Tryptamine and its substitution derivatives.
| Member | Definition | Role |
|---|
| 2-methyl-5-ht | | 2-methylserotonin |
| 3-(1H-indol-3-yl)-N-[4-(2-pyrimidinylsulfamoyl)phenyl]propanamide | | 3-(1H-indol-3-yl)-N-[4-(2-pyrimidinylsulfamoyl)phenyl]propanamide |
| 5-(nonyloxy)tryptamine | A tryptamine derivative that consists of serotonin bearing an additional O-nonyl substituent. 5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). | 5-nonyloxytryptamine |
| 5-carboxamidotryptamine | | 5-carboxamidotryptamine |
| 5-methoxy-alpha-methyltryptamine | | 1-(5-methoxy-1H-indol-3-yl)-2-propanamine |
| 5-methoxy-n,n-diisopropyltryptamine | | 5-methoxy-N,N-diisopropyltryptamine |
| 5-methoxytryptamine | A member of the class of tryptamines that is the methyl ether derivative of serotonin. | 5-methoxytryptamine |
| 5-methyltryptamine | | 2-(5-methyl-1H-indol-3-yl)ethanamine |
| 6-hydroxyindoramin | | 6-Hydroxyindoramin |
| 6-hydroxymelatonin | A member of the class of tryptamines that is melatonin with a hydroxy group substituent at position 6. | 6-hydroxymelatonin |
| alpha-methylserotonin | | alpha-methylserotonin |
| avitriptan | | avitriptan |
| bw 723c86 | | 1-[5-(thiophen-2-ylmethoxy)-1H-indol-3-yl]-2-propanamine |
| deformylflustrabromine | | Desformylflustrabromine |
| gr 159897 | | 5-fluoro-3-[2-[4-methoxy-4-[[(R)-phenylsulfinyl]methyl]-1-piperidinyl]ethyl]-1H-indole |
| indopan | A tryptamine derivative having a methyl substituent at the alpha-position. | alpha-methyltryptamine |
| indoramin | | indoramin |
| l 694247 | | N-[4-[[5-[3-(2-aminoethyl)-1H-indol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]phenyl]methanesulfonamide |
| melatonin | A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans. | melatonin |
| n-(2-(5-methoxy-2-oxo-2,3-dihydro-1h-indol-3-yl)ethyl)acetamide | A member of the class of hydroxyindoles that is melatonin in which the hydrogen at position 2 of the indole ring has been replaced by a hydroxy group. A predominant hydroxylated melatonin metabolite in plants. | 2-hydroxymelatonin |
| N-ethyl-3-(1H-indol-3-yl)-N-[2-oxo-2-(thiophen-2-ylmethylamino)ethyl]propanamide | | N-ethyl-3-(1H-indol-3-yl)-N-[2-oxo-2-(thiophen-2-ylmethylamino)ethyl]propanamide |
| N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]-2-propenamide | | N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]-2-propenamide |
| N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide | | N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide |
| n-methylserotonin | A member of the class of tryptamines that is serotonin in which one of the hydrogens attached to the primary amino group is replaced by a methyl group. | N-methylserotonin |
| n-methyltryptamine | | N-methyltryptamine |
| n,n-diallyl-5-methoxytryptamine | | 1h-indole-3-ethanamine, 5-methoxy-n,n-di-2-propen-1-yl- |
| n,n-diisopropyltryptamine | | N,N-diisopropyltryptamine |
| n,n-dimethyltryptamine | A tryptamine derivative having two N-methyl substituents on the side-chain. | N,N-dimethyltryptamine |
| naratriptan | | naratriptan |
| rizatriptan | | rizatriptan |
| Serotonin hydrochloride | | Serotonin hydrochloride |
| sumatriptan | A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults. | sumatriptan |
| tryptamine | An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position. | tryptamine |
| zolmitriptan | A member of the class of tryptamines that is N,N-dimethyltryptamine in which the hydrogen at position 5 of the indole ring has been replaced by a [(4S)-2-oxo-1,3-oxazolidin-4-yl]methyl group. A serotonin 5-HT1 B and D receptor agonist, it is used for the treatment of migraine. | zolmitriptan |