EC 3.4.21.26 (prolyl oligopeptidase) inhibitor

Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26).

ChEBI ID: 76779

Members (22)

Member	Definition	Class
adp-ribosylarginine		N(omega)-(ADP-D-ribosyl)-L-arginine
baicalein	A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.	baicalein
baicalin	The glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis.	baicalin
berberine		berberine
buspirone	An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.	buspirone
buspirone hydrochloride	A hydrochloride salt resulting from the reaction of equimolar amounts of buspirone and hydrogen chloride.	buspirone hydrochloride
chlorpromazine	A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.	chlorpromazine
clozapine	A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.	clozapine
desipramine	A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.	desipramine
escitalopram	A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram.	escitalopram
imipramine	A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.	imipramine
ketanserin	A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.	ketanserin
lamotrigine	A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6.	lamotrigine
methotrimeprazine	A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.	methotrimeprazine
mianserin	A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.	mianserin
prazosin	A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.	prazosin
prochlorperazine	A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.	prochlorperazine
promazine	A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.	promazine
reserpine	An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.	reserpine
risperidone	A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.	risperidone
ritanserin	A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action.	ritanserin
thioridazine	A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.	thioridazine

Research

Studies (82,619)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	39,099 (47.32)	18.7374
1990's	13,744 (16.64)	18.2507
2000's	12,999 (15.73)	29.6817
2010's	12,419 (15.03)	24.3611
2020's	4,358 (5.27)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	8,371 (8.50%)	5.53%
Reviews	5,885 (5.97%)	6.00%
Case Studies	6,981 (7.09%)	4.05%
Observational	198 (0.20%)	0.25%
Other	77,067 (78.24%)	84.16%

Protein Targets (556)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	19.4896	1	8
15-lipoxygenase, partial	Homo sapiens (human)	Potency	14.9701	1	4
67.9K protein	Vaccinia virus	Potency	22.1136	2	10
acetylcholinesterase	Homo sapiens (human)	Potency	28.0825	3	18
activating transcription factor 6	Homo sapiens (human)	Potency	25.8333	1	3
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	17.7900	1	19
alpha-galactosidase	Homo sapiens (human)	Potency	38.3007	2	7
Alpha-synuclein	Homo sapiens (human)	Potency	4.4668	1	1
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	15.8489	1	1
AR protein	Homo sapiens (human)	Potency	30.8016	9	61
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	34.9391	2	8
arylsulfatase A	Homo sapiens (human)	Potency	19.0645	1	6
ATAD5 protein, partial	Homo sapiens (human)	Potency	17.8004	4	12
Ataxin-2	Homo sapiens (human)	Potency	20.9166	2	13
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	18.0950	4	12
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	27.6881	2	5
atrial natriuretic peptide receptor 1 precursor	Homo sapiens (human)	Potency	0.8492	1	1
atrial natriuretic peptide receptor 2 precursor	Homo sapiens (human)	Potency	16.3592	1	7
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	27.1547	2	10
BRCA1	Homo sapiens (human)	Potency	10.8820	1	2
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	40.7626	1	4
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	42.2312	1	4
caspase-1 isoform alpha precursor	Homo sapiens (human)	Potency	7.9433	1	1
caspase-3	Cricetulus griseus (Chinese hamster)	Potency	33.4915	1	2
caspase-3	Homo sapiens (human)	Potency	42.2312	1	4
Caspase-7	Cricetulus griseus (Chinese hamster)	Potency	33.4915	1	2
Caspase-7	Homo sapiens (human)	Potency	7.9433	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	23.6392	2	10
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	15.2678	2	11
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	16.9501	1	8
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	16.3482	1	3
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	25.2171	1	3
Chain A, Cruzipain	Trypanosoma cruzi	Potency	25.1189	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	40.0748	2	2
Chain A, HADH2 protein	Homo sapiens (human)	Potency	24.3660	2	13
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	60.9175	1	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	12.2304	2	10
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	8.6406	1	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	31.2931	1	8
Chain B, HADH2 protein	Homo sapiens (human)	Potency	24.3660	2	13
chromobox protein homolog 1	Homo sapiens (human)	Potency	50.6928	2	13
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	7.8972	1	8
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	16.6644	1	7
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	27.8392	1	5
cytochrome P450 2D6	Homo sapiens (human)	Potency	9.7438	1	14
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	10.9974	1	22
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	14.0051	2	35
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	18.9114	2	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	33.4088	1	5
D(1A) dopamine receptor	Homo sapiens (human)	Potency	4.0382	3	23
D(1A) dopamine receptor	Sus scrofa (pig)	Potency	14.4499	1	7
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)	Potency	0.6310	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	Homo sapiens (human)	Potency	31.6228	1	1
DNA polymerase beta	Homo sapiens (human)	Potency	55.5278	1	2
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	8.7357	2	3
DNA polymerase III, partial	Bacillus subtilis	Potency	21.1923	1	1
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	54.4985	2	9
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	10.6165	1	6
dopamine D1 receptor	Homo sapiens (human)	Potency	0.0326	1	2
endonuclease IV	Escherichia coli	Potency	7.1264	2	2
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	32.3697	11	72
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	22.7110	2	8
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	24.7609	9	61
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	21.9181	2	27
EWS/FLI fusion protein	Homo sapiens (human)	Potency	23.0705	4	26
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	24.3038	4	11
flap endonuclease 1	Homo sapiens (human)	Potency	29.3924	1	5
Fumarate hydratase	Homo sapiens (human)	Potency	27.9580	1	14
G	Vesicular stomatitis virus	Potency	27.8392	1	5
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
GALC protein	Homo sapiens (human)	Potency	13.7422	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	13.6439	1	18
geminin	Homo sapiens (human)	Potency	14.0624	4	21
GLI family zinc finger 3	Homo sapiens (human)	Potency	14.4917	2	22
glp-1 receptor, partial	Homo sapiens (human)	Potency	21.1490	1	3
GLS protein	Homo sapiens (human)	Potency	14.4301	2	10
glucocerebrosidase	Homo sapiens (human)	Potency	22.5198	1	9
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	21.8171	4	15
Glutamate receptor 1	Rattus norvegicus (Norway rat)	Potency	0.6310	1	1
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	35.3198	2	8
Glutamate receptor 3	Rattus norvegicus (Norway rat)	Potency	0.6310	1	1
Glutamate receptor 4	Rattus norvegicus (Norway rat)	Potency	0.6310	1	1
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	11.5821	1	1
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	18.0636	1	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	35.4813	1	1
heat shock protein beta-1	Homo sapiens (human)	Potency	31.6680	1	2
hemoglobin subunit beta	Homo sapiens (human)	Potency	31.6228	2	2
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	14.5914	2	47
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	31.6279	1	4
histone deacetylase 9 isoform 3	Homo sapiens (human)	Potency	13.9228	2	3
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	53.8623	2	7
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	28.1838	1	1
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	27.8392	1	5
huntingtin isoform 2	Homo sapiens (human)	Potency	30.3051	2	3
hypothetical protein, conserved	Trypanosoma brucei	Potency	35.4813	1	1
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	3.5140	1	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	13.6471	2	14
IDH1	Homo sapiens (human)	Potency	19.9967	1	8
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	28.1252	2	2
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	27.8392	1	10
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	6.1546	2	6
Integrin alpha-IIb	Homo sapiens (human)	Potency	20.6056	1	5
Integrin beta-3	Homo sapiens (human)	Potency	20.6056	1	5
Interferon beta	Homo sapiens (human)	Potency	21.2583	3	13
interleukin 8	Homo sapiens (human)	Potency	66.8242	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	9.1943	2	14
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	16.1324	1	12
lethal(3)malignant brain tumor-like protein 1 isoform I	Homo sapiens (human)	Potency	22.0164	1	2
Luciferase	Photinus pyralis (common eastern firefly)	Potency	40.5334	1	3
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	36.4261	1	2
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	26.6806	1	7
Microtubule-associated protein tau	Homo sapiens (human)	Potency	20.1884	2	19
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	21.3907	2	9
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	6.2733	2	23
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	20.7945	1	2
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	13.8932	1	4
NFKB1 protein, partial	Homo sapiens (human)	Potency	11.7394	2	12
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	13.5826	1	4
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	58.0479	1	4
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	29.3290	3	17
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	27.5110	1	2
nuclear factor NF-kappa-B p105 subunit isoform 1	Homo sapiens (human)	Potency	42.2395	1	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	33.7044	1	3
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	37.5780	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	21.4513	2	14
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	26.9995	3	19
Ornithine decarboxylase	Rattus norvegicus (Norway rat)	Potency	0.0063	1	2
Parkin	Homo sapiens (human)	Potency	23.1093	1	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	20.6251	2	5
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	21.2535	2	11
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	65.7701	1	6
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	18.8489	5	20
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	20.2770	4	12
phosphopantetheinyl transferase	Bacillus subtilis	Potency	53.4924	3	9
plasminogen precursor	Mus musculus (house mouse)	Potency	11.2947	1	2
polyprotein	Zika virus	Potency	27.9580	1	14
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	3.5481	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	12.9170	1	13
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	10.2426	1	16
PPM1D protein	Homo sapiens (human)	Potency	14.4961	1	4
pregnane X nuclear receptor	Homo sapiens (human)	Potency	22.0243	3	11
progesterone receptor	Homo sapiens (human)	Potency	20.2389	2	7
pyruvate kinase PKM isoform b	Homo sapiens (human)	Potency	0.0063	2	3
Rap guanine nucleotide exchange factor 3	Homo sapiens (human)	Potency	31.6228	1	1
Rap guanine nucleotide exchange factor 4	Homo sapiens (human)	Potency	26.2000	1	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	23.2077	2	15
ras-related protein Rab-9A	Homo sapiens (human)	Potency	74.2382	1	5
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	18.6670	1	8
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	30.8741	3	12
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	17.5248	4	16
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	16.9200	4	19
SMAD family member 2	Homo sapiens (human)	Potency	22.1477	2	9
SMAD family member 3	Homo sapiens (human)	Potency	22.1477	2	9
Smad3	Homo sapiens (human)	Potency	27.0180	1	4
snurportin-1	Homo sapiens (human)	Potency	28.1252	2	2
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	21.9873	1	10
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	13.2641	1	8
TDP1 protein	Homo sapiens (human)	Potency	19.1046	2	57
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	27.3980	3	15
Thrombopoietin	Homo sapiens (human)	Potency	18.9019	2	10
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	23.1546	3	25
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	42.7696	3	4
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	21.5440	6	21
transcriptional regulator ERG isoform 3	Homo sapiens (human)	Potency	3.9811	1	1
transient receptor potential cation channel subfamily V member 1	Homo sapiens (human)	Potency	12.5893	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	Homo sapiens (human)	Potency	0.6310	1	1
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	11.2947	1	2
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	11.2947	1	2
USP1 protein, partial	Homo sapiens (human)	Potency	41.0427	2	15
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	10.4924	2	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	16.9856	5	17
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	50.8468	1	6
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	40.2754	1	7
WRN	Homo sapiens (human)	Potency	5.3233	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
1-deoxy-D-xylulose 5-phosphate reductoisomerase	Escherichia coli K-12	IC50	2.2000	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Rattus norvegicus (Norway rat)	Ki	0.0240	1	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	Homo sapiens (human)	Ki	0.0006	1	1
4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)	IC50	12,800.0000	1	1
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	IC50	0.2428	4	4
5-hydroxytryptamine receptor 1A	Mus musculus (house mouse)	IC50	1.2150	1	2
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	IC50	1.2449	11	21
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	Ki	0.3477	49	64
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	Ki	0.4058	26	37
5-hydroxytryptamine receptor 1B	Homo sapiens (human)	IC50	8.2500	2	2
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	IC50	3.0711	6	15
5-hydroxytryptamine receptor 1B	Homo sapiens (human)	Ki	7.7000	1	1
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	Ki	1.0517	7	15
5-hydroxytryptamine receptor 1D	Homo sapiens (human)	IC50	2.2581	5	5
5-hydroxytryptamine receptor 1D	Rattus norvegicus (Norway rat)	IC50	1.3962	3	5
5-hydroxytryptamine receptor 1D	Homo sapiens (human)	Ki	0.0003	1	1
5-hydroxytryptamine receptor 1D	Rattus norvegicus (Norway rat)	Ki	0.4261	4	4
5-hydroxytryptamine receptor 1F	Rattus norvegicus (Norway rat)	IC50	1.3962	3	5
5-hydroxytryptamine receptor 1F	Rattus norvegicus (Norway rat)	Ki	0.4261	4	4
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	IC50	0.0847	24	38
5-hydroxytryptamine receptor 2A	Mus musculus (house mouse)	IC50	0.0148	1	2
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	IC50	1.6425	25	39
5-hydroxytryptamine receptor 2A	Bos taurus (cattle)	Ki	0.1780	1	1
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Ki	0.0693	66	101
5-hydroxytryptamine receptor 2A	Mus musculus (house mouse)	Ki	0.0008	1	1
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	Ki	0.0531	55	68
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	IC50	0.3890	3	16
5-hydroxytryptamine receptor 2B	Mus musculus (house mouse)	IC50	0.0148	1	2
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	IC50	1.8183	19	29
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	Ki	0.2582	6	15
5-hydroxytryptamine receptor 2B	Mus musculus (house mouse)	Ki	0.0008	1	1
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	Ki	0.1145	20	25
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	IC50	0.0290	10	21
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	IC50	1.7336	21	31
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	Ki	0.0536	36	69
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	Ki	0.2126	29	34
5-hydroxytryptamine receptor 2C	Mus musculus (house mouse)	IC50	0.0148	1	2
5-hydroxytryptamine receptor 2C	Mus musculus (house mouse)	Ki	0.0804	2	2
5-hydroxytryptamine receptor 3A	Cavia porcellus (domestic guinea pig)	IC50	110.0000	1	1
5-hydroxytryptamine receptor 3A	Homo sapiens (human)	IC50	1.4125	2	2
5-hydroxytryptamine receptor 3A	Mus musculus (house mouse)	IC50	1.4125	1	1
5-hydroxytryptamine receptor 3A	Rattus norvegicus (Norway rat)	IC50	1.7980	1	3
5-hydroxytryptamine receptor 3A	Homo sapiens (human)	Ki	2.7511	4	4
5-hydroxytryptamine receptor 3A	Mus musculus (house mouse)	Ki	0.1420	2	2
5-hydroxytryptamine receptor 3A	Rattus norvegicus (Norway rat)	Ki	0.0615	2	2
5-hydroxytryptamine receptor 3B	Homo sapiens (human)	IC50	1.4125	2	2
5-hydroxytryptamine receptor 3B	Mus musculus (house mouse)	IC50	1.4125	1	1
5-hydroxytryptamine receptor 3B	Rattus norvegicus (Norway rat)	IC50	1.7980	1	3
5-hydroxytryptamine receptor 3B	Homo sapiens (human)	Ki	0.4091	2	2
5-hydroxytryptamine receptor 3B	Mus musculus (house mouse)	Ki	0.2520	1	1
5-hydroxytryptamine receptor 3B	Rattus norvegicus (Norway rat)	Ki	0.0615	2	2
5-hydroxytryptamine receptor 3C	Homo sapiens (human)	IC50	1.4125	2	2
5-hydroxytryptamine receptor 3C	Homo sapiens (human)	Ki	0.4091	2	2
5-hydroxytryptamine receptor 3D	Homo sapiens (human)	IC50	1.4125	2	2
5-hydroxytryptamine receptor 3D	Homo sapiens (human)	Ki	0.4091	2	2
5-hydroxytryptamine receptor 3E	Homo sapiens (human)	IC50	1.4125	2	2
5-hydroxytryptamine receptor 3E	Homo sapiens (human)	Ki	0.4091	2	2
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	IC50	0.0383	2	8
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	Ki	0.0264	2	9
5-hydroxytryptamine receptor 4	Homo sapiens (human)	Ki	0.2239	1	1
5-hydroxytryptamine receptor 4	Rattus norvegicus (Norway rat)	IC50	1.7980	1	3
5-hydroxytryptamine receptor 5A	Rattus norvegicus (Norway rat)	IC50	1.7980	1	3
5-hydroxytryptamine receptor 5A	Homo sapiens (human)	Ki	13.6667	2	3
5-hydroxytryptamine receptor 5B	Rattus norvegicus (Norway rat)	IC50	1.7980	1	3
5-hydroxytryptamine receptor 6	Homo sapiens (human)	IC50	0.0914	4	9
5-hydroxytryptamine receptor 6	Rattus norvegicus (Norway rat)	IC50	1.7980	1	3
5-hydroxytryptamine receptor 6	Homo sapiens (human)	Ki	0.5498	23	45
5-hydroxytryptamine receptor 7	Cavia porcellus (domestic guinea pig)	IC50	29.6000	1	12
5-hydroxytryptamine receptor 7	Homo sapiens (human)	IC50	183.3716	2	3
5-hydroxytryptamine receptor 7	Cavia porcellus (domestic guinea pig)	Ki	0.0035	1	1
5-hydroxytryptamine receptor 7	Homo sapiens (human)	Ki	0.6122	37	57
5-hydroxytryptamine receptor 7	Rattus norvegicus (Norway rat)	IC50	1.7980	1	3
5-hydroxytryptamine receptor 7	Rattus norvegicus (Norway rat)	Ki	0.0279	4	10
Acetylcholinesterase	Electrophorus electricus (electric eel)	IC50	0.7827	3	3
Acetylcholinesterase	Homo sapiens (human)	IC50	0.4000	2	2
Adenosine receptor A1	Rattus norvegicus (Norway rat)	Ki	0.3530	1	1
Adenylate cyclase type 1	Rattus norvegicus (Norway rat)	IC50	0.7200	2	2
Adenylate cyclase type 1	Rattus norvegicus (Norway rat)	Ki	0.1180	1	1
Adenylate cyclase type 2	Rattus norvegicus (Norway rat)	IC50	0.7200	2	2
Adenylate cyclase type 2	Rattus norvegicus (Norway rat)	Ki	0.1180	1	1
Adenylate cyclase type 3	Rattus norvegicus (Norway rat)	IC50	0.7200	2	2
Adenylate cyclase type 3	Rattus norvegicus (Norway rat)	Ki	0.1180	1	1
Adenylate cyclase type 4	Rattus norvegicus (Norway rat)	IC50	0.7200	2	2
Adenylate cyclase type 4	Rattus norvegicus (Norway rat)	Ki	0.1180	1	1
Adenylate cyclase type 5	Rattus norvegicus (Norway rat)	IC50	0.7200	2	2
Adenylate cyclase type 5	Rattus norvegicus (Norway rat)	Ki	0.1180	1	1
Adenylate cyclase type 6	Rattus norvegicus (Norway rat)	IC50	0.7200	2	2
Adenylate cyclase type 6	Rattus norvegicus (Norway rat)	Ki	0.1180	1	1
Adenylate cyclase type 8	Rattus norvegicus (Norway rat)	IC50	0.7200	2	2
Adenylate cyclase type 8	Rattus norvegicus (Norway rat)	Ki	0.1180	1	1
Adenylyl cyclase 7	Rattus norvegicus (Norway rat)	IC50	0.7200	2	2
Adenylyl cyclase 7	Rattus norvegicus (Norway rat)	Ki	0.1180	1	1
Albumin	Homo sapiens (human)	IC50	3.5000	1	2
Aldehyde oxidase	Homo sapiens (human)	IC50	0.5700	1	1
Aldehyde oxidase	Homo sapiens (human)	Ki	2.3000	1	1
Aldehyde oxidase 1	Oryctolagus cuniculus (rabbit)	IC50	20.0000	1	1
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	IC50	0.6027	1	6
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	Ki	0.5975	1	6
Aldo-keto reductase family 1 member C2	Homo sapiens (human)	IC50	6.7100	1	1
Aldo-keto reductase family 1 member C3	Homo sapiens (human)	IC50	4.9900	2	2
Alpha-1A adrenergic receptor	Homo sapiens (human)	IC50	0.0791	11	11
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	1.4746	20	39
Alpha-1A adrenergic receptor	Bos taurus (cattle)	Ki	1.0667	5	8
Alpha-1A adrenergic receptor	Homo sapiens (human)	Ki	0.0063	27	33
Alpha-1A adrenergic receptor	Oryctolagus cuniculus (rabbit)	Ki	0.0002	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0540	31	46
Alpha-1B adrenergic receptor	Homo sapiens (human)	IC50	0.0006	4	4
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	1.5111	20	38
Alpha-1B adrenergic receptor	Homo sapiens (human)	Ki	0.0059	24	28
Alpha-1B adrenergic receptor	Mesocricetus auratus (golden hamster)	Ki	0.0008	1	1
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0538	33	45
Alpha-1D adrenergic receptor	Homo sapiens (human)	IC50	0.0904	6	14
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	1.6405	17	35
Alpha-1D adrenergic receptor	Homo sapiens (human)	Ki	0.0216	24	36
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0508	29	47
Alpha-2A adrenergic receptor	Bos taurus (cattle)	IC50	0.0250	1	1
Alpha-2A adrenergic receptor	Homo sapiens (human)	IC50	0.3448	3	11
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	4.3267	5	10
Alpha-2A adrenergic receptor	Bos taurus (cattle)	Ki	0.1060	1	1
Alpha-2A adrenergic receptor	Homo sapiens (human)	Ki	0.5290	19	30
Alpha-2A adrenergic receptor	Mus musculus (house mouse)	Ki	0.2828	5	8
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	1.4368	25	31
Alpha-2A adrenergic receptor	Sus scrofa (pig)	Ki	4.1000	1	1
Alpha-2B adrenergic receptor	Homo sapiens (human)	IC50	0.0825	2	10
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	4.3267	5	10
Alpha-2B adrenergic receptor	Homo sapiens (human)	Ki	0.5047	16	25
Alpha-2B adrenergic receptor	Mus musculus (house mouse)	Ki	0.2828	5	8
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	1.5825	22	27
Alpha-2C adrenergic receptor	Homo sapiens (human)	IC50	0.1508	4	12
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	4.3267	5	10
Alpha-2C adrenergic receptor	Homo sapiens (human)	Ki	0.4372	17	28
Alpha-2C adrenergic receptor	Mus musculus (house mouse)	Ki	0.2828	5	8
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	1.5825	22	27
Alpha-synuclein	Homo sapiens (human)	IC50	8.2000	1	1
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	IC50	9.7690	2	8
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	Ki	7.3322	2	9
Angiotensin-converting enzyme	Rattus norvegicus (Norway rat)	Ki	0.5000	1	3
Angiotensin-converting enzyme	Homo sapiens (human)	IC50	0.0240	1	1
Angiotensin-converting enzyme 2	Homo sapiens (human)	IC50	11.2400	1	2
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	9
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	6.6447	11	11
ATP-dependent translocase ABCB1	Homo sapiens (human)	Ki	5.6971	6	7
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	Ki	10.9650	2	2
Aurora kinase B	Homo sapiens (human)	IC50	8.1250	1	2
Beta-1 adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	1.0000	1	1
Beta-1 adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	19.3333	2	3
Beta-1 adrenergic receptor	Cavia porcellus (domestic guinea pig)	Ki	0.1500	1	1
Beta-2 adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.5700	2	2
Beta-2 adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	10.0000	1	1
Beta-3 adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	1.0000	1	1
Beta-3 adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	10.0000	1	1
Beta-casein	Rattus norvegicus (Norway rat)	Ki	0.0004	1	1
Bile salt export pump	Homo sapiens (human)	IC50	95.5603	8	38
Bile salt export pump	Rattus norvegicus (Norway rat)	IC50	229.5333	1	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	14.3257	4	4
Bromodomain-containing protein 2	Homo sapiens (human)	IC50	0.0009	1	1
Bromodomain-containing protein 2	Homo sapiens (human)	Ki	0.0006	1	1
Calmodulin	Bos taurus (cattle)	IC50	2.5000	1	2
Calmodulin-1	Homo sapiens (human)	IC50	37.1120	4	5
Calmodulin-1	Homo sapiens (human)	Ki	19.2800	1	1
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	124.9250	1	8
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	Ki	295.0000	1	1
Canalicular multispecific organic anion transporter 1	Rattus norvegicus (Norway rat)	Ki	7.9500	1	1
Casein kinase II subunit alpha	Homo sapiens (human)	IC50	10.0000	1	1
Casein kinase II subunit alpha 3	Homo sapiens (human)	IC50	10.0000	1	1
Casein kinase II subunit alpha'	Homo sapiens (human)	IC50	10.0000	1	1
Casein kinase II subunit beta	Homo sapiens (human)	IC50	10.0000	1	1
Cathepsin D	Bos taurus (cattle)	IC50	0.0600	1	1
Chain A, RNA-directed RNA polymerase NS5	Dengue virus 2 16681-PDK53	IC50	35.0600	1	1
Cholecystokinin receptor type A	Cavia porcellus (domestic guinea pig)	Ki	0.0600	1	1
Cholinesterase	Equus caballus (horse)	IC50	15.2667	3	3
Cholinesterase	Homo sapiens (human)	IC50	15.8950	2	2
Chromaffin granule amine transporter	Homo sapiens (human)	IC50	0.0500	2	2
Cyclin-dependent kinase 1	Homo sapiens (human)	IC50	10.4450	1	2
Cys-loop ligand-gated ion channel	Dickeya chrysanthemi	IC50	158.0000	1	1
Cytochrome P450 11B1, mitochondrial	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Cytochrome P450 1A1	Homo sapiens (human)	Ki	1.2200	1	1
Cytochrome P450 1A2	Homo sapiens (human)	IC50	5.6662	1	2
Cytochrome P450 1B1	Homo sapiens (human)	IC50	0.9747	3	3
Cytochrome P450 1B1	Homo sapiens (human)	Ki	0.1520	2	2
Cytochrome P450 2C19	Homo sapiens (human)	IC50	6.3778	1	1
Cytochrome P450 2C9	Homo sapiens (human)	IC50	33.5000	2	5
Cytochrome P450 2D6	Homo sapiens (human)	IC50	1.5302	2	5
Cytochrome P450 2D6	Homo sapiens (human)	Ki	7.0000	1	1
Cytochrome P450 2J2	Homo sapiens (human)	IC50	34.6250	1	4
Cytochrome P450 3A4	Homo sapiens (human)	IC50	9.2000	1	1
Cytochrome P450 3A4	Homo sapiens (human)	Ki	0.1205	1	4
D	Bos taurus (cattle)	IC50	61.2104	5	9
D	Rattus norvegicus (Norway rat)	IC50	0.6166	19	37
D	Bos taurus (cattle)	Ki	0.4200	8	13
D	Mus musculus (house mouse)	Ki	1.0000	1	1
D	Rattus norvegicus (Norway rat)	Ki	0.8754	17	29
D(1A) dopamine receptor	Homo sapiens (human)	IC50	0.5953	1	7
D(1A) dopamine receptor	Homo sapiens (human)	Ki	0.2220	12	23
D(1B) dopamine receptor	Rattus norvegicus (Norway rat)	IC50	0.3968	13	26
D(1B) dopamine receptor	Homo sapiens (human)	Ki	0.3833	2	3
D(1B) dopamine receptor	Rattus norvegicus (Norway rat)	Ki	0.1208	2	3
D(2) dopamine receptor	Bos taurus (cattle)	IC50	1.7010	9	14
D(2) dopamine receptor	Homo sapiens (human)	IC50	0.7251	15	24
D(2) dopamine receptor	Mus musculus (house mouse)	IC50	0.1565	1	4
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	IC50	0.5929	41	74
D(2) dopamine receptor	Bos taurus (cattle)	Ki	0.6900	1	1
D(2) dopamine receptor	Chlorocebus aethiops (grivet)	Ki	0.2540	2	2
D(2) dopamine receptor	Homo sapiens (human)	Ki	0.1329	89	113
D(2) dopamine receptor	Mus musculus (house mouse)	Ki	0.7260	1	1
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	Ki	0.2970	44	75
D(3) dopamine receptor	Homo sapiens (human)	IC50	0.8797	4	10
D(3) dopamine receptor	Rattus norvegicus (Norway rat)	IC50	0.3968	13	26
D(3) dopamine receptor	Chlorocebus aethiops (grivet)	Ki	0.4660	1	1
D(3) dopamine receptor	Homo sapiens (human)	Ki	0.4371	40	61
D(3) dopamine receptor	Rattus norvegicus (Norway rat)	Ki	0.4024	7	8
D(4) dopamine receptor	Homo sapiens (human)	IC50	0.7483	15	17
D(4) dopamine receptor	Rattus norvegicus (Norway rat)	IC50	0.3968	13	26
D(4) dopamine receptor	Homo sapiens (human)	Ki	0.3170	53	65
D(4) dopamine receptor	Rattus norvegicus (Norway rat)	Ki	0.0808	4	5
Death-associated protein kinase 1	Homo sapiens (human)	IC50	120.0000	1	1
Delta-type opioid receptor	Homo sapiens (human)	IC50	20.8940	1	1
Delta-type opioid receptor	Homo sapiens (human)	Ki	7.3650	1	1
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.0006	1	1
Diacylglycerol kinase alpha	Homo sapiens (human)	IC50	12.8500	2	2
Dihydrofolate reductase	Escherichia coli K-12	IC50	348.9000	1	1
Dihydrofolate reductase	Escherichia coli K-12	Ki	15.2400	1	1
Dipeptidyl peptidase 4	Homo sapiens (human)	IC50	212.5000	1	2
DNA topoisomerase 1	Homo sapiens (human)	IC50	160.0000	1	1
Endothelin receptor type B	Homo sapiens (human)	Ki	0.0305	2	6
Endothelin receptor type B	Rattus norvegicus (Norway rat)	Ki	0.0305	1	3
Endothelin-1 receptor	Homo sapiens (human)	IC50	0.1148	1	1
Epidermal growth factor receptor	Homo sapiens (human)	IC50	15.9075	1	2
Fructose-1,6-bisphosphatase 1	Homo sapiens (human)	IC50	29.0000	1	1
G protein-coupled receptor kinase 6	Homo sapiens (human)	IC50	8.7000	1	1
G-protein coupled receptor	Apis mellifera (honey bee)	IC50	73.0000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	IC50	28.2000	1	1
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	IC50	10.4450	1	2
GABA theta subunit	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
GABA theta subunit	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit delta	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit epsilon	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	IC50	1.0000	2	7
Gamma-aminobutyric acid receptor subunit gamma-1	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit gamma-2	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit gamma-3	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	IC50	1.0000	2	3
Gamma-aminobutyric acid receptor subunit pi	Homo sapiens (human)	Ki	41.6241	1	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Ki	1.0000	1	1
Gamma-aminobutyric acid receptor subunit theta	Homo sapiens (human)	Ki	41.6241	1	2
Gastrin/cholecystokinin type B receptor	Mus musculus (house mouse)	Ki	0.0036	1	4
Glucocorticoid receptor	Homo sapiens (human)	IC50	19.0000	1	1
Glutamate receptor ionotropic, NMDA 1	Homo sapiens (human)	IC50	0.8500	2	2
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	IC50	7.6500	2	2
Glutamate receptor ionotropic, NMDA 2A	Homo sapiens (human)	IC50	0.8500	2	2
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	IC50	7.6500	2	2
Glutamate receptor ionotropic, NMDA 2B	Homo sapiens (human)	IC50	0.8500	2	2
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	IC50	7.6500	2	2
Glutamate receptor ionotropic, NMDA 2C	Homo sapiens (human)	IC50	0.8500	2	2
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	IC50	7.6500	2	2
Glutamate receptor ionotropic, NMDA 2D	Homo sapiens (human)	IC50	0.8500	2	2
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	IC50	7.6500	2	2
Glutamate receptor ionotropic, NMDA 3A	Homo sapiens (human)	IC50	0.8500	2	2
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	IC50	7.6500	2	2
Glutamate receptor ionotropic, NMDA 3B	Homo sapiens (human)	IC50	0.8500	2	2
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	IC50	7.6500	2	2
Histamine H1 receptor	Homo sapiens (human)	IC50	0.3331	9	16
Histamine H1 receptor	Rattus norvegicus (Norway rat)	IC50	0.0163	3	9
Histamine H1 receptor	Cavia porcellus (domestic guinea pig)	Ki	0.0437	5	6
Histamine H1 receptor	Homo sapiens (human)	Ki	0.0123	14	25
Histamine H1 receptor	Rattus norvegicus (Norway rat)	Ki	0.0050	1	2
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	IC50	2.1933	1	3
Histamine H2 receptor	Homo sapiens (human)	IC50	2.0892	1	6
Histamine H2 receptor	Homo sapiens (human)	Ki	2.0543	1	6
Histamine H3 receptor	Homo sapiens (human)	Ki	1.7473	4	5
Histamine H3 receptor	Rattus norvegicus (Norway rat)	Ki	5.0000	1	1
Histamine H4 receptor	Homo sapiens (human)	Ki	0.1925	3	3
Integrase	Human immunodeficiency virus 1	IC50	3.2960	5	5
Interstitial collagenase	Homo sapiens (human)	IC50	4.0360	1	1
Kappa-type opioid receptor	Homo sapiens (human)	IC50	6.7860	1	2
Kappa-type opioid receptor	Homo sapiens (human)	Ki	2.7145	1	2
Lactoylglutathione lyase	Homo sapiens (human)	IC50	11.0000	1	1
Linoleate 9S-lipoxygenase-4	Glycine max (soybean)	IC50	22.0000	1	1
Lysine-specific demethylase 4E	Homo sapiens (human)	IC50	3.0000	1	1
Lysine-specific demethylase 4E	Homo sapiens (human)	Ki	4.3300	1	1
Lysine-specific histone demethylase 1A	Homo sapiens (human)	IC50	5.8080	4	5
Lysosomal alpha-glucosidase	Bos taurus (cattle)	IC50	0.0300	1	1
Lysosomal alpha-glucosidase	Homo sapiens (human)	IC50	500.0000	1	1
Matrix metalloproteinase-9	Homo sapiens (human)	IC50	6.9630	1	1
Mcl-1	Homo sapiens (human)	IC50	3.7733	1	1
Melanocortin receptor 3	Homo sapiens (human)	IC50	24.3430	1	1
Melanocortin receptor 3	Homo sapiens (human)	Ki	21.2440	1	1
Melanocortin receptor 4	Homo sapiens (human)	IC50	15.2040	1	1
Melanocortin receptor 4	Homo sapiens (human)	Ki	14.6190	1	1
Melanocortin receptor 5	Homo sapiens (human)	IC50	7.6170	1	1
Melanocortin receptor 5	Homo sapiens (human)	Ki	7.1450	1	1
Mu-type opioid receptor	Homo sapiens (human)	IC50	9.2745	1	2
Mu-type opioid receptor	Homo sapiens (human)	Ki	3.7650	1	2
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Homo sapiens (human)	IC50	3.7650	2	2
Multidrug and toxin extrusion protein 1	Homo sapiens (human)	IC50	3.7250	2	4
Multidrug and toxin extrusion protein 2	Homo sapiens (human)	IC50	118.8500	2	4
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	119.6111	1	9
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	IC50	0.3802	3	8
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	IC50	0.1211	5	8
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	Ki	0.9133	7	15
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Ki	0.0292	2	3
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	IC50	1.0855	1	6
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	IC50	0.1455	5	6
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	Ki	0.9188	2	8
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	Ki	0.0438	2	3
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	IC50	14.2136	3	8
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	IC50	0.1455	5	6
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	Ki	0.7276	2	8
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	Ki	0.0427	1	2
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	IC50	0.6670	1	6
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)	IC50	0.1455	5	6
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	Ki	0.5763	3	10
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)	Ki	0.0427	1	2
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	IC50	0.1085	1	6
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	IC50	0.3841	6	8
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	Ki	0.6878	2	8
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	Ki	0.0427	1	2
NADPH oxidase 1	Homo sapiens (human)	IC50	17.0000	1	1
Neuraminidase	Influenza A virus (A/USSR/90/1977(H1N1))	IC50	35.3500	2	2
Neuraminidase	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Ki	14.3000	1	1
neutrophil cytosol factor 1	Homo sapiens (human)	IC50	50.0000	1	1
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	IC50	10.8789	1	7
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	Ki	8.9128	1	7
Pleiotropic ABC efflux transporter of multiple drugs	Saccharomyces cerevisiae S288C	IC50	8.4000	1	6
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)	IC50	50.4250	1	2
Polyunsaturated fatty acid 5-lipoxygenase	Rattus norvegicus (Norway rat)	IC50	10.0000	2	2
Polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	IC50	31.5320	2	5
Polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Ki	1.6000	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15	Homo sapiens (human)	IC50	33.1800	2	5
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	IC50	15.9510	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15	Homo sapiens (human)	Ki	0.6000	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	IC50	51.0929	3	7
Polyunsaturated fatty acid lipoxygenase ALOX15B	Rattus norvegicus (Norway rat)	IC50	0.2600	1	1
Potassium channel subfamily K member 2	Homo sapiens (human)	IC50	2.7000	1	1
Potassium voltage-gated channel subfamily E member 1	Homo sapiens (human)	IC50	158.4890	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	17.3396	33	78
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	Ki	8.1014	6	13
Potassium voltage-gated channel subfamily KQT member 1	Homo sapiens (human)	IC50	158.4890	1	1
Procathepsin L	Homo sapiens (human)	IC50	11.2400	1	2
Progesterone receptor	Homo sapiens (human)	IC50	15.0000	1	1
Prolyl endopeptidase	Homo sapiens (human)	IC50	69.4600	4	5
Prostaglandin G/H synthase 1	Ovis aries (sheep)	IC50	150.0000	1	1
Prostaglandin G/H synthase 1	Ovis aries (sheep)	Ki	0.1600	1	2
Prostaglandin G/H synthase 1	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Prostaglandin G/H synthase 2	Homo sapiens (human)	IC50	150.0000	1	1
Prostaglandin G/H synthase 2	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Quinolone resistance protein NorA	Staphylococcus aureus	IC50	8.5429	7	7
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50	19.3660	1	1
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	IC50	10.0000	1	1
Receptor-type tyrosine-protein phosphatase S	Homo sapiens (human)	IC50	10.3000	1	1
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	IC50	11.2400	1	2
Replicase polyprotein 1ab	Betacoronavirus England 1	IC50	10.8267	2	3
Replicase polyprotein 1ab	Human coronavirus 229E	IC50	11.2400	1	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	4.0790	11	18
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	7.4575	2	4
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	IC50	0.0078	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus (rabbit)	IC50	23.0000	1	1
Seed linoleate 13S-lipoxygenase-1	Glycine max (soybean)	IC50	22.6000	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	IC50	6.3050	2	2
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	IC50	314.0000	1	1
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	IC50	40.0000	1	1
Sialidase-2	Homo sapiens (human)	IC50	130.0000	1	1
Sigma intracellular receptor 2	Rattus norvegicus (Norway rat)	Ki	2.1070	1	1
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	IC50	0.2451	3	9
Sigma non-opioid intracellular receptor 1	Rattus norvegicus (Norway rat)	IC50	3.9167	3	3
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	Ki	1.6597	3	7
Sigma non-opioid intracellular receptor 1	Rattus norvegicus (Norway rat)	Ki	0.3430	1	1
Sodium channel protein type 1 subunit alpha	Homo sapiens (human)	IC50	3.9500	2	2
Sodium channel protein type 1 subunit alpha	Rattus norvegicus (Norway rat)	IC50	82.6333	2	3
Sodium channel protein type 10 subunit alpha	Homo sapiens (human)	IC50	50.4750	4	4
Sodium channel protein type 11 subunit alpha	Homo sapiens (human)	IC50	3.9500	2	2
Sodium channel protein type 2 subunit alpha	Homo sapiens (human)	IC50	26.9800	5	5
Sodium channel protein type 2 subunit alpha	Rattus norvegicus (Norway rat)	IC50	63.5800	4	5
Sodium channel protein type 3 subunit alpha	Homo sapiens (human)	IC50	8.3000	3	3
Sodium channel protein type 3 subunit alpha	Rattus norvegicus (Norway rat)	IC50	82.6333	2	3
Sodium channel protein type 4 subunit alpha	Homo sapiens (human)	IC50	3.9500	2	2
Sodium channel protein type 4 subunit alpha	Homo sapiens (human)	Ki	17.0000	1	1
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	IC50	39.3826	8	8
Sodium channel protein type 7 subunit alpha	Homo sapiens (human)	IC50	3.9500	2	2
Sodium channel protein type 8 subunit alpha	Homo sapiens (human)	IC50	3.9500	2	2
Sodium channel protein type 9 subunit alpha	Homo sapiens (human)	IC50	8.3000	3	3
Sodium- and chloride-dependent betaine transporter	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Sodium- and chloride-dependent GABA transporter 1	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Sodium- and chloride-dependent GABA transporter 2	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Sodium- and chloride-dependent GABA transporter 3	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	IC50	3.2350	2	9
Sodium-dependent dopamine transporter	Mus musculus (house mouse)	Ki	10.0000	1	1
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	Ki	1.5262	6	10
Sodium-dependent dopamine transporter	Homo sapiens (human)	IC50	26.7060	6	9
Sodium-dependent dopamine transporter	Homo sapiens (human)	Ki	0.9345	4	9
Sodium-dependent noradrenaline transporter	Mus musculus (house mouse)	Ki	0.0140	2	2
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	IC50	0.1626	17	23
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	Ki	0.6178	17	23
Sodium-dependent serotonin transporter	Homo sapiens (human)	IC50	0.3547	21	29
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	IC50	7.9033	3	3
Sodium-dependent serotonin transporter	Homo sapiens (human)	Ki	0.8229	27	33
Sodium-dependent serotonin transporter	Mus musculus (house mouse)	Ki	0.0235	2	2
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	Ki	0.0605	4	4
Solute carrier family 22 member 1	Rattus norvegicus (Norway rat)	IC50	16.7500	2	2
Solute carrier family 22 member 1	Rattus norvegicus (Norway rat)	Ki	11.4000	1	2
Solute carrier family 22 member 1	Homo sapiens (human)	IC50	21.6245	5	11
Solute carrier family 22 member 1	Homo sapiens (human)	Ki	5.3600	1	1
Solute carrier family 22 member 2	Homo sapiens (human)	IC50	27.4400	3	5
Solute carrier family 22 member 2	Rattus norvegicus (Norway rat)	IC50	9.9500	2	2
Solute carrier family 22 member 2	Homo sapiens (human)	Ki	16.0000	1	1
Solute carrier family 22 member 3	Homo sapiens (human)	IC50	12.6000	1	1
Solute carrier family 22 member 3	Rattus norvegicus (Norway rat)	IC50	68.0000	1	1
Solute carrier family 22 member 3	Homo sapiens (human)	Ki	28.0000	1	2
Solute carrier family 22 member 4	Rattus norvegicus (Norway rat)	IC50	80.0000	1	1
Sphingomyelin phosphodiesterase	Homo sapiens (human)	IC50	8.0000	1	2
Spike glycoprotein	Betacoronavirus England 1	IC50	11.2400	1	2
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	IC50	11.2400	1	2
Substance-K receptor	Homo sapiens (human)	IC50	27.1950	1	1
Substance-K receptor	Homo sapiens (human)	Ki	9.0650	1	1
Sucrase-isomaltase, intestinal	Homo sapiens (human)	IC50	43.5000	2	2
Sucrase-isomaltase, intestinal	Rattus norvegicus (Norway rat)	IC50	156.0000	2	2
Synaptic vesicular amine transporter	Homo sapiens (human)	IC50	0.0560	3	4
Synaptic vesicular amine transporter	Rattus norvegicus (Norway rat)	IC50	0.0177	1	10
Synaptic vesicular amine transporter	Bos taurus (cattle)	Ki	0.0010	1	1
Synaptic vesicular amine transporter	Homo sapiens (human)	Ki	0.4442	3	6
Telomerase reverse transcriptase	Homo sapiens (human)	IC50	37.0000	1	1
Testosterone 17-beta-dehydrogenase 3	Homo sapiens (human)	IC50	97.6100	2	2
Transient receptor potential cation channel subfamily V member 1	Rattus norvegicus (Norway rat)	Ki	0.9100	2	2
Transmembrane protease serine 2	Homo sapiens (human)	IC50	11.2400	1	2
Transporter	Rattus norvegicus (Norway rat)	IC50	4.4308	4	5
Transporter	Rattus norvegicus (Norway rat)	Ki	3.8533	5	9
Trypanothione reductase	Trypanosoma cruzi	IC50	49.7333	2	3
Trypanothione reductase	Trypanosoma cruzi	Ki	20.9750	3	4
Trypsin-1	Homo sapiens (human)	IC50	501.8500	1	2
Trypsin-2	Homo sapiens (human)	IC50	501.8500	1	2
Trypsin-3	Homo sapiens (human)	IC50	501.8500	1	2
Tryptophan 5-hydroxylase 1	Rattus norvegicus (Norway rat)	IC50	0.0600	1	1
Tryptophan 5-hydroxylase 1	Rattus norvegicus (Norway rat)	Ki	0.0005	1	1
Type-1 angiotensin II receptor	Oryctolagus cuniculus (rabbit)	Ki	0.0020	2	3
Type-2 angiotensin II receptor	Rattus norvegicus (Norway rat)	IC50	0.2100	1	1
Type-2 angiotensin II receptor	Rattus norvegicus (Norway rat)	Ki	0.5000	1	1
Tyrosine-protein kinase Fyn	Homo sapiens (human)	IC50	6.4713	1	3
Tyrosine-protein kinase Yes	Homo sapiens (human)	IC50	3.3000	1	1
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	IC50	67.0000	1	1
ubiquitin-conjugating enzyme E2 N	Homo sapiens (human)	IC50	20.0000	1	1
UDP-glucuronosyltransferase 1A1	Homo sapiens (human)	IC50	5.7000	2	2
Urease subunit alpha	Helicobacter pylori 26695	IC50	291.0000	1	1
Urease subunit beta	Helicobacter pylori 26695	IC50	291.0000	1	1
Vesicular acetylcholine transporter	Rattus norvegicus (Norway rat)	Ki	10.0000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	Cavia porcellus (domestic guinea pig)	IC50	4.1120	2	5
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	IC50	335.9044	9	9
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	IC50	10.6000	5	5
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	IC50	10.6000	5	5
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	IC50	10.6000	5	5
Voltage-dependent N-type calcium channel subunit alpha-1B	Homo sapiens (human)	IC50	16.5000	1	2
Xanthine dehydrogenase/oxidase	Bos taurus (cattle)	IC50	37.4000	2	2
Xanthine dehydrogenase/oxidase	Homo sapiens (human)	IC50	2.7900	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	EC50	1.0707	10	10
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	Kd	0.3703	1	5
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	EC50	0.0010	1	1
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	Kd	0.0015	3	3
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	EC50	0.0200	1	1
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	Kd	0.0513	4	5
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	EC50	0.2500	1	1
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	Kd	0.0015	3	3
Albumin	Homo sapiens (human)	Kd	453.0460	1	2
Albumin	Rattus norvegicus (Norway rat)	Kd	35.2475	1	4
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	EC50	0.0800	1	1
Alpha-1A adrenergic receptor	Homo sapiens (human)	Kd	0.0020	1	1
Alpha-1A adrenergic receptor	Oryctolagus cuniculus (rabbit)	Kd	0.0050	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	Kd	0.2290	11	20
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	EC50	0.0800	1	1
Alpha-1B adrenergic receptor	Homo sapiens (human)	Kd	0.0040	2	3
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	Kd	0.2543	10	18
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	EC50	0.0800	1	1
Alpha-1D adrenergic receptor	Homo sapiens (human)	Kd	0.0020	1	1
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	Kd	0.2410	11	19
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	Kd	3.3794	8	10
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	Kd	3.3794	8	10
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	Kd	3.3794	8	10
Alpha-mannosidase 2C1	Rattus norvegicus (Norway rat)	Kd	3.7154	1	1
Angiotensin-converting enzyme 2	Homo sapiens (human)	EC50	6.8633	1	6
Calmodulin	Bos taurus (cattle)	Kd	32.0500	1	2
Calmodulin-1	Homo sapiens (human)	Kd	1.2400	1	1
Cytochrome P450 1A2	Homo sapiens (human)	EC50	2.0000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	EC50	2.0000	1	1
Envelope glycoprotein	Ebola virus - Mayinga, Zaire, 1976	Kd	584.0000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	EC50	16.5000	2	2
Glycine receptor subunit alpha-1	Homo sapiens (human)	EC50	0.3200	1	1
Histamine H1 receptor	Homo sapiens (human)	EC50	0.0004	1	1
Histamine H1 receptor	Homo sapiens (human)	Kd	0.0031	1	1
Histamine H4 receptor	Homo sapiens (human)	Kd	0.0294	4	4
Major prion protein	Homo sapiens (human)	EC50	5.6667	1	3
Major prion protein	Mus musculus (house mouse)	EC50	2.0000	1	1
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	EC50	10.0000	1	1
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	EC50	10.0000	1	1
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	EC50	10.0000	1	1
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	EC50	10.0000	1	1
Procathepsin L	Homo sapiens (human)	EC50	6.8633	1	6
Proteasome subunit alpha type-6	Homo sapiens (human)	EC50	12.2333	1	3
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	EC50	6.8633	1	6
Replicase polyprotein 1ab	Betacoronavirus England 1	EC50	6.8633	1	6
Replicase polyprotein 1ab	Human coronavirus 229E	EC50	6.8633	1	6
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	EC50	6.2311	3	9
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	EC50	6.3029	2	7
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Kd	15.8200	3	5
short transient receptor potential channel 6 isoform 1	Mus musculus (house mouse)	EC50	15.8500	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	Kd	0.0008	1	1
Sodium-dependent serotonin transporter	Homo sapiens (human)	EC50	5.4500	2	2
Sodium-dependent serotonin transporter	Homo sapiens (human)	Kd	0.0026	1	1
Spike glycoprotein	Betacoronavirus England 1	EC50	6.8633	1	6
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	EC50	6.8633	1	6
Synaptic vesicular amine transporter	Homo sapiens (human)	Kd	0.0080	1	1
Transmembrane protease serine 2	Homo sapiens (human)	EC50	6.8633	1	6

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Activity	0.0054	1	1
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	INH	0.0054	1	1
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Kb	0.0020	3	3
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Ke	0.0320	1	1
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	Kb	1.9800	1	1
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	Kb	0.1120	1	1
5-hydroxytryptamine receptor 6	Homo sapiens (human)	INH	0.0064	1	1
5-hydroxytryptamine receptor 6	Homo sapiens (human)	Kb	0.0300	1	1
Aldehyde oxidase	Homo sapiens (human)	Kii	1.3000	1	1
Aldehyde oxidase	Homo sapiens (human)	Kis	1.3000	1	1
Alpha-1A adrenergic receptor	Homo sapiens (human)	EC40	0.0045	2	4
Alpha-1A adrenergic receptor	Homo sapiens (human)	Kb	0.0002	1	1
Alpha-1A adrenergic receptor	Homo sapiens (human)	Ke	0.0011	2	2
Alpha-1A adrenergic receptor	Homo sapiens (human)	Ke(app)	0.0011	1	1
Alpha-1B adrenergic receptor	Homo sapiens (human)	EC40	0.0045	2	4
Alpha-1B adrenergic receptor	Homo sapiens (human)	Kb	0.0000	1	1
Alpha-1D adrenergic receptor	Homo sapiens (human)	EC40	0.0045	2	4
Alpha-1D adrenergic receptor	Homo sapiens (human)	Kb	0.0000	1	1
Alpha-2A adrenergic receptor	Homo sapiens (human)	EC40	1.3000	2	3
Alpha-2B adrenergic receptor	Homo sapiens (human)	EC40	1.3000	2	3
Alpha-2C adrenergic receptor	Homo sapiens (human)	EC40	1.3000	2	3
Androgen receptor	Homo sapiens (human)	EC150	18.9000	1	1
ATP-dependent translocase ABCB1	Homo sapiens (human)	Km	29.4500	2	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	Kact	1.0000	1	1
Cyclic AMP-responsive element-binding protein 1	Homo sapiens (human)	AC50	13.5000	1	1
Cytochrome P450 1A2	Homo sapiens (human)	Km	5.0000	1	1
Cytochrome P450 2C19	Homo sapiens (human)	Km	15.1500	2	2
Cytochrome P450 2C9	Homo sapiens (human)	Km	25.3000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	Km	43.7667	3	3
Cytochrome P450 2J2	Homo sapiens (human)	Km	25.3000	1	1
Cytochrome P450 3A4	Homo sapiens (human)	Km	38.5333	5	6
D(1A) dopamine receptor	Homo sapiens (human)	Kb	5.5000	1	2
D(1B) dopamine receptor	Homo sapiens (human)	Kb	5.5000	1	2
D(2) dopamine receptor	Homo sapiens (human)	Activity	0.2560	1	1
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	K0.5	0.0009	2	3
D(2) dopamine receptor	Homo sapiens (human)	Kb	2.7505	3	4
D(2) dopamine receptor	Homo sapiens (human)	pKi	0.0069	1	1
D(3) dopamine receptor	Homo sapiens (human)	Kb	5.5000	1	2
D(3) dopamine receptor	Homo sapiens (human)	pKi	0.0066	1	1
D(4) dopamine receptor	Homo sapiens (human)	Kb	5.5000	1	2
D(4) dopamine receptor	Homo sapiens (human)	pKi	0.0073	1	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	Rattus norvegicus (Norway rat)	AC50	14.5280	1	1
Glucocorticoid receptor	Homo sapiens (human)	EC150	18.9000	1	1
Histamine H1 receptor	Homo sapiens (human)	Activity	0.0012	1	1
Histamine H1 receptor	Homo sapiens (human)	INH	0.0012	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	K0.5	0.0207	2	16
interferon gamma precursor	Homo sapiens (human)	AC50	18.7000	2	2
Pleiotropic ABC efflux transporter of multiple drugs	Saccharomyces cerevisiae S288C	INH	78.5333	1	6
Proteasome subunit alpha type-1	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit alpha type-2	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit alpha type-3	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit alpha type-4	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit alpha type-5	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit alpha type-6	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit alpha type-7	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit alpha-type 8	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit beta type-1	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit beta type-10	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit beta type-11	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit beta type-2	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit beta type-3	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit beta type-4	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit beta type-5	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit beta type-6	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit beta type-7	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit beta type-8	Homo sapiens (human)	EC200	45.1250	4	4
Proteasome subunit beta type-9	Homo sapiens (human)	EC200	45.1250	4	4
Quinolone resistance protein NorA	Staphylococcus aureus	MMC	6.5700	1	1
Snq2p	Saccharomyces cerevisiae EC1118	INH	81.1667	1	6
Sodium channel protein type 4 subunit alpha	Homo sapiens (human)	Kr	1,440.0000	1	1
UDP-glucuronosyltransferase 1A3	Homo sapiens (human)	Km	472.0000	1	1
UDP-glucuronosyltransferase 1A4	Homo sapiens (human)	Km	193.7500	2	4