Sclera Diseases

General disorders of the sclera or white of the eye. They may include anatomic, embryologic, degenerative, or pigmentation defects.

Synonym
Scleral Diseases
Sclera Diseases

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	27 (14.44)	23.3326
1990's	38 (20.32)	12.5806
2000's	53 (28.34)	18.1394
2010's	54 (28.88)	28.8240
2020's	15 (8.02)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	3	0
lactic acid	low	1	0
formaldehyde	low	1	0
glycerol	low	1	0
histamine	low	2	0
homogentisic acid	low	3	0
methanol	low	1	0
antazoline	low	1	0
azathioprine	low	1	0
erythrosine	low	1	0
fluconazole	low	1	0
fluorouracil	low	1	0
gentamicin	low	1	0
miltefosine	low	1	0
lidocaine	low	1	0
2-propanol	low	8	0
naphazoline	low	3	0
oxyphenbutazone	low	1	0
phenylbutazone	low	1	0
mitomycin	medium	24	1
prednisolone	low	4	0
prednisolone acetate	low	1	0
prednisone	low	1	0
methylprednisolone acetate	low	1	0
chloramphenicol	low	2	0
lactose	low	1	0
colchicine	low	1	0
fluocinolone acetonide	low	1	0
cytarabine	low	1	0
trichloroacetic acid	low	1	0
perflutren	low	3	0
triamcinolone acetonide	low	2	0
methylprednisolone	low	1	0
fluocortolone	low	1	0
betamethasone	low	1	0
ethambutol	low	1	0
durapatite	low	2	0
vancomycin	low	1	0
amiloride	low	1	0
fluorescein	low	1	0
sulfur hexafluoride	low	1	0
enbucrilate	low	1	0
palladium	low	1	0
silver	low	2	0
tantalum	low	1	0
gadolinium	low	1	0
calcium phosphate, dibasic, anhydrous	low	1	0
calcium phosphate, monobasic, anhydrous	low	1	0
tricalcium phosphate	low	2	0
calcium pyrophosphate	low	2	0
trolamine salicylate	low	10	0
timolol	low	1	0
tobramycin	low	1	0
etoposide	medium	1	1
amikacin	low	1	0
idarubicin	medium	1	1
propiconazole	low	12	0
itraconazole	low	1	0
mk 458	low	1	0
histamine phosphate	low	1	0
bendamustine hydrochloride	low	1	0
clarithromycin	low	1	0
yttrium radioisotopes	medium	1	1
methotrexate	low	1	0
calcium pyrophosphate	low	1	0
cortisone	low	5	0
carboplatin	medium	2	1
inositol 3-phosphate	low	1	0
genipin	low	1	0
mycophenolic acid	low	1	0
keratan sulfate	low	1	0
iridoids	low	1	0
bromochloroacetic acid	low	2	0
leuprolide	low	1	0
methimazole	low	1	0
dermatan sulfate	low	1	0
alpha-chymotrypsin	low	1	0
11-cis-retinal	low	1	0
amphotericin b	low	2	0
hydrocortisone valerate	low	1	0
phosphorus	low	2	0
strontium radioisotopes	low	2	0
gadolinium dtpa	low	1	0
indocyanine green	low	4	0
ro13-9904	low	1	0
methylcellulose	low	1	0
ascorbic acid	low	1	0
tetracycline	low	2	0
minocycline	low	22	0
warfarin	low	1	0
cyclosporine	low	2	0
orabase	low	1	0
muramidase	low	2	0
chondroitin sulfates	low	1	0
acyclovir	low	1	0
rifampin	low	1	0
eye	low	21	0
2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	low	1	0

Protein Targets (795)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Retinaldehyde-binding protein 1	0	0	1	1
Chain A, Retinaldehyde-binding protein 1	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
RAR-related orphan receptor gamma	23	0	0	23
GLI family zinc finger 3	29	0	0	29
AR protein	39	0	0	39
aldehyde dehydrogenase 1 family, member A1	19	0	0	19
retinoic acid nuclear receptor alpha variant 1	28	0	0	28
retinoid X nuclear receptor alpha	24	0	0	24
estrogen nuclear receptor alpha	43	0	0	43
peroxisome proliferator-activated receptor delta	16	0	0	16
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	19	0	0	19
activating transcription factor 6	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	18	0	0	18
Histone H2A.x	14	0	0	14
thyroid hormone receptor beta isoform a	9	0	0	9
heat shock protein beta-1	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	26	0	0	26
lamin isoform A-delta10	26	0	0	26
Voltage-dependent calcium channel gamma-2 subunit	17	0	0	17
Glutamate receptor 2	18	1	0	19
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Ferritin light chain	8	0	0	8
Thymidine kinase	0	1	0	1
thioredoxin reductase	15	0	0	15
phosphopantetheinyl transferase	11	0	0	11
GLS protein	8	0	0	8
TDP1 protein	29	0	0	29
Smad3	4	0	0	4
thyroid stimulating hormone receptor	9	0	0	9
EWS/FLI fusion protein	13	0	0	13
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	21	0	0	21
Bloom syndrome protein isoform 1	8	0	0	8
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Solute carrier family 22 member 1	0	1	0	3
ATP-binding cassette sub-family C member 3	0	22	0	22
Multidrug resistance-associated protein 4	0	22	0	23
Solute carrier family 22 member 6	0	2	0	3
Bile salt export pump	0	8	0	8
Bile salt export pump	0	29	0	29
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	9	1	10
Cytochrome P450 2J2	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	5
Canalicular multispecific organic anion transporter 1	0	21	0	22
Thymidine kinase	0	2	0	2
peripheral myelin protein 22	9	0	0	9
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	11	0	0	11
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	15	0	0	15
Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
acid sphingomyelinase	2	0	0	2
acetylcholinesterase	13	0	0	13
regulator of G-protein signaling 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	31	0	0	31
glucocerebrosidase	2	0	0	2
alpha-galactosidase	2	0	0	2
cytochrome P450 2D6 isoform 1	5	0	0	5
lysosomal alpha-glucosidase preproprotein	1	0	0	1
cytochrome P450 2C19 precursor	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
thyroid hormone receptor beta isoform 2	25	0	0	25
huntingtin isoform 2	3	0	0	3
geminin	24	0	0	24
Membrane primary amine oxidase	0	1	0	1
Prothrombin	0	1	0	2
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Urokinase-type plasminogen activator	0	2	0	2
Tissue-type plasminogen activator	0	2	0	2
Cationic trypsin	0	1	0	1
Coagulation factor XI	0	1	0	1
Plasma kallikrein	0	1	0	3
Vitamin K-dependent protein C	0	1	0	1
Cellular tumor antigen p53	28	0	0	28
Urokinase-type plasminogen activator	0	2	0	2
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Sodium/hydrogen exchanger 1	0	2	0	2
Sodium/hydrogen exchanger 3	0	2	0	2
Adenosine receptor A2a	0	1	0	1
Trypsin-3	0	1	0	1
Amiloride-sensitive sodium channel subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Sodium/hydrogen exchanger 2	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium/hydrogen exchanger 5	0	2	0	2
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	2	0	3
Acid-sensing ion channel 3	0	1	0	1
Sodium/hydrogen exchanger	0	1	0	1
Chain A, Cruzipain	4	0	0	4
interleukin 8	6	0	0	6
farnesoid X nuclear receptor	17	0	0	17
vitamin D (1,25- dihydroxyvitamin D3) receptor	21	0	0	21
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	9	0	0	9
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 3A4	0	9	1	10
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C19	0	2	0	2
Nuclear receptor ROR-gamma	5	0	0	5
Aurora kinase B	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
USP1 protein, partial	11	0	0	11
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
lethal factor (plasmid)	5	0	0	5
Histamine H1 receptor	0	1	4	5
Inositol monophosphatase 1	2	0	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	21	0	0	21
estrogen-related nuclear receptor alpha	32	0	0	32
IDH1	12	0	0	12
chromobox protein homolog 1	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 2	17	0	0	17
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Polyphenol oxidase 2	0	4	0	6
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Spike glycoprotein	7	0	0	7
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
SMAD family member 2	9	0	0	9
ATAD5 protein, partial	9	0	0	9
Fumarate hydratase	8	0	0	8
SMAD family member 3	9	0	0	9
Microtubule-associated protein tau	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	20	0	0	20
pregnane X nuclear receptor	24	0	0	24
G	12	0	0	12
polyprotein	8	0	0	8
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	20	0	0	20
aryl hydrocarbon receptor	14	0	0	14
thyroid stimulating hormone receptor	9	0	0	9
peripheral myelin protein 22 isoform 1	4	0	0	4
cellular tumor antigen p53 isoform a	6	0	0	6
DNA polymerase iota isoform a (long)	15	0	0	15
survival motor neuron protein isoform d	9	0	0	9
cytochrome P450 3A4 isoform 1	10	0	0	10
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	7	0	0	7
muscarinic acetylcholine receptor M1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	10	0	1	11
Interferon beta	17	0	0	17
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
Gamma-aminobutyric acid receptor subunit beta-1	10	0	1	11
Gamma-aminobutyric acid receptor subunit delta	10	0	1	11
Gamma-aminobutyric acid receptor subunit gamma-2	10	0	1	11
Gamma-aminobutyric acid receptor subunit alpha-5	10	0	1	11
Gamma-aminobutyric acid receptor subunit alpha-3	10	0	1	11
Gamma-aminobutyric acid receptor subunit gamma-1	10	0	1	11
Gamma-aminobutyric acid receptor subunit alpha-2	10	0	1	11
Gamma-aminobutyric acid receptor subunit alpha-4	10	0	1	11
Gamma-aminobutyric acid receptor subunit gamma-3	10	0	1	11
Gamma-aminobutyric acid receptor subunit alpha-6	10	0	1	11
Gamma-aminobutyric acid receptor subunit alpha-1	10	0	1	11
Gamma-aminobutyric acid receptor subunit beta-3	10	0	1	11
Gamma-aminobutyric acid receptor subunit beta-2	10	0	1	11
GABA theta subunit	10	0	1	11
Inositol hexakisphosphate kinase 1	12	0	0	12
ATPase family AAA domain-containing protein 5	11	0	0	11
Ataxin-2	13	0	0	13
Gamma-aminobutyric acid receptor subunit epsilon	10	0	1	11
Protein-arginine deiminase type-4	0	5	0	5
cytochrome P450 2C9, partial	12	0	0	12
pregnane X receptor	7	0	0	7
progesterone receptor	20	0	0	20
nuclear receptor subfamily 1, group I, member 2	10	0	0	10
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	14	2	21
Glycine receptor subunit alpha-1	0	14	0	14
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
ORF73	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
estrogen receptor 2 (ER beta)	15	0	0	15
cytochrome P450 2D6	12	0	0	12
DNA polymerase kappa isoform 1	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
streptokinase A precursor	0	0	2	2
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
50S ribosomal protein L36 2	0	2	0	2
Methionine--tRNA ligase, mitochondrial	0	0	1	1
importin subunit beta-1 isoform 1	3	0	0	3
mitogen-activated protein kinase 1	6	0	0	6
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
urokinase-type plasminogen activator precursor	9	0	0	9
plasminogen precursor	9	0	0	9
urokinase plasminogen activator surface receptor precursor	9	0	0	9
ATP-dependent translocase ABCB1	0	5	0	7
Solute carrier organic anion transporter family member 1B3	0	5	0	7
Solute carrier organic anion transporter family member 1B1	0	3	0	4
Chain A, Beta-lactamase	9	0	0	9
Luciferase	10	0	0	10
endonuclease IV	5	0	0	5
PAX8	0	0	0	1
PPM1D protein	5	0	0	5
Thrombopoietin	2	0	0	2
67.9K protein	8	0	0	8
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C9 precursor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
flap endonuclease 1	6	0	0	6
ras-related protein Rab-9A	3	0	0	3
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Solute carrier family 22 member 3	0	2	0	3
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	3	0	3
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Histamine H2 receptor	4	0	1	5
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	3	0	3
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	2	0	4
Dihydrofolate reductase	0	2	0	2
Chymotrypsinogen A	0	1	0	2
Beta-lactamase	0	2	0	2
Amyloid-beta precursor protein	2	2	0	4
Beta-lactamase	0	0	0	1
5-hydroxytryptamine receptor 2A	0	1	0	2
Beta-galactosidase	0	1	0	2
5-hydroxytryptamine receptor 1A	0	3	2	5
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
dopamine D1 receptor	2	0	0	2
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	8	0	0	8
Multidrug and toxin extrusion protein 1	0	2	0	2
glp-1 receptor, partial	7	0	0	7
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	3	0	4
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
D(1A) dopamine receptor	2	0	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
hypothetical protein, conserved	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
thyrotropin-releasing hormone receptor	3	0	0	3
eyes absent homolog 2 isoform a	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Pantothenate synthetase	0	1	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
DNA topoisomerase 2	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	1	3
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
Integrase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
apical membrane antigen 1, AMA1	2	0	0	2
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	1	0	1
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	1	4
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	5	0	0	5
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	5
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Carbonic anhydrase 12	0	1	0	2
Carbonic anhydrase 1	0	2	0	3
Carbonic anhydrase 2	0	3	1	6
Carbonic anhydrase 3	0	1	0	2
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Histamine H2 receptor	0	1	2	3
Adenosine receptor A1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Histamine H1 receptor	0	2	2	4
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 13	0	1	0	2
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Histamine H3 receptor	0	1	2	3
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
DNA polymerase III, partial	1	0	0	1
NPYLR7B	0	0	1	1
Parkin	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
D(1A) dopamine receptor	2	0	0	2
glucokinase regulatory protein	1	0	0	1
DNA polymerase beta	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	6	0	0	6
Glutamate receptor 1	1	1	0	2
Glutamate receptor 3	1	1	0	2
Glutamate receptor 4	1	1	0	2
Single-stranded DNA cytosine deaminase	1	0	0	1
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
Platelet-activating factor receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Albumin	0	1	4	5
Stromelysin-1	0	2	1	3
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	2	3	6
Alpha-synuclein	1	2	0	3
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	0	1	1
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 1D	0	0	1	1
5-hydroxytryptamine receptor 1F	0	0	1	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
Nischarin	0	1	0	1
Nrf2	1	0	0	1
Microphthalmia-associated transcription factor	0	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
caspase recruitment domain family, member 15	0	1	0	1
Caspase-7	1	0	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
caspase-3	1	0	0	1
histone deacetylase 9 isoform 3	2	0	0	2
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Nicotinate phosphoribosyltransferase	0	3	0	3
Beta lactamase (plasmid)	0	1	0	1
Estrogen receptor 1	0	1	0	1
fMet-Leu-Phe receptor	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Cytochrome P450 2B6	0	0	1	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
Free fatty acid receptor 1	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	0	1	1
Glutamate receptor ionotropic, NMDA 3B	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Cytochrome P450 3A5	0	0	1	1
Amine oxidase [flavin-containing] A	0	1	0	1
Catechol O-methyltransferase	0	0	1	1
Peroxisome proliferator-activated receptor alpha	0	1	1	2
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
C-C chemokine receptor type 2	0	1	0	1
Cannabinoid receptor 2	0	0	1	1
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	2	1	3
Glutamate receptor ionotropic, NMDA 1	0	0	1	1
Peroxisome proliferator-activated receptor alpha	0	2	1	3
ATP-binding cassette sub-family C member 8	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	1	1
Glutamate receptor ionotropic, NMDA 2B	0	0	1	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	1	1
Sodium/bile acid cotransporter	0	1	0	1
Thrombin	0	0	1	1
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
NFKB1 protein, partial	1	0	0	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	0	1	1
Protein Rev	0	0	1	1
Microtubule-associated protein tau	0	2	0	2
Alpha-2A adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research

Studies (187)

Protein Targets (795)

Sclera Diseases

Synonyms(2)

Research

Studies (187)

Drugs Studied (109)

Protein Targets (795)