Roles > phytoalexin
Page last updated: 2024-08-05 15:25:38

phytoalexin

A toxin made by a plant that acts against an organism attacking it.

ChEBI ID: 26115

Members (8)

MemberDefinitionClass
avenanthramide bA monohydroxybenzoic acid resulting from the formal condensation of the carboxy group of ferulic acid with the amino group of 2-amino-5-hydroxybenzoic acid. It is an oat phytoalexin produced in response to pathogen attack and elicitation.avenanthramide B
benzoxazoloneA member of the class of benzoxazoles that is 2,3-dihydro-1,3-benzoxazole carrying an oxo group at position 2.2-benzoxazolinone
lubiminA vetispirane sesquiterpenoid that consists of (2R,5S,6S,8S,10R)-8-hydroxy-10-methyl-2-(prop-1-en-2-yl)spiro[4.5]decane bearing a formyl substituent at position 6.lubimin
n-cinnamoyltyramineA member of the class of cinnamamides that is tyramine substituted by a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at the nitrogen atom. It is found in rice and exhibits an allelopathic effect to suppress the growth of weeds.N-trans-cinnamoyltyramine
resveratrolA stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.resveratrol
resveratrolA resveratrol in which the double bond has E configuration.trans-resveratrol
solavetivoneA cyclic ketone derived from spiro[4.5]dec-6-en-8-one by substitution of hydrogens by methyl groups at positions 6 and 10, and by an isopropenyl group at position 2 (the (2R,5S,10R)-diastereoisomer).solavetivone
vestitolA member of the class of hydroxyisoflavans that is isoflavan substituted by hydroxy groups at positions 7 and 2' and a methoxy group at position 4'. Isolated from Glycyrrhiza uralensis, it exhibits anti-inflammatory activity.vestitol

Research

Studies (10,844)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199018 (0.17)18.7374
1990's136 (1.25)18.2507
2000's2,141 (19.74)29.6817
2010's6,204 (57.21)24.3611
2020's2,345 (21.62)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials241 (2.17%)5.53%
Reviews1,365 (12.28%)6.00%
Case Studies11 (0.10%)4.05%
Observational8 (0.07%)0.25%
Other9,495 (85.39%)84.16%

Protein Targets (240)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency21.197215
67.9K proteinVaccinia virusPotency28.183811
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency33.822515
AR proteinHomo sapiens (human)Potency8.00411126
aryl hydrocarbon receptorHomo sapiens (human)Potency10.375837
arylsulfatase AHomo sapiens (human)Potency0.379311
ATAD5 protein, partialHomo sapiens (human)Potency7.027244
Ataxin-2Homo sapiens (human)Potency3.593024
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency9.528311
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency2.975126
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency20.749111
Bloom syndrome protein isoform 1Homo sapiens (human)Potency50.118722
BRCA1Homo sapiens (human)Potency12.589311
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency3.056012
caspase-3Homo sapiens (human)Potency3.056012
Cellular tumor antigen p53Homo sapiens (human)Potency49.974925
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency8.769923
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency29.734914
Chain A, Beta-lactamaseEscherichia coli K-12Potency22.615412
Chain A, HADH2 proteinHomo sapiens (human)Potency34.352123
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency31.622811
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency35.481311
Chain B, HADH2 proteinHomo sapiens (human)Potency34.352123
chromobox protein homolog 1Homo sapiens (human)Potency0.000011
ClpPBacillus subtilisPotency25.118911
cytochrome P450 2C9, partialHomo sapiens (human)Potency9.771711
cytochrome P450 2D6Homo sapiens (human)Potency15.487111
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency3.981124
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency9.511422
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency2.608713
D(1A) dopamine receptorSus scrofa (pig)Potency3.689811
DNA polymerase betaHomo sapiens (human)Potency44.668411
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency44.668411
DNA polymerase kappa isoform 1Homo sapiens (human)Potency14.125411
Endothelin receptor type BRattus norvegicus (Norway rat)Potency17.782811
Endothelin-1 receptorRattus norvegicus (Norway rat)Potency17.782811
estrogen nuclear receptor alphaHomo sapiens (human)Potency21.28831229
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency9.848637
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency5.75041024
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency7.943311
EWS/FLI fusion proteinHomo sapiens (human)Potency16.736444
farnesoid X nuclear receptorHomo sapiens (human)Potency21.954713
GVesicular stomatitis virusPotency9.771711
GABA theta subunitRattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency3.981112
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency3.981112
gemininHomo sapiens (human)Potency17.720534
GLI family zinc finger 3Homo sapiens (human)Potency16.106226
glp-1 receptor, partialHomo sapiens (human)Potency28.183811
GLS proteinHomo sapiens (human)Potency5.011911
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency16.078425
glucokinase regulatory proteinHomo sapiens (human)Potency22.387211
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency31.099413
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency0.648822
hexokinase-4 isoform 1Homo sapiens (human)Potency22.387211
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency19.952612
histone deacetylase 9 isoform 3Homo sapiens (human)Potency2.039626
Histone H2A.xCricetulus griseus (Chinese hamster)Potency42.294026
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency9.771711
huntingtin isoform 2Homo sapiens (human)Potency2.238711
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency10.000022
IDH1Homo sapiens (human)Potency32.642711
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency9.771712
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency10.000011
Integrin alpha-IIbHomo sapiens (human)Potency10.000011
Integrin beta-3Homo sapiens (human)Potency10.000011
Interferon betaHomo sapiens (human)Potency9.771711
lamin isoform A-delta10Homo sapiens (human)Potency16.025223
LuciferasePhotinus pyralis (common eastern firefly)Potency2.986735
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency39.506811
M-phase phosphoprotein 8Homo sapiens (human)Potency0.158511
Microtubule-associated protein tauHomo sapiens (human)Potency11.266427
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency69.905412
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency11.989912
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency17.3172410
Nuclear receptor ROR-gammaHomo sapiens (human)Potency2.371011
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency11.3026410
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency23.497839
P53Homo sapiens (human)Potency50.118711
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency3.981111
ParkinHomo sapiens (human)Potency1.158211
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency42.561511
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency22.272535
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency31.284344
plasminogen precursorMus musculus (house mouse)Potency13.529422
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency19.952611
pregnane X nuclear receptorHomo sapiens (human)Potency30.834136
progesterone receptorHomo sapiens (human)Potency22.554324
pyruvate kinaseLeishmania mexicana mexicanaPotency17.782822
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency19.952611
RAR-related orphan receptor gammaMus musculus (house mouse)Potency2.120826
ras-related protein Rab-9AHomo sapiens (human)Potency16.537012
regulator of G-protein signaling 4Homo sapiens (human)Potency15.003011
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency32.178337
retinoid X nuclear receptor alphaHomo sapiens (human)Potency27.785211
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency11.091222
SMAD family member 2Homo sapiens (human)Potency10.682211
SMAD family member 3Homo sapiens (human)Potency10.682211
survival motor neuron protein isoform dHomo sapiens (human)Potency17.777114
TDP1 proteinHomo sapiens (human)Potency12.7916210
thioredoxin reductaseRattus norvegicus (Norway rat)Potency20.517823
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency29.791024
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency112.202011
thyroid stimulating hormone receptorHomo sapiens (human)Potency61.690511
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency13.529422
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency13.529422
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency3.089911
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency31.099413

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseElectrophorus electricus (electric eel)IC501,000.000011
AcetylcholinesteraseHomo sapiens (human)IC505.000011
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1Homo sapiens (human)IC50100.000011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC5013.656022
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)Ki2.293011
Alpha-glucosidase MAL12Saccharomyces cerevisiae S288CKi21.500011
Amine oxidase [flavin-containing] AHomo sapiens (human)IC509.829844
Amine oxidase [flavin-containing] BHomo sapiens (human)IC5022.236733
Amyloid-beta precursor proteinHomo sapiens (human)IC5011.53751212
AromataseHomo sapiens (human)IC5030.226766
AromataseHomo sapiens (human)Ki41.670011
Aryl hydrocarbon receptorOryctolagus cuniculus (rabbit)Ki0.374323
ATP-dependent translocase ABCB1Homo sapiens (human)IC5060.000011
Bcl-2-like protein 1Homo sapiens (human)IC50190.000011
Breakpoint cluster region proteinHomo sapiens (human)IC5028.000011
Cannabinoid receptor 1Mus musculus (house mouse)IC501,000.000012
Carbonic anhydrase 1Homo sapiens (human)Ki2.195022
Carbonic anhydrase 12Homo sapiens (human)Ki4.540022
Carbonic anhydrase 13Homo sapiens (human)Ki6.170022
Carbonic anhydrase 14Homo sapiens (human)Ki1.390022
Carbonic anhydrase 15Mus musculus (house mouse)Ki5.965022
Carbonic anhydrase 2Homo sapiens (human)Ki2.260022
Carbonic anhydrase 3Homo sapiens (human)Ki7.920022
Carbonic anhydrase 4Homo sapiens (human)Ki4.240022
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki3.805022
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki3.940022
Carbonic anhydrase 6Homo sapiens (human)Ki8.350022
Carbonic anhydrase 7Homo sapiens (human)Ki6.665022
Carbonic anhydrase 9Homo sapiens (human)Ki5.170022
Cathepsin DHomo sapiens (human)IC50138.000011
cathepsin L1Homo sapiens (human)IC5059.642011
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)IC50212.0000117
CholinesteraseEquus caballus (horse)IC50400.000011
CholinesteraseHomo sapiens (human)IC505.000011
Cytochrome P450 1A1Homo sapiens (human)IC5022.666733
Cytochrome P450 1A2Homo sapiens (human)IC50186.500022
Cytochrome P450 1B1Homo sapiens (human)IC5028.200022
Cytochrome P450 1B1Homo sapiens (human)Ki3.231844
Cytochrome P450 2C19Homo sapiens (human)IC503.000011
Cytochrome P450 2C9 Homo sapiens (human)IC507.000011
Cytochrome P450 3A4Homo sapiens (human)IC508.150022
Cytochrome P450 3A4Homo sapiens (human)Ki20.000011
Dipeptidyl peptidase 4Homo sapiens (human)IC500.000611
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)IC5025.310011
DNA polymerase alpha catalytic subunitHomo sapiens (human)IC503.300011
Estrogen receptorHomo sapiens (human)Ki0.579723
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)IC5066.893333
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)IC50100.000011
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)IC500.680011
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)IC50100.000011
large T antigenBetapolyomavirus macacaeIC5026.200011
Leukotriene A-4 hydrolaseHomo sapiens (human)IC50289.000022
Luciferin 4-monooxygenasePhotinus pyralis (common eastern firefly)IC500.058911
Lysine-specific histone demethylase 1AHomo sapiens (human)IC5012.600022
Lysosomal alpha-glucosidaseRattus norvegicus (Norway rat)IC50400.000011
M18 aspartyl aminopeptidasePlasmodium falciparum 3D7IC502.242011
Myc proto-oncogene proteinHomo sapiens (human)IC5060.000011
N1L Vaccinia virusIC5021.900022
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)IC500.685022
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)IC500.685022
Nitric oxide synthase, inducibleMus musculus (house mouse)IC5020.466733
Nuclear factor NF-kappa-B p100 subunit Homo sapiens (human)IC502.500011
Nuclear factor NF-kappa-B p105 subunitHomo sapiens (human)IC502.500011
Ornithine decarboxylaseHomo sapiens (human)IC5019.000011
Polyphenol oxidase 2Agaricus bisporusIC5045.950033
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)IC504.900011
Prostaglandin G/H synthase 1Homo sapiens (human)IC5049.513844
Prostaglandin G/H synthase 1Ovis aries (sheep)IC502.025044
Prostaglandin G/H synthase 2Homo sapiens (human)IC506.004677
Prostaglandin G/H synthase 2Ovis aries (sheep)IC503.490011
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)IC501.39721212
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)Ki0.088011
Serine/threonine-protein kinase PAK 1Homo sapiens (human)IC5015.000011
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)IC5040.000012
Sodium-dependent noradrenaline transporter Homo sapiens (human)IC502.312011
Sodium-dependent noradrenaline transporter Homo sapiens (human)Ki2.293011
Squalene synthaseRattus norvegicus (Norway rat)IC5050.000011
Sucrase-isomaltase, intestinalRattus norvegicus (Norway rat)IC50400.000011
Transcription factor p65Homo sapiens (human)IC502.500011
Transient receptor potential cation channel subfamily A member 1Homo sapiens (human)IC5015.375022
Transient receptor potential cation channel subfamily A member 1Rattus norvegicus (Norway rat)IC506.197544
Tubulin beta-2B chainBos taurus (cattle)IC5040.000011
TyrosinaseHomo sapiens (human)IC50985.175044
TyrosinaseMus musculus (house mouse)IC5010.780011
TyrosinaseMus musculus (house mouse)Ki2,900.000011
Tyrosine-protein kinase ABL1Homo sapiens (human)IC5028.000011
Tyrosine-protein kinase LckHomo sapiens (human)IC50112.000011
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50525.000022
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)IC5011.900011
VifHuman immunodeficiency virus 1IC5025.310011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Amyloid-beta precursor proteinHomo sapiens (human)Kd38.500011
Chain A, Troponin C, slow skeletal and cardiac musclesHomo sapiens (human)Kd243.000011
Estrogen receptorMus musculus (house mouse)EC505.203012
Estrogen receptor betaMus musculus (house mouse)EC505.203012
NAD-dependent protein deacetylase sirtuin-1Homo sapiens (human)EC5052.333333
NAD-dependent protein deacetylase sirtuin-2Homo sapiens (human)EC50300.000011
NAD-dependent protein deacetylase sirtuin-3, mitochondrialHomo sapiens (human)EC50177.595022
Nuclear factor erythroid 2-related factor 2Homo sapiens (human)EC505.400011
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)EC505.203011
POsterior SegregationCaenorhabditis elegansEC50300.000012
Prostaglandin G/H synthase 1Ovis aries (sheep)Kd11.700011
Protein kinase C alpha typeHomo sapiens (human)EC505,780.000011
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)Kd0.054011
serine/threonine-protein kinase 33 isoform aHomo sapiens (human)EC5012.330011
Sodium-dependent noradrenaline transporter Homo sapiens (human)EC50163.131011
transcription factor p65 isoform 1Homo sapiens (human)EC505.203011
Transient receptor potential cation channel subfamily A member 1Homo sapiens (human)EC5030.000011
TransthyretinHomo sapiens (human)Kd0.470011
Zinc finger protein mex-5Caenorhabditis elegansEC50163.131011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)AC50100.000011
ATP-dependent translocase ABCB1Homo sapiens (human)AC50100.000011
Breakpoint cluster region proteinHomo sapiens (human)AC50100.000011
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)AC50100.000011
FAD-linked sulfhydryl oxidase ALRHomo sapiens (human)AC504.021011
Myc proto-oncogene proteinHomo sapiens (human)MED55.000011
NAD-dependent protein deacetylase sirtuin-1Homo sapiens (human)Activity48.000011
NAD-dependent protein deacetylase sirtuin-1Homo sapiens (human)EC1.546.133333
NAD(P)H dehydrogenase [quinone] 1Mus musculus (house mouse)Activity20.000011
NAD(P)H dehydrogenase [quinone] 1Mus musculus (house mouse)CD29.285777
Nuclear factor erythroid 2-related factor 2Homo sapiens (human)CD21.000011
Prenyltransferase homologStreptomyces coelicolor A3(2)Km440.000011
Tyrosine-protein kinase ABL1Homo sapiens (human)AC50100.000011