, K; Tanaka, T; Terui, Y; Tomizuka, H; Ueki, J; Uwai, M, 1999) |
| "About 30% of patients with severe aplastic anaemia (SAA) unresponsive to one course of immunosuppressive (IS) therapy with antithymocyte or antilymphocyte globulin can achieve complete or partial remission after a second IS treatment." | ( Bacigalupo, A; Bruno, B; Camba, L; Comotti, B; De Rossi, G; De Rossi, V; Di Bona, E; Dufour, C; Foa, P; Gabbas, A; Iacopino, P; Iori, AP; Lippi, A; Locasciulli, A; Porta, F; Rodeghiero, F; Rosanelli, C; Saracco, P, 1999) |
| "We analysed sera from 63 patients with aplastic anaemia and describe a significant reduction of TGF-beta1 that was directly related to their treatment status." | ( Ball, SE; Dilger, P; Gibson, FM; Gordon-Smith, EC; Killick, SB; Patel, S; Rizzo, S; Wadhwa, M, 1999) |
| "Severe aplastic anaemia is uniformly fatal unless treated with immunosuppressive therapy or bone marrow transplantation." | ( Charles, W; Daisley, H; Jones-Lecointe, A; Murphy, A; Pitt-Miller, P, 1999) |
| "We report the cases of two severe aplastic anemia (SAA) patients who were successfully treated with syngeneic peripheral blood stem cell transplantation (PBSCT) using immunosuppression without high-dose chemotherapy or irradiation for conditioning." | ( Chen, GR; Hwang, WL; Jour, JH; Tsai, CS; Yang, Y, 2000) |
| "Severe aplastic anemia (SAA) has a poor prognosis in the absence of treatment." | ( Dunn, DE; Maciejewski, J; Tisdale, JF, 2000) |
| "Severe aplastic anemia is a well-recognized complication of ticlopidine therapy that carries a high mortality." | ( Liebman, HA; Murata-Collins, JL; Pullarkat, VA; Rho, H, 2000) |
| "A 58-year-old woman with a diagnosis of aplastic anemia had been treated with anabolic steroid for mild anemia in 1984." | ( Kajiguchi, T; Miyata, Y; Saito, M; Takeyama, H, 2000) |
| "After being diagnosed with aplastic anemia at 14 years of age, she had been treated with oxymetholone (30 mg/day) for 6 years." | ( Amimoto, T; Isozaki, H; Komazawa, K; Nakao, A; Nakashima, K; Nakata, Y; Sakagami, K; Takakura, N; Tanaka, N, 2000) |
| "We analysed 144 patients with aplastic anaemia treated with immunosuppression protocols with or without G-CSF, with normal cytogenetics at diagnosis or immediately after immunosuppression." | ( Arcese, W; Bacigalupo, A; Di Bona, E; Locasciulli, A; Locatelli, F, 2001) |
| "We describe a man who developed aplastic anaemia after 5 months of treatment with clopidogrel." | ( Cambier, N; Caron, J; Mahieu, M; Rose, C; Trivier, JM, 2001) |
| "Patients with aplastic anemia who do not have suitably HLA-matched, related donors generally receive immunosuppressive treatment as first-line therapy and are considered for transplantation from an unrelated donor only if they fail to respond to immunosuppressive treatment." | ( Amylon, ID; Anasetti, C; Beatty, PG; Burdach, S; Collins, R; Deeg, HJ; Feig, S; Hackman, R; Harris, RE; Khan, SP; Leis, JF; Mueller, B; Pamphilon, D; Ramsay, N; Storer, B; Territo, M, 2001) |
| "Both benzene-treatment schemes caused aplastic anemia, however, the disease was masked by spleen toxicity in group 1B." | ( Barrera Escorcia, E; Betancourt Rule, M; García Lorenzana, M; González Ramírez, C; Muñoz Torres, A; Ortiz Monroy, V; Tapia Aguilar, R; Velasco Lezama, R, 2001) |
| "In severe aplastic anaemia, the treatment of choice for young patients with a human leucocyte antigen-matched sibling is now established as allogeneic bone marrow transplantation (BMT)." | ( Durrant, S; Gillett, EA; Lockwood, L; Mollee, P; Morton, J; Rowell, J; Woodward, N, 2001) |
| "Optimal treatment strategies for severe aplastic anaemia remain to be determined." | ( Durrant, S; Gillett, EA; Lockwood, L; Mollee, P; Morton, J; Rowell, J; Woodward, N, 2001) |
| "A diagnosis of hepatitis-associated aplastic anemia was made on the basis of liver dysfunction (AST 156 IU/l, ALT 386 IU/l), hypoplastic bone marrow, and pancytopenia (WBC 4,400/microliter, neutrophils 3,340/microliter under G-CSF administration, Hb 9." | ( Adachi, Y; Iki, S; Kazama, H; Matsuya, S; Urabe, A; Usuki, K, 2001) |
| "She had been diagnosed with severe aplastic anemia 1 year previously and, while hospitalized, had received methyl prednisolone pulse therapy, which was not successful." | ( Adachi, M; Akaike, J; Hayashi, T; Hinoda, Y; Hirayama, T; Imai, K; Kasahara, K; Minami, T; Takahashi, S; Takahashi, T, 2001) |
| "Using YSSXT to treat aplastic anemia that the effectiveness might be realized through promoting the proliferation of hematopoietic stem cells of bone marrow, enhancing the non-specific immunity, and the anti-infection as well as body resistance." | ( Wang, T; Yang, J; Zhou, A, 1999) |
| "A case of hepatitis B-associated severe aplastic anemia is described which only partially responded to conventional immunosuppressive treatment but went into complete clinical remission after clearance of the hepatitis B virus." | ( Arat, M; Bozdayi, AM; Bozkaya, H; Cinar, K; Erekul, S; Koç, H; Törüner, M; Uzunalimoğlu, O; Yurdaydin, C, 2002) |
| "Second, a rarer aplastic anaemia (AA), developing after treatment, is irreversible, and often fatal." | ( Andrews, CM; Gibson, FM; Havard, AC; Robinson, S; Turton, JA; Williams, TC; York, M, 2002) |
| "The occurrence of aplastic anemia following topical administration of ophthalmic chloramphenicol is controversial and debated internationally." | ( Jassim Al Khaja, KA; Mathur, VS; Sequeira, RR, 2003) |
| "The diagnosis was severe aplastic anemia, and the patient was treated with antithymocyte globulin and cyclosporin A." | ( Kato, K; Kojima, S; Kudo, K; Matsuyama, T; Nakamoto, C; Nakamura, Y; Yoshimi, A, 2003) |
| "Transformation of hepatitis-associated aplastic anemia to MDS with the monosomy 7, monosomy 6 and marker chromosome in this patient was considered to have been related to the administration of high doses of immunosuppressive drugs plus growth factors." | ( Ishii, S; Obinata, K; Shibuya, A, 2002) |
| "Of 156 patients with severe aplastic anemia (SAA) or very severe AA treated with ISA (antithymocyte globulin [ATG] or ATG plus cyclosporine), 46." | ( Ahn, MJ; Cho, KS; Choi, IY; Choi, JH; Im, SA; Jung, CW; Jung, SY; Ki, M; Kim, BK; Kim, IS; Kim, SR; Lee, JA; Lee, JH; Lee, YY; Oh, D; Park, SY; Son, HJ; Suh, C; Sung, JM; Yoon, HJ; Yoon, SS; Yuh, YJ, 2003) |
| "We treated three aplastic anemia patients complicated by various organ failures, with a conditioning regimen consisting of fludarabine (Flu), cyclophosphamide(CY), and antithymocyte globulin (ATG)." | ( Nakao, S, 2003) |
| "With modest to severe aplastic anemia, one previously untreated patient and 13 patients who had failed immunosuppressive therapy were studied." | ( Chen, H; Chen, J; Liu, W; Wang, X; Wu, J; Wu, L; Yang, D; Yang, Y, 2003) |
| "We report a 12-year-old girl with aplastic anemia accompanied by chromosome 8 trisomy during growth hormone (GH) therapy." | ( Hanaki, K; Hayashi, A; Kanzaki, S; Kawashima, Y; Kinoshita, T; Nagaishi, J; Sugimoto, S, 2003) |
| "We describe a patient with aplastic anaemia who, following multiple treatments with rabbit and horse Anti-Thymocyte Globulin and anabolic steroids developed marked splenomegaly and hypersplenism." | ( Burton, I; Byers, R; Liu Yin, JA; Roulson, JA; Tholouli, E, 2003) |
| "We describe a patient who developed aplastic anemia complicated by sepsis after receiving etanercept, a TNF-alpha receptor analog, for the treatment of rheumatoid arthritis." | ( Al-Saab, S; Galbraith, PF; Kuruvilla, J; Leitch, HA; Li, CH; Naiman, SC; Vickars, LM, 2003) |
| "Severe aplastic anemia has an elevated mortality if treatment is unsatisfactory." | ( Cabrera, ME; Pinto, D, 2003) |
| "The treatment options for patients with aplastic anemia who do not respond to conventional immunosuppression are limited." | ( Brodsky, I; Brodsky, RA; Chen, AR; Jones, RJ, 2004) |
| "The authors treated a girl with severe aplastic anemia that developed following urinary tract infection." | ( Aslan, D; Cetin, M; Ozyürek, E; Yetgin, S, 2004) |
| "Outcome of patients with aplastic anaemia (AA), whether treated with allogeneic BMT or immunosuppressive therapy has steadily increased over the last three decades." | ( Marsh, JC, 2005) |
| "To report a case of aplastic anemia in a patient treated with cyanamide, an alcohol-aversive drug." | ( Ballarín, E; Force, L; Hernández, JA; Ibáñez, L; Laporte, JR, 2005) |
| "Sixty-five chronic aplastic anemia patients were randomized into treatment group and control group." | ( Hu, H; Tang, Q; Zhang, H, 2005) |
| "Severe aplastic anaemia (SAA) can be successfully treated with immunosuppressive therapies or haematopoietic stem cell transplantation (HSCT)." | ( Nunez, O; Scheinberg, P; Wu, C; Young, NS, 2006) |
| "Treatment of severe aplastic anemia (SAA) patients who lack human leukocyte antigen (HLA)-matched donors and failed immunosuppressive therapy (IST) is challenging." | ( Goto, K; Hara, T; Hattori, S; Ichino, K; Nakamura, K; Nomura, A; Ohga, S; Takada, H, 2006) |
| "Relapse of aplastic anemia was not associated with a worse outcome in patients who did not receive G-CSF as first therapy, whereas relapse was associated with a significantly worse outcome in those patients who received G-CSF." | ( Bacigalupo, A; Bekassy, A; Fuehrer, M; Locasciulli, A; Marsh, J; Mary, JY; Passweg, J; Schrezenmeier, H; Socie, G; Tichelli, A, 2007) |
| "Myelodysplastic syndromes (MDS) and aplastic anemia (AA) are the most common anemias that require transfusion therapy in Japan." | ( Harada, M; Kanakura, Y; Murate, T; Nakahata, T; Nakao, S; Okamoto, S; Ozawa, K; Sawada, K; Takatoku, M; Tomonaga, M; Uchiyama, T, 2007) |
| "A PNH patient with aplastic anemia was treated with the complement inhibitor eculizumab, followed by concurrent treatment with recombinant human erythropoietin (rHuEpo)." | ( Hill, A; Hillmen, P; Richards, SJ; Rother, RP, 2007) |
| "A 41-year-old man diagnosed with severe aplastic anemia was treated with ATG and cyclosporine." | ( Barakat, RK; Finkel, KW; Foringer, JR; Schmolck, JP, 2007) |
| "It is widely used to treat severe aplastic anemia and to manage acute transplant rejection." | ( Barakat, RK; Finkel, KW; Foringer, JR; Schmolck, JP, 2007) |
| "We report of a patient in whom aplastic anemia, mucormycosis and aspergillosis complicated during the course of IM and successfully treated with liposomal amphotericin B." | ( Baykal, B; Ergene, U; Metin Ciris, I; Ozbalci, D; Yariktas, M, 2007) |
| "Twenty three (17M: 6F) patients of aplastic anemia (11 very severe aplastic anemia (VSAA) and 12 severe aplastic anemia (SAA), were administered antithymocyte globulin and cyclosporin." | ( Chandra, J; Dutta, AK; Naithani, R; Narayan, S; Pemde, H; Ravi, R; Sharma, S; Singh, V, 2008) |
| "Hepatitis-associated aplastic anemia (HAA) has been reported to show a successful outcome following immunosuppressive treatment." | ( Fujisaki, T; Joko, K; Kobayashi, Y; Muta, T; Takeshita, E; Tanaka, Y; Tokuyama, T; Ueda, Y; Yokota, E, 2008) |
| "We report an unusual case of aplastic anemia associated with allopurinol therapy for hyperuricemia in a patient with chronic kidney disease." | ( Kang, SW; Kim, YH; Kim, YW; Park, BS; Park, SJ; Ryu, CH; Shon, JH; Song, IS, 2009) |
| "Acquired severe aplastic anemia can be treated successfully with either immunosuppressive therapy or bone marrow transplantation." | ( Bacigalupo, A; Passweg, J, 2009) |
| "HLA-DR15 (DR2) is overrepresented in aplastic anemia (AA) patients, and its presence is associated with a better response to cyclosporine-based immunosuppressive therapy (IST)." | ( Ahn, HS; Kang, HJ; Kim, BK; Kim, I; Park, MH; Park, S; Shin, HY; Song, EY; Yoon, SS, 2010) |
| "Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disorder that can be treated with bone marrow transplantation, immunosuppressive therapy, and high-dose cyclophosphamide." | ( Ambinder, RF; Brodsky, RA; Chen, AR; Dorr, D; Fuchs, EJ; Goodman, SN; Huff, CA; Jones, RJ; Luznik, L; Matsui, WH; Smith, BD, 2010) |
| "He had been affected by aplastic anemia for 8 years, and was previously treated with antithymocyte globulin." | ( Kawabe, K; Nunomura, M; Yamada, H; Yokota, S, 2010) |
| "To analyze the outcome of childhood aplastic anemia received allogenic hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST)." | ( Chen, J; Dong, L; Gu, LJ; Jiang, H; Luo, CJ; Luo, CY; Pan, C; Tang, JY; Xue, HL; Ye, QD; Zhou, M, 2010) |
| "Adult SAA or very severe aplastic anemia (VSAA) patients treated with rabbit ATG + CsA as first line therapy in our hospital from 2003 to 2008 were retrospectively analysed and the therapeutic response relevant factors were analysed." | ( Cao, HM; Chu, YL; Jing, LP; Li, HQ; Liu, QG; Liu, YZ; Wang, HJ; Wu, YH; Yan, ZS; Yang, DL; Zhang, FK; Zhang, L; Zhou, K, 2011) |
| "Twenty patients with severe aplastic anemia treated with rabbit anti-thymocyte globulin were compared to 67 historical control cases with matched clinical characteristics treated with horse anti-thymocyte globulin." | ( Advani, A; Afable, MG; Clemente, M; Elson, P; Kalaycio, M; Lichtin, A; Maciejewski, JP; Makishima, H; O'Keefe, CL; Sekeres, MA; Shaik, M; Sugimoto, Y; Tiu, RV, 2011) |
| "To improve diagnosis and therapy for aplastic anaemia (AA) in Shanghai, clinical and laboratory data for patients with AA (n = 142) and hypocellular myelodysplastic syndrome (MDS; n = 22) were comparatively analysed (follow-up 2 - 6 years)." | ( Lin, G; Wang, W; Wang, X; Xu, X, 2011) |
| "Fifty children with chronic aplastic anemia were enrolled, among whom 30 received cyclosporine treatment (cyclosporine group) and 20 were treated with conventional methods (conventional group)." | ( Cao, YM; Liu, S; Qiao, JY; Wang, M; Wang, XG; Yang, J; Zhao, XM; Zhou, YJ, 2011) |
| "The treatment of aplastic anemia in pediatric patients is a challenging task." | ( Bhatia, B; Gupta, V; Kumar, A; Saini, I; Tilak, V, 2012) |
| "Severe aplastic anemia, which is characterized by immune-mediated bone marrow hypoplasia and pancytopenia, can be treated effectively with immunosuppressive therapy or allogeneic transplantation." | ( Biancotto, A; Calvo, KR; Desmond, R; Dumitriu, B; Dunbar, CE; Feng, X; Lozier, J; Olnes, MJ; Parikh, AR; Scheinberg, P; Soto, S; Tang, Y; Wu, CO; Young, NS, 2012) |
| "Patient was diagnosed with aplastic anaemia secondary to methimazole and was treated with high-dose granulocyte colony stimulating factor, thrombopoietin and mesterolone." | ( Buenaluz-Sedurante, M; Castillo, G; Josol, CV; Sandoval, MA, 2010) |
| "A patient with aplastic anaemia, successively treated with caspofungin then liposomal amphotericin, developed a disseminated infection due to Acremonium, further confirmed as resistant in vitro to these drugs." | ( Aline-Fardin, A; Buot, G; Dannaoui, E; Degulys, A; Guitard, J; Hennequin, C; Lapusan, S; Marie, JP; Rio, B, 2014) |
| "Refractory aplastic anemia (AA) is defined as a lack of response to first-line immunosuppressive therapy (IST) with antithymocyte globulin and cyclosporin and is manifested as persistence of severe cytopenias at 6 months after IST." | ( Kulasekararaj, AG; Marsh, JC, 2013) |
| "About a quarter of patients with severe aplastic anemia remain pancytopenic despite immunosuppressive therapy." | ( Bevans, M; Broder, K; Calvo, KR; Desmond, R; Dumitriu, B; Dunbar, CE; Olnes, MJ; Parikh, AR; Scheinberg, P; Townsley, DM; Wu, CO; Young, NS, 2014) |
| "A 21-year-old man with aplastic anemia was treated with an allogeneic stem cell transplant." | ( Cheng, P; Meng, F; Zhang, D, 2014) |
| "Severe aplastic anemia (SAA), which is considered to be an immune-mediated destruction of bone marrow stem cells with pancytopenia and hypoplasia, can be successfully treated with immunosuppressive therapy or hematopoietic stem cell transplantation (HSCT)." | ( Guan, J; Jiang, L; Wei, J; Xu, J; Yin, J; Zhang, Y; Zhao, L; Zhu, X, 2014) |
| "First-line therapy of severe aplastic anemia (SAA) with high-dose cyclophosphamide causes toxicity and increased short-term mortality." | ( Daphtary, M; Dumitriu, B; Rios, O; Scheinberg, P; Townsley, D; Weinstein, B; Wu, CO; Young, NS, 2014) |
| "The treatment of aplastic anemia is currently with immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG) and cyclosporine, to which two thirds of patients respond." | ( Desmond, R; Dunbar, C; Townsley, DM; Young, NS, 2015) |
| "In patients with severe aplastic anaemia refractory to prior immunosuppressive therapy, oral eltrombopag at dosages ≤150 mg once daily for 12-16 weeks produced a haematological response in at least one cell lineage in 40 % of patients." | ( McCormack, PL, 2015) |
| "A 10-year-old girl with severe aplastic anemia developed invasive pulmonary aspergillosis after high-dose cyclophosphamide therapy and required high doses of voriconazole for longer than 2 months." | ( Arav-Boger, R; Dabb, A; Hsu, AJ, 2015) |
| "According to the International Aplastic Anemia Treatment and Effect standards." | ( He, W; Qiao, XH; Shi, W; Xie, XT; Zhou, XX, 2016) |
| "Many patients with IND-PALF or aplastic anemia with acute hepatitis that were treated with corticosteroids improved, but survival with native liver may not be different from historical reports." | ( Alonso, EM; Blondet, N; Chapin, CA; Horslen, SP; Lin, H; Mohammad, S; Squires, JE, 2019) |
| "The China Aplastic Anemia Committee and British Committee for Standards in Haematology guidelines recommend hematopoietic stem-cell transplantation (HSCT) or immunosuppressive therapy (IST) comprising antithymocyte globulin (ATG) with cyclosporine (CsA) as initial treatment for AA patients." | ( Chen, XQ; Fang, JP; Han, B; He, HL; Hu, JD; Jin, J; Li, W; Liang, YM; Liu, F; Shi, HX; Tang, JY; Wang, SQ; Wu, DP; Wu, LQ; Xia, LH; Ye, TZ; Zhang, DH; Zhang, FK; Zhang, X; Zhou, F; Zhu, HL; Zhu, XF, 2019) |
| "In severe aplastic anemia (SAA), predictive markers of response to immunosuppressive therapy (IST) of porcine antilymphocyte globulin (pALG) have not been well defined." | ( Chang, LX; Chen, X; Chen, XJ; Chen, YM; Guo, Y; Liu, F; Liu, LP; Liu, TF; Ruan, M; Yang, WY; Yi, MH; Zhang, FK; Zhang, L; Zhou, K; Zhu, XF; Zou, Y, 2019) |
| "The therapy algorithm for severe aplastic anaemia (sAA) is established but moderate AA (mAA), which likely reflects a more diverse pathogenic mechanism, often represents a treatment/management conundrum." | ( Advani, A; Barot, SV; Carraway, HE; Kalaycio, M; Kerr, C; Kuzmanovic, T; Lee, S; Lichtin, A; Maciejewski, JP; Patel, BJ; Patel, S; Przychodzen, BP; Radivoyevitch, T; Sekeres, MA; Thota, S, 2020) |
| "Severe aplastic anemia (SAA) is a stem cell disorder often treated with bone marrow transplantation (BMT) to reconstitute hematopoiesis." | ( Ambinder, RF; Bolaños-Meade, J; Borrello, I; Brodsky, RA; Cooke, KR; DeZern, AE; Fuchs, EJ; Gladstone, DE; Huff, CA; Imus, P; Jones, RJ; Luznik, L; Rosner, GL; Swinnen, LJ; Symons, HJ; Wagner-Johnston, N; Zahurak, ML, 2020) |
| "Patients with severe aplastic anemia (SAA) who fail immunosuppressive therapy have a dismal prognosis." | ( Araujo, RC; Arcuri, LJ; Atta, EH; Bonfim, C; Loth, G; Nabhan, SK; Nichele, S; Oliveira, M, 2020) |
| "Hepatitis-associated aplastic anemia (HAAA) is a potentially life-threatening diagnosis without clear treatment guidelines." | ( Brigham, D; Feldman, AG; Kemme, S; Lovell, MA; Mack, C; Nakano, T; Stahl, M, 2021) |
| "Treatment options for newly diagnosed aplastic anemia (AA) patient includes upfront allogeneic hematopoietic stem cell transplant (HSCT) or immunosuppressive therapy (IST)." | ( Ahmed, P; Ansar, I; Anwer, F; Ashraf, R; Chaudhry, QUN; Farhan, M; Ghafoor, T; Iftikhar, R; Khan, M; Khan, MA; Khattak, TA; Mahmood, SK; Marsh, J; Neupane, K; Rafae, A; Rehman, J; Satti, TM; Shahbaz, N; Shamshad, GU, 2021) |
| "Acquired severe aplastic anaemia (SAA) has an immune pathogenesis, and immunosuppressive therapy (IST) with anti-thymocyte globulin and cyclosporine is effective therapy." | ( Baldoni, D; Groarke, EM; Gutierrez-Rodrigues, F; Lotter, J; Patel, BA; Rios, O; Shalhoub, R; St Pierre, A; Townsley, DM; Wu, CO; Young, NS, 2021) |
| "First-line treatment of aplastic anemia(AA) and for AA patients ineligible for hematopoietic stem cell transplantation (HSCT) has consisted of antithymocyte globulin (ATG), the calcineurin inhibitor cyclosporine A (CsA), and more recently eltrombopag." | ( Chiu, V; Hermel, D; Martynova, A; Mert, M; Weitz, IC, 2021) |
| "When it comes to the treatment of aplastic anemia fever, the Guidelines for Aplastic Anemia regards Anti-thymocyte globulin (ATG) combined with eltrombopag as the standard immunosuppressive treatment plan, and ATG is the main mode to treat severe aplastic anemia." | ( Chen, L; Han, S; Liu, J; Peng, Y; Wang, H; Wu, Y; Zhang, J, 2021) |
| "The recommended therapy for severe aplastic anemia (SAA) in younger patients with a matched sibling donor (MSD) is allogeneic hematopoietic cell transplantation (allo-HCT)." | ( Ahmed, SO; Alahmari, A; Alfraih, F; Alhakim, A; Alhayli, S; Aljurf, M; Almohareb, F; Alsadi, H; Alshaibani, A; Alsharif, F; Alshomar, A; Alzahrani, H; Assiri, A; Babiker, F; Balbaid, A; Chaudhri, N; El Fakih, R; Elhassan, T; Ghabashi, E; Hanbali, A; Kotb, A; Rasheed, W; Samarkandi, H; Shaheen, M, 2021) |
| "Treatments of aplastic anemia comprise supportive therapy and aplastic anemia-specific therapy to recover from hematopoiesis." | ( Usuki, K, 2021) |
| "Patients with severe aplastic anemia (SAA) are either treated with bone marrow transplant (BMT) or immunosuppression (IST) depending on their age, comorbidities, and available donors." | ( Groarke, EM; Gutierrez-Rodrigues, F; Lotter, J; Patel, BA; Quinones Raffo, D; Rios, O; Shalhoub, R; Wu, CO; Young, NS, 2022) |
| "Temozolomide-induced aplastic anemia (TIAA) is a rare but highly challenging complication of temozolomide (TMZ) therapy." | ( Al-Samkari, H; Forst, DA; Park, AK; Waheed, A, 2022) |
| "The early diagnosis of aplastic anemia related to Nilotinib therapy is needed to avoid further detrimental effects of the drug." | ( Ben Said, F; Elloumi, M; Kallel, F; Kassar, O; Khabir, A; Ksouda, K; Mallek, R, 2022) |
| "Here, we report two cases of aplastic anemia in which diffuse large B-cell lymphoma developed during treatment with CsA." | ( Edahiro, Y; Fukuda, Y; Furuya, C; Hamano, Y; Koike, M; Komatsu, N; Shirane, S; Takaku, T, 2022) |
| "At present, a number of very severe aplastic anemia (VSAA) patients cannot receive hematopoietic stem cell transplantation (HSCT) or standard immunosuppressive therapy (IST) due to the high cost of therapy, shortage of sibling donors, and lack of resources to support the HSCT." | ( Chen, HB; Jin, RM; Qiu, YN; Shen, YQ; Wang, ZJ; Wu, XY; Yu, H; Zhou, F, 2022) |
| "Acquired aplastic anemia (AA) is a bone marrow failure disorder characterized by pancytopenia, and immunosuppressive therapy (IST) is the optional first-line management." | ( Chen, Y; Hu, H; Hu, Z; Li, H; Li, Y; Lin, S; Liu, Q; Liu, S; Liu, W; Shen, J; Shen, Y; Wu, D; Wu, L; Ye, B; Yu, Q; Zhao, Y; Zheng, Z; Zhou, Y; Zhuang, H, 2023) |
| "For patients with severe aplastic anemia (SAA) in China who have had an insufficient response to the first-line treatment with hematopoietic stem cell transplantation or immunosuppressive therapy, there is no established standard of care other than transfusion support and treatment of infections." | ( Chang, H; Fu, R; Han, B; He, G; Jin, H; Li, F; Li, T; Liu, L; Mittal, H; Zhang, F, 2023) |