A membrane transport modulator that is able to regulate intracellular calcium levels.
ChEBI ID: 38808
| Member | Definition | Class |
|---|---|---|
| calcitriol | A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol. | calcitriol |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 3,004 (19.42) | 18.7374 |
| 1990's | 4,738 (30.63) | 18.2507 |
| 2000's | 3,655 (23.63) | 29.6817 |
| 2010's | 3,359 (21.71) | 24.3611 |
| 2020's | 713 (4.61) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,224 (7.60%) | 5.53% |
| Reviews | 1,802 (11.19%) | 6.00% |
| Case Studies | 999 (6.20%) | 4.05% |
| Observational | 40 (0.25%) | 0.25% |
| Other | 12,042 (74.76%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 19.9526 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 10.0000 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 21.1360 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 32.9993 | 1 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 13.4574 | 2 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.0057 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 32.9993 | 1 | 2 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 39.8107 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 39.7000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 0.0093 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.0093 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| Vitamin D3 receptor | Bos taurus (cattle) | IC50 | 0.0000 | 1 | 1 |
| Vitamin D3 receptor | Homo sapiens (human) | IC50 | 0.3401 | 19 | 19 |
| Vitamin D3 receptor | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 11 | 11 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | Homo sapiens (human) | EC50 | 0.0030 | 1 | 1 |
| Chain A, Vitamin D Nuclear Receptor | Homo sapiens (human) | Kd | 0.0006 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | EC50 | 0.0000 | 1 | 1 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | EC50 | 0.0016 | 1 | 1 |
| Vitamin D-binding protein | Homo sapiens (human) | Kd | 0.0240 | 1 | 1 |
| Vitamin D3 receptor | Bos taurus (cattle) | EC50 | 0.0001 | 2 | 2 |
| Vitamin D3 receptor | Homo sapiens (human) | EC50 | 0.0394 | 36 | 36 |
| Vitamin D3 receptor | Mus musculus (house mouse) | EC50 | 0.1000 | 1 | 1 |
| Vitamin D3 receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0002 | 7 | 7 |
| Vitamin D3 receptor | Homo sapiens (human) | Kd | 0.0001 | 1 | 1 |
| Vitamin D3 receptor | Sus scrofa (pig) | Kd | 0.0001 | 1 | 1 |
| Vitamin D3 receptor A | Danio rerio (zebrafish) | EC50 | 0.0055 | 1 | 1 |
| Vitamin D3 receptor A | Danio rerio (zebrafish) | Kd | 1.2000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 1A2 | Homo sapiens (human) | ED50 | 0.0002 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | ED50 | 0.0002 | 1 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | ED50 | 0.0002 | 1 | 1 |
| Vitamin D3 receptor | Homo sapiens (human) | ED50 | 0.1007 | 4 | 4 |
| Vitamin D3 receptor | Rattus norvegicus (Norway rat) | ED50 | 500,000.0002 | 6 | 6 |