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mammalian metabolite

Any animal metabolite produced during a metabolic reaction in mammals.

ChEBI ID: 75768

Members (31)

MemberDefinitionClass
14-methylhexadecanoic acidA methyl-branched fatty acid that is hexadecanoic acid (palmitic acid) substituted by a methyl group at position 14.14-methylhexadecanoic acid
18-methyleicosanoic acidA methyl-branched fatty acid that is arachidic acid substituted by a methyl group at position 18.18-methylicosanoic acid
2-aminoadipic acidAn alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.2-aminoadipic acid
2,3,4-trimethylpentaneAn alkane that is pentane substituted by a methyl group at positions 2,3 and 4. It is a constituent of gasoline.2,3,4-trimethylpentane
2,8-dihydroxyadenineAn oxopurine that is adenine bearing two oxo substituents at positions 2 and 8.2,8-dihydroxyadenine; 2,8-dioxoadenine
3-chloro-4-hydroxyphenylacetic acidA hydroxy monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 3-chloro-4-hydroxyphenyl group. It is a major chlorinated metabolite of chlorotyrosine.(3-chloro-4-hydroxyphenyl)acetic acid
4-methyl-3-heptanoneA dialkyl ketone that is 4-methylheptane substituted by an oxo group at position 3.4-methylheptan-3-one
6 beta-hydroxycortisolA C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.6beta-hydroxycortisol
aflatoxin m1A member of the class of aflatoxins that is aflatoxin B1 in which the hydrogen at position 9a is replaced by a hydroxy group.aflatoxin M1
albicanolA drimane-type sesquiterpenoid orginally isolated from the liverwort Diplophyllum albicans. It exhibits fish antifeedant, antifungal and antineoplastic activities.(+)-albicanol
ambreinA triterpenoid alcohol that is a constituent of ambergris, an intestinal secretion of the sperm whale Physeter catodon.ambrein
androst-16-en-3-oneAn androstanoid that is 5alpha-androst-16-ene substituted by an oxo group at position 3. It is a steroid pheromone found in high concentrations in the saliva of male pigs,.5alpha-androst-16-en-3-one
androstane-3,6,17-triolA 3beta sterol that is 5alpha-androstane which is substituted by beta-hydroxy groups at positions 3 and 17 and by an alpha-hydroxy group at position 6.5alpha-androstane-3beta,6alpha,17beta-triol
androstane-3,7,17-triolA 3beta sterol that is 5alpha-androstane which is substituted by beta-hydroxy groups at positions 3 and 17 and by an alpha-hydroxy group at position 7.5alpha-androstane-3beta,7alpha,17beta-triol
benzamidoximeA member of the class of amidoximes obtained by formal condensation of the carbonyl group of benzamide with hydroxylamine.benzamidoxime
cyclic 3',5'-uridine monophosphateA 3',5'-cyclic pyrimidine nucleotide having uridine as the nucleobase.3',5'-cyclic UMP
cyclic impA 3',5'-cyclic purine nucleotide having hypoxanthine as the nucleobase.3',5'-cyclic IMP
cystathionine ketimineA 1-thia-4-azacyclohepta-3-ene-3,5-dicarboxylic acid that has R-configuration. It is cyclic sulfur-containing imino acid detected in bovine brain extracts.cystathionine ketimine
delta-1-piperidine-6-carboxylic acidA tetrahydropyridine that is 2,3,4,5-tetrahydropyridine having a carboxy group at the 2-position.1-piperideine-6-carboxylic acid
dimethyldiselenideAn organoselenium compound that is diselane covalently bound to two methyl groups. It has been detected in onion-family vegetables and soft-necked garlics. It induces ER stress and toxic protein aggregation in the budding yeast, S. cerevisiae and used as a reagent to identify distonic radical cations.dimethyl diselenide
equileninA 3-hydroxy steroid that is estrone which carries two double bonds at positions 6 and 8. It is found in the urine of pregnant mare's and extensively used for estrogen replacement therapy in postmenopausal women.equilenin
erucyl amideA primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia. It is commonly used as a slip additive in the plastic manufacturing industry.erucamide
estradiol-3-sulfateA steroid sulfate obtained by the formal condensation of sulfuric acid with the 3-hydroxy group of 17beta-estradiol.17beta-estradiol 3-sulfate
felinineA cysteine thioether that is the S-(4-hydroxy-2-methylbutan-2-yl) derivative of L-cysteine. It is a major component of the urine of the domestic cat.felinine zwitterion; felinine
glutaurineA dipeptide resulting from the formal condensation of the amino group of taurine with the gamma-carboxy group of L-glutamic acid. It was initially found in the parathyroid in 1980 and later in the brain of mammals.glutaurine zwitterion; glutaurine
isovaleric acidA C5, branched-chain saturated fatty acid.isovaleric acid
margaric acidA C17 saturated fatty acid and trace component of fats in ruminants.heptadecanoic acid
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucoseAn amino trisaccharide that is the carbohydrate portion of ganglioside GM3. It comprises a linear sequence of alpha-N-acetylneuraminyl, beta-D-galactosyl and beta-D-glucose residues linked (2->3) and (1->4).3)-beta-D-galactosyl-(1->4)-beta-D-glucose.html>N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose
n-arachidonoyl l-serineAn N-acyl-amino acid resulting from the formal condensation of the carboxy group of arachidonic acid with the amino group of L-serine. It is an endocannabinoid-like lipid isolated from bovine brains.N-arachidonoyl-L-serine
n-arachidonoylalanineAn N-acyl-L-alanine resulting from the formal condensation of the amino group of L-alanine with the carboxy group of arachidonic acid.N-arachidonoyl-L-alanine
skatoleA methylindole carrying a methyl substituent at position 3. It is produced during the anoxic metabolism of L-tryptophan in the mammalian digestive tract.skatole

Research

Studies (3,150)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990957 (30.38)18.7374
1990's494 (15.68)18.2507
2000's644 (20.44)29.6817
2010's812 (25.78)24.3611
2020's243 (7.71)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials99 (2.92%)5.53%
Reviews135 (3.99%)6.00%
Case Studies159 (4.70%)4.05%
Observational4 (0.12%)0.25%
Other2,988 (88.27%)84.16%

Protein Targets (49)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AR proteinHomo sapiens (human)Potency9.220134
ATAD5 protein, partialHomo sapiens (human)Potency11.582111
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency23.934111
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency0.005611
Chain A, Beta-lactamaseEscherichia coli K-12Potency14.348412
chromobox protein homolog 1Homo sapiens (human)Potency100.000011
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency5.185211
estrogen nuclear receptor alphaHomo sapiens (human)Potency10.321656
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency7.719625
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency3.162311
gemininHomo sapiens (human)Potency9.331924
GLI family zinc finger 3Homo sapiens (human)Potency14.960122
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency1.000011
Microtubule-associated protein tauHomo sapiens (human)Potency22.387211
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency53.266022
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency45.335233
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency44.668411
plasminogen precursorMus musculus (house mouse)Potency2.818411
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency25.118911
pregnane X nuclear receptorHomo sapiens (human)Potency59.765511
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency20.143124
retinoid X nuclear receptor alphaHomo sapiens (human)Potency8.741822
serine-protein kinase ATM isoform aHomo sapiens (human)Potency35.481311
TDP1 proteinHomo sapiens (human)Potency23.109311
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency33.491511
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency2.818411
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency2.818411

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Beta-carbonic anhydrase 1Mycobacterium tuberculosis H37RvKi10.300011
Cannabinoid receptor 1Homo sapiens (human)Ki10.000011
Cannabinoid receptor 2 Homo sapiens (human)Ki10.000011
Carbonic anhydraseCandida albicans SC5314Ki1.080011
Carbonic anhydrase Cryptococcus neoformans var. grubiiKi1.120011
Carbonic anhydrase Mycobacterium tuberculosis H37RvKi10.800011
Carbonic anhydrase 1Homo sapiens (human)Ki265.000011
Carbonic anhydrase 2Homo sapiens (human)Ki8.600011
Multidrug resistance-associated protein 1 Homo sapiens (human)Ki0.380011
Sialic acid-binding Ig-like lectin 7Homo sapiens (human)IC5036,900.000011
Sodium- and chloride-dependent glycine transporter 2Homo sapiens (human)IC509.000011
Solute carrier family 22 member 20Mus musculus (house mouse)Ki32.329712
Solute carrier family 22 member 6Mus musculus (house mouse)Ki2,339.615012
Solute carrier organic anion transporter family member 1A1Rattus norvegicus (Norway rat)Ki1.100011
Transient receptor potential cation channel subfamily V member 2Rattus norvegicus (Norway rat)IC503.885022

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, ChloroPhenol Reduction gene KDesulfitobacterium hafnienseKd4.100011
Chain A, Steroid Delta-isomeraseComamonas testosteroniKd1.400011
Chain B, ChloroPhenol Reduction gene KDesulfitobacterium hafnienseKd4.100011
Galectin-8Homo sapiens (human)Kd2.300011
Sex hormone-binding globulinHomo sapiens (human)Kd0.002411
Sialic acid-binding Ig-like lectin 7Homo sapiens (human)Kd680.000011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Carbonic anhydrase 1Homo sapiens (human)Kinact265.000011
Carbonic anhydrase 2Homo sapiens (human)Kinact8.600011
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Kinact0.100011
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Kinact0.118011