Page last updated: 2024-08-05 10:44:52
guaiacols
Any phenol carrying an additional methoxy substituent at the ortho-position.
ChEBI ID: 134251
Members (16)
| Member | Definition | Role |
|---|---|---|
| (2S,3R)-dihydrodehydrodiconiferyl alcohol | (2S,3R)-dihydrodehydrodiconiferyl alcohol | |
| 2-vanillin | A member of the class of benzaldehydes that is salicylaldehyde substituted by a methoxy group at position 3. | ortho-vanillin |
| 4-hydroxy-3-methoxybenzene-1-sulfonic acid | An arenesulfonic acid that is guaiacol sulfated at position 4. Commonly used (in the form of its potassium salt) as an expectorant. | 4-hydroxy-3-methoxybenzene-1-sulfonic acid |
| coniferaldehyde | A member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3. | coniferyl aldehyde |
| coniferyl alcohol | A phenylpropanoid that is one of the main monolignols, produced by the reduction of the carboxy functional group in cinnamic acid and the addition of a hydroxy and a methoxy substituent to the aromatic ring. | coniferol |
| dehydrodiconiferyl alcohol | A guaiacyl lignin obtained by cyclodimerisation of coniferol. | dehydrodiconiferyl alcohol |
| dihydroferulic acid | A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 3 has been replaced by a 4-hydroxy-3-methoxyphenyl group. | dihydroferulic acid |
| gingerol | A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger. | gingerol |
| guaiacol | A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position. | guaiacol |
| hetacillin | A lignan that consists of tetrahydrofuran substituted by a 3,4-dihydroxyphenyl group at position 2, a hydroxymethyl group at position 3 and a 4-hydroxy-3-methoxybenzyl group at position 4. It has been isolated from Taxus yunnanensis. | taxiresinol |
| homovanillic acid | A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite. | homovanillic acid |
| isolariciresinol | A lignan that is 5,6,7,8-tetrahydronaphthalen-2-ol substituted by hydroxymethyl groups at positions 6 and 7, a methoxy group at position 3 and a 4-hydroxy-3-methoxyphenyl group at position 8. It has been isolated from the roots of Rubia yunnanensis. | (+)-isolariciresinol |
| meso-dihydroguaiaretic acid | A lignan that is 2,3-dimethylbutane substituted by 2-methoxyphenol groups at positions 1 and 4 respectively. It has been isolated from the bark of Machilus robusta. | meso-dihydroguaiaretic acid |
| methyl ferulate | A cinnamate ester that is the methyl ester of ferulic acid. It has been isolated from Pisonia aculeata. | trans-methylferulate |
| N-octylhomovanillamide | A monocarboxylic acid amide that is the N-octyl amide of homovanillic acid. | N-octylhomovanillamide |
| vanillyl alcohol | A monomethoxybenzene that is 2-methoxyphenol substituted by a hydroxymethyl group at position 4. | vanillyl alcohol |
Research
Studies (8,511)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3,217 (37.80) | 18.7374 |
| 1990's | 1,992 (23.41) | 18.2507 |
| 2000's | 1,414 (16.61) | 29.6817 |
| 2010's | 1,465 (17.21) | 24.3611 |
| 2020's | 423 (4.97) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 346 (3.84%) | 5.53% |
| Reviews | 248 (2.76%) | 6.00% |
| Case Studies | 199 (2.21%) | 4.05% |
| Observational | 2 (0.02%) | 0.25% |
| Other | 8,204 (91.17%) | 84.16% |