ascorbic-acid and Hemophilia-A

Topics: Ascorbic Acid; Avitaminosis; Blood Vessels; Cushing Syndrome; Diagnosis, Differential; Ehlers-Danlos Syndrome; Hemophilia A; Hemorrhagic Disorders; Humans; Purpura; Telangiectasia, Hereditary Hemorrhagic; Thrombocytopenia; Vascular Diseases

There is no dietary strategy that has yet been specifically advocated for haemophilia. Therefore, we sought to assess the effect of the Dietary Approaches to Stop Hypertension (DASH) diet in adolescents with haemophilia. In this parallel trial, forty male adolescents with haemophilia were dichotomised into the DASH group or control group for 10 weeks. The serum high sensitivity C-reactive protein, IL-6, complete blood count (CBC), serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, partial thromboplastin time (PTT), waist circumference (WC), percentage of body fat, fat-free mass and liver steatosis were measured at the beginning and end of the study. Serum vitamin C was measured as a biomarker of compliance with the DASH diet. The DASH diet was designed to include high amounts of whole grains, fruits, vegetables and low-fat dairy products, as well as low amounts of saturated fats, cholesterol, refined grains, sweets and red meat. Serum vitamin C in the DASH group was significantly increased compared with the control (

Topics: Adolescent; Ascorbic Acid; Blood Cell Count; Body Composition; Child; Dietary Approaches To Stop Hypertension; Hemophilia A; Humans; Hypertension; Inflammation; Liver; Male; Prothrombin Time

Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Hemophilia A; Hemorrhage; Humans

Blood levels of ascorbic acid, vitamin A, folic acid, and amino acids were studied in patients at the South Texas Comprehensive Hemophilia Center, San Antonio, TX. The mean plasma ascorbic acid level in hemophiliacs was significantly lower than controls (p less than 0.0001). This was observed despite a dietary ascorbic acid intake in excess of 66% of the Recommended Dietary Allowances (RDA). However, those subjects receiving specific factor replacement therapy at home and consuming at least 66% RDA of ascorbic acid maintained a mean plasma ascorbic acid level not significantly less than controls. Hemophilic subjects not on home therapy, on the other hand, had a mean plasma ascorbic acid level significantly below that of controls while receiving optimal dietary ascorbic acid. With prompt adequate medical care of bleeding episodes and with optimal nutrition, the demand for ascorbic acid needed for tissue repair in hemophilic patients may be lessened. Hemophiliacs had mean serum vitamin A, mean serum folate, and mean red cell folate levels that were not significantly different from controls. Significantly higher mean plasma arginine and lower, but not significantly lower, mean plasma ornithine levels were found in hemophilic subjects, suggesting altered arginase activity.

Topics: Adolescent; Adult; Amino Acids; Ascorbic Acid; Child; Child, Preschool; Folic Acid; Hemarthrosis; Hemophilia A; Humans; Male; Middle Aged; Vitamin A

Topics: Antigens; Ascorbic Acid; Blood Coagulation; Chromatography, Gel; Dithiothreitol; Factor VIII; Glutathione; Hemophilia A; Humans; Kinetics; Thioctic Acid; von Willebrand Diseases

Topics: Aminocaproates; Ascorbic Acid; Factor VIII; Family; Hemophilia A; Hepatitis A; Hepatitis B Antigens; Home Nursing; Humans; Male; Tooth Extraction; Vasopressins

Topics: Administration, Oral; Aniline Compounds; Ascorbic Acid; Chalcones; Coloring Agents; Flavonoids; Hemophilia A; Hesperidin; Hypoprothrombinemias; Leukemia; Prothrombin; Purpura; Purpura, Thrombocytopenic; Tolonium Chloride; Vitamins