Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
| Excerpt | Reference |
|---|
| "Chronic pain is pain that persists past the normal time of healing, and is seen as a common problem with a significant socioeconomic impact." | ( Mehta, V; Snidvongs, S, 2012) |
| "However, chronic pain is multifactorial and this apaproach ignores the fact that different causative mechanisms may be involved." | ( Alegre, C; Alén, JC; Álvaro, ÁO; Blake, D; Caporali, R; Casser, HR; Correa-Illanes, G; Fernandes, P; Galilea, E; Jany, R; Jones, A; Mejjad, O; Morovic-Vergles, J; Oteo-Álvaro, Á; Pergolizzi, J; Radrigán Araya, FJ; Simões, ME; Uomo, G, 2012) |
| "Chronic pain is a common problem in clinical practice and women are affected more often than men." | ( Aloisi, AM; Aurilio, C; Barbarisi, M; Bravi, F; Ceccarelli, I; Massafra, C; Pace, MC; Passavanti, MB; Pota, V; Sansone, P, 2011) |
| "Treatment of chronic pain is complicated by the evidence that abuse of prescription opioids is rising; therefore, in many cases, chronic pain remains undertreated." | ( El-Feky, G; Kamel, R; Mahmoud, A, 2012) |
| "Chronic pain is a widespread public health issue that has many effects on physical, emotional and cognitive functions." | ( Vellucci, R, 2012) |
| "Chronic pain is a common healthcare problem worldwide that ranks as a predominant reason for consulting a physician, yet effective management of chronic pain remains suboptimal, often resulting in unnecessary suffering and decreased quality of life, lost productivity and excessive healthcare costs." | ( Cherubino, P; Fornasari, D; Labianca, R; Sarzi-Puttini, P; Vellucci, R; Zuccaro, SM, 2012) |
| "Chronic pain is a major healthcare issue in Europe and globally, and inadequate or undertreated pain significantly reduces the ability of many patients to participate in ordinary daily activities, adversely affects their employment status and contributes to a substantial rate of depression and anxiety in patients with chronic pain." | ( Cherubino, P; Labianca, R; Sarzi-Puttini, P; Zuccaro, SM, 2012) |
| "Chronic pain is a debilitating condition that is associated with many common diseases; this places a major burden on the healthcare system." | ( Cherubino, P; Fornasari, D; Labianca, R; Sarzi-Puttini, P; Vellucci, R; Zuccaro, SM, 2012) |
| "Chronic pain is highly variable between individuals, as is the response to analgesics." | ( Austin, JS; Beggs, S; Costigan, M; Diatchenko, L; Dorfman, R; Gershon, E; Herbert, TA; John, SL; Jordan, J; Livneh, J; Maixner, W; Mogil, JS; Peltz, G; Ritchie, J; Salter, MW; Seltzer, Z; Slade, GD; Smith, SB; Sorge, RE; Tan, K; Tichauer, D; Trang, T; Vander Meulen, H; Woolf, CJ; Yarkoni-Abitbul, M; Zaykin, DV; Zheng, M, 2012) |
| "Patients suffering chronic pain are at high risk of suffering long-lasting emotional disturbances characterized by persistent low mood and anxiety." | ( Alba-Delgado, C; Berrocoso, E; Horrillo, I; Llorca-Torralba, M; Meana, JJ; Mico, JA; Ortega, JE; Sánchez-Blázquez, P, 2013) |
| "While chronic pain is a main symptom in endometriosis, the underlying mechanisms and effective therapy remain elusive." | ( Alvarez, P; Chen, X; Giudice, LC; Green, PG; Hendrich, J; Irwin, JC; Levine, JD, 2012) |
| "Chronic pain is currently considered a public health problem with high costs to the individual and society." | ( Ekholm, O; Højsted, J; Juel, K; Kurita, GP; Sjøgren, P, 2012) |
| "Chronic pain is a common but undertreated health problem in the United States." | ( Parker, AJ, 2012) |
| "Chronic pain is a widespread social problem." | ( Habacher, W; Krahulec, E; Kratzer, H; Schmidt, LJ, 2012) |
| "Chronic pain is also a significant concern after direct spinal cord trauma." | ( Kerr, BJ; Kulkarni, A; Tenorio, G, 2013) |
| "Chronic pain is a prevalent condition in the United States." | ( Ackerman, SJ; Anastassopoulos, KP; Baik, R; Biondi, D; Chow, W; Kim, MS; Tapia, CI, 2012) |
| "Chronic pain is inadequately treated because of a combination of cultural, societal, educational, political and religious constraints." | ( Cherubino, P; Fornasari, D; Labianca, R; Sarzi-Puttini, P; Vellucci, R; Zuccaro, SM, 2012) |
| "Chronic pain is a common healthcare problem worldwide that ranks as a predominant reason for consulting a physician, yet effective management of chronic pain remains suboptimal, often resulting in unnecessary suffering and decreased quality of life, lost productivity and excessive healthcare costs." | ( Cherubino, P; Fornasari, D; Labianca, R; Sarzi-Puttini, P; Vellucci, R; Zuccaro, SM, 2012) |
| "Chronic pain is a major healthcare issue in Europe and globally, and inadequate or undertreated pain significantly reduces the ability of many patients to participate in ordinary daily activities, adversely affects their employment status and contributes to a substantial rate of depression and anxiety in patients with chronic pain." | ( Cherubino, P; Labianca, R; Sarzi-Puttini, P; Zuccaro, SM, 2012) |
| "Chronic pain is a debilitating condition that is associated with many common diseases; this places a major burden on the healthcare system." | ( Cherubino, P; Fornasari, D; Labianca, R; Sarzi-Puttini, P; Vellucci, R; Zuccaro, SM, 2012) |
| "Opiate use for chronic pain is becoming increasingly controversial." | ( Brasel, K; deRoon-Cassini, T; Trevino, CM, 2013) |
| "Chronic pain is extremely difficult to manage, in part due to lack of progress in reversing the underlying pathophysiology." | ( Bogen, O; Chu, C; Ferrari, LF; Levine, JD, 2013) |
| "Chronic pain is largely mediated by the activation of purinergic P2X3- and P2X2/3-receptors." | ( Kryshtal', OO; Petrenko, NS, 2013) |
| "Chronic pain is becoming a more common medical diagnosis and is especially prevalent in older individuals." | ( Carter, CS; Mitzelfelt, JD; Morgan, D, 2014) |
| "Chronic pain is prevalent among older adults but is underrecognized and undertreated." | ( Sean Morrison, R; Tracy, B, 2013) |
| "Chronic pain is the most prominent and disabling symptom of osteoarthritis (OA)." | ( Li, Y; Liu, F; Liu, M; Mao, Y; Wang, X; Yu, D; Zhao, X; Zhu, Z, 2013) |
| "Chronic pain is a major clinical problem, yet the mechanisms underlying the transition from acute to chronic pain remain poorly understood." | ( Eijkelkamp, N; Heijnen, CJ; Ishikawa, Y; Kavelaars, A; Sood, AK; van Velthoven, CT; Vroon, A; Wang, H; Willemen, HL; Zhang, X, 2013) |
| "Chronic pain is frequently treated with our most potent analgesics, the opioids." | ( Sloan, P, 2014) |
| "Chronic pain is of concern to health professionals, patients, society, and negatively impacts quality of life (QoL)." | ( Dureja, GP; Ghosh, P; Goswami, S; Iyer, R; Jain, PN; Joshi, M; Kadhe, G; Mandal, SP; Natarajan, KB; Phansalkar, AA; Prabhoo, R; Saxena, A; Shetty, N; Tanna, DD, 2014) |
| "Chronic pain is a leading cause of disability and represents a relevant societal burden." | ( Coluzzi, F; Ruggeri, M, 2014) |
| "Chronic pain is an important public health problem that negatively impacts quality of life of affected individuals and exacts an enormous socio-economic cost." | ( Morimura, K; Ossipov, MH; Porreca, F, 2014) |
| "The experience of chronic pain is one of the commonest reasons individuals seek medical attention, making the management of chronic pain a major issue in clinical practice." | ( Kapur, BM; Lala, PK; Shaw, JL, 2014) |
| "Chronic pain is a prevalent problem that exacts a significant toll on society." | ( Garland, EL, 2014) |
| "Chronic pain is associated with impairments in sleep; however, the relationship between prescription opioid status and sleep is unclear." | ( Dobscha, SK; Morasco, BJ; O'Hearn, D; Turk, DC, 2014) |
| "However, if chronic pain is accompanied by a depressive or anxiety disorder, typically related to hypercortisolemia, the association between cortisol levels and chronic multi-site musculoskeletal pain appears to be partly masked." | ( Dekker, J; Geenen, R; Generaal, E; Macfarlane, GJ; Penninx, BW; Smit, JH; Vogelzangs, N, 2014) |
| "Chronic pain is often challenging to address appropriately." | ( Drost, T; Kern, KU; Sánchez Del Águila, MJ; Schenk, M; Steigerwald, I, 2015) |
| "Chronic pain is a highly prevalent medical problem in the United States." | ( Pergolizzi, JV; Raffa, RB; Smith, HS; Tallarida, RJ; Taylor, R, 2014) |
| "Chronic pain is a major public health problem." | ( Kapoor, S; Thorn, BE, 2014) |
| "Outcomes in chronic pain are best when multiple treatment strategies with a focus on functional restoration are employed, and this is often best done in an interdisciplinary pain rehabilitation program." | ( Davin, S; Mathews, M, 2014) |
| "Chronic pain is a prevalent health problem among the elderly in Malaysia and is associated with higher hospitalization rate among the elderly population." | ( Hairi, NN; Mohamed Zaki, LR, 2014) |
| "Chronic pain is common in HIV-infected individuals." | ( Chamot, E; Herbey, I; Kertesz, SG; Merlin, JS; Ritchie, C; Saag, M; Turan, JM; Walcott, M, 2014) |
| "Chronic pain is a common reason for emergency department (ED) visits." | ( Bebarta, VS; Ganem, VJ; Mora, AG; Varney, SM, 2015) |
| "Chronic pain is highly prevalent in older adults." | ( Guerriero, F; Marcassa, C; Ricevuti, G; Rollone, M; Sgarlata, C, 2015) |
| "Chronic pain is common in CKD with a significant relationship between the severity of pain and both proper and improper analgesic usage." | ( Chen, J; Diamantidis, CJ; Fink, JC; Ginsberg, JS; Woods, C; Wu, J; Zhan, M, 2015) |
| "Chronic pain is common among drug injectors in our study population although it was unusual for chronic pain to have preceded non-medical opioid use." | ( Grau, LE; Heimer, R; Zhan, W, 2015) |
| "Chronic pain is one of the most common complaints in the United States." | ( Berkowitz, O; Daum, AM; Renner, JA, 2015) |
| "chronic pain, is of major concern." | ( Kurita, GP; Sjøgren, P, 2015) |
| "Chronic pain is one of the main problems in this population and prevalence varies between 16% and 50%." | ( Kurita, GP; Sjøgren, P, 2015) |
| "Chronic pain is a major risk factor for opioid relapse within the addiction treatment setting." | ( Bawor, M; Daiter, J; Dennis, BB; Desai, D; Marsh, DC; Pare, G; Paul, J; Plater, C; Samaan, Z; Thabane, L; Varenbut, M; Worster, A, 2015) |
| "Chronic pain is a devastating amalgam of symptoms that affects millions of Americans at tremendous cost to our healthcare system and, more importantly, to patients' quality of life." | ( Burkard, JF; Giron, SE; Griffis, CA, 2015) |
| "Chronic pain is a prevalent and serious problem in the province of Ontario." | ( Arora, S; Cameron, L; Carlin, L; Chmelnitsky, D; Dubin, RE; Fabico, R; Flannery, J; Furlan, AD; Sidrak, H; Smith, A; Smith, K; Taenzer, P; Williams, R; Zhao, J, 2015) |
| "Chronic pain is a major public health problem with limited treatment options." | ( Bekker, A; Lutz, BM; Nia, S; Tao, YX; Xiong, M, 2015) |
| "Patients with chronic pain are stratified according to the level of opioid use as persistent users of opioids, intermittent users, and persons not using opioids." | ( Borchgrevink, PC; Dale, O; Fredheim, OM; Hansen, AB; Mahic, M; Romundstad, PR; Skurtveit, S, 2015) |
| "Non-oncologic chronic pain is a very common symptom." | ( Castellà Kastner, M; Lombraña Mencia, M; Molas Ferrer, G, 2014) |
| "Chronic pain is an international health issue of immense importance that is influenced by both physical and psychological factors." | ( Jamison, RN; Mao, J, 2015) |
| "Chronic pain is one of the most debilitating and expensive diseases, yet current therapies are often insufficient in bringing about long-term relief." | ( Sowa, NA; Street, SE, 2015) |
| "Chronic pain is a highly disabling condition, which can significantly reduce patients' quality of life." | ( Fanelli, A; Fanelli, G, 2015) |
| "Chronic pain is a common and important medical problem worldwide." | ( Chang, CS; Cheng, IC; Tsay, WI, 2016) |
| "Chronic pain is a significant health problem that affects an estimated 100 million American adults (aged ≥ 18 years)." | ( Berner, T; Ernst, FR; Herndon, C; House, J; Mills, JR, 2015) |
| "Chronic pain is pervasive and afflicts >100 million Americans." | ( Al-Hasani, R; Cahill, CM; Gutstein, H; Salter, MW; Salvemini, D; Trang, T, 2015) |
| "Chronic pain is common among patients receiving opioid maintenance treatment (OMT) for opioid use disorder." | ( Dunn, KE; Finan, PH; Fingerhood, M; Strain, EC; Tompkins, DA, 2015) |
| "Obesity and chronic pain are often comorbid and their rates are increasing." | ( Gower, BA; Quinn, TL; Sorge, RE; Tomkovich, A; Totsch, SK; Waite, ME, 2016) |
| "Most patients with chronic pain are managed by primary care clinicians who are typically ill prepared to effectively and efficiently manage these cases." | ( Cheatle, MD, 2016) |
| "Chronic pain is common in children and adolescents and is often associated with severe functional disability and mood disorders." | ( Finkel, JC; Lippold, C; Muller, EA; Nouraie, M; Quezado, ZM; Sheehy, KA, 2015) |
| "Mood disorders and chronic pain are closely linked, but limited progress has been made in understanding the role of chronic and neuropathic pain in the aetiopathogenesis of depression." | ( González-Sepúlveda, M; Marcos, J; Pozo, OJ; Valverde, O, 2016) |
| "Chronic pain is a major health issue and most patients suffer from spontaneous pain." | ( Feng, ZH; Li, XY; Liu, L; Mei, SH; Wang, M; Wang, Y; Wang, YJ; Zuo, ZX, 2015) |
| "Chronic pain is one of the most common complaints for people seeking medical care, with a series of potential detrimental effects on the individual and his social texture." | ( Fanelli, G; Leonardi, C; Mammucari, M; Vellucci, R, 2015) |
| "While chronic pain is considered by some to be a CNS disease, little is understood about underlying neurobiological mechanisms." | ( Borsook, D; Elman, I, 2016) |
| "Chronic pain is implicated as a risk factor for illicit opioid use among patients with opioid addiction treated with methadone." | ( Bawor, M; Daiter, J; Dennis, BB; Desai, D; Marsh, DC; Pare, G; Paul, J; Plater, C; Roshanov, PS; Samaan, Z; Thabane, L; Varenbut, M; Worster, A, 2016) |
| "Chronic pain is associated with increased risk of suicide, and opioids are commonly used to treat moderate to severe pain." | ( Bair, MJ; Blow, FC; Bohnert, ASB; Ganoczy, D; Ilgen, MA; McCarthy, JF, 2016) |
| "Chronic pain is an important public health problem that negatively impacts the quality of life of affected individuals and exacts enormous socioeconomic costs." | ( Atcherley, CW; Morimura, K; Navratilova, E; Ossipov, MH; Porreca, F; Xie, JY, 2016) |
| "Chronic pain is considered one of the most prevalent causes of costly and disabling medical conditions." | ( Khouzam, HR, 2016) |
| "Chronic pain is a massive clinical problem." | ( Emery, EC; Luiz, AP; Wood, JN, 2016) |
| "Chronic pain is categorized as inflammatory and neuropathic, and there are common mechanisms underlying the generation of each pain state." | ( Fang, Y; Gao, LY; Ge, WH; Wu, DL; Zhou, HH, 2016) |
| "Chronic pain is an issue encountered by many health care providers in their routine clinical practice." | ( Grandhe, R; Gritsenko, K; Souzdalnitski, D, 2016) |
| "Chronic pain is a component of the multisymptom disease known as Gulf War Illness (GWI)." | ( Cooper, BY; Johnson, RD; Nutter, TJ, 2016) |
| "Chronic pain is a common and important disease state in North America, but many medical students and practicing physicians feel poorly prepared to treat this condition." | ( Antoun, J; Everard, KM; Schiel Zoberi, K, 2016) |
| "Chronic pain is associated with symptoms that may impair a patient's quality of life, including emotional distress, fatigue, and sleep disturbance." | ( Cheatle, MD; Dhingra, L; Foster, S; Lesneski, M; Pinkett, A; Qu, D, 2016) |
| "Chronic pain is more prevalent in women than in men, with increasing differences between sexes in advanced age." | ( Bierma-Zeinstra, SMA; de Kruijf, M; de Rijke, YB; Hofman, A; Huygen, FJPM; Stolk, L; Uitterlinden, AG; van Meurs, JBJ; Zillikens, MC, 2016) |
| "Background." | ( Chen, H; Fillingim, RB; McEwen, BS; Nielsen, CS; Schirmer, H; Sibille, KT; Steingrímsdóttir, ÓA; Stubhaug, A, 2016) |
| "Management of chronic pain is a challenge shared by healthcare providers in various clinical settings." | ( St Marie, B, 2016) |
| "Chronic pain is a common problem, affecting more than 100 million people in the United States, and primary care providers are highly likely to encounter patients on chronic opioid therapy." | ( Owston, CL, 2016) |
| "Chronic pain is common in multimorbid patients." | ( Battegay, E; Blaser, J; Eschmann, E; Holzer, BM; Kienast, A; Minder, CE; Saller, R; Schneider, D; Siebenhuener, K; Zimmerli, L, 2017) |
| "Additionaly, chronic pain is more or less an economic burden for the patients because it requires immediate medical treatments and seriously hinders pepople in their work." | ( Bai, B; Liu, W; Xin, Q, 2017) |
| "Treatments for chronic pain are inadequate, and new options are needed." | ( Chew, LA; Gilbraith, KB; Ibrahim, MM; Khanna, R; Largent-Milnes, T; Malan, TP; Moutal, A; Patwardhan, A; Porreca, F; Vanderah, TW; Yang, X, 2017) |
| "Chronic pain is associated with comorbidities that have an impact on the quality of life of patients and, among others, affect their sexual functioning." | ( Ajo, R; Ballester, P; Ferrández, G; Inda, MD; Margarit, C; Martínez, E; Peiró, AM; Sánchez-Barbie, Á; Segura, A, 2017) |
| "Chronic pain is a significant health problem strongly associated with a wide range of physical and mental health problems, including addiction." | ( Bremner, S; Durant, S; Katz, J; McCartney, CJ; Oosenbrug, E; Webster, F, 2017) |
| "Managing chronic pain is challenging for primary care clinicians for many reasons, including the lack of evidence to guide practice." | ( Alford, DP; Cohen, ML; Reynolds, EE, 2017) |
| "Chronic pain is frequently associated with hypersensitivity of the nervous system, and drugs that increase central inhibition are therefore a potentially effective treatment." | ( Arendt-Nielsen, L; Bütikofer, L; Curatolo, M; Juni, P; Limacher, A; Schliessbach, J; Siegenthaler, A; Vuilleumier, PH; Zeilhofer, HU, 2017) |
| "Chronic pain is now recognized as a neural disease, which results from a maladaptive functional and structural transformation process occurring over time." | ( Coluzzi, F; Fornasari, D; Pergolizzi, J; Romualdi, P, 2017) |
| "Chronic pain is often measured with a severity score that overlooks its spatial distribution across the body." | ( Andriole, GL; Apkarian, AV; Buchwald, D; Clauw, DJ; Clemens, JQ; Deutsch, G; Farmer, MA; Hampson, JP; Harris, RE; Ichesco, E; Klumpp, DJ; Kreder, KJ; Kusek, JW; Kutch, JJ; Labus, JS; Lai, HH; Landis, JR; Mackey, SC; Martucci, KT; Mayer, EA; Mullins, C; Ness, TJ; Rodriguez, LV; Schaeffer, AJ, 2017) |
| "Individuals with chronic pain are commonly prescribed opioids to treat pain, and by this mere exposure are at increased risk for the development of problematic opioid use." | ( Dunn, KE; Finan, PH; Remeniuk, B, 2018) |
| "Chronic pain is a serious condition that significantly impairs the quality of life, affecting an estimate of 1." | ( Diaz-delCastillo, M; Heegaard, AM; Woldbye, DPD, 2018) |
| "The management of chronic pain is a complex challenge worldwide." | ( Aviram, J; Samuelly-Leichtag, G, 2017) |
| "Chronic pain is common and can be challenging to manage." | ( Els, C; Hagtvedt, R; Jackson, TD; Kolahdooz, F; Kunyk, D; Lappi, VG; Sharma, S; Sonnenberg, B; Straube, S, 2017) |
| "Chronic pain is typically described as pain on most days for at least three months." | ( Els, C; Hagtvedt, R; Jackson, TD; Kunyk, D; Lappi, VG; Sonnenberg, B; Straube, S, 2017) |
| "Living with chronic pain is disruptive to patients' lives on multiple dimensions." | ( Al Achkar, M; Dennis, B; Grannis, S; Gupta, S; MacKie, P; Revere, D, 2017) |
| "Chronic pain is common in the United States and prescribed opioid analgesics use for noncancer pain has increased dramatically in the past two decades, possibly accounting for the current opioid addiction epidemic." | ( Arnsten, JH; Bachhuber, MA; Cunningham, CO; Jost, J; Khalid, L; Nahvi, S; Sohler, NL; Starrels, JL, 2018) |
| "Chronic pain is a major public health concern, and widespread use of prescription opioids for chronic pain has contributed to the escalating problem of opioid use disorder." | ( Craner, JR; Cunningham, JL; Evans, MM; Gilliam, WP; Loukianova, LL; Luedtke, CA; Morrison, EJ; Sperry, JA, 2018) |
| "Chronic pain is one of the most common, disabling, and expensive public health problems in the United States." | ( Benes, L; Bonifay, A; DeBar, L; Deyo, RA; Elder, CR; Keefe, FJ; Leo, MC; Mayhew, M; McMullen, C; Owen-Smith, A; Smith, DH; Trinacty, CM; Vollmer, WM, 2018) |
| "Chronic pain is an important yet overlooked non-motor symptom of Parkinson's disease (PD), caused by an imbalance of the dopaminergic and glutamatergic systems." | ( Castellani, P; Cattaneo, C; Kulisevsky, J; Tubazio, V, 2018) |
| "Chronic pain is a major therapeutic problem in kidney transplant patients owing to nephrotoxicity associated with nonsteroidal antiiflammatory drugs." | ( Arnaiz, J; Cuñetti, L; Curi, L; Manzo, L; Orihuela, S; Peyraube, R, 2018) |
| "Chronic pain is increasingly recognized as a public health problem." | ( Betz, W; Cardarelli, R; Elder, W; Kim, C; King, D; Roper, KL; Stewart, K; Weatherford, S; Workman, C, 2018) |
| "Chronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases but also "a disease itself." | ( Di Carlo, M; Giacobazzi, G; Salaffi, F, 2018) |
| "The development of chronic pain is considered a major complication after surgery." | ( Capdevila, X; Richebé, P; Rivat, C, 2018) |
| "Chronic pain is a serious health problem with high rates of health care utilization (HCU)." | ( Kapoor, S; Newman, AK; Thorn, BE, 2018) |
| "Background and aims Chronic pain is a life altering condition and common among elderly persons." | ( Dahm, P; Norrlid, H; Tennvall, GR, 2015) |
| "Chronic pain is currently a significant health problem in the United States." | ( Cao, L; Cattabriga, G; Koh, WY; Li, E; Malon, J; Shah, P, 2018) |
| "Chronic pain is one of the most prevalent health problems worldwide." | ( Ashrafi, H; Azadi, A; Barati, M; Mohammadi Samani, S; Pourtalebi Jahromi, L, 2018) |
| "Chronic pain is a widespread debilitating condition affecting millions of people worldwide." | ( Arsenault, J; Certo, M; Davletov, B; Echeverria-Altuna, I; Hunt, SP; Leese, C; Maiarù, M; Mangione, AS, 2018) |
| "Chronic pain is both a global public health concern and a serious source of personal suffering for which current treatments have limited efficacy." | ( Domenichiello, AF; Jensen, JR; Pitcher, MH; Ramsden, CE; Yuan, ZX, 2018) |
| "Chronic pain is known to induce an amplified aversive reaction to peripheral nociceptive inputs." | ( Chen, Z; Dale, J; Hu, S; Huang, D; Liu, K; Martinez, E; Wang, J; Yang, G; Zhang, E; Zhang, Q; Zhou, H, 2018) |
| "Chronic pain is a main symptom of many diseases in internal medicine." | ( Häuser, W; Schuler, M, 2018) |
| "Chronic pain is common and use of long-term opioid therapy for chronic pain has increased dramatically." | ( Blazina, I; Bougatsos, C; Chou, R; Dana, T; Devine, B; Deyo, R; Hansen, R; Jarvik, JG; Sullivan, S; Turner, J, 2014) |
| "The management of chronic pain is complex and often involves the integration of multiple clinical, humanistic, and economic factors." | ( Giannetti, V; Kamal, KM; Provenzano, DA, 2018) |
| "Chronic pain is an important public health issue." | ( Carvalho, ACP; DosSantos, MF; Ferreira, NR; Oliveira, AT; Rosado de Castro, PH, 2018) |
| "Chronic pain is associated with neuroplastic changes in the amygdala that may promote hyper-responsiveness to mechanical and thermal stimuli (allodynia and hyperalgesia) and/or enhance emotional and affective consequences of pain." | ( Hein, M; Ji, G; Navratilova, E; Neugebauer, V; Phelps, C; Porreca, F; Qu, C; Yakhnitsa, V, 2019) |
| "Chronic pain is common, costly, and challenging to treat." | ( Boehnke, KF; Clauw, DJ; Litinas, E; Scott, JR; Sisley, S; Williams, DA, 2019) |
| "Chronic pain is currently and historically the most common qualifying condition reported by medical cannabis patients (64." | ( Boehnke, KF; Clauw, DJ; Gangopadhyay, S; Haffajee, RL, 2019) |
| "The treatment of chronic pain is particularly important to anesthesiologists given our unique role as perioperative physicians and pain medicine specialists." | ( Cordonnier, SA; Forman, TE; Haight, ES; James, ML; Tawfik, VL, 2019) |
| "Chronic pain is characterized by abnormal sensitivity to normal stimulation coupled with a feeling of unpleasantness." | ( Andoh, T; Doi, A; Kato, G; Koga, K; Kume, T; Uta, D; Yoshimura, M, 2019) |
| "Chronic pain is the most common non-motor symptom among Parkinson's disease (PD) patients, with 1." | ( Feustel, P; Kaszuba, BC; Maietta, T; Pilitsis, JG; Shin, DS; Slyer, J; Stapleton, A; Walling, I, 2019) |
| "Chronic pain is a significant public health problem that is associated with several negative health outcomes, including increased health care cost, decreased productivity, and prescription opioid misuse." | ( Bakhshaie, J; Ditre, JW; Orr, MF; Rogers, AH; Zvolensky, MJ, 2020) |
| "Education on chronic pain is scattered, unstructured and optional." | ( Cristóvão, I; Reis-Pina, P, 2019) |
| "Chronic pain is strongly related to the emotional state of the individual and may be associated with suicidal ideation." | ( Bondolfi, G; Cedraschi, C; Chytas, V; Costanza, A; Piguet, V, 2019) |
| "Chronic pain is one of the most common reasons individuals seek medical attention." | ( Ballester, P; Conte, AL; Inda, MD; Margarit, C; Morales, D; Moreu, R; Muriel, J; Nuñez, A; Peiró, AM; Roca, R, 2019) |
| "Chronic pain is a highly prevalent problem, involving high costs and seriously affecting a patient's quality of life." | ( Backhaus, I; La Torre, G; Mannocci, A, 2019) |
| "Although chronic pain is not homogenous, most estimates of its costs are averages that ignore severity (impact)." | ( Broten, N; Coulter, ID; Herman, PM; Lavelle, TA; Sorbero, ME, 2019) |
| "Chronic pain is also associated with emotion dysregulation." | ( Bakhshaie, J; Buckner, JD; Ditre, JW; Orr, MF; Rogers, AH; Shepherd, JM; Zvolensky, MJ, 2020) |
| "Chronic pain is associated with altered affective state, stress, anxiety and depression." | ( Abelson, KS; Brønnum Pedersen, T; Hestehave, S; Munro, G, 2019) |
| "Postoperative chronic pain is characterized by high incidence, long duration, and complex pathogenesis." | ( Huang, C; Ma, G; Wang, R; Yang, J; Zhao, B, 2019) |
| "Chronic pain is a debilitating condition that often emerges as a clinical symptom of inflammatory diseases." | ( Tozaki-Saitoh, H; Tsuda, M, 2019) |
| "Chronic pain is a public health problem associated with opioid misuse." | ( Bakhshaie, J; Paulus, DJ; Rogers, AH; Vowles, KE; Zvolensky, MJ, 2019) |
| "Chronic pain is common among people living with HIV (PLWH)." | ( Cheng, DM; Colasanti, J; Del Rio, C; Forman, LS; Liebschutz, JM; Lira, MC; Merlin, JS; Samet, JH; Tsui, JI; Walley, AY, 2019) |
| "Globally, chronic pain is a major therapeutic challenge and affects more than 15% of the population." | ( Maharajan, MK; Woon, SS; Yap, KX; Yap, KY; Yeap, KM; Yip, HY; Yip, SC; Yong, YJ, 2020) |
| "Chronic pain is the most common indication, as health claims data and the accompanying survey show." | ( Gastmeier, K; Häuser, W; Karst, M; Petzke, F; Radbruch, L; Steffen, E, 2019) |
| "Chronic pain is a devastating condition affecting the physical, psychological, and socioeconomic status of the patient." | ( Buchfelder, M; Chakravarthy, KV; Chaudhry, SR; Deer, TR; Georgius, P; Hurlemann, R; Kinfe, TM; Muhammad, S; Rasheed, M; Russo, M; Yearwood, TL, 2019) |
| "Alcohol use and chronic pain are highly comorbid." | ( Bagdas, D; Contreras, KM; Damaj, MI; Ditre, JW; Miles, MF; Neddenriep, B; Wolstenholme, JT, 2019) |
| "Chronic pain is a common condition that affects the physical, emotional, and mental well-being of patients and can significantly diminish their quality of life." | ( Al-Kaisy, A; Amirdelfan, K; Caraway, D; Gliner, B; Kapural, L; Rotte, A; Subbaroyan, J; Van Buyten, JP, 2020) |
| "Chronic pain is common in people living with HIV (PLWH)." | ( Cheatle, MD; Denis, CM; Metzger, DS; Morales, KH; Wu, Q, 2019) |
| "Chronic pain is common in patients with prescription opioid use disorder (OUD), and pain severity has been shown to predict opioid use for those with chronic pain." | ( Fitzmaurice, GM; Griffin, ML; Jamison, RN; McDermott, KA; McHugh, RK; Provost, SE; Weiss, RD, 2019) |
| "Chronic pain is frequently irreversible, representing a major health problem." | ( Del Gaudio, A; Mastroluca, A; Varano, L; Visconti, C, 2019) |
| "Chronic pain is highly prevalent in the elderly, and the prolonged use of long-term opioids for the management of chronic musculoskeletal pain is controversial." | ( Aurilio, C, 2019) |
| "Chronic pain is a heavy burden disease." | ( Boudieu, L; Bourdier, J; Daulhac, L; Eschalier, A; Kerckhove, N; Mallet, C; Ourties, G, 2019) |
| "Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive, and affective symptoms." | ( Pryce, KD; Serafini, RA; Zachariou, V, 2020) |
| "Chronic pain is a complex phenomenon that can adversely affect quality of life and is associated with psychiatric conditions such as anxiety and depression." | ( Åström, J; Lidén, Y; Sjölund, KF; Wicksell, RK; Wincent, A, 2020) |
| "In the community, chronic pain is a common reason for visits to the doctor's office." | ( Gil, T; Metts, J; Ugwueze, G, 2019) |
| "Chronic pain is pain greater than 3 months duration that may result from disease, trauma, surgery, or unknown origin." | ( Barry, D; Drago, T; Gallagher, H; King, R; Levins, KJ; Martin, A; Murphy, P; O'Hanlon, E; Roddy, DW; Roman, E, 2019) |
| "Living with chronic pain is predominantly represented as a struggle, with a lesser focus on the ability to successfully self-manage and live a meaningful life." | ( Avery, C; Devan, H; Elder, L; Grainger, R; Khasyanova, Y; Manning, D; Scrimgeour, M; Young, J, 2020) |
| "Chronic pain is long-lasting nociceptive state, impairing the patient's quality of life." | ( Hao, S; Kanao-Kanda, M; Kanda, H; Liu, S; Roy, S; Toborek, M, 2020) |
| "Chronic pain is the most common reason reported for using medical cannabis." | ( Britch, SC; Craft, RM; Goodman, AG; Pondelick, AM; Wiley, JL, 2020) |
| "Chronic pain is prevalent, and approximately half of patients with chronic pain experience sleep disturbance." | ( Adam, R; Columb, M; Galley, H; Kanakarajan, S; Onyeakazi, U, 2020) |
| "Chronic pain is frequently comorbid with opioid abuse and severe depression, a combination that greatly compounds suicide risk." | ( Cáceda, R; Clothier, JL; Delgado, PL; Gibbs, HM; Price, D, 2020) |
| "Chronic pain is the leading cause of disability in the world, is associated with multiple psychiatric comorbidities, and has been causally linked to the opioid crisis." | ( Baber, ZB; Buvanendran, A; Chen, Y; Cohen, SP; Fowler, IM; Hayek, SM; Hooten, WM; Kennedy, DJ; King, SA; Laker, SR; McLean, BC; Phillips, CR; Sandbrink, F; Stojanovic, MP; Wasan, AD, 2020) |
| "The development of chronic pain is a complex mechanism that is still not fully understood." | ( Bruno, KA; Castellanos, JP; Furnish, T; Halberstadt, A; Woolley, C; Zeidan, F, 2020) |
| "The management of chronic pain is an important topic for training competent family physicians." | ( Everard, KM; Schiel, KZ, 2020) |
| "Chronic pain is one of the most common health-related conditions experienced by Americans over the age of 65." | ( Bobitt, J; Croker, JA; Kang, H; Kaskie, B; Quintero Silva, L, 2020) |
| "Chronic pain is common in the older population and a significant public health concern." | ( Brenner, H; Chen, LJ; Haefeli, WE; Laetsch, DC; Meid, AD; Nguyen, TNM; Schöttker, B, 2020) |
| "Chronic pain is a common and undertreated nonmotor symptom in Parkinson's disease (PD)." | ( Luan, YW; Tang, DL; Xiao, C; Zhou, CY, 2021) |
| "Chronic pain is prevalent among people living with human immunodeficiency virus (PLWH); managing pain with chronic opioid therapy (COT) is common." | ( Abrams, C; Armstrong, WS; Bridden, CL; Cheng, DM; Colasanti, JA; Del Rio, C; Forman, LS; Harris, C; Liebschutz, JM; Lira, MC; Outlaw, K; Root, C; Samet, JH; Shanahan, CW; Sullivan, MM; Tsui, JI; Walley, AY, 2021) |
| "Chronic pain is a public health concern and additional treatment options are essential." | ( Kennedy, AG; Littenberg, B; Rose, GL; Tarleton, EK, 2020) |
| "Chronic pain is one of the most challenging and debilitating symptoms to manage after traumatic brain injury (TBI), yet the underlying mechanisms remain elusive." | ( Clark, JD; Ferguson, AR; Irvine, KA; Sahbaie, P, 2020) |
| "Chronic pain is a serious debilitating condition that affects ∼20% of the world's population." | ( Brierley, SM; Cardoso, FC; Castro, J; Garcia-Caraballo, S; Grundy, L; Herzig, V; King, GF; Lewis, RJ; Schober, G; Zhao, T, 2021) |
| "High-quality chronic pain care emphasizes multimodal treatments that include medication and nonpharmacological treatments." | ( Bartman, AE; Bernstein, C; Gillman, AG; Jeong, JH; Wasan, AD; Zhang, D, 2020) |
| "Chronic pain is a common symptom of most clinical diseases, which seriously affects the psychosomatic health of patients and brings some pain to patients." | ( Luo, HL; Zhang, WJ; Zhu, ZM, 2020) |
| "Chronic pain is a major public health challenge in the United States and around the world." | ( Bickel, WK; Craft, WH; Tegge, AN, 2020) |
| "Chronic pain is considered a public health crisis due to its high prevalence, impact, costs, and disparities in pain prevalence and treatment." | ( Kerns, RD; Palermo, TM, 2020) |
| "Chronic pain is a common and costly condition, and some people with chronic pain engage in problematic opioid use." | ( Aaron, RV; Finan, PH; Keefe, FJ; Lumley, MA; Wegener, ST, 2020) |
| "Chronic pain is a major health problem and the effective treatment for chronic pain is still lacking." | ( Chen, QY; Li, XH; Zhuo, M, 2020) |
| "Chronic pain is a relevant health condition affecting one out of five individuals that is often not adequately treated by currently available analgesics." | ( Bedini, A, 2021) |
| "Individuals with chronic pain are prescribed extended release opioids in an effort to maintain stable drug levels and for more convenient dosing, though evidence to support improvements in pain or function is lacking." | ( Brands, B; Grant, D; Murphy, L; Smith, A; Sproule, BA; Zhang, M, 2021) |
| "Chronic pain is a common condition that is being increasingly recognized, diagnosed, and treated in a variety of settings." | ( Charipova, K; Gress, K; Jung, JW; Kaye, AD; Paladini, A; Urits, I; Varrassi, G; Viswanath, O, 2020) |
| "A subtype of chronic pain is neuropathic pain (NP), which is defined as "pain caused by a lesion or disease of the somatosensory system," according to the International Association for the Study of Pain (IASP)." | ( Artounian, KA; Bandi, P; Berardino, K; Jung, JW; Kaye, AD; Kaye, AM; Kaye, RJ; Li, N; Manchikanti, L; Simopoulos, T; Torres, M; Urits, I; Viswanath, O, 2020) |
| "Chronic pain is a life-altering condition affecting millions of people." | ( Salvemini, D; Spiegel, S; Squillace, S, 2020) |
| "Chronic pain is a debilitating condition that often occurs following peripheral tissue inflammation and nerve injury." | ( Inoue, K; Tsuda, M, 2021) |
| "Chronic pain is a painful condition defined by its duration where pain persists three months or more." | ( Gašparini, D; Ljubičić, R; Mršić-Pelčić, J, 2020) |
| "Chronic pain is a common condition among primary care attendees associated with significant burden of medical and mental health comorbidity." | ( Bajaj, A; Chaturvedi, SK; Desai, G; G R, G; G, SK; K, T; L, M; T S, J, 2020) |
| "Chronic pain is a significant public health problem associated with functional impairment, increased medical expenditures, and opioid misuse." | ( Allan, NP; Garey, L; Rogers, AH; Zvolensky, MJ, 2021) |
| "Chronic pain is a major public health issue that frequently leads to analgesic opioid prescriptions." | ( Authier, N; Bertin, C; Chenaf, C; Delage, N; Delorme, J; Fatseas, M; Pennel, L; Rolland, B; Trouvin, AP, 2021) |
| "Chronic pain is a significant secondary condition following SCI, and traditional treatments (e." | ( Bombardier, CH; Carter, GT; Thomas, PA, 2022) |
| "Individuals with chronic pain are uniquely challenged by the COVID-19 pandemic, as increased stress may exacerbate chronic pain, and there are new barriers to receiving chronic pain treatment." | ( Aaron, RV; Campbell, CM; McGill, LS; Mun, CJ, 2021) |
| "Chronic pain is not well understood in opioid-dependent populations." | ( Latif, ZH; Skjaervø, I; Solli, KK; Tanum, L, 2021) |
| "Chronic pain is a major public health concern, as is the associated use of opioid medications, highlighting the importance of alternative treatments, such as spinal cord stimulation (SCS)." | ( Boesel, T; Brooker, C; Cousins, MJ; Gmel, GE; Hanson, E; Holford, L; Martin, R; Parker, J; Poree, L; Russo, M; Shariati, NH; Sullivan, R; Taylor, N, 2021) |
| "Management of chronic pain is an essential aspect of HIV primary care." | ( Colasanti, JA; Del Rio, C; Forman, LS; Ganguly, AP; Liebschutz, JM; Lira, MC; Lodi, S; Samet, JH; Tsui, JI; Williams, EC, 2021) |
| "Chronic pain is recognized as an important problem in communities." | ( Azizi, H; Farahani, F; Janahmadi, M; Semnanian, S; Seutin, V, 2021) |
| "The high costs of chronic pain are particularly relevant for anesthesiologists because surgery represents an inciting event that can lead to chronic pain and long-term opioid use." | ( Clark, JD; Elsharkawy, H; Gabriel, RA; Gulur, P; Harrison, TK; Mariano, ER; Merrick, SK; Narouze, S; Sun, EC, 2021) |
| "Chronic pain is associated with mental and physical health difficulties and is prevalent among veterans." | ( Aharonovich, E; Bohnert, KM; Browne, KC; Cerda, M; Enkema, MC; Fink, DS; Hasin, DS; Keyhani, S; Martins, SS; Olfson, M; Saxon, AJ; Sherman, SE; Shmulewitz, D; Stohl, M; Wall, M, 2022) |
| "Chronic pain is highly prevalent among people in methadone maintenance treatment (MMT) for opioid use disorder and is known to be an important contributor to treatment discontinuation and opioid relapse." | ( Cooperman, NA; Garland, EL; Hanley, AW; Kline, A, 2021) |
| "Chronic pain is a leading cause of disability worldwide and its prevalence is likely to increase over the next decades." | ( Apkarian, AV; Barroso, J; Branco, P, 2021) |
| "In particular, chronic pain is associated with altered medial prefrontal anatomy and biochemistry." | ( Alam, M; Gustin, SM; Hesam-Shariati, N; Kang, D; McAuley, JH; Rae, CD; Trost, Z, 2021) |
| "Chronic pain is common among people living with cystic fibrosis (CF) and associated with worse clinical outcomes." | ( Allgood, S; Dellon, E; Goggin, J; Kapnadak, SG; Lechtzin, N; Zemlak, JL, 2022) |
| "Chronic pain is a common, under-treated problem." | ( Butler, J; Dempsey, MT; Fugh-Berman, A; Goodwin, B; Lim, HD; O Connor, B; Paglia, D, 2021) |
| "Chronic pain is highly prevalent among adults treated with maintenance haemodialysis (HD) and has profound negative effects." | ( Becker, WC; Dember, LM; Eneanya, ND; Fischer, MJ; Jhamb, M; Kimmel, PL; Lockwood, MB; Nolin, TD; Tobin, DG, 2022) |
| "Chronic pain is a common postsurgery symptom." | ( Chen, Y; Zhang, GZ, 2021) |
| "Chronic pain is a debilitating condition involving neuronal dysfunction, but the synaptic mechanisms underlying the persistence of pain are still poorly understood." | ( Dravid, SM; Gakare, SG; Gandhi, PJ; Gawande, DY; Ji, G; Kiritoshi, T; Liu, J; Misra, B; Neugebauer, V; Pavuluri, R; Shelkar, GP, 2021) |
| "Clinically, chronic pain is the most common and disabling symptom of osteoarthritis (OA)." | ( Chen, LM; Liu, CC; Wang, XP; Wu, GH; Xu, LJ, 2021) |
| "Chronic pain is common, disabling, and costly." | ( Benes, L; Bonifay, A; DeBar, L; Deyo, RA; Elder, CR; Keefe, FJ; Leo, MC; Mayhew, M; McMullen, C; Owen-Smith, A; Smith, DH; Trinacty, CM; Vollmer, WM, 2022) |
| "Chronic pain is prevalent and interferes with post-injury functioning and quality of life, whereas substance use disorder (SUD) is the third most common neuropsychiatric diagnosis after TBI." | ( Barr, GA; Best, KM; Cohen, AS; Mojena, MM; Schmidt, HD, 2022) |
| "Chronic pain is a debilitating disorder that can occur as painful episodes that alternates with bouts of remission and occurs despite healing of the primary insult." | ( Gerum, M; Simonin, F, 2022) |
| "Chronic pain is caused by cellular damage with an obligatory inflammatory component." | ( Illes, P; Ren, WJ, 2022) |
| "Chronic pain is highly prevalent among patients with opioid use disorder (OUD)." | ( Choo, TH; Langleben, DD; Nunes, EV; Pavlicova, M; Rotrosen, J; Shulman, M; Wang, AL, 2022) |
| "MC use for chronic pain is increasing with cannabis legalization." | ( Aebischer, JH; Dieckmann, NF; Jones, KD; St John, AW, 2022) |
| "Chronic pain is debilitating and profoundly affects health-related quality of life." | ( Amirdelfan, K; Brounstein, D; Burgher, AH; Carlson, J; Costandi, SJ; Deer, TR; Falowski, SM; Gilbert, S; Gilmore, CA; Gmel, GE; Gorman, R; Gould, I; Hanson, E; Hunter, CW; Kapural, L; Karantonis, DM; Khurram, A; Kim, CK; Leitner, A; Levy, RM; Li, S; McJunkin, T; Mekhail, N; Mugan, D; Obradovic, M; Ouyang, Z; Parker, J; Pilitsis, J; Pope, JE; Poree, L; Qureshi, FA; Rosen, SM; Scowcroft, J; Single, P; Soliday, N; Staats, PS; Stauss, T; Yang, MI, 2022) |
| "Chronic pain is most frequently reported and at the center of patients' level of disease burden." | ( Achenbach, J; Frieling, H; Glahn, A; Karst, M; Rhein, M, 2022) |
| "Chronic pain is a debilitating condition that often occurs following peripheral tissue inflammation and nerve injury." | ( Inoue, K, 2022) |
| "Chronic pain is associated with insomnia." | ( Bamgbade, DO; Bamgbade, OA; Fadire, A; Mumporeze, L; Murphy-Akpieyi, O; Soni, NK; Tai-Osagbemi, J, 2022) |
| "Chronic pain is more common among caregivers with high caregiver burden." | ( Camelo Castillo, W; dosReis, S; Hogans, B; Onasanya, O; Reeves, G, 2022) |
| "Chronic pain is among the most burdensome and devastating disorders affecting millions of people worldwide." | ( Gadepalli, A; Modi, A; Tiwari, V; Uniyal, A, 2022) |
| "Chronic pain is one of the most common medical conditions in developed countries." | ( Ceccarelli, G; Ladiana, N; Notaro, P; Nunnari, P, 2022) |
| "Chronic pain is prevalent and costly; cost-effective nonpharmacological approaches that reduce pain and improve patient functioning are needed." | ( Benes, L; Bonifay, A; DeBar, L; Deyo, RA; Elder, CR; Keefe, FJ; Leo, MC; Mayhew, M; McMullen, C; O'Keeffe-Rosetti, M; Owen-Smith, A; Smith, DH; Trinacty, CM; Vollmer, WM, 2022) |
| "Chronic pain is common among persons living with HIV and changes in opioid prescribing practices may complicate HIV care management." | ( Appa, A; Coffin, PO; Dobbins, S; Haq, N; McMahan, VM; Rowe, CL; Silvis, J; Vittinghoff, E, 2022) |
| "Individuals with chronic pain are significantly more likely to have experienced overwhelming trauma early and often in key developmental years." | ( Bruehl, S; Johnson, BN; McKernan, LC, 2022) |
| "Chronic pain is a significant worldwide health problem." | ( Nethra, A; Slattery, B; Vashisht, H; Ward, T; Zhang, L, 2022) |
| "Chronic pain is the leading cause of disability worldwide and is strongly associated with the epidemic of opioid overdosing events." | ( Arah, OA; Inoue, K; Ritz, B, 2022) |
| "Chronic pain is debilitating and represents a significant burden in terms of personal and socio-economic costs." | ( Baiula, M; Bedini, A; Cuna, E; Spampinato, S, 2022) |
| "Chronic pain is currently considered a disease state with biopsychosocial consequences and a negative impact on patients' quality of life (QoL)." | ( Fornasari, D; Magni, A; Pais, P; Palao, T; Polati, E; Sansone, P, 2022) |
| "Patients with chronic pain are thus at increased risk of being hastily dismissed and sent on their way." | ( Eich, W; Lucas, V; Tesarz, J, 2022) |
| "Chronic pain is associated with impaired regulation of cardiovascular and analgesia systems, which may predispose to persistent BP elevation." | ( Coscarelli, A; Giordano, A; Menale, S; Rivasi, G; Turrin, G; Ungar, A, 2022) |
| "Chronic pain is highly prevalent in older adults and is associated with poor functional outcomes." | ( Habermann, EB; Hooten, WM; Knopman, DS; Mielke, MM; Verdoorn, BP; Warner, DO; Warner, NS, 2023) |
| "Anxiety and chronic pain are common comorbidities in patients with chronic obstructive pulmonary disease (COPD), which are frequently managed with benzodiazepines (BZDs) and opioids, respectively." | ( Kuo, YF; Raji, MA; Sharma, G; Sood, A; Westra, J, 2023) |
| "Treatment of chronic pain is challenged by concurrent anxiety symptoms." | ( Chai, XQ; Chen, DY; Gao, W; Hu, R; Jin, Y; Long, DD; Mao, Y; Pan, TT; Wang, D; Zhang, Z, 2022) |
| "Chronic pain is associated with dysfunctional cortical excitability." | ( Corti, EJ; Gasson, N; Loftus, AM; Marinovic, W; Nguyen, AT, 2022) |
| "The mechanisms of chronic pain are complex, and genetic factors play an essential role in the development of chronic pain." | ( Du, L; Huang, W; Wang, S; Ye, F, 2022) |
| "Chronic pain is a persistent, complex condition that contributes to impaired mood, anxiety and emotional problems." | ( Boccella, S; Infantino, R; Kędziora, M; Maione, S; Marabese, I; Mlost, J; Starowicz, K, 2023) |
| "The incidence of chronic pain is around 8% in the general population, and its impact on quality of life, mood, and sleep exceeds the burden of its causal pathology." | ( Leite-Panissi, CRA; Silva-Cardoso, GK, 2023) |
| "Chronic pain is a highly prevalent health problem especially in rural regions." | ( Donaghy, M; Halabecki, M; Lakha, SF; Lyon, A; Mailis, A; Shojaei, H, 2022) |
| "Chronic pain is a highly prevalent health problem especially in rural regions." | ( Donaghy, M; Halabecki, M; Lakha, SF; Lyon, A; Mailis, A; Shojaei, H, 2022) |
| "Chronic pain is a highly prevalent health problem especially in rural regions." | ( Donaghy, M; Halabecki, M; Lakha, SF; Lyon, A; Mailis, A; Shojaei, H, 2022) |
| "Chronic pain is a common disease that severely disrupts the quality of life." | ( Cao, W; Cheng, Y; Liu, M; Qin, X; Tong, J; Wu, X, 2023) |
| "Chronic pain is a common disease that severely disrupts the quality of life." | ( Cao, W; Cheng, Y; Liu, M; Qin, X; Tong, J; Wu, X, 2023) |
| "Chronic pain is a common disease that severely disrupts the quality of life." | ( Cao, W; Cheng, Y; Liu, M; Qin, X; Tong, J; Wu, X, 2023) |
| "Chronic pain is the predominant problem for rheumatoid arthritis patients, and negatively affects quality of life." | ( Chen, CX; Cheng, DW; Cheng, ML; Hu, YD; Li, D; Liu, L; Tang, Q; Xie, M; Yue, YF; Zhu, HL, 2022) |
| "Chronic pain is the predominant problem for rheumatoid arthritis patients, and negatively affects quality of life." | ( Chen, CX; Cheng, DW; Cheng, ML; Hu, YD; Li, D; Liu, L; Tang, Q; Xie, M; Yue, YF; Zhu, HL, 2022) |
| "Chronic pain is a significant health problem associated with disability and reduced quality of life." | ( Gupta, N; Lesnak, JB; McMillan, A; Meyerholz, DK; Nakhla, DS; Phruttiwanichakun, P; Plumb, AN; Rasmussen, L; Saha, S; Salem, AK; Sluka, KA; Xu, Y, 2023) |
| "Chronic pain is a significant health problem associated with disability and reduced quality of life." | ( Gupta, N; Lesnak, JB; McMillan, A; Meyerholz, DK; Nakhla, DS; Phruttiwanichakun, P; Plumb, AN; Rasmussen, L; Saha, S; Salem, AK; Sluka, KA; Xu, Y, 2023) |
| "Chronic pain is a common and complex problem, with an unknown etiology." | ( Kooijman, NI; Kramers, C; Mulleners, WM; Reuser, A; van der Wal, SEI; Vissers, KCP; Willegers, T, 2023) |
| "Chronic pain is frequently reported in clinical practice." | ( Chen, G; Lu, K; Wang, YT; Yao, DD; Zhang, SX, 2023) |
| "It is clear chronic pain is a complex multidimensional biological challenge plagued with difficulties in pain management, specifically opioid use." | ( Bajic, JE; Barry, B; Evans, S; Grace, PM; Hutchinson, MR; Mustafa, S; Siemens, KR, 2023) |
| "Chronic pain is common and worsens daytime sleepiness, insomnia, and quality of life in veterans with obstructive sleep apnea." | ( Compton, PA; Keenan, BT; Kuna, ST; Polomano, RC; Saconi, B; Sawyer, AM, 2023) |
| "Chronic pain is a significant global health issue, described as a bio-psychosocial phenomenon that hampers the integration of body, mind, and social functions." | ( Kannan, A; Mahawar, B; Mahawar, V; Srinivasan, S, 2023) |
| "Chronic pain is common in people living with HIV (PLWH), causes substantial disability and is associated with limitations in daily activities." | ( Abrantes, AM; Anderson, BJ; Baker, JV; Busch, AM; Pinkston, MM; Stein, MD; Uebelacker, LA; Yeh, JC, 2023) |
| "Chronic pain is now included in the designation of chronic diseases, such as cancer, diabetes, and cardiovascular disease, which can impair quality of life and are major causes of death and disability worldwide." | ( Ghosh, R; Howlader, MMR; Pazuki, D, 2023) |
| "Chronic pain is a major source of morbidity for which there are limited effective treatments." | ( Bornemann-Cimenti, H; Brenna, CTA; Klivinyi, C; Lang-Illievich, K; Lasser, C; Szilagyi, IS, 2023) |
| "Chronic pain is a leading cause of disability, reduced productivity, healthcare seeking behavior, and a contributor to opioid overdose in the United States." | ( Baumann, MH; Belouin, SJ; Berger, A; Dworkin, RH; Ghauri, MH; Hendricks, PS; Henningfield, JE; Lanier, RK; Ross, S; Zia, FZ, 2023) |
| "Chronic pain is considered a key factor contributing to alcohol use disorder (AUD)." | ( Bajo, M; Borgonetti, V; Galeotti, N; Roberto, M; Roberts, AJ, 2023) |
| "Chronic pain is an independent disease associated with multiple changes in the nervous, endocrine and immune systems." | ( Putilina, MV, 2023) |
| "Chronic pain is one of the most prevalent health problems worldwide." | ( Chen, D; Chen, L; Ding, X; Luo, SZ; Pei, C; Wang, Y; Xu, J; Zhang, R; Zhang, S; Zhang, Y, 2023) |
| "The origin of chronic pain is linked to inflammation, characterized by increased levels of proinflammatory cytokines in local tissues and systemic circulation." | ( Camacho-Domenech, J; Haystead, T; Hughes, P; Nackley, AG; Ricano, J; Scarneo, S; Wang, Y; Zhang, X, 2023) |
| "Individuals with chronic pain are more likely to experience mental disorders compared to individuals without chronic pain, but large-scale estimates are lacking." | ( Borchgrevink, PC; Clausen, T; Gjerde, LC; Hamina, A; Handal, M; Lid, TG; Nesvåg, R; Odsbu, I; Skurtveit, S, 2023) |
| "Chronic pain is common in adults, and often has a detrimental impact upon physical ability, well-being, and quality of life." | ( Birkinshaw, H; Cole, P; Eccleston, C; Friedrich, CM; Moore, RA; Phillippo, D; Pincus, T; Serfaty, M; Stewart, G; White, S, 2023) |
| "Chronic pain is an enormous public health concern, and its treatment is still an unmet medical need." | ( Allegretti, M; Aramini, A; Bianchini, G; Boccella, S; Bordignon, S; Brandolini, L; Canestrari, D; Castelli, V; Chierotti, MR; Cimini, A; Cocchiaro, P; d'Angelo, M; d'Egidio, F; Dragani, MC; Lillini, S; Luongo, L; Maione, S; Mattioli, S; Novelli, R; Pacchiarotti, N; Palmerio, F; Tomassetti, M, 2023) |
| "Chronic pain is a recognized complication of surgery, and it has been hypothesized that regional anesthesia might reduce the risk of development of chronic pain after upper extremity surgery." | ( Coert, JH; Droog, W; Galvin, EM; Konijn, JB; Lucas, BMJ; Stolker, RJ; Walbeehm, ET, 2023) |
| "Chronic pain is a devastating problem affecting one in five individuals around the globe, with neuropathic pain the most debilitating and poorly treated type of chronic pain." | ( Brudno, M; Finn, DP; Ghazisaeidi, S; Kim, D; Kolahdouzan, M; Muley, MM; Pitcher, GM; Ramani, AK; Salter, MW; Sengar, AS; Tu, Y, 2023) |
| "Chronic pain is a common public health problem and remains an unmet medical need." | ( Chen, YM; Huang, CN; Jiang, X; Li, Z; Qin, HM; Xiao, XY; Zhang, GS; Zhou, HL; Zhu, J; Zhuang, T, 2023) |
| "Chronic pain is among the most common conditions presenting to primary care and guideline-based care faces several challenges." | ( Abelleira, A; Becker, WC; Edmond, SN; Falker, C; Frank, JW; Moore, BA; Nolan, C; Rogers, DG; Schroeder, A; Wesolowicz, DM, 2023) |
| "Chronic pain is a significant health concern that adversely affects all aspects of life, including emotional well-being." | ( Barrett, BP; Brown, R; Burzinski, CA; Edwards, RR; Garland, EL; Jamison, RN; Lennon, RP; Nakamura, Y; Schiefelbein, T; Zgierska, AE, 2023) |
| "Chronic pain is a tremendous burden for afflicted individuals and society." | ( Kunczt, A; McGehee, DS; Sullere, S, 2023) |
| "Chronic pain is a frequent, distressing and poorly understood health problem." | ( Luo, C; Wu, SX; Xie, RG; Xu, GY, 2023) |
| "Chronic pain is a highly prevalent and disabling condition which is often undertreated and poorly managed in the community." | ( Gregoire, N; Holtzman, S; Kaseweter, K; Louw, WF; Nazemi, M; Walsh, Z, 2023) |
| "Chronic pain is a common reason for which people in the USA seek medical care." | ( Chen, Y; Cox, CJ; Noordin, NS; Sivanesan, E; Wilkinson, MM, 2023) |
| "Chronic pain is one of the most common reasons that people in the USA seek medical care." | ( Chen, Y; Cox, CJ; Noordin, NS; Sivanesan, E; Wilkinson, MM, 2023) |
| Excerpt | Reference |
|---|
| "Strong opioids are efficient drugs for treating chronic pain." | ( Lahajnar Čavlović, S; Pirc, J; Stepanović, A, 2011) |
| "Inadequately treated chronic pain can seriously affect one's quality of life." | ( Bernhofer, EI; Sorrell, JM, 2012) |
| "Random drug testing of people being treated for chronic pain has become more common." | ( Collen, M, 2012) |
| "Patients (n = 133) undergoing treatment for chronic pain at four clinics participated in the study and provided paired oral fluid and urine specimens." | ( Black, DL; Caplan, YH; Cone, EJ; Crouch, DJ; Depriest, A; Heltsley, R; Marshall, L; Meadors, VM; Robert, T, 2012) |
| "When prescribing opioids to treat chronic pain, physicians face the dilemma of balancing effective pain management while avoiding iatrogenic opioid addiction." | ( Ashrafioun, L; Blondell, RD; Fox, CH; Keller, CE; Neumann, AM; Van Klein, J, 2012) |
| "In the treatment of chronic pain in the frail elderly, the opioids of first choice are buprenorphine, fentanyl, hydromorphone, morphine and oxycodone." | ( Brouwers, JR; Jansen, PA; van Ojik, AL; van Roon, EN, 2012) |
| "Treatment approaches that balance treating chronic pain while minimizing risks for opioid abuse, misuse, and diversion are much needed." | ( Manchikanti, L; Sehgal, N; Smith, HS, 2012) |
| "Physicians who treat patients with chronic pain must be cognizant of the federal and state policies that govern the distribution of opioid medications as well as the current standards of medical practice for opioid prescribing." | ( Copenhaver, DJ; Stayner, RS, 2012) |
| "To improve prevention and treatment of chronic pain, epidemiologic studies are mandatory for assessing chronic pain." | ( Ekholm, O; Højsted, J; Juel, K; Kurita, GP; Sjøgren, P, 2012) |
| "The anaesthetic ketamine is used to treat various chronic pain syndromes, especially those that have a neuropathic component." | ( Dahan, A; Martini, C; Niesters, M, 2014) |
| "However, treatment of chronic pain conditions in depressive patients has, so far, received limited attention in research." | ( Beekman, AT; Bet, PM; de Heer, EW; Dekker, J; Hakkaart-Van Roijen, L; Holwerda, TJ; Kat, F; Ringoir, L; Roth, J; van der Feltz-Cornelis, CM; van Eck van der Sluijs, JF; van Marwijk, HW, 2013) |
| "Uncertainties about opioid treatment for chronic pain, particularly addiction and misuse, play an important role in communicating about pain treatment." | ( Bair, MJ; Bergman, AA; Coffing, J; Collins, LA; Krebs, EE; Matthias, MS, 2013) |
| "The pharmacological treatment of chronic pains induced by an excess of nociception is mainly based on analgesics which are classified according to their pharmacological nature (not opioid/opioid) and to their power according to the three World Health Organization steps." | ( Lantéri-Minet, M, 2013) |
| "Opioids are routinely prescribed for treatment of chronic pain (CP)." | ( Colson, J; Sehgal, N; Smith, HS, 2013) |
| "Under-treatment or lack of appropriate treatment for chronic pain remains an ongoing major healthcare problem." | ( Dejonckheere, J; Eggers, A; Müller-Schwefe, GH; Vellucci, R; Wimmer, AM, 2014) |
| "With appropriate assessment and treatment, COT for chronic pain patients with a history of SUD can be successful, leading to improved functionality and quality of life." | ( Chang, YP; Compton, P, 2013) |
| "Systemic gabapentin, commonly used to treat chronic pain, impaired the novel object recognition task in normal but not SNL animals." | ( Eisenach, JC; Hayashida, K; Suto, T, 2014) |
| "Individuals seeking treatment for chronic pain in multidisciplinary pain management services are typically already on high doses of pain medications." | ( Allen, AR; Arnold, CA; Gibson, SJ; Giummarra, MJ; Pichler, AS, 2015) |
| "Opioids are controversial in the treatment of chronic pain due to the risk of addiction, misuse, and death." | ( Fredheim, O; Pedersen, L, 2015) |
| "Opioid treatment for chronic pain is a known risk factor for falls and/or fractures in elderly patients." | ( Akehurst, R; Dunlop, W; Hirst, A; Hirst, M; Knight, C, 2016) |
| "Opioids are frequently used to treat chronic pain, although adverse effects often restrict their long-term benefits." | ( Alarcão, J; Costa, J; Fareleira, F; Santos, J; Vaz-Carneiro, A, 2015) |
| "Opioids remain a routine treatment for chronic pain, but extended exposure to opioid therapy can produce opioid tolerance and hyperalgesia." | ( Bekker, A; Lutz, BM; Nia, S; Tao, YX; Xiong, M, 2015) |
| "Opioids are useful in treating chronic pain but have accompanying complications." | ( Jamison, RN; Mao, J, 2015) |
| "The report in this paper of long-term treatment of chronic pain patients from 7 months to 22 years principally confirms its persistent effectiveness and tolerability." | ( Wörz, R, 2014) |
| "Current treatments for chronic pain have limited effectiveness and commonly known side effects." | ( Amirdelfan, K; Benyamin, R; Brown, LL; Bundschu, R; Burgher, AH; Burton, AW; Doust, MW; Gliner, BE; Kapural, L; Morgan, DM; Sitzman, BT; Vallejo, R; Yang, T; Yearwood, TL; Yu, C, 2015) |
| "Further, many treatments for chronic pain also carry significant side effects." | ( Sowa, NA; Street, SE, 2015) |
| "Opioids are commonly used to treat chronic pain, but their metabolic interactions with concurrently prescribed medications for concomitant disease burdens can affect potency and efficacy of pain therapy." | ( Berner, T; Ernst, FR; Herndon, C; House, J; Mills, JR, 2015) |
| "Cognitive-behavioral treatments for chronic pain typically target pain-related fear; exposure in vivo is a common treatment focusing on disconfirming harm expectancy of feared movements." | ( Claes, N; Karsdorp, PA; Meulders, A; Vlaeyen, JWS, 2015) |
| "The use of opioids to treat chronic pain has come under increased scrutiny, as such use has been associated with significant risk of death, with limited data regarding the long-term effectiveness, especially when used to treat noncancer pain." | ( Ashburn, MA; Chen, A, 2015) |
| "The pharmacological treatment of chronic pain in children and adolescents can be challenging, ineffective, and is mostly based on expert opinions and consensus." | ( Finkel, JC; Lippold, C; Muller, EA; Nouraie, M; Quezado, ZM; Sheehy, KA, 2015) |
| "High-dose opioids prescribed for the treatment of chronic pain have been associated with increased risk of opioid overdose." | ( Ahmed, S; Hartung, DM; Nicolaidis, C; Weimer, MB, 2016) |
| "Opioids are commonly used to treat patients with chronic pain (CP), though there is little evidence that they are effective for long term CP treatment." | ( Boehnke, KF; Clauw, DJ; Litinas, E, 2016) |
| "This study of the long-term treatment of chronic pain in a geriatric population with OXN-PR shows satisfying analgesic effects achieved with a stable low daily dose, coupled with a good safety profile and, in particular, with a reduction of constipation, often present during opioid therapy." | ( Corli, O; Greco, MT; Guerriero, F; Roberto, A; Rollone, M; Sgarlata, C, 2016) |
| "Confidence in treating chronic pain patients also correlated with the likelihood of covering several specific pain subtopics, including pain assessment, documentation skills, non-pharmacologic treatment, treatment with opioids, and treatment with non-opioids." | ( Antoun, J; Everard, KM; Schiel Zoberi, K, 2016) |
| "Long-term opioid treatment of chronic pain may interfere with treatment of depression." | ( Ahmedani, B; Bucholz, KK; Burroughs, T; Copeland, L; Lustman, PJ; Salas, J; Scherrer, JF; Schneider, FD; Sullivan, MD, 2016) |
| "Oxycodone is increasingly used for the treatment of chronic pain conditions as oral controlled release (CR) tablets; however, evidence about this drug and its metabolites' dialyzability is lacking." | ( Cavallari, G; Croci Chiocchini, AL; Di Nino, G; Donati, G; Gori, A; La Manna, G; Mandrioli, R; Melotti, RM; Mercolini, L; Protti, M; Samolsky Dekel, BG; Vasarri, A, 2017) |
| "No common nonopioid treatment for chronic pain has been studied in aggregate over longer intervals of active treatment than opioids." | ( Barreiro, AE; Bradshaw, YS; Carr, DB; Chui, KK; Tayeb, BO, 2016) |
| "Methadone is effective for the treatment of chronic pain, but its unique pharmacology requires additional considerations with dosing and monitoring." | ( Atayee, RS; Edmonds, KP; Hollenbach, KA; Hur, GH; Karimian, P, 2017) |
| "Opioids are increasingly used for treatment of chronic pain." | ( Andresen, T; Drewes, AM; Gram, M; Grosen, K; Jonsson, T; Kamp-Jensen, M; Morlion, B; Nielsen, C; Olesen, AE; Pfeiffer-Jensen, M; Pozlep, G, 2017) |
| "Intrathecal ziconotide is used for the treatment of chronic pain and is delivered by an implanted drug delivery device." | ( Edwards, DA; Hafez, O; Patel, S; Sexton, WJ, 2017) |
| "The assessment and treatment of chronic pain will continue to be one of the most common functions of a health care provider." | ( Compton, P; Hobelmann, JG; Tompkins, DA, 2017) |
| "A common treatment for chronic pain is prescription of analgesics, but their long-term use entails risk of morbidity, addiction and misuse." | ( Bell, P; Glinn, MA; Harvey, A; Lickteig, AJ; Rappold, B; Recer, S; Salske, M; Stensland, J; Weber, L, 2017) |
| "Despite the availability of multiple treatment options, chronic pain is largely untreated and contributes to disability and mortality." | ( Ahdal, J; Das, G; Dureja, GP; Jain, PN; Joshi, M; Narang, P; Saxena, A, 2017) |
| "Patients in addiction treatment with chronic pain (N = 501) were classified based on use of non-pharmacological pain treatments." | ( Bohnert, ASB; Goesling, J; Ilgen, MA; Jannausch, M; Lin, LA, 2017) |
| "Evaluation and treatment of chronic pain worldwide are limited by the lack of standardized assessment tools incorporating consistent definitions of pain chronicity and specific queries of known social and psychological risk factors for chronic pain." | ( Baxter, K; Chapman, H; Couldridge, M; Jackson, T; Jense, RJ; Joshi, HR; Kassebaum, NJ; Kundra, P; Liu, X; McQueen, KAK; Nair, D; Sethuramachandran, A; Shotwell, MS; Sullivan, B; Walters, JL, 2017) |
| "At present, medical professionals who treat patients in chronic pain are recommended to provide comprehensive and multidisciplinary treatments, which may include pharmacotherapy." | ( Benzon, HT; Hurley, RW; Nicol, AL, 2017) |
| "Opioid-treated chronic pain patients at a specialty pain practice who screened positive for aberrant drug-related behavior (N = 110) were randomized to receive treatment as usual plus the web-based program or treatment as usual alone." | ( Acosta, MC; Cruciani, RA; Fong, C; Guarino, H; Marsch, LA; Moore, SK; Portenoy, RK; Rosenblum, A; Syckes, C; Turk, DC, 2018) |
| "Findings suggest that opioid-treated chronic pain patients exhibit Pavlovian conditioned responses to opioid cues strengthened by an associative learning process of second-order conditioning when primed by pain-related images." | ( Bryan, CJ; Froeliger, B; Garland, EL; Howard, MO; Kreighbaum, L; Nakamura, Y, 2018) |
| "Opioid-treated chronic pain patients may be at risk for prescription opioid misuse due to heightened opioid craving coupled with deficits in attention to naturally rewarding, positive stimuli." | ( Baker, AK; Garland, EL; Hanley, AW; Platt, KA; Priddy, SE; Riquino, MR, 2018) |
| "Opioid analgesics are commonly used to treat acute and chronic pain; in 2016 alone, more than 60 million patients had at least 1 prescription for opioid analgesics filled or refilled." | ( Hagemeier, NE, 2018) |
| "Non-addictive treatments for chronic pain are, therefore, highly needed." | ( Haleem, DJ, 2018) |
| "The respondents on average treated 30 chronic pain patients per month predominately in a community setting." | ( Giannetti, V; Kamal, KM; Provenzano, DA, 2018) |
| "Providers who treat patients with chronic pain face a dual challenge: providing adequate access to opioid therapies for appropriate pain management while adopting strategies to minimize the risk for abuse." | ( Rauck, RL, 2019) |
| "Among opioid-treated chronic pain patients, deficient response inhibition in the context of emotional distress may contribute to maladaptive pain coping and prescription opioid misuse." | ( Bryan, MA; Froeliger, B; Garland, EL; Howard, MO; Priddy, SE; Riquino, MR, 2019) |
| "IV ketamine is widely used to treat patients with chronic pain, yet the long-term impact remains uncertain." | ( Bhatia, A; Cohen, SP; Orhurhu, MS; Orhurhu, V, 2019) |
| "Approaches used to treat chronic pain outside the eye can be applied to ocular pain that is not responsive to traditional therapies." | ( Felix, ER; Galor, A; Horn, DB; Levitt, RC; Sarantopoulos, CD; Small, LR, 2020) |
| "Ketamine has been used to treat chronic pain; however, it is still unknown as to what types of chronic pain is ketamine effective against." | ( Izuta, S; Kan, S; Mizobuchi, S; Motoyama, Y; Obata, N; Oshiro, Y; Sato, H; Takao, Y, 2019) |
| "Opioid treatment for chronic pain has garnered heightened public attention and political pressure to control a devastating public health crisis in the United States (U." | ( DeBar, LL; Firemark, A; Gruß, I; Mayhew, M; McMullen, CK, 2019) |
| "Patients with opioid-treated chronic pain (N = 95; age = 56." | ( Atchley, R; Baker, AK; Bedford, CE; Bryan, MA; Froeliger, B; Garland, EL; Hanley, AW; Howard, MO; Nakamura, Y; Reese, SE; Riquino, MR; Salas, K; Yack, BP, 2019) |
| "Buprenorphine is an effective treatment for chronic pain and may reduce opioid-induced hyperalgesia." | ( Hann, JE; Klaire, SS; Lee, DS; Negraeff, MD; Nikoo, M; Rezazadeh-Azar, P, 2020) |
| "Effectively treating chronic pain remains a therapeutic challenge in the clinic." | ( Atone, J; Hammock, BD; Wagner, KM, 2020) |
| "Current treatments for chronic pain have limited effectiveness and tolerability." | ( Campbell, F; Gilron, I; Haroutounian, S; Mizubuti, GB; Mohiuddin, MM; Park, R; Rice, ASC; Smith, SM, 2020) |
| "The long-term treatment of chronic pain by opioids is limited by tolerance and risk of addiction/dependence." | ( Brewer, KL; Clemens, S; Dinkins, ML; Lim, SA; Patton, R; Rodgers, HM; Yow, J, 2020) |
| "In clinical trials of treatments for chronic pain, the percentage of participants who withdraw early can be as high as 50%." | ( Cai, X; Dworkin, RH; Gewandter, JS; He, H; McDermott, MP; Turk, DC, 2020) |
| "In the US, first-line treatment for chronic pain is often opioids." | ( Block-Lerner, J; Lomauro, T; Marks, D; Rhodes, A, 2021) |
| "Opioids are one of the most prescribed treatments for chronic pain (CP)." | ( De Sola, H; Failde, I; Goicolea, I; Maquibar, A; Salazar, A, 2020) |
| "Pulsed radiofrequency (PRF) treatments for chronic pain consist in the delivery of a train of sinusoidal electric bursts to the targeted nerve." | ( Ivorra, A; Mercadal, B; Vicente, R, 2020) |
| "Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control." | ( Guevara, N; Guido, PC; Maldonado, C; Schaiquevich, P; Vázquez, M, 2020) |
| "Future or reality? Treating acute and chronic pain is a part of the daily routine of clinical anesthesiologists." | ( Latoschik, ME; Lindner, S; Rittner, H, 2020) |
| "Gabapentin is effective in treating some chronic pain conditions." | ( Daniels, JP; Doust, AM; Hewitt, CA; Horne, AW; Koscielniak, M; Middleton, LJ; Szubert, W; Vincent, K, 2020) |
| "Opioids can be used to treat chronic pain but at the cost of adverse effects and risk of dependence." | ( Charipova, K; Gress, K; Jung, JW; Kaye, AD; Paladini, A; Urits, I; Varrassi, G; Viswanath, O, 2020) |
| "Current therapies for the treatment of chronic pain provide inadequate relief for millions of suffering patients, demonstrating the need for better therapies that will treat pain effectively and improve the quality of patient's lives." | ( Krajewski, JL, 2020) |
| "Multidisciplinary approach in treating chronic pain and its comorbidities and proper education of primary care physicians and different specialists involved in the management of chronic pain are crucial for better clinical outcomes." | ( Gašparini, D; Ljubičić, R; Mršić-Pelčić, J, 2020) |
| "The efficacy of cannabinoids for the treatment of chronic pain is not well established." | ( Befus, D; Longo, R; Oudshoorn, A, 2021) |
| "Among opioid-treated chronic pain patients, response inhibition deficits in emotional contexts may contribute to opioid misuse." | ( Garland, EL; Howard, MO, 2021) |
| "This has been shown in treatment of chronic pain but postoperative studies are sparse." | ( Comelon, M; Drægni, T; Lenz, H; Lieng, M; Raeder, J, 2021) |
| "Opioids, which are widely used for the treatment of chronic pain, have an analgesic effect by mainly activating mu-opioid receptor (MOR)." | ( Kim, SA; Kim, YJ; Lee, GJ; Oh, SB, 2021) |
| "Long-term use of opioids for treatment of chronic pain is associated with significant risks including worsening unrecognized or untreated sleep apnea that may increase morbidity and mortality." | ( Chung, F; Ryan, C; Waseem, R; Wong, J, 2021) |
| "Cannabis has been put forth as a treatment for chronic pain, and changes in laws, attitudes, and use patterns have occurred over the past 2 decades." | ( Aharonovich, E; Bohnert, KM; Browne, KC; Cerda, M; Enkema, MC; Fink, DS; Hasin, DS; Keyhani, S; Martins, SS; Olfson, M; Saxon, AJ; Sherman, SE; Shmulewitz, D; Stohl, M; Wall, M, 2022) |
| "Opioids are used worldwide to treat chronic pain conditions, but there is still an ambiguous and inadequate understanding about their therapeutic use, mostly because of their dual effect in acutely reducing pain and inducing, at the same time, tolerance, dependence, and a risk for opioid use disorder." | ( Balzani, E; Bonci, A; Ilari, S; Malafoglia, V; Muscoli, C; Raffaeli, W; Tenti, M; Vitiello, L, 2022) |
| "Chronic pain is a common, under-treated problem." | ( Butler, J; Dempsey, MT; Fugh-Berman, A; Goodwin, B; Lim, HD; O Connor, B; Paglia, D, 2021) |
| "Current treatments for chronic pain (eg, opioids) can have adverse side effects and rarely result in resolution of pain." | ( Campbell, TS; Cooper, L; Flusk, D; MacInnes, A; Mekhael, AA; Nasr-Esfahani, M; Poulin, PA; Rash, JA; Robert, M; Yi, Y, 2021) |
| "As traditional treatments for chronic pain in general and nociplastic pain in particular are imperfect, there is a need to identify other treatment options." | ( Fitzcharles, MA; Häuser, W; Petzke, F; Tölle, TR, 2021) |
| "Such interventions may help prevent and treat chronic pain characterized by enhanced spinal nociception." | ( Danneels, L; Dhondt, E; Rhudy, JL; Van Branteghem, T; Van Oosterwijck, J; Van Oosterwijck, S, 2022) |
| "Forty-one men (>18 years) with opioid-treated chronic pain and serum total testosterone < 12 nmol/L were randomized to 24 weeks testosterone replacement therapy (testosterone undecanoate injection three times/6 months, n = 20) or placebo injections (n = 21)." | ( Andersen, MS; Caserotti, P; Christensen, LL; Glintborg, D; Kolind, MI, 2022) |
| "Few studies have treated chronic pain or concurrent depression and pain with ketamine." | ( Haroutounian, S; Lenze, EJ; Palanca, BJA; Subramanian, S, 2022) |
| "Opioid therapy is a common treatment for chronic pain, despite accumulating evidence regarding harm and a lack of data to support the efficacy of long-term treatment." | ( Fischer, MR; Grelz, H; Midlöv, P; Priouzifard, M; Ringqvist, Å, 2022) |
| "However, optimal treatments for chronic pain-related sleep disorders are not well established." | ( Ito, H; Matsuo, M; Sasaoka, T; Toyooka, N; Tsuneki, H; Yamazaki, M, 2022) |
| "Duloxetine is proposed as a treatment for chronic pain." | ( Ammitzbøll, N; Arendt-Nielsen, L; Bertoli, D; Brock, C; Drewes, AM; Olesen, AE; Petersen, KK, 2022) |
| "To choose the appropriate treatment for chronic pains, such as PHN, not only efficacy but also tolerability, manageability, practicality, and compliance are important factors, especially in the long term." | ( Fornasari, D; Magni, A; Pais, P; Palao, T; Polati, E; Sansone, P, 2022) |
| "Nonpharmacological approaches for treating chronic pain can be effective for many patients." | ( Braverman, MT; Govier, DJ; Volmar, KM, 2023) |
| "Multidisciplinary approaches to treating chronic pain have been proven effective." | ( Carvès, S; Colin, F; Collet, MP; Coste, J; Deleens, R; Laroche, F; Medkour, T; Meyer, S; Perrot, S; Rouquette, A; Trouvin, AP, 2022) |
| "Thus, new and effective treatments for chronic pain are urgently needed and eagerly pursued." | ( Jiang, X; Li, Q; Zhang, W; Zhang, Y; Zhou, R; Zhu, T, 2022) |
| "Providers in specialties treating chronic pain - primary care, pain management, and neurology-will be coming across medical cannabis as a treatment for chronic pain, regardless of whether they are prescribers." | ( Fermo, O; Shah, J, 2022) |
| "Existing treatment for chronic pain in sickle cell disease (SCD) is opioid-dependent, which is ineffective and carries risks." | ( Aboul-Hassan, D; Bergmans, R; Clauw, DJ; Cofield, C; Sidhom, D, 2023) |