Page last updated: 2024-08-05 14:53:00
fungal xenobiotic metabolite
Any fungal metabolite produced by metabolism of a xenobiotic compound in fungi.
ChEBI ID: 76968
Members (9)
| Member | Definition | Class |
|---|---|---|
| 1-hydroxy-2-naphthoic acid | A naphthoic acid with the carboxy group at position 2 and carrying a hydroxy substituent at the 1-position. It is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms. | 1-hydroxy-2-naphthoic acid |
| 1-naphthoic acid | A naphthoic acid carrying a carboxy group at position 1. | 1-naphthoic acid |
| 2-amino-4,6-dinitrotoluene | An amino-nitrotoluene that is 4,6-dinitrotoluene substituted at position 2 by an amino group. | 2-amino-4,6-dinitrotoluene |
| 4-amino-2,6-dinitrotoluene | An amino-nitrotoluene that is 2,6-dinitrotoluene substituted at position 4 by an amino group. | 4-amino-2,6-dinitrotoluene |
| 4-ethylphenol | A member of the class of phenols carrying an ethyl substituent at position 4. | 4-ethylphenol |
| 4',7-dihydroxyflavanone | A dihydroxyflavanone in which the two hydroxy substituents are located at positions 4' and 7. | 4',7-dihydroxyflavanone |
| 6-hydroxyflavanone | A monohydroxyflavanone that is flavanone substituted by a hydroxy group at position 6. | 6-hydroxyflavanone |
| 9-fluorenone | The simplest member of the class fluoren-9-ones that is 9H-fluorene bearing an oxo substituent at position 9. | fluoren-9-one |
| melilotic acid | A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 3 is substituted by a 2-hydroxyphenyl group. | 3-(2-hydroxyphenyl)propanoic acid |
Research
Studies (379)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 35 (9.23) | 18.7374 |
| 1990's | 31 (8.18) | 18.2507 |
| 2000's | 128 (33.77) | 29.6817 |
| 2010's | 161 (42.48) | 24.3611 |
| 2020's | 24 (6.33) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (0.47%) | 5.53% |
| Reviews | 7 (1.65%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 414 (97.87%) | 84.16% |
Protein Targets (19)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 0.5012 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 55.6071 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 55.9264 | 2 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 72.9531 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 28.0296 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 55.8217 | 3 | 3 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 18.6209 | 1 | 1 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| L-lactate dehydrogenase A chain | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| L-lactate dehydrogenase A chain | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| L-lactate dehydrogenase B chain | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 100.0000 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 1,000.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 850.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Trichosurin | Trichosurus vulpecula (common brushtail) | Kd | 30.0000 | 1 | 1 |
| glycogen synthase kinase-3 beta isoform 1 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 1 |
| L-lactate dehydrogenase A chain | Homo sapiens (human) | Kd | 640.0000 | 2 | 2 |
| L-lactate dehydrogenase A chain | Rattus norvegicus (Norway rat) | Kd | 640.0000 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Sulfotransferase 1A1 | Rattus norvegicus (Norway rat) | Km | 10.0000 | 1 | 1 |