Triadimefon is a systemic fungicide that belongs to the triazole class of chemicals. It is used to control a wide range of fungal diseases in various crops, including wheat, barley, rice, and fruit trees. Triadimefon works by inhibiting the biosynthesis of ergosterol, an essential component of fungal cell membranes. This disruption in ergosterol production leads to cell death and prevents the spread of the fungal infection. The synthesis of triadimefon involves a multi-step process that begins with the reaction of 1,2,4-triazole with a substituted benzaldehyde. The resulting intermediate is then reacted with a suitable alkyl halide to produce the final product. Triadimefon has been shown to be effective in controlling fungal diseases such as powdery mildew, rust, and leaf spot. It is also used in the treatment of fungal infections in humans and animals. Due to its effectiveness and relatively low toxicity, triadimefon has been widely used in agriculture. However, concerns have been raised about its potential environmental impact and the development of fungal resistance to the compound. Researchers continue to study the effects of triadimefon on various organisms, including plants, animals, and humans, to better understand its safety and environmental impact. Studies also investigate the potential for developing new and more sustainable fungicides that can replace triadimefon.'
1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one : A member of the class of triazoles that is 1-hydroxy-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one in which the hydroxyl hydrogen is replaced by a 4-chlorophenyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 39385 |
| CHEMBL ID | 520897 |
| CHEBI ID | 84002 |
| SCHEMBL ID | 21204 |
| MeSH ID | M0102383 |
| Synonym |
|---|
| AC-12579 |
| OPREA1_827146 |
| BRD-A39506880-001-02-9 |
| 2-butanone,3-dimethyl-1-(1h-1,2,4-triazol-1-yl)- |
| 2-butanone,3-dimethyl-1-(1,2,4-triazol-1-yl)- |
| nsc-303303 |
| nsc303303 |
| 1-(4-chlorophenoxy)-3,2,4-triazol-1-yl)-butan-2-one |
| bay 6681f |
| 2-butanone, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1h-1,2,4-triazol-1-yl)- |
| IFLAB1_000075 |
| epa pesticide chemical code 109901 |
| miltek |
| triadimefone |
| azocene |
| strike |
| bayleton cf |
| bayleton bm |
| nsc 303303 |
| 1h-1,2,4-triazole, 1-((tert-butylcarbonyl-4-chlorophenoxy)methyl)- |
| reach |
| bayleton bm gel |
| 2-butanone, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)- |
| 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butanone |
| amiral |
| caswell no. 862aa |
| bay meb 6447 |
| acizol |
| 1-(1,2,4-triazoyl-1)-1-(4-chloro-phenoxy)-3,3-dimethylbutanone |
| diametom b |
| einecs 256-103-8 |
| 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-one |
| otria 25 |
| rofon |
| triadimefon [bsi:iso] |
| typhon |
| tenor |
| bayleton total |
| meb 6447 |
| mighty |
| brn 0619231 |
| 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1h-1,2,4-triazol-1-yl)-2-butanone |
| nurex |
| hsdb 6857 |
| adifon |
| haleton |
| bay 6681 f |
| bay-meb-6447 |
| triadimefone [iso-french] |
| OPREA1_598872 |
| IDI1_008294 |
| EU-0066688 |
| 43121-43-3 |
| triadimefon , |
| triadimefon, analytical standard |
| BSPBIO_003562 |
| NCGC00094573-04 |
| NCGC00094573-01 |
| NCGC00094573-02 |
| NCGC00094573-03 |
| KBIO3_002907 |
| SPECTRUM3_001962 |
| SPECTRUM2_001707 |
| SPBIO_001694 |
| SPECTRUM1505307 |
| 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1h-1,2,4-triazol-1-yl)butan-2-one |
| bayleton |
| NCGC00094573-06 |
| NCGC00094573-05 |
| MLS002695917 |
| smr000778089 |
| 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one |
| AKOS000583075 |
| HMS1412D09 |
| chebi:84002 , |
| CHEMBL520897 , |
| FT-0639834 |
| bdbm50295561 |
| NCGC00094573-07 |
| fenxiunin |
| HMS3089A16 |
| dtxcid403897 |
| cas-43121-43-3 |
| dtxsid3023897 , |
| NCGC00254790-01 |
| tox21_300886 |
| CCG-39446 |
| STL281794 |
| 1hw039cjf0 , |
| unii-1hw039cjf0 |
| 5-26-01-00123 (beilstein handbook reference) |
| (+/-)-triadimefon |
| triadimefon [mi] |
| triadimefon [hsdb] |
| 2-butanone, 1- (4-chlorophenoxy)-3,3-dimethyl-1-(1h-1,2,4-triazol-1-yl)- |
| triadimefon [iso] |
| triadimefon, (+/-)- |
| AKOS016050579 |
| SCHEMBL21204 |
| T2817 |
| bayleton 250 ec |
| tidifon |
| tartan (fungicide) |
| bayleton special |
| 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1h-1,2,4-triazol-1-yl) butan-2-one |
| bay-meb 6447 |
| bayleton 5 |
| 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1h-1,2,4-triazol-1-yl)-butan-2-one |
| W-106246 |
| 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1h-1,2,4-triazole -1-yl)-2-butanone |
| SR-01000388703-1 |
| sr-01000388703 |
| 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone |
| triadimefon, pestanal(r), analytical standard |
| triadimefon 10 microg/ml in cyclohexane |
| triadimefon 10 microg/ml in acetonitrile |
| triadimefon (m01) |
| triadimenol tp |
| Q2452254 |
| triadimefon 1000 microg/ml in acetone |
| AMY22463 |
| A12522 |
| HY-123037 |
| CS-0080945 |
| BS-42468 |
| mfcd00055506 |
Triadimefon (TDF) is a broad-spectrum antifungal agent, which is widely used in agriculture to control mold and fungal infections. It is a triazole fungicide known to cause severe developmental defects in several model organisms and in humans.
Triadimefon has been shown to inhibit monoamine uptake, bind to the dopamine (DA) transporter, and stimulate dopamine efflux in rat brain tissue, in vitro. As triadimeFon treatment has proved to be beneficial to plants, this result suggests that BR-biosynthesis inhibitors can be applied to crops.
| Excerpt | Reference | Relevance |
|---|---|---|
| "As triadimefon treatment has proved to be beneficial to plants, this result suggests that BR-biosynthesis inhibitors can be applied to crops." | ( Triadimefon, a fungicidal triazole-type P450 inhibitor, induces brassinosteroid deficiency-like phenotypes in plants and binds to DWF4 protein in the brassinosteroid biosynthesis pathway. Asami, T; Fujioka, S; Goda, H; Han, SY; Kitahata, N; Mizutani, M; Sakata, K; Sekimata, K; Shimada, Y; Takatsuto, S; Yoshida, S, 2003) | 2.28 |
| "Triadimefon has been shown to inhibit monoamine uptake, bind to the dopamine (DA) transporter, and stimulate dopamine efflux in rat brain tissue, in vitro. " | ( Effects of triadimefon on extracellular dopamine, DOPAC, HVA and 5-HIAA in adult rat striatum. Gagnaire, F; Micillino, JC, 2006) | 2.17 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Triadimefon could inhibit the increase of peroxide (POD) activity and H2O2 content in different degree." | ( [Effect of triadimefon on activity of peroxidase and soluble protein content in detached cucumber cotyledons]. Feng, Z; Wang, J, 2002) | 1.43 |
Triadimefon treatment also reduced the accumulation of both the ROS (H2O2 and O2*-) in 5-day-old Amaranthus seedlings. This result suggests that BR-biosynthesis inhibitors can be applied to crops.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Triadimefon treatment also reduced the accumulation of both the ROS (H2O2 and O2*-) in 5-day-old Amaranthus seedlings." | ( Triadimefon pretreatment protects newly assembled membrane system and causes up-regulation of stress proteins in salinity stressed Amaranthus lividus L. during early germination. Bhattacharjee, S, 2008) | 2.51 |
| "As triadimefon treatment has proved to be beneficial to plants, this result suggests that BR-biosynthesis inhibitors can be applied to crops." | ( Triadimefon, a fungicidal triazole-type P450 inhibitor, induces brassinosteroid deficiency-like phenotypes in plants and binds to DWF4 protein in the brassinosteroid biosynthesis pathway. Asami, T; Fujioka, S; Goda, H; Han, SY; Kitahata, N; Mizutani, M; Sakata, K; Sekimata, K; Shimada, Y; Takatsuto, S; Yoshida, S, 2003) | 2.28 |
The particular mode of toxic and tumorigenic action for these compounds is not known. It has been proposed that triadimefon-induced rat thyroid tumors arise through the specific mechanism of increased TSH.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Ascidians proved to be good models to study the toxic effects of pesticides since they offered both the convenience of working with an invertebrate species and the tissue sensitivity to chemical compound comparable to vertebrates." | ( Toxic effects of two pesticides, Imazalil and Triadimefon, on the early development of the ascidian Phallusia mammillata (Chordata, Ascidiacea). Biggiogero, M; De Bernardi, F; Groppelli, S; Pennati, R; Sotgia, C; Zega, G, 2006) | 0.59 |
| "Triazole fungicides associated with a range of reported male reproductive effects in experimental animals were selected to assess potential toxic modes of action." | ( Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat. Best, DS; Blystone, CR; Dix, DJ; Goetz, AK; Narotsky, MG; Nichols, HP; Ren, H; Rockett, JC; Schmid, JE; Strader, LF; Thillainadarajah, I; Wolf, DC, 2007) | 0.34 |
| " The particular mode of toxic and tumorigenic action for these compounds is not known, however it has been proposed that triadimefon-induced rat thyroid tumors arise through the specific mechanism of increased TSH." | ( Toxicity profiles in rats treated with tumorigenic and nontumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil. Allen, JW; Delker, D; George, MH; Hester, SD; Jones, C; Leavitt, S; Moore, T; Nelson, G; Nesnow, S; Roop, BC; Sun, G; Thai, SF; Thibodeaux, J; Winkfield, E; Wolf, DC, 2006) | 0.75 |
| "Mechanistic and stereoselective based in vitro metabolism assays were utlilized to gain insight into the toxic mode of action of the 1,2,4-triazole fungicide, triadimefon, with black fly (Diptera: Simuliidae) larvae." | ( Mechanistic approach to understanding the toxicity of the azole fungicide triadimefon to a nontarget aquatic insect and implications for exposure assessment. Kellock, KA; Kenneke, JF; Mazur, CS; Overmyer, JP, 2009) | 0.78 |
| " Under foliage application or soil irrigation application, S-(+)-triadimefon was preferentially degraded, resulting in relative enrichment of the more toxic R-(-)-enantiomer in tomato, cucumber, and soil." | ( Chiral fungicide triadimefon and triadimenol: Stereoselective transformation in greenhouse crops and soil, and toxicity to Daphnia magna. Dong, F; Han, Y; Li, Y; Liu, X; Xu, J; Zheng, Y, 2014) | 0.98 |
| " In growth inhibition experiments, triadimenol was more toxic than triadimefon, and (1S,2R)-triadimenol, which has the largest fungicidal activity, presented the highest toxicity to the algae." | ( Stereoselective bioaccumulation, transformation, and toxicity of triadimefon in Scenedesmus obliquus. Huang, L; Xu, P, 2017) | 0.93 |
| " We therefore demonstrated that zebrafish provide an excellent system for study of compounds with toxic significance and can be used as an alternative model for developmental toxicity studies to predict effects in mammals." | ( Zebrafish as an Alternative Vertebrate Model for Investigating Developmental Toxicity-The Triadimefon Example. Machera, K; Zoupa, M, 2017) | 0.68 |
| " Therefore, firstly we explored the toxic effects and possible mechanism of cardiovascular toxicity induced by TF using zebrafish model." | ( The cardiovascular toxicity of triadimefon in early life stage of zebrafish and potential implications to human health. Chen, LL; Chu, TY; Gui, WJ; Liu, HC; Zhu, GN, 2017) | 0.74 |
| " In this study, the selective metabolism of triadimenol (TN) in the male Eremias argus lizards and the toxic effects of TN on lizards were studied." | ( Stereoselective metabolism and potential adverse effects of chiral fungicide triadimenol on Eremias argus. Chen, L; Diao, J; Li, Y; Tian, Z; Wang, Z; Zhang, L; Zhang, W; Zhou, Z, 2020) | 0.56 |
| " In this study, we aimed to explore the mixture toxic effects of fludioxonil (FLU) and triadimefon (TRI) on zebrafish (Danio rerio) by employing different toxicological endpoints." | ( Combined toxic effects of fludioxonil and triadimefon on embryonic development of zebrafish (Danio rerio). Guo, D; Wang, D; Wang, Q; Wang, X; Wang, Y; Weng, H; Xu, C; Yang, G; Yu, R, 2020) | 1.05 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "A physiologically based pharmacokinetic (PBPK) model was developed for the conazole fungicide triadimefon and its primary metabolite, triadimenol." | ( Development and application of a physiologically based pharmacokinetic model for triadimefon and its metabolite triadimenol in rats and humans. Crowell, SR; Fisher, JW; Henderson, WM; Kenneke, JF, 2011) | 0.81 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Excessive pesticide levels in soil can exert negative effects on soil-dwelling organisms by decreasing their bioavailability and, consequently, lowering soil quality." | ( Microbiological and biochemical properties of soil polluted with a mixture of spiroxamine, tebuconazole, and triadimenol under the cultivation of Triticum aestivum L. Baćmaga, M; Kucharski, J; Wyszkowska, J, 2019) | 0.51 |
Rats were dosed with the conazoles at three dose levels by gavage for 14 days. Field investigation of the dissipation rate kinetics for triadimefon and malathion during storage indicated that their half-life was twice as high when 5 times the recommended dosage was used.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response functions were determined during 5-min extinction sessions." | ( Discriminative stimulus properties of triadimefon: comparison with methylphenidate. Eckerman, DA; MacPhail, RC; Perkins, AN, 1991) | 0.55 |
| " Dosage-effect, time-effect, and the effect of repeated dosing (7 days) were determined following triadimefon exposure." | ( Hyperactivity induced by triadimefon, a triazole fungicide. Boncek, VM; Crofton, KM; Reiter, LW, 1988) | 0.8 |
| " There has been a long tradition in preclinical behavioral pharmacology of using episodic-exposure paradigms in order to establish dose-response functions in individual organisms." | ( Episodic exposures to chemicals: what relevance to chemical intolerance? MacPhail, RC, 2001) | 0.31 |
| " Studies in this laboratory have found that repeated dosing with TDF in adult mice leads to the development and robust expression of behavioral sensitization, a response mediated by dopaminergic and glutamatergic neurotransmitter systems, and causing long-term changes in dopaminergic function." | ( The effect of developmental exposure to the fungicide triadimefon on behavioral sensitization to triadimefon during adulthood. Cory-Slechta, DA; Reeves, R; Richfield, EK; Thiruchelvam, M, 2004) | 0.57 |
| " Bioassay indicated that most of the compounds showed significant fungicidal activity against Rhizoctonia solani, Botrytis cinereapers, and Dothiorella gregaria at a dosage of 50microg/mL." | ( Microwave-assisted, one-pot syntheses and fungicidal activity of polyfluorinated 2-benzylthiobenzothiazoles. Huang, W; Yang, GF, 2006) | 0.33 |
| " Rats were dosed with the conazoles at three dose levels by gavage for 14 days: myclobutanil (150, 75, and 10mgkg(-1) body weight day(-1); triadimefon (115, 50, and 10 mg kg(-1) body weight day-'), which included their maximum tolerated dose levels (MTD)." | ( Induction of cytochrome P450 enzymes in rat liver by two conazoles, myclobutanil and triadimefon. Dix, DJ; Grindstaff, RD; Lambert, GR; Nesnow, S; Sun, G; Thai, SF; Tully, DB, 2007) | 0.77 |
| " Bioassay indicated that compounds 33, 35, 37 and 39 exhibited much higher activities against Botryodiplodia theobromae than commercial fungicide triadimefon at the dosage of 150 mg/L." | ( One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation. Duan, AN; Ma, WF; Wu, SG; Yan, YC; You, WW; Zhao, PL; Zou, M, 2012) | 0.58 |
| " Field investigation of the dissipation rate kinetics for triadimefon and malathion during storage indicated that their half-life was twice as high when 5 times the recommended dosage was used." | ( Behavior of field-applied triadimefon, malathion, dichlorvos, and their main metabolites during barley storage and beer processing. Bao, Y; Chen, J; Dai, X; Fan, B; Francis, F; Gui, Y; Jian, Q; Kong, Z; Li, M, 2016) | 0.98 |
| " Identifying toxicological effects and dose-response relationship of SR-(-)-triadimenol and RR-(+)-triadimenol will help fully assess the risk of TF enantiomers use in the future." | ( Enantioselective metabolism of triadimefon and its chiral metabolite triadimenol in lizards. Li, J; Li, W; Shen, Q; Wang, Y; Xu, P; Zhuang, G, 2017) | 0.74 |
| " We found out that TDF triggers both, preference and aversion depending on the dosage used during conditioning." | ( Triadimefon triggers circling behavior and conditioned place preference/aversion in zebrafish in a dose dependent manner. Allende, ML; Ormeño, F; Paredes-Zúñiga, S, ) | 1.57 |
| " In this study, based on the advantages of high efficiency, rapidity, reliability, simplicity and low cost of immunology, a test strip product for the rapid detection of triadimenol residues in tobacco was designed based on the optimization of conditions such as pH and dosage of diluent, concentration of antibody stock solution, type of confining solution and complex solution, with high specificity, accuracy and The results of 20 samples of fresh and first roasted tobacco were all consistent with the method of gas chromatography, which proved the reliability of the test strips." | ( Development of Colloidal Gold Test Strips for the Detection of Triadimenol Residues in Tobacco. Bu, Y; Cai, J; Cai, Y; Chen, D; Ding, Y; Gu, J; Li, D; Long, J; Sun, H; Wang, C; Zhang, K; Zhang, X, 2023) | 0.91 |
| Class | Description |
|---|---|
| triazoles | An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms. |
| monochlorobenzenes | Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine. |
| aromatic ether | Any ether in which the oxygen is attached to at least one aryl substituent. |
| ketone | A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H). |
| hemiaminal ether | An organic amino compound that is a hemiaminal in which the hydrogen atom of the hydroxy group has been replaced by an organyl group. General formula: R2C(OR')NR2 ( R =/= H ). Also known as alpha-amino ethers. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 1.9953 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 47.3935 | 0.0251 | 27.9203 | 501.1870 | AID651751 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 0.1947 | 3.1890 | 29.8841 | 59.4836 | AID1224846 |
| AR protein | Homo sapiens (human) | Potency | 49.5390 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247; AID743035 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 30.6067 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224893 |
| progesterone receptor | Homo sapiens (human) | Potency | 30.6067 | 0.0004 | 17.9460 | 75.1148 | AID1346795 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 46.6813 | 0.0015 | 30.6073 | 15,848.9004 | AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 37.2525 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982; AID720659 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 12.9398 | 0.0002 | 29.3054 | 16,493.5996 | AID588513; AID588514; AID743069; AID743075; AID743077; AID743080; AID743091 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 14.1254 | 0.0010 | 24.5048 | 61.6448 | AID588534 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 51.6626 | 0.0007 | 23.0674 | 1,258.9301 | AID651777; AID743085; AID743122 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 54.4273 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 32.9050 | 0.0016 | 28.0151 | 77.1139 | AID1224843; AID1224895 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0071 | 0.0100 | 39.5371 | 1,122.0200 | AID588545 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 19.3312 | 0.0006 | 27.2152 | 1,122.0200 | AID651741 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 0.7943 | 0.0316 | 10.2792 | 39.8107 | AID884; AID885 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 1.1220 | 0.5623 | 9.3985 | 25.1189 | AID652106 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 11.2202 | 1.7783 | 16.2081 | 35.4813 | AID652104 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 (µMol) | 9.2897 | 0.0001 | 1.7536 | 10.0000 | AID428564 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Cytochrome P450 14alpha-demethylase | Penicillium digitatum | Kd | 0.7050 | 0.3200 | 0.5925 | 0.9900 | AID1080729; AID1104784 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Skn7p | Saccharomyces cerevisiae (brewer's yeast) | AbsAC40_uM | 2.0200 | 0.6600 | 5.2696 | 18.2300 | AID624258 |
| HSP40, subfamily A [Plasmodium falciparum 3D7] | Plasmodium falciparum 3D7 | AbsAC1000_uM | 4.7030 | 0.1290 | 4.1169 | 11.3160 | AID540271 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1112995 | Fungicidal activity against Penicillium digitatum assessed as inhibition of mycelium measured after 48 hr | 2013 | Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7 | Synthesis, fungicidal activity, and sterol 14α-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum. |
| AID445611 | Antifungal activity against Rhizoctonia solani at 50 mg/L relative to control | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | A facile synthesis and biological activity of novel tetrahydrobenzo[4',5']thieno[3',2':5,6]pyrido[4,3-d]pyrimidin-4(3H)-ones. |
| AID1110818 | Fungicidal activity against Botryotinia fuckeliana Pers assessed as inhibition of fungal growth at 50 ug/ml after 48 hr | 2006 | Bioorganic & medicinal chemistry, Dec-15, Volume: 14, Issue:24 | Microwave-assisted, one-pot syntheses and fungicidal activity of polyfluorinated 2-benzylthiobenzothiazoles. |
| AID1112998 | Fungicidal activity against Penicillium digitatum assessed as inhibition of mycelium at 25 ug/ml measured after 48 hr | 2013 | Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7 | Synthesis, fungicidal activity, and sterol 14α-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID1080728 | Fungicidal activity against Penicillium digitatum at 50 mg/l at 26 degC after 48 hr by growth inhibition test | 2009 | Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15 | Determination of stereoselective interaction between enantiomers of chiral gamma-aryl-1H-1,2,4-triazole derivatives and Penicillium digitatum. |
| AID1113000 | Fungicidal activity against Penicillium digitatum assessed as inhibition of mycelium at 5 ug/ml measured after 48 hr | 2013 | Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7 | Synthesis, fungicidal activity, and sterol 14α-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum. |
| AID378242 | Antimicrobial activity against Helminthosporium sativum after 96 hrs by paper disk assay | 2000 | Journal of natural products, Nov, Volume: 63, Issue:11 | Metabolites of Colletotrichum gloeosporioides, an endophytic fungus in Artemisia mongolica. |
| AID1081293 | Fungicidal activity against Rhizoctonia solani assessed as induction of electrolyte leakage from hyphae at 50 ug/mL by cell membrane permeability assay | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Primary study on mode of action for macrocyclic fungicide candidates (7B3, D1) against Rhizoctonia solani Kuhn. |
| AID613970 | Fungicidal activity against Sclerotinia sclerotiorum assessed as mycelium growth inhibition at 30 ug/mL after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID667796 | Growth inhibition of Fusarium oxysporum f. sp. cubense at 150 mg/mL after 48 hrs by mycelium growth rate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation. |
| AID613968 | Fungicidal activity against Fusarium moniliforme assessed as mycelium growth inhibition at 30 ug/mL after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID1080470 | In vitro fungicidal activity against Rhizoctonia solani assessed as mycelial growth inhibition at 50 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID613969 | Fungicidal activity against Bipolaris sorokiniana assessed as mycelium growth inhibition at 30 ug/mL after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID1379644 | Fungicidal activity against Venturia inaequalis grown under potato-saccharose agar assessed as inhibition of mycelial radial growth at 30 mg/l incubated for 72 hrs | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis and biological evaluation of new substituted thioglycolurils, their analogues and derivatives. |
| AID1080460 | In vitro fungicidal activity against Colletotrichum gossypii assessed as mycelial growth inhibition at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID613965 | Fungicidal activity against Venturia inaequalis assessed as mycelium growth inhibition at 30 ug/mL after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID613975 | Fungicidal activity against Bipolaris sorokiniana assessed as mycelium growth inhibition after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID1080474 | In vitro fungicidal activity against Fusarium graminearum assessed as mycelial growth inhibition at 100 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID1080464 | In vitro fungicidal activity against Rhizoctonia solani assessed as mycelial growth inhibition at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID428564 | Inhibition of CYP3A4 | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. |
| AID1090621 | Antifungal activity against Dothiorella gregaria assessed as inhibition rate at 50 ug/mL | 2007 | Journal of agricultural and food chemistry, Apr-18, Volume: 55, Issue:8 | Design, synthesis, and fungicidal activities of new strobilurin derivatives. |
| AID613973 | Fungicidal activity against Fusarium oxysporum assessed as mycelium growth inhibition after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID1080469 | In vitro fungicidal activity against Botryotinia fuckeliana assessed as mycelial growth inhibition at 50 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID667795 | Growth inhibition of Fusarium oxysporum f. sp. niveum at 150 mg/mL after 48 hrs by mycelium growth rate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation. |
| AID1091496 | Fungicidal activity against Cladosporium cucumerinum assessed as growth inhibition at 50 ug/ml at 23 degC after 3 days | 2008 | Journal of agricultural and food chemistry, Nov-26, Volume: 56, Issue:22 | Synthesis and biological activities of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID1080729 | Binding affinity to Penicillium digitatum CYP51 expressed in Escherichia coli BL21 (DE3) cells by binding spectrum method | 2009 | Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15 | Determination of stereoselective interaction between enantiomers of chiral gamma-aryl-1H-1,2,4-triazole derivatives and Penicillium digitatum. |
| AID613972 | Fungicidal activity against Rhizoctonia solani assessed as mycelium growth inhibition after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID643469 | Antifungal activity against Rhizoctonia solani by agar plate method | 2012 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3 | Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity. |
| AID1112996 | Fungicidal activity against Penicillium digitatum assessed as inhibition of mycelium at 1 ug/ml measured after 48 hr | 2013 | Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7 | Synthesis, fungicidal activity, and sterol 14α-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum. |
| AID376577 | Antifungal activity against Colletotrichum fragariae assessed as zone of inhibition | 2000 | Journal of natural products, Aug, Volume: 63, Issue:8 | A new 2D-TLC bioautography method for the discovery of novel antifungal agents To control plant pathogens. |
| AID1080462 | In vitro fungicidal activity against Fusarium graminearum assessed as mycelial growth inhibition at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID1080727 | Fungicidal activity against Penicillium digitatum at 26 degC after 48 hr by growth inhibition test | 2009 | Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15 | Determination of stereoselective interaction between enantiomers of chiral gamma-aryl-1H-1,2,4-triazole derivatives and Penicillium digitatum. |
| AID1090624 | Antifungal activity against Botrytis cinereapers assessed as inhibition rate at 50 ug/mL | 2007 | Journal of agricultural and food chemistry, Apr-18, Volume: 55, Issue:8 | Design, synthesis, and fungicidal activities of new strobilurin derivatives. |
| AID1080475 | In vitro fungicidal activity against Botryotinia fuckeliana assessed as mycelial growth inhibition at 100 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID1080467 | In vitro fungicidal activity against Dothiorella gregaria assessed as mycelial growth inhibition at 50 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID1112999 | Fungicidal activity against Penicillium digitatum assessed as inhibition of mycelium at 10 ug/ml measured after 48 hr | 2013 | Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7 | Synthesis, fungicidal activity, and sterol 14α-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum. |
| AID1090623 | Antifungal activity against Rhizoctonia solani assessed as inhibition rate at 50 ug/mL | 2007 | Journal of agricultural and food chemistry, Apr-18, Volume: 55, Issue:8 | Design, synthesis, and fungicidal activities of new strobilurin derivatives. |
| AID1110817 | Fungicidal activity against Dothiorella gregaria assessed as inhibition of fungal growth at 50 ug/ml after 48 hr | 2006 | Bioorganic & medicinal chemistry, Dec-15, Volume: 14, Issue:24 | Microwave-assisted, one-pot syntheses and fungicidal activity of polyfluorinated 2-benzylthiobenzothiazoles. |
| AID1104783 | Antifungal activity against Penicillium digitatum after 48 hr | 2010 | Pest management science, Dec, Volume: 66, Issue:12 | Optimised expression and spectral analysis of the target enzyme CYP51 from Penicillium digitatum with possible new DMI fungicides. |
| AID1379647 | Fungicidal activity against Fusarium moniliforme grown under potato-saccharose agar assessed as inhibition of mycelial radial growth at 30 mg/l incubated for 72 hrs | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis and biological evaluation of new substituted thioglycolurils, their analogues and derivatives. |
| AID434343 | Binding affinity to Penicillium digitatum CYP51 expressed in Escherichia coli by UV-visible spectrophotometry | 2009 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 19, Issue:14 | Organocatalytic synthesis and sterol 14alpha-demethylase binding interactions of enantioriched 3-(1H-1,2,4-triazol-1-yl)butyl benzoates. |
| AID1379645 | Fungicidal activity against Rhizoctonia solani grown under potato-saccharose agar assessed as inhibition of mycelial radial growth at 30 mg/l incubated for 72 hrs | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis and biological evaluation of new substituted thioglycolurils, their analogues and derivatives. |
| AID1091498 | Fungicidal activity against Mycosphaerella arachidis assessed as growth inhibition at 50 ug/ml at 23 degC after 3 days | 2008 | Journal of agricultural and food chemistry, Nov-26, Volume: 56, Issue:22 | Synthesis and biological activities of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety. |
| AID613967 | Fungicidal activity against Fusarium oxysporum assessed as mycelium growth inhibition at 30 ug/mL after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID1090620 | Antifungal activity against Colletotrichum gossypii assessed as inhibition rate at 50 ug/mL | 2007 | Journal of agricultural and food chemistry, Apr-18, Volume: 55, Issue:8 | Design, synthesis, and fungicidal activities of new strobilurin derivatives. |
| AID1112997 | Fungicidal activity against Penicillium digitatum assessed as inhibition of mycelium at 50 ug/ml measured after 48 hr | 2013 | Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7 | Synthesis, fungicidal activity, and sterol 14α-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum. |
| AID750178 | Antifungal activity against Cercospora beticola assessed as inhibition of mycelia elongation rate at 50 ppm after 48 hrs relative to control | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety. |
| AID1090622 | Antifungal activity against Fusarium graminearum assessed as inhibition rate at 50 ug/mL | 2007 | Journal of agricultural and food chemistry, Apr-18, Volume: 55, Issue:8 | Design, synthesis, and fungicidal activities of new strobilurin derivatives. |
| AID667798 | Growth inhibition of Phyricularia oryzae Cav. at 150 mg/mL after 48 hrs by mycelium growth rate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation. |
| AID750177 | Antifungal activity against Rhizoctonia solani assessed as inhibition of mycelia elongation rate at 50 ppm after 48 hrs relative to control | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety. |
| AID1080471 | In vitro fungicidal activity against Fusarium oxysporum assessed as mycelial growth inhibition at 50 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID1104784 | Binding affinity to Penicillium digitatum recombinant N-terminal-His6 tagged CYP51 expressed in Escherichia coli BL21(DE3) by spectrophotometric analysis | 2010 | Pest management science, Dec, Volume: 66, Issue:12 | Optimised expression and spectral analysis of the target enzyme CYP51 from Penicillium digitatum with possible new DMI fungicides. |
| AID1080466 | In vitro fungicidal activity against Colletotrichum gossypii assessed as mycelial growth inhibition at 50 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID750180 | Antifungal activity against Gibberella saubinettii assessed as inhibition of mycelia elongation rate at 50 ppm after 48 hrs relative to control | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety. |
| AID1112994 | Binding affinity to Penicillium digitatum CYP51 | 2013 | Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7 | Synthesis, fungicidal activity, and sterol 14α-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum. |
| AID613971 | Fungicidal activity against Venturia inaequalis assessed as mycelium growth inhibition after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID1080468 | In vitro fungicidal activity against Fusarium graminearum assessed as mycelial growth inhibition at 50 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID1091499 | Fungicidal activity against Botryosphaeria berengeriana assessed as growth inhibition at 50 ug/ml at 23 degC after 3 days | 2008 | Journal of agricultural and food chemistry, Nov-26, Volume: 56, Issue:22 | Synthesis and biological activities of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety. |
| AID445782 | Antifungal activity against Gibberella zeae at 50 mg/L relative to control | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | A facile synthesis and biological activity of novel tetrahydrobenzo[4',5']thieno[3',2':5,6]pyrido[4,3-d]pyrimidin-4(3H)-ones. |
| AID1379646 | Fungicidal activity against Fusarium oxysporum grown under potato-saccharose agar assessed as inhibition of mycelial radial growth at 30 mg/l incubated for 72 hrs | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis and biological evaluation of new substituted thioglycolurils, their analogues and derivatives. |
| AID667794 | Growth inhibition of Botryodiplodia theobromae at 150 mg/mL after 48 hrs by mycelium growth rate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation. |
| AID750179 | Antifungal activity against Physalospora pyricola assessed as inhibition of mycelia elongation rate at 50 ppm after 48 hrs relative to control | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety. |
| AID613976 | Fungicidal activity against Sclerotinia sclerotiorum assessed as mycelium growth inhibition after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID1379649 | Fungicidal activity against Sclerotinia sclerotiorum grown under potato-saccharose agar assessed as inhibition of mycelial radial growth at 30 mg/l incubated for 72 hrs | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis and biological evaluation of new substituted thioglycolurils, their analogues and derivatives. |
| AID1091500 | Fungicidal activity against Fusarium graminearum assessed as growth inhibition at 50 ug/ml at 23 degC after 3 days | 2008 | Journal of agricultural and food chemistry, Nov-26, Volume: 56, Issue:22 | Synthesis and biological activities of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety. |
| AID1080477 | In vitro fungicidal activity against Fusarium oxysporum assessed as mycelial growth inhibition at 100 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID1091497 | Growth regulation of Cucumis sativus (cucumber) seeds assessed as rhizogenesis at 10 ug/ml at 24 degC after 3 days by cucumber cotyledon test | 2008 | Journal of agricultural and food chemistry, Nov-26, Volume: 56, Issue:22 | Synthesis and biological activities of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety. |
| AID1080473 | In vitro fungicidal activity against Dothiorella gregaria assessed as mycelial growth inhibition at 100 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID1080476 | In vitro fungicidal activity against Rhizoctonia solani assessed as mycelial growth inhibition at 100 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID1080465 | In vitro fungicidal activity against Fusarium oxysporum assessed as mycelial growth inhibition at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID667797 | Growth inhibition of Colletotrichum musae at 150 mg/mL after 48 hrs by mycelium growth rate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation. |
| AID1379648 | Fungicidal activity against Bipolaris sorokiniana grown under potato-saccharose agar assessed as inhibition of mycelial radial growth at 30 mg/l incubated for 72 hrs | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis and biological evaluation of new substituted thioglycolurils, their analogues and derivatives. |
| AID613966 | Fungicidal activity against Rhizoctonia solani assessed as mycelium growth inhibition at 30 ug/mL after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID1080463 | In vitro fungicidal activity against Botryotinia fuckeliana assessed as mycelial growth inhibition at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID1110819 | Fungicidal activity against Rhizoctonia solani assessed as inhibition of fungal growth at 50 ug/ml after 48 hr | 2006 | Bioorganic & medicinal chemistry, Dec-15, Volume: 14, Issue:24 | Microwave-assisted, one-pot syntheses and fungicidal activity of polyfluorinated 2-benzylthiobenzothiazoles. |
| AID1090625 | Antifungal activity against Fusarium oxysporum assessed as inhibition rate at 50 ug/mL | 2007 | Journal of agricultural and food chemistry, Apr-18, Volume: 55, Issue:8 | Design, synthesis, and fungicidal activities of new strobilurin derivatives. |
| AID1091501 | Fungicidal activity against Alternaria solani assessed as growth inhibition at 50 ug/ml at 23 degC after 3 days | 2008 | Journal of agricultural and food chemistry, Nov-26, Volume: 56, Issue:22 | Synthesis and biological activities of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety. |
| AID1080472 | In vitro fungicidal activity against Colletotrichum gossypii assessed as mycelial growth inhibition at 100 mg/l at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID1110816 | Fungicidal activity against Colletotrichum gossypii assessed as inhibition of fungal growth at 50 ug/ml after 48 hr | 2006 | Bioorganic & medicinal chemistry, Dec-15, Volume: 14, Issue:24 | Microwave-assisted, one-pot syntheses and fungicidal activity of polyfluorinated 2-benzylthiobenzothiazoles. |
| AID750181 | Antifungal activity against Fusarium oxysporum assessed as inhibition of mycelia elongation rate at 50 ppm after 48 hrs relative to control | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety. |
| AID613974 | Fungicidal activity against Fusarium moniliforme assessed as mycelium growth inhibition after 72 hrs | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles. |
| AID1080730 | Binding affinity to Penicillium digitatum CYP51 expressed in Escherichia coli BL21 (DE3) cells assessed as absorption spectral changes with maximum at 420-430 nm and trough at 390-410 nm (type II) by binding spectrum method | 2009 | Journal of agricultural and food chemistry, Aug-12, Volume: 57, Issue:15 | Determination of stereoselective interaction between enantiomers of chiral gamma-aryl-1H-1,2,4-triazole derivatives and Penicillium digitatum. |
| AID445781 | Antifungal activity against Botrytis cinerea at 50 mg/L relative to control | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23 | A facile synthesis and biological activity of novel tetrahydrobenzo[4',5']thieno[3',2':5,6]pyrido[4,3-d]pyrimidin-4(3H)-ones. |
| AID1080461 | In vitro fungicidal activity against Dothiorella gregaria assessed as mycelial growth inhibition at 26 degC after 48 hr by agar diffusion assay | 2008 | Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23 | Chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities. |
| AID667799 | Growth inhibition of Colletotrichum gloeosporioides at 150 mg/mL after 48 hrs by mycelium growth rate method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 8 (3.45) | 18.7374 |
| 1990's | 27 (11.64) | 18.2507 |
| 2000's | 82 (35.34) | 29.6817 |
| 2010's | 87 (37.50) | 24.3611 |
| 2020's | 28 (12.07) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (28.61) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (1.23%) | 6.00% |
| Case Studies | 1 (0.41%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 240 (98.36%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||