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nucleobase analogue

A molecule that can substitute for a normal nucleobase in nucleic acids.

ChEBI ID: 67142

Members (24)

MemberDefinitionRole
1-methyluracilA pyrimidone that is uracil with a methyl group substituent at position 1.1-methyluracil
1,(n2)-ethenoguanineA nucleobase analogue obtained by addition of an etheno group across positions 1 and N2 of guanine.1,N(2)-ethenoguanine
2-amino-n(6)-hydroxyadenineA 2,6-diaminopurine that is the N(6)-hydroxy derivative of 2,6-diamino-3H-purine.2-amino-6-hydroxyaminopurine
2-aminopurineThe parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.2-aminopurine
3-methyluracilA pyrimidone that is uracil with a methyl group at position 3.3-methyluracil
5-formylcytosineA nucleobase analogue that is cytosine in which the hydrogen at position 5 is replaced by a formyl group.5-formylcytosine
5-formyluracilA pyrimidone resulting from the formal oxidation of the alcoholic hydroxy group of 5-hydroxymethyluracil to the corresponding aldehyde. It is a major one-electron photooxidation product of thymine in oligodeoxynucleotides.5-formyluracil
5-hydroxymethylcytosineA nucleobase analogue that is cytosine in which the hydrogen at position 5 is replaced by a hydroxymethyl group.5-(hydroxymethyl)cytosine
6-azathymineA nucleobase analogue that is thymine in which the CH group at position 6 is replaced by nitrogen.6-azathymine
6-n-hydroxylaminopurineA member of the class of 6-aminopurinnes that is adenine in which one of the exocyclic amino hydrogens is replaced by a hydroxy group.N(6)-hydroxyadenine
8-azaadenineA triazolopyrimidine that is [1,2,3]triazolo[4,5-d]pyrimidine bearing an amino substituent at position 7.8-azaadenine
8-azahypoxanthineA triazolopyrimidine that consists of 1,4-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing an oxo substituent at position 7.8-azahypoxanthine
8-hydroxyadenineAn oxopurine that is adenine bearing a single oxo substituent at position 8.8-hydroxyadenine; 8-oxoadenine
8-hydroxyadenineA nucleobase analogue that is adenine bearing a single hydroxy substituent at position 8.8-hydroxyadenine; 8-oxoadenine
allopurinolA bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.allopurinol
azaguanineA triazolopyrimidine that consists of 3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing amino and oxo substituents at positions 5 and 7 respectively.8-azaguanine
azauracilA 1,2,4-triazine compound having oxo-substituents at the 3- and 5-positions.6-azauracil
bromouracilA pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen.5-bromouracil
fluorouracilA nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.5-fluorouracil
hypoxanthineA purine nucleobase that consists of purine bearing an oxo substituent at position 6.hypoxanthine
isodialuric acidA nucleobase analogue that is uracil substituted at positions 5 and 6 by hydroxy groups.5,6-dihydroxyuracil
n(2),3-ethenoguanineA nucleobase analogue obtained by addition of an etheno group across positions N2 and 3 of guanine.N(2),3-ethenoguanine
sofosbuvirA nucleobase analogue that is cytosine in which the hydrogen at position 5 is replaced by a carboxy group.5-carboxycytosine
thiouracilA nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group.thiouracil

Research

Studies (65,034)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-199016,627 (25.57)18.7374
1990's11,863 (18.24)18.2507
2000's14,776 (22.72)29.6817
2010's16,965 (26.09)24.3611
2020's4,803 (7.39)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials10,220 (14.54%)5.53%
Reviews5,388 (7.67%)6.00%
Case Studies5,782 (8.23%)4.05%
Observational223 (0.32%)0.25%
Other48,679 (69.25%)84.16%