A chemical substance that interrupts pregnancy after implantation.
ChEBI ID: 50691
| Member | Definition | Class |
|---|---|---|
| carboprost | Prostaglandin F2alpha in which the hydrogen at position 15 is substituted by methyl (S configuration). It is used as an abortifacient agent that is effective in both the first and second trimesters of pregnancy. | carboprost |
| fluprostenol | An organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea. | fluprostenol |
| methotrexate | methotrexate | |
| mifepristone | mifepristone | |
| trilostane | An epoxy steroid that is 3,17beta-dihydroxy-5alpha-androst-2-ene-2-carbonitrile in which the oxygen of the epoxy group is joined to the 4alpha and 5 alpha positions. | trilostane |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 12,702 (27.85) | 18.7374 |
| 1990's | 8,833 (19.36) | 18.2507 |
| 2000's | 9,255 (20.29) | 29.6817 |
| 2010's | 10,869 (23.83) | 24.3611 |
| 2020's | 3,957 (8.67) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 6,319 (12.95%) | 5.53% |
| Reviews | 5,266 (10.79%) | 6.00% |
| Case Studies | 6,891 (14.12%) | 4.05% |
| Observational | 373 (0.76%) | 0.25% |
| Other | 29,937 (61.36%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 30.3001 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 1.4862 | 2 | 4 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 32.5597 | 1 | 3 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 19.6222 | 1 | 2 |
| Androgen receptor | Homo sapiens (human) | Potency | 0.0050 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 14.1254 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 15.7737 | 12 | 38 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 16.5095 | 2 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 16.9433 | 2 | 4 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 18.9695 | 1 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 13.6344 | 2 | 4 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 23.2809 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Caspase-7 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 26.8244 | 3 | 12 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 0.1000 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 29.9033 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 25.1189 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 29.2954 | 2 | 4 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 16.0604 | 2 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 60.1349 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 31.8261 | 2 | 3 |
| ClpP | Bacillus subtilis | Potency | 23.7358 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 1.7377 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 7.7619 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.2302 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 16.1854 | 1 | 4 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 2.3108 | 1 | 1 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 11.6681 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 54.4152 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 46.7791 | 1 | 2 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 2.3106 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 17.9536 | 10 | 37 |
| Estrogen receptor | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 5.0625 | 3 | 6 |
| Estrogen receptor beta | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 18.0016 | 10 | 40 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.6838 | 1 | 6 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.1553 | 4 | 8 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 25.9377 | 3 | 8 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 33.1734 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 1.7377 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 12.6944 | 1 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 30.2035 | 2 | 8 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Potency | 0.0008 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 17.6293 | 3 | 8 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 29.3732 | 1 | 3 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 17.5836 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 28.6855 | 1 | 5 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 55.0495 | 2 | 6 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 1.7377 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 19.8384 | 2 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 43.6412 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 0.0052 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 1.7377 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 0.1000 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 0.1000 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 1.7377 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 4.4983 | 2 | 4 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 45.6750 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 21.8865 | 2 | 4 |
| Mineralocorticoid receptor | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 14.1254 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 11.5182 | 3 | 14 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 12.2837 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 8.9125 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 25.6890 | 2 | 6 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 23.9341 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 18.1126 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 10.8675 | 5 | 16 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 13.3281 | 5 | 9 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 50.1187 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 8.9125 | 1 | 1 |
| polyprotein | Zika virus | Potency | 33.1734 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 24.6176 | 2 | 3 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 7.5429 | 2 | 7 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 32.8669 | 2 | 8 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 15.0030 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 25.5204 | 3 | 9 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 13.4354 | 4 | 13 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 17.4745 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 23.0393 | 2 | 7 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 23.0393 | 2 | 7 |
| snurportin-1 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 5.0119 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 6.0044 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 10.5571 | 2 | 13 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 28.4313 | 3 | 7 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 15.0286 | 2 | 9 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 8.9125 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 8.9125 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 53.1764 | 1 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 26.9523 | 4 | 7 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 48.0224 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 29.3732 | 1 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0014 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0011 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0146 | 2 | 2 |
| 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens (human) | Ki | 136.7000 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 26.4600 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 12.0820 | 1 | 1 |
| Androgen receptor | Homo sapiens (human) | IC50 | 0.2988 | 18 | 21 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0083 | 1 | 1 |
| Androgen receptor | Homo sapiens (human) | Ki | 0.0087 | 6 | 6 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.0056 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| ATP-binding cassette sub-family C member 3 | Rattus norvegicus (Norway rat) | Ki | 90.0000 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | IC50 | 0.0840 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | IC50 | 5.7614 | 29 | 39 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Trypanosoma cruzi | IC50 | 0.1100 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Leishmania major | Ki | 0.0001 | 1 | 1 |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | IC50 | 10.0050 | 2 | 2 |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | Ki | 0.8800 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 400.5033 | 4 | 6 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 341.3333 | 3 | 3 |
| Chain A, PROGESTERONE RECEPTOR | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Coagulation factor VII | Homo sapiens (human) | IC50 | 0.0003 | 1 | 1 |
| Cytochrome P450 11B1, mitochondrial | Bos taurus (cattle) | IC50 | 0.0012 | 2 | 5 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 1.5000 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 4.9000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 9.5000 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 4.7000 | 2 | 2 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| Dihydrofolate reductase | Enterococcus faecium | IC50 | 0.0014 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | IC50 | 4.1688 | 24 | 34 |
| Dihydrofolate reductase | Gallus gallus (chicken) | IC50 | 0.0545 | 2 | 2 |
| Dihydrofolate reductase | Homo sapiens (human) | IC50 | 1.5079 | 80 | 94 |
| Dihydrofolate reductase | Lacticaseibacillus casei | IC50 | 0.0138 | 29 | 30 |
| Dihydrofolate reductase | Mus musculus (house mouse) | IC50 | 0.0331 | 11 | 11 |
| Dihydrofolate reductase | Mycobacterium tuberculosis H37Rv | IC50 | 0.0174 | 3 | 3 |
| Dihydrofolate reductase | Pneumocystis carinii | IC50 | 0.0717 | 12 | 13 |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | IC50 | 0.0047 | 10 | 11 |
| Dihydrofolate reductase | Escherichia coli K-12 | Ki | 34.5460 | 5 | 5 |
| Dihydrofolate reductase | Homo sapiens (human) | Ki | 0.4019 | 11 | 11 |
| Dihydrofolate reductase | Lacticaseibacillus casei | Ki | 0.0000 | 1 | 1 |
| Dihydrofolate reductase | Mus musculus (house mouse) | Ki | 0.2167 | 17 | 18 |
| Dihydrofolate reductase | Pneumocystis carinii | Ki | 0.0000 | 1 | 1 |
| Dihydrofolate reductase | Staphylococcus aureus | Ki | 0.0005 | 2 | 2 |
| Dihydrofolate reductase | Bacillus anthracis | IC50 | 0.0136 | 1 | 2 |
| Dihydrofolate reductase | Bos taurus (cattle) | IC50 | 722.1480 | 11 | 11 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 6.6102 | 8 | 8 |
| Estrogen receptor | Homo sapiens (human) | Ki | 6.7385 | 4 | 4 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 3.5140 | 4 | 4 |
| Estrogen receptor beta | Homo sapiens (human) | Ki | 4.5420 | 3 | 3 |
| Fatty-acid amide hydrolase 1 | Mus musculus (house mouse) | IC50 | 0.0800 | 1 | 1 |
| Folate receptor alpha | Homo sapiens (human) | IC50 | 0.2262 | 4 | 4 |
| Folate receptor beta | Homo sapiens (human) | IC50 | 0.1585 | 4 | 4 |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| Folylpolyglutamate synthase, mitochondrial | Mus musculus (house mouse) | Ki | 166.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 0.2587 | 51 | 51 |
| Glucocorticoid receptor | Mus musculus (house mouse) | IC50 | 0.0022 | 1 | 1 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.7740 | 6 | 9 |
| Glucocorticoid receptor | Sus scrofa (pig) | IC50 | 0.0153 | 2 | 2 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 0.0149 | 21 | 21 |
| Glucocorticoid receptor | Canis lupus familiaris (dog) | IC50 | 0.0264 | 2 | 2 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 91.0000 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0022 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0022 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0022 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.0022 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| Histidine decarboxylase | Rattus norvegicus (Norway rat) | IC50 | 0.0014 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 20.0960 | 1 | 1 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 8.0380 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | IC50 | 2.5337 | 10 | 13 |
| Mineralocorticoid receptor | Homo sapiens (human) | Ki | 3.8303 | 3 | 3 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 83.0610 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 2.4570 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.9970 | 1 | 1 |
| Multidrug resistance associated protein | Homo sapiens (human) | Ki | 1,200.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| nuclear receptor coactivator 1 isoform 1 [Homo sapiens] | Homo sapiens (human) | IC50 | 35.8790 | 2 | 2 |
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | IC50 | 18.0450 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 0.5550 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 0.1347 | 42 | 45 |
| Progesterone receptor | Homo sapiens (human) | Ki | 0.0045 | 13 | 13 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 0.0078 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 0.0003 | 1 | 1 |
| Protein-arginine deiminase type-4 | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| Proton-coupled folate transporter | Homo sapiens (human) | IC50 | 0.1208 | 2 | 2 |
| Pteridine reductase 1 | Leishmania major | Ki | 0.1095 | 2 | 2 |
| Reduced folate transporter | Homo sapiens (human) | IC50 | 0.0120 | 2 | 2 |
| Reduced folate transporter | Homo sapiens (human) | Ki | 3.5000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 26.2800 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 11.0470 | 1 | 1 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 599.7800 | 1 | 2 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 896.1255 | 1 | 2 |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Rattus norvegicus (Norway rat) | IC50 | 0.0016 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0015 | 2 | 2 |
| Thymidylate synthase | Escherichia coli K-12 | IC50 | 11.4303 | 3 | 12 |
| Thymidylate synthase | Homo sapiens (human) | IC50 | 33.6082 | 12 | 21 |
| Thymidylate synthase | Lacticaseibacillus casei | IC50 | 158.1000 | 10 | 10 |
| Thymidylate synthase | Mus musculus (house mouse) | IC50 | 20.0000 | 2 | 2 |
| Thymidylate synthase | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| Thymidylate synthase | Mus musculus (house mouse) | Ki | 45.0000 | 1 | 1 |
| Thymidylate synthase | Escherichia coli | IC50 | 60.6000 | 3 | 3 |
| Thymidylate synthase | Escherichia coli LF82 | IC50 | 18.0000 | 1 | 1 |
| Thyroid hormone receptor alpha | Homo sapiens (human) | Ki | 1.2500 | 1 | 1 |
| Thyroid hormone receptor beta | Homo sapiens (human) | Ki | 2.2500 | 1 | 1 |
| Tissue factor | Homo sapiens (human) | IC50 | 0.0003 | 1 | 1 |
| Toll-like receptor 4 | Homo sapiens (human) | IC50 | 1.0400 | 1 | 1 |
| transactivating tegument protein VP16 [Human herpesvirus 1] | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | IC50 | 35.8790 | 2 | 2 |
| Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | IC50 | 10.0050 | 2 | 2 |
| Trifunctional purine biosynthetic protein adenosine-3 | Mus musculus (house mouse) | IC50 | 20.0000 | 2 | 2 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 21.3570 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | EC50 | 0.0092 | 2 | 2 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | EC50 | 0.0158 | 1 | 2 |
| Androgen receptor | Homo sapiens (human) | EC50 | 0.0113 | 3 | 3 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Kd | 20.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | EC50 | 0.0010 | 1 | 1 |
| Chain B, DIHYDROFOLATE REDUCTASE | Escherichia coli | Kd | 0.1344 | 1 | 5 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | EC50 | 0.0010 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | EC50 | 0.0010 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | Kd | 0.3062 | 10 | 10 |
| Estrogen receptor | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Estrogen receptor beta | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | EC50 | 0.7292 | 6 | 6 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0025 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Kd | 0.0150 | 1 | 1 |
| High mobility group protein B1 | Homo sapiens (human) | Kd | 0.2620 | 2 | 2 |
| Mineralocorticoid receptor | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | EC50 | 5.0002 | 2 | 2 |
| Progesterone receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0158 | 1 | 1 |
| Prostacyclin receptor | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Prostaglandin E2 receptor EP3 subtype | Homo sapiens (human) | EC50 | 3.4000 | 1 | 1 |
| Prostaglandin F2-alpha receptor | Homo sapiens (human) | EC50 | 0.0036 | 1 | 1 |
| Tegument protein VP16 | Human alphaherpesvirus 1 strain 17 | EC50 | 0.0007 | 1 | 1 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | EC50 | 0.0010 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | ID50 | 0.0500 | 1 | 1 |
| ATP-binding cassette sub-family C member 11 | Homo sapiens (human) | Km | 957.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Rattus norvegicus (Norway rat) | Km | 8.1000 | 2 | 2 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | Km | 2,560.0000 | 3 | 3 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Km | 296.0000 | 1 | 1 |
| Dihydrofolate reductase | Homo sapiens (human) | IC80 | 1.4400 | 1 | 1 |
| Dihydrofolate reductase | Lacticaseibacillus casei | ID50 | 0.0130 | 5 | 5 |
| Dihydrofolate reductase | Mus musculus (house mouse) | ID50 | 0.0171 | 6 | 6 |
| Folylpolyglutamate synthase, mitochondrial | Mus musculus (house mouse) | Concentration | 47.0000 | 1 | 2 |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | Km | 71.3333 | 3 | 3 |
| Folylpolyglutamate synthase, mitochondrial | Mus musculus (house mouse) | Km | 165.0000 | 1 | 1 |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | Vmax | 0.8200 | 1 | 1 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | Activity | 0.2700 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Kapp | 32.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Kif | 0.0020 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | Kif | 0.0100 | 1 | 1 |
| Multidrug resistance associated protein | Homo sapiens (human) | Km | 768.6667 | 3 | 3 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | Km | 1,540.0000 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | Km | 1,300.0000 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | Activity | 0.0013 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | Kif | 0.0118 | 1 | 1 |
| Solute carrier family 22 member 11 | Homo sapiens (human) | Km | 17.8000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | Km | 553.8000 | 1 | 1 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Km | 16.0000 | 2 | 2 |
| Solute carrier organic anion transporter family member 1A3 | Rattus norvegicus (Norway rat) | Km | 1.6333 | 3 | 3 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Km | 24.7000 | 1 | 1 |