Page last updated: 2024-12-05

coumarin-3-carboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Coumarin-3-carboxylic acid (3-CCA) is a naturally occurring compound found in various plants. It exhibits diverse biological activities, including anti-inflammatory, antimicrobial, and anticancer properties. Its synthesis involves various methods, including the Knoevenagel condensation of coumarin with malonic acid. 3-CCA has garnered significant research interest due to its potential therapeutic applications. Studies have investigated its ability to inhibit the growth of various cancer cell lines, suggesting its potential as a chemotherapeutic agent. Furthermore, its anti-inflammatory properties have been explored for the treatment of inflammatory diseases such as arthritis. The compound's ability to modulate various biological pathways, including apoptosis, angiogenesis, and inflammation, makes it a promising candidate for drug development.'

coumarin-3-carboxylic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10752
CHEMBL ID83294
CHEBI ID192605
SCHEMBL ID93571
MeSH IDM0272317

Synonyms (75)

Synonym
CBDIVE_014214
CHEMBL83294 ,
BB 0217624
nsc-44926
nsc53239
nsc-53239
nsc44926
IFLAB1_000764
NCI60_004309
g 1 (van)
brn 0154276
einecs 208-518-0
g 1 (the rodenticide) (van)
nsc 53239
malonic acid, salicylidene-, delta-lactone
nsc 14797
g 1 (rodenticide)
2-oxo-2h-chromene-3-carboxylic acid
ai3-36066
g 1 (the rodenticide)
malonic acid, .delta.-lactone
531-81-7
coumarin-3-carboxylic acid
nsc14797
3-carboxycoumarin
nsc-14797
2-oxobenzopyran-3-carboxylic acid
wln: t66 bovj dvq
2h-1-benzopyran-3-carboxylic acid, 2-oxo-
OPREA1_710975
STK298836
2-oxochromene-3-carboxylic acid
smr000015715
MLS000100456
coumarin-3-carboxylic acid, 99%
SR-01000389273-3
NCI60_001013
bdbm50131066
AKOS000104806
HMS1414C16
CHEBI:192605
BBL005487
HMS2250I22
S9361
CCG-42658
unii-v85uov8788
v85uov8788 ,
BP-11788
F0266-1412
FT-0624080
AE-641/00583032
coumarin-3-carboxylic acid [mi]
1,2-benzopyran-3-carboxylic acid, 2-keto-
2h-1-benzopyran-2-one-3-carboxylic acid
3-carboxylcoumarin
2-oxo-2h-1-benzopyran-3-carboxylic acid
SCHEMBL93571
3-carboxy-coumarin
3-carboxy coumarine
benzopyran-3-carboxylic acid, 2h-1-, 2-oxo
malonic acid, salicylidene-, .delta.-lactone
2-oxo-2h-chromene-3-carboxylic acid #
mfcd00006852
DTXSID70201183
SR-01000389273-1
sr-01000389273
coumarin-3-carboxylicacid
Z56824632
HY-W027968
C3129
EN300-16938
STR04665
Q27291656
CS-0071992
2-oxo-2h-chromene-3-carboxylicacid

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The most significant protective effect was demonstrated when 1 mg/kg dosage of C(60)HyFn was administered before irradiation."( Peculiarities of the antioxidant and radioprotective effects of hydrated C60 fullerene nanostuctures in vitro and in vivo.
Andrievsky, GV; Bruskov, VI; Gudkov, SV; Tykhomyrov, AA, 2009
)
0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
coumarins
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (26)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Beta-lactamaseEscherichia coli K-12Potency56.23410.044717.8581100.0000AID485294
LuciferasePhotinus pyralis (common eastern firefly)Potency23.93410.007215.758889.3584AID588342
ATAD5 protein, partialHomo sapiens (human)Potency18.35640.004110.890331.5287AID504466
thyroid stimulating hormone receptorHomo sapiens (human)Potency19.95260.001318.074339.8107AID926; AID938
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency25.11890.28189.721235.4813AID2326
IDH1Homo sapiens (human)Potency2.59290.005210.865235.4813AID686970
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency89.12510.035520.977089.1251AID504332
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency1.41250.00798.23321,122.0200AID2546
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency3.16230.00419.962528.1838AID2675
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency10.00000.251215.843239.8107AID504327
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carbonic anhydrase 12Homo sapiens (human)Ki2.90000.00021.10439.9000AID444780
Carbonic anhydrase 1Homo sapiens (human)Ki9.30000.00001.372610.0000AID444771
Carbonic anhydrase 2Homo sapiens (human)Ki500.00000.00000.72369.9200AID444772
Carbonic anhydrase 3Homo sapiens (human)Ki6.60000.00022.010210.0000AID444773
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50 (µMol)1,000.00000.00053.49849.7600AID164993
Carbonic anhydrase 4Homo sapiens (human)Ki9.70000.00021.97209.9200AID444774
Carbonic anhydrase 6Homo sapiens (human)Ki76.30000.00011.47109.9200AID444777
Amine oxidase [flavin-containing] BHomo sapiens (human)IC50 (µMol)0.01740.00001.89149.5700AID744457
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki4.50000.00001.27259.9000AID444775
Carbonic anhydrase 7Homo sapiens (human)Ki6.20000.00021.37379.9000AID444778
Carbonic anhydrase 9Homo sapiens (human)Ki6.50000.00010.78749.9000AID444779
Carbonic anhydrase 15Mus musculus (house mouse)Ki8.80000.00091.884610.0000AID444783
Carbonic anhydrase 13Mus musculus (house mouse)Ki20.30000.00021.39749.9000AID444781
G-protein coupled receptor 35Homo sapiens (human)IC50 (µMol)100.00000.03001.39804.6600AID1460082
Carbonic anhydrase 14Homo sapiens (human)Ki8.20000.00021.50999.9000AID444782
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki34.30000.00001.34129.9700AID444776
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
G-protein coupled receptor 35Homo sapiens (human)EC50 (µMol)92.26000.00202.50079.8000AID1460081
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (67)

Processvia Protein(s)Taxonomy
estrous cycleCarbonic anhydrase 12Homo sapiens (human)
chloride ion homeostasisCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 1Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 2Homo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 2Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 2Homo sapiens (human)
angiotensin-activated signaling pathwayCarbonic anhydrase 2Homo sapiens (human)
regulation of monoatomic anion transportCarbonic anhydrase 2Homo sapiens (human)
secretionCarbonic anhydrase 2Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 2Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 2Homo sapiens (human)
positive regulation of dipeptide transmembrane transportCarbonic anhydrase 2Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 2Homo sapiens (human)
carbon dioxide transportCarbonic anhydrase 2Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 2Homo sapiens (human)
response to bacteriumCarbonic anhydrase 3Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 3Homo sapiens (human)
positive regulation of JUN kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
actin cytoskeleton organizationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of endocytosisTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulum unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of intracellular protein transportTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cellular response to unfolded proteinTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of MAP kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of protein tyrosine kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of receptor catabolic processTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
bicarbonate transportCarbonic anhydrase 4Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 4Homo sapiens (human)
detection of chemical stimulus involved in sensory perception of bitter tasteCarbonic anhydrase 6Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 6Homo sapiens (human)
response to xenobiotic stimulusAmine oxidase [flavin-containing] BHomo sapiens (human)
response to toxic substanceAmine oxidase [flavin-containing] BHomo sapiens (human)
response to aluminum ionAmine oxidase [flavin-containing] BHomo sapiens (human)
response to selenium ionAmine oxidase [flavin-containing] BHomo sapiens (human)
negative regulation of serotonin secretionAmine oxidase [flavin-containing] BHomo sapiens (human)
phenylethylamine catabolic processAmine oxidase [flavin-containing] BHomo sapiens (human)
substantia nigra developmentAmine oxidase [flavin-containing] BHomo sapiens (human)
response to lipopolysaccharideAmine oxidase [flavin-containing] BHomo sapiens (human)
dopamine catabolic processAmine oxidase [flavin-containing] BHomo sapiens (human)
response to ethanolAmine oxidase [flavin-containing] BHomo sapiens (human)
positive regulation of dopamine metabolic processAmine oxidase [flavin-containing] BHomo sapiens (human)
hydrogen peroxide biosynthetic processAmine oxidase [flavin-containing] BHomo sapiens (human)
response to corticosteroneAmine oxidase [flavin-containing] BHomo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 7Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 7Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 7Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 7Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 7Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 7Homo sapiens (human)
response to hypoxiaCarbonic anhydrase 9Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 9Homo sapiens (human)
response to xenobiotic stimulusCarbonic anhydrase 9Homo sapiens (human)
response to testosteroneCarbonic anhydrase 9Homo sapiens (human)
secretionCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 9Homo sapiens (human)
cytoskeleton organizationG-protein coupled receptor 35Homo sapiens (human)
G protein-coupled receptor signaling pathwayG-protein coupled receptor 35Homo sapiens (human)
positive regulation of cytosolic calcium ion concentrationG-protein coupled receptor 35Homo sapiens (human)
chemokine-mediated signaling pathwayG-protein coupled receptor 35Homo sapiens (human)
negative regulation of voltage-gated calcium channel activityG-protein coupled receptor 35Homo sapiens (human)
negative regulation of neuronal action potentialG-protein coupled receptor 35Homo sapiens (human)
positive regulation of Rho protein signal transductionG-protein coupled receptor 35Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathwayG-protein coupled receptor 35Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 14Homo sapiens (human)
response to bacteriumCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (26)

Processvia Protein(s)Taxonomy
zinc ion bindingCarbonic anhydrase 12Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 12Homo sapiens (human)
arylesterase activityCarbonic anhydrase 1Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 1Homo sapiens (human)
protein bindingCarbonic anhydrase 1Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 1Homo sapiens (human)
hydro-lyase activityCarbonic anhydrase 1Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 1Homo sapiens (human)
arylesterase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 2Homo sapiens (human)
protein bindingCarbonic anhydrase 2Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 2Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 3Homo sapiens (human)
protein bindingCarbonic anhydrase 3Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 3Homo sapiens (human)
nickel cation bindingCarbonic anhydrase 3Homo sapiens (human)
RNA bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
zinc ion bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
enzyme bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cadherin bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
ephrin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein phosphatase 2A bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein bindingCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 4Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 6Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 6Homo sapiens (human)
protein bindingAmine oxidase [flavin-containing] BHomo sapiens (human)
primary amine oxidase activityAmine oxidase [flavin-containing] BHomo sapiens (human)
electron transfer activityAmine oxidase [flavin-containing] BHomo sapiens (human)
identical protein bindingAmine oxidase [flavin-containing] BHomo sapiens (human)
aliphatic amine oxidase activityAmine oxidase [flavin-containing] BHomo sapiens (human)
monoamine oxidase activityAmine oxidase [flavin-containing] BHomo sapiens (human)
flavin adenine dinucleotide bindingAmine oxidase [flavin-containing] BHomo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 7Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 7Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 9Homo sapiens (human)
protein bindingCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 9Homo sapiens (human)
molecular function activator activityCarbonic anhydrase 9Homo sapiens (human)
C-X-C chemokine receptor activityG-protein coupled receptor 35Homo sapiens (human)
G protein-coupled receptor activityG-protein coupled receptor 35Homo sapiens (human)
C-X-C chemokine receptor activityG-protein coupled receptor 35Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 14Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 14Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (36)

Processvia Protein(s)Taxonomy
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
membraneCarbonic anhydrase 12Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 12Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 12Homo sapiens (human)
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
cytosolCarbonic anhydrase 1Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 1Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
myelin sheathCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 2Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytoplasmCarbonic anhydrase 3Homo sapiens (human)
plasma membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial matrixTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial cristaTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
sorting endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein-containing complexTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 4Homo sapiens (human)
rough endoplasmic reticulumCarbonic anhydrase 4Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartmentCarbonic anhydrase 4Homo sapiens (human)
Golgi apparatusCarbonic anhydrase 4Homo sapiens (human)
trans-Golgi networkCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
external side of plasma membraneCarbonic anhydrase 4Homo sapiens (human)
cell surfaceCarbonic anhydrase 4Homo sapiens (human)
membraneCarbonic anhydrase 4Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 4Homo sapiens (human)
transport vesicle membraneCarbonic anhydrase 4Homo sapiens (human)
secretory granule membraneCarbonic anhydrase 4Homo sapiens (human)
brush border membraneCarbonic anhydrase 4Homo sapiens (human)
perinuclear region of cytoplasmCarbonic anhydrase 4Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
extracellular regionCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
cytosolCarbonic anhydrase 6Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
mitochondrionAmine oxidase [flavin-containing] BHomo sapiens (human)
mitochondrial envelopeAmine oxidase [flavin-containing] BHomo sapiens (human)
mitochondrial outer membraneAmine oxidase [flavin-containing] BHomo sapiens (human)
dendriteAmine oxidase [flavin-containing] BHomo sapiens (human)
neuronal cell bodyAmine oxidase [flavin-containing] BHomo sapiens (human)
mitochondrionAmine oxidase [flavin-containing] BHomo sapiens (human)
mitochondrial matrixCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
cytosolCarbonic anhydrase 7Homo sapiens (human)
cytoplasmCarbonic anhydrase 7Homo sapiens (human)
nucleolusCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
membraneCarbonic anhydrase 9Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 9Homo sapiens (human)
microvillus membraneCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
plasma membraneG-protein coupled receptor 35Homo sapiens (human)
plasma membraneG-protein coupled receptor 35Homo sapiens (human)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
membraneCarbonic anhydrase 14Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 14Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 14Homo sapiens (human)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrial matrixCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (57)

Assay IDTitleYearJournalArticle
AID444775Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID1182960Antioxidant activity assessed as OH-induced DNA oxidation at 150 uM by TBARS method2014European journal of medicinal chemistry, Sep-12, Volume: 84Design and synthesis of coumarin-3-acylamino derivatives to scavenge radicals and to protect DNA.
AID1105455Antifungal activity against Aspergillus flavus LM 210 after 72 hr by broth microdilution method2013International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity.
AID444777Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID444780Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID444782Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID1182959Antioxidant activity assessed as protection against Cu2+/GSH-induced DNA oxidation at 150 uM up to 180 mins by TBARS method2014European journal of medicinal chemistry, Sep-12, Volume: 84Design and synthesis of coumarin-3-acylamino derivatives to scavenge radicals and to protect DNA.
AID444776Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID444783Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID1776685Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Synthesis and Biological Activity of Triterpene-Coumarin Conjugates.
AID444772Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID1105458Antifungal activity against Aspergillus fumigatus ATCC 40640 after 72 hr by broth microdilution method2013International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity.
AID1460082Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zaprinast stimulation measured after 8 minutes by DMR assay2017Journal of medicinal chemistry, 01-12, Volume: 60, Issue:1
Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists.
AID724211Binding affinity to Klebsiella pneumoniae ATCC 700603 assessed per 10'8 cells/ml at 50 uM after overnight incubation by fluorescence analysis2013European journal of medicinal chemistry, Jan, Volume: 59Novel fluorescent cephalosporins: synthesis, antimicrobial activity and photodynamic inactivation of antibiotic resistant bacteria.
AID736813Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as photodynamic inactivation measured as lethality at 10 uM2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
Novel fluorescent risedronates: synthesis, photodynamic inactivation and imaging of Bacillus subtilis.
AID1105459Antifungal activity against Aspergillus fumigatus ATCC 46913 after 72 hr by broth microdilution method2013International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity.
AID444774Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID750755Inhibition of Gloeobacter violaceus ligand-gated ion channel expressed in Xenopus laevis oocytes assessed as inhibition of MES buffer pH 5.5 -induced currents at 1 mM after 30 secs by voltage clamp technique2013Journal of medicinal chemistry, Jun-13, Volume: 56, Issue:11
Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC.
AID1105461Antifungal activity against Aspergillus fumigatus ATCC 16913 after 72 hr by broth microdilution method2013International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity.
AID1776683Cytotoxicity against mouse B16-F10 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Synthesis and Biological Activity of Triterpene-Coumarin Conjugates.
AID444778Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID1105457Antifungal activity against Aspergillus flavus LM 247 after 72 hr by broth microdilution method2013International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity.
AID750756Antagonist activity at Gloeobacter violaceus ligand-gated ion channel expressed in Xenopus oocytes assessed as inhibition of MES buffer pH 5.5 -induced currents after 30 secs by voltage clamp technique2013Journal of medicinal chemistry, Jun-13, Volume: 56, Issue:11
Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC.
AID444771Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID744457Inhibition of MAO-B (unknown origin)2013Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease.
AID1105460Antifungal activity against Aspergillus fumigatus IPP 210 after 72 hr by broth microdilution method2013International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity.
AID444781Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID1460083Agonist activity at GPR35 in human HT-29 cells in presence of antagonist ML-145 by DMR assay2017Journal of medicinal chemistry, 01-12, Volume: 60, Issue:1
Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists.
AID444773Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID744455Selectivity index, ratio of pIC50 for MAO-B (unknown origin) to pIC50 for MAO-A (unknown origin)2013Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease.
AID750752Dissociation constant, pKa of the compound2013Journal of medicinal chemistry, Jun-13, Volume: 56, Issue:11
Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC.
AID724209Binding affinity to methicillin-resistant Staphylococcus aureus MRSA2 assessed per 10'8 cells/ml at 50 uM after overnight incubation by fluorescence analysis2013European journal of medicinal chemistry, Jan, Volume: 59Novel fluorescent cephalosporins: synthesis, antimicrobial activity and photodynamic inactivation of antibiotic resistant bacteria.
AID1182961Antioxidant activity assessed as reaction rate at time zero for ABTS+ scavenging activity at 20 uM after 10 to 30 mins2014European journal of medicinal chemistry, Sep-12, Volume: 84Design and synthesis of coumarin-3-acylamino derivatives to scavenge radicals and to protect DNA.
AID1776684Cytotoxicity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Synthesis and Biological Activity of Triterpene-Coumarin Conjugates.
AID444779Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration assay2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
AID1460081Agonist activity at GPR35 in human HT-29 cells by DMR assay2017Journal of medicinal chemistry, 01-12, Volume: 60, Issue:1
Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists.
AID1105456Antifungal activity against Aspergillus flavus ATCC 16013 after 72 hr by broth microdilution method2013International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity.
AID724210Binding affinity to methicillin-resistant Staphylococcus aureus MRSA1 assessed per 10'8 cells/ml at 50 uM after overnight incubation by fluorescence analysis2013European journal of medicinal chemistry, Jan, Volume: 59Novel fluorescent cephalosporins: synthesis, antimicrobial activity and photodynamic inactivation of antibiotic resistant bacteria.
AID164993Inhibition of human Protein-tyrosine phosphatase 1B2003Bioorganic & medicinal chemistry letters, Aug-04, Volume: 13, Issue:15
Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors.
AID1105454Antifungal activity against Aspergillus flavus LM 26 after 72 hr by broth microdilution method2013International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity.
AID1182962Antioxidant activity assessed as rate constant for ABTS+ scavenging activity at 20 uM after 10 to 30 mins2014European journal of medicinal chemistry, Sep-12, Volume: 84Design and synthesis of coumarin-3-acylamino derivatives to scavenge radicals and to protect DNA.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (54)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (1.85)18.7374
1990's4 (7.41)18.2507
2000's12 (22.22)29.6817
2010's28 (51.85)24.3611
2020's9 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 34.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index34.35 (24.57)
Research Supply Index4.08 (2.92)
Research Growth Index5.33 (4.65)
Search Engine Demand Index42.88 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (34.35)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (1.72%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other57 (98.28%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]