Page last updated: 2024-08-05 14:23:09

epitope

The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.

ChEBI ID: 53000

Members (56)

MemberDefinitionClass
(e)-4-hydroxy-3-methylbut-2-enyl diphosphateA prenol phosphate comprising (2E)-4-hydroxy-3-methylbut-2-en-1-ol having an O-diphosphate substituent.(2E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate
(n-(p-cyanophenyl)-n'-(diphenylmethyl)guanidine)acetic acidA trisubstituted guanidine, carrying 4-cyanophenyl, diphenylmethyl and carboxymethyl substituents, which is known to act as a highly potent sweetening agent.[N-(4-cyanophenyl)-N'-(diphenylmethyl)guanidine]acetic acid
1-lauryl-2-pyrrolidonePyrrolidin-2-one substituted at nitrogen by an n-dodecyl group.1-dodecylpyrrolidin-2-one
15-acetyldeoxynivalenolA trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-15. A skin and eye irritant, along with its 3-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.15-acetyldeoxynivalenol
2-acetylaminofluoreneThe parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.2-acetamidofluorene
3-acetyldeoxynivalenolA trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-3. A skin and eye irritant, along with its 15-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.3-acetyldeoxynivalenol
3,3-dimethylallyl pyrophosphateA prenol phosphate that is a phosphoantigen comprising the O-pyrophosphate of prenol.prenyl diphosphate
3,4-dichloroanilineA dichloroaniline having the two chloro-substituents at the 3- and 4-positions.3,4-dichloroaniline
4-nitrophenylphosphorylcholineA phosphocholine that is the 4-nitrophenyl ester of choline phosphate.p-nitrophenylphosphocholine
acenaphthenequinoneAn orthoquinone that is the 1,2-dioxo derivative of acenaphthene.acenaphthoquinone
acetylgalactosamineAn N-acetyl-D-galactosamine having beta-configuration at the anomeric centre.N-acetyl-beta-D-galactosamine
acetylglucosamineAn N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.N-acetyl-beta-D-glucosamine
alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAcA branched amino tetrasaccharide consisting of a sialyl residue, linked (2->3) to a galactosyl residue that in turn is linked (1->4) to a glucosaminyl residue, which is also carrying a fucosyl residue at the 3-position.3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc.html>alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc
argpyrimidineA member of the class of hydroxypyrimidines obtained by cyclocondensation of L-arginine and methylglyoxal; a methyl glyoxal-derived advanced glycation end-product (AGE) in familial amyloidotic polyneuropathy and human cancers.argpyrimidine
benzoylecgonineA benzoate ester metabolite of cocaine formed by hydrolysis of the methyl ester group, catalysed by carboxylesterases.ecgonine benzoate
benzyl cinnamateThe cinnamate ester derived from cinnamic acid and benzyl alcohol. Occuring in Balsam of Peru and Tolu balsam, in Sumatra and Penang benzoin, and as the main constituent of copaiba balsam, it is used in heavy oriental perfumes, as a fixative and as a flavouring agent.benzyl cinnamate
berylliumAlkaline earth metal atom with atomic number 4.beryllium atom; beryllium(0)
blood group a trisaccharideA branched amino trisaccharide consisting of beta-D-galactose having an alpha-L-fucosyl residue at the 2-position and an N-acetyl-alpha-D-galactosaminyl residue at the 3-position.3)-[alpha-L-Fucp-(1->2)]-beta-D-Galp.html>alpha-D-GalpNAc-(1->3)-[alpha-L-Fucp-(1->2)]-beta-D-Galp
blood group b trisaccharideA branched trisaccharide consisting of beta-D-galactose having an alpha-L-fucosyl residue at the 2-position and an alpha-D-galactosyl residue at the 3-position.2)-[alpha-D-Gal-(1->3)]-beta-D-Gal.html>alpha-L-Fuc-(1->2)-[alpha-D-Gal-(1->3)]-beta-D-Gal
cellobioseA cellobiose with beta configuration at the reducing-end glucose residue.beta-cellobiose
dansyllysineAn L-lysine derivative with a dansyl group at the N(6)-position.N(6)-dansyl-L-lysine
digoxinA cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.digoxin
dinitrochlorobenzeneA C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.1-chloro-2,4-dinitrobenzene
dronabinolA diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy.Delta(9)-tetrahydrocannabinol
estriol 3-glucuronideA steroid glucosiduronic acid that is the 3-beta-D-glucuronide of estriol; a steroid hormone ligand recognised by the monoclonal antibody 4155.estriol 3-O-(beta-D-glucuronide)
feesA glycophytoceramide comprising (2S,3S,4R)-2-aminononane-1,3,4-triol having an alpha-D-galctopyranosyl residue at the O-1 position and an tetracosanoyl group attached to the nitrogen.1-O-(alpha-D-galactopyranosyl)-N-tetracosanyl-2-aminononane-1,3,4-triol
fixb protein, e coliD-Mannopyranose having alpha-configuration at the anomeric centre.alpha-D-mannose
flucofuronA member of the class of phenylureas that is urea in which each nitrogen is substituted by a 4-chloro-3-(trifluoromethyl)phenyl group.flucofuron
g(m1)-oligosaccharideA branched amino pentasaccharide consisting of the linear sequence beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc having a Neu5Ac residue attached to the inner galactose via an alpha-(2->3) linkage. The oligosaccharide of ganglioside GM1a.3)-beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp.html>beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp
galactoseA D-galactopyranose having beta-configuration at the anomeric centre.beta-D-galactose
globo-hAn amino trisaccharide consisting of alpha-L-fucose, beta-D-galactose and N-acetyl-beta-D-glucosamine residues joined by sequential (1->2)- and (1->3)-linkages.2)-beta-D-Galp-(1->3)-beta-D-GlcpNAc.html>alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-beta-D-GlcpNAc
glucose, (beta-d)-isomerD-Glucopyranose with beta configuration at the anomeric centre.beta-D-glucose
hemoglobin randwickA D-mannopyranose in which the anomeric centre has beta-configuration.beta-D-mannose
inositol cyclic phosphateA myo-inositol cyclic phosphate that is the 1,2-cyclic phosphate derivative of 1D-myo-inositol.1D-myo-inositol 1,2-cyclic phosphate
isopentenyl pyrophosphateA prenol phosphate comprising 3-methylbut-3-en-1-ol having an O-diphosphate substituent.isopentenyl diphosphate
krn 7000A glycophytoceramide having an alpha-D-galactosyl residue at the O-1 position and a hexacosanoyl group attached to the nitrogen.1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine
marinobufageninA cardiotonic steroid secreted by the toad Bufo rubescens and other related species such as Bufo marinus. An endogenous Na/K-ATPase inhibitor, it is a vasoconstrictor with effects similar to digitalis.marinobufagenin
methacholineA quaternary ammonium ion in which the nitrogen is substituted with three methyl groups and a 2-acetoxypropyl group. Parasympathomimetic bronchoconstrictor drug used in clinical diagnosis.methacholine
methylphosphateA monoalkyl phosphate having methyl as the alkyl group.methyl dihydrogen phosphate
monoethyl phosphateA monoalkyl phosphate epitope having ethyl as the alkyl group.ethyl dihydrogen phosphate
N-acetyl-alpha-D-galactosamineAn N-acetyl-D-galactosamine having alpha-configuration at the anomeric centre.N-acetyl-alpha-D-galactosamine
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucoseAn amino trisaccharide that is the carbohydrate portion of ganglioside GM3. It comprises a linear sequence of alpha-N-acetylneuraminyl, beta-D-galactosyl and beta-D-glucose residues linked (2->3) and (1->4).3)-beta-D-galactosyl-(1->4)-beta-D-glucose.html>N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose
n-acetylneuraminic acidN-Acetylneuraminic acid with beta configuration at the anomeric centre.N-acetyl-beta-neuraminic acid
n-acetylneuraminosyl(alpha2-6)lactosamineAn amino trisaccharide consisting of an N-acetyl-alpha-neuraminyl residue attached to the galactose residue of N-acetyllactosamine via an alpha-(2->6)-linkage.6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine.html>alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
nickelChemical element (nickel group element atom) with atomic number 28.nickel atom
o-phthalaldehydeA dialdehyde in which two formyl groups are attached to adjacent carbon centres on a benzene ring.phthalaldehyde
oregon green 488 carboxylic acidA xanthene dye having two fluoro substituents at the 2- and 7-positions and a 2,4-dicarboxyphenyl group at the 9-position.oregon green 488
ornidazoleA C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by 3-chloro-2-hydroxypropyl and methyl groups, respectively. It is used in the treatment of susceptible protozoal infections and for the treatment of anaerobic bacterial infections.ornidazole
penicillin gA penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.benzylpenicillin
phosphorylcholineThe phosphate of choline; and the parent compound of the phosphocholine family.phosphocholine
picryl chlorideThe C-nitro compound that is chlorobenzene with three nitro substituents in the 2-, 4- and 6-positions.1-chloro-2,4,6-trinitrobenzene
s-adenosylhomocysteineAn organic sulfide that is the S-adenosyl derivative of L-homocysteine.S-adenosyl-L-homocysteine zwitterion; S-adenosyl-L-homocysteine
secnidazoleA C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by 2-hydroxypropyl and methyl groups, respectively.1-(2-methyl-5-nitro-1-imidazolyl)-2-propanol; secnidazole
sulfamethoxazoleAn isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.sulfamethoxazole
trimellitic anhydrideA 2-benzofuran compound having oxo groups at the 1- and 3-positions and a carboxy substituent at the 5-position; the cyclic anhydride formed from the carboxy groups at the 1- and 2-positions of trimellitic acid.trimellitic anhydride
trinitrobenzenesulfonic acidThe arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.2,4,6-trinitrobenzenesulfonic acid

Research

Studies (106,318)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199032,683 (30.74)18.7374
1990's14,261 (13.41)18.2507
2000's21,239 (19.98)29.6817
2010's28,545 (26.85)24.3611
2020's9,590 (9.02)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials4,667 (4.14%)5.53%
Reviews5,581 (4.95%)6.00%
Case Studies4,927 (4.37%)4.05%
Observational177 (0.16%)0.25%
Other97,375 (86.38%)84.16%

Protein Targets (405)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency21.315623
acetylcholinesteraseHomo sapiens (human)Potency50.916924
activating transcription factor 6Homo sapiens (human)Potency16.142418
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency24.435412
alpha-galactosidaseHomo sapiens (human)Potency31.622811
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency39.810711
AR proteinHomo sapiens (human)Potency15.18241279
aryl hydrocarbon receptorHomo sapiens (human)Potency39.1158315
ATAD5 protein, partialHomo sapiens (human)Potency17.116325
Ataxin-2Homo sapiens (human)Potency14.9313111
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency42.561511
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency15.0200218
Bloom syndrome protein isoform 1Homo sapiens (human)Potency44.668411
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency51.786615
caspase-3Cricetulus griseus (Chinese hamster)Potency21.689911
caspase-3Homo sapiens (human)Potency51.786615
Caspase-7Cricetulus griseus (Chinese hamster)Potency21.689911
Cellular tumor antigen p53Homo sapiens (human)Potency18.5810321
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency0.179022
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency3.981111
Chain A, Beta-lactamaseEscherichia coli K-12Potency16.093524
Chain A, CruzipainTrypanosoma cruziPotency22.474813
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency79.432811
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency32.310512
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency2.233411
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency26.968022
chromobox protein homolog 1Homo sapiens (human)Potency72.679612
cytochrome P450 2C9, partialHomo sapiens (human)Potency12.301811
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency25.118922
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency3.682222
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency8.839118
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency46.679413
DNA polymerase kappa isoform 1Homo sapiens (human)Potency23.778111
estrogen nuclear receptor alphaHomo sapiens (human)Potency22.02151289
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency31.5829212
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency22.0822664
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency29.754414
EWS/FLI fusion proteinHomo sapiens (human)Potency32.642533
farnesoid X nuclear receptorHomo sapiens (human)Potency29.0409519
GVesicular stomatitis virusPotency12.301811
GABA theta subunitRattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency25.118911
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency25.118911
gemininHomo sapiens (human)Potency7.7963216
GLI family zinc finger 3Homo sapiens (human)Potency20.8922322
glp-1 receptor, partialHomo sapiens (human)Potency12.589311
GLS proteinHomo sapiens (human)Potency6.409222
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency22.7965528
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency18.814219
Guanine nucleotide-binding protein GHomo sapiens (human)Potency44.668411
heat shock protein beta-1Homo sapiens (human)Potency23.080729
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.810711
histone deacetylase 9 isoform 3Homo sapiens (human)Potency33.686222
Histone H2A.xCricetulus griseus (Chinese hamster)Potency52.375825
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency35.481311
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency12.301811
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency20.526226
IDH1Homo sapiens (human)Potency6.510013
importin subunit beta-1 isoform 1Homo sapiens (human)Potency125.892011
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency12.301812
Integrin alpha-IIbHomo sapiens (human)Potency0.199511
Integrin beta-3Homo sapiens (human)Potency0.199511
Interferon betaHomo sapiens (human)Potency3.103224
interleukin 8Homo sapiens (human)Potency33.561412
lamin isoform A-delta10Homo sapiens (human)Potency5.711814
lethal factor (plasmid)Bacillus anthracis str. A2012Potency0.031611
LuciferasePhotinus pyralis (common eastern firefly)Potency31.077926
Microtubule-associated protein tauHomo sapiens (human)Potency8.912511
mitogen-activated protein kinase 1Homo sapiens (human)Potency5.011911
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency24.803312
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency0.223912
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency16.2995423
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency8.705723
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency34.570527
Nuclear receptor ROR-gammaHomo sapiens (human)Potency9.439211
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency2.185926
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency24.8530333
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency4.466812
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency40.533411
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency16.6431526
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency15.9584517
phosphopantetheinyl transferaseBacillus subtilisPotency11.220211
plasminogen precursorMus musculus (house mouse)Potency1.258911
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency35.481312
PPM1D proteinHomo sapiens (human)Potency0.037012
pregnane X nuclear receptorHomo sapiens (human)Potency27.5039313
progesterone receptorHomo sapiens (human)Potency24.3092314
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency79.432811
RAR-related orphan receptor gammaMus musculus (house mouse)Potency11.8391224
ras-related protein Rab-9AHomo sapiens (human)Potency0.252812
regulator of G-protein signaling 4Homo sapiens (human)Potency1.263612
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency19.2608326
retinoid X nuclear receptor alphaHomo sapiens (human)Potency13.7267421
serine-protein kinase ATM isoform aHomo sapiens (human)Potency7.079511
SMAD family member 2Homo sapiens (human)Potency13.085628
SMAD family member 3Homo sapiens (human)Potency13.085628
Smad3Homo sapiens (human)Potency3.275213
snurportin-1Homo sapiens (human)Potency125.892011
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency5.011911
TAR DNA-binding protein 43Homo sapiens (human)Potency14.501512
TDP1 proteinHomo sapiens (human)Potency5.9082217
thioredoxin glutathione reductaseSchistosoma mansoniPotency3.109912
thioredoxin reductaseRattus norvegicus (Norway rat)Potency2.818412
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency21.5095219
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency26.023346
thyroid stimulating hormone receptorHomo sapiens (human)Potency23.3454620
tumor necrosis factorHomo sapiens (human)Potency0.375811
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency43.239711
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency1.258911
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency1.258911
USP1 protein, partialHomo sapiens (human)Potency30.059412
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency31.252028
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency17.9139518
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency19.952611
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency18.814219
VprHuman immunodeficiency virus 1Potency18.548212

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
17beta-hydroxysteroid dehydrogenaseCurvularia lunataIC503.850022
3-oxoacyl-[acyl-carrier-protein] synthase 3 Escherichia coliIC5028.500011
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)IC504.700011
5-hydroxytryptamine receptor 2BHomo sapiens (human)IC503.170011
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki2.017011
5-hydroxytryptamine receptor 2CHomo sapiens (human)IC502.143011
5-hydroxytryptamine receptor 2CHomo sapiens (human)Ki1.122011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)IC502.143011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)Ki1.122011
AcetylcholinesteraseHomo sapiens (human)Ki100.000022
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC508.595011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)Ki8.524011
Alpha-2A adrenergic receptorHomo sapiens (human)IC5021.061011
Alpha-2A adrenergic receptorHomo sapiens (human)Ki7.898011
Amine oxidase [flavin-containing] AHomo sapiens (human)IC500.059011
Asialoglycoprotein receptor 1Homo sapiens (human)IC5015,524.500012
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000012
ATP-dependent 6-phosphofructokinaseTrypanosoma brucei bruceiIC5057.000011
ATP-dependent translocase ABCB1Homo sapiens (human)IC5050.000033
ATP-dependent translocase ABCB1Mus musculus (house mouse)IC5050.000044
Beta-lactamase TEMEscherichia coliKi20.000011
Bile salt export pumpHomo sapiens (human)IC50279.183336
Butyrophilin subfamily 3 member A1Homo sapiens (human)IC50104.16671012
C-type lectin domain family 4 member MHomo sapiens (human)IC503,386.000011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000012
Cannabinoid receptor 1Homo sapiens (human)IC500.002811
Cannabinoid receptor 1Rattus norvegicus (Norway rat)IC501.364922
Cannabinoid receptor 1Homo sapiens (human)Ki0.02951818
Cannabinoid receptor 1Mus musculus (house mouse)Ki0.040522
Cannabinoid receptor 1Rattus norvegicus (Norway rat)Ki0.04681010
Cannabinoid receptor 2Rattus norvegicus (Norway rat)IC500.218011
Cannabinoid receptor 2Mus musculus (house mouse)Ki0.030334
Cannabinoid receptor 2Rattus norvegicus (Norway rat)Ki0.046011
Cannabinoid receptor 2 Homo sapiens (human)IC500.009511
Cannabinoid receptor 2 Homo sapiens (human)Ki0.03662222
CD209 antigenHomo sapiens (human)IC506,400.000011
Chain 1, Mannose-binding Protein-cRattus rattus (black rat)Ki5,700.000014
Chain A, Endoglucanase BSalipaludibacillus agaradhaerensKi4,500.000011
Chain A, Ermc' MethyltransferaseBacillus subtilisKi33.000011
Chain A, Ermc' Rrna MethyltransferaseBacillus subtilisKi33.000011
Chain A, Histamine N-MethyltransferaseHomo sapiens (human)Ki6.900012
Chain A, Isopentenyl-diphosphate delta-isomeraseEscherichia coliIC5050.000011
Chain A, Uroporphyrin-III C-methyltransferasePseudomonas denitrificans (nom. rej.)Ki0.320011
Chain B, lectin I B chainViscum album (European mistletoe)IC50900.000011
CholinesteraseHomo sapiens (human)Ki21.228235
Coagulation factor XIIHomo sapiens (human)Ki1.057013
Cocaine esteraseHomo sapiens (human)Ki0.170011
Cytochrome P450 1A2Homo sapiens (human)IC500.016011
Cytochrome P450 3A4Homo sapiens (human)IC5025.997622
Dihydrofolate reductasePneumocystis cariniiIC500.100011
Dihydropteroate synthaseEscherichia coli K-12IC504.700011
DNA (cytosine-5)-methyltransferase 1Homo sapiens (human)IC501.42121010
DNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)IC5050.000011
DNA (cytosine-5)-methyltransferase 3BHomo sapiens (human)IC5010.290055
Early activation antigen CD69Homo sapiens (human)IC50480.707033
Endothelin-1 receptorRattus norvegicus (Norway rat)IC50223.333333
exodeoxyribonuclease V subunit RecBEscherichia coli str. K-12 substr. MG1655IC50106.438022
exodeoxyribonuclease V subunit RecCEscherichia coli str. K-12 substr. MG1655IC50106.438022
exodeoxyribonuclease V subunit RecDEscherichia coli str. K-12 substr. MG1655IC50106.438022
Fatty acid synthaseHomo sapiens (human)Ki150.000011
Fatty acid-binding protein, liverMus musculus (house mouse)Ki1.000011
Fatty-acid amide hydrolase 1Homo sapiens (human)IC5043.600011
G-protein coupled receptor 55Homo sapiens (human)IC5014.200011
Glutathione S-transferase omega-1Homo sapiens (human)IC50900.000011
Glycogen phosphorylase, muscle formOryctolagus cuniculus (rabbit)Ki7,400.000011
Histamine N-methyltransferaseHomo sapiens (human)Ki14.300012
Histone-arginine methyltransferase CARM1Homo sapiens (human)Ki0.630022
Histone-lysine N-methyltransferase 2AHomo sapiens (human)IC501.512022
Histone-lysine N-methyltransferase EHMT1Homo sapiens (human)IC500.230011
Histone-lysine N-methyltransferase EHMT2Homo sapiens (human)IC502.640033
Histone-lysine N-methyltransferase EHMT2Homo sapiens (human)Ki0.570011
Histone-lysine N-methyltransferase EZH1Homo sapiens (human)IC506.400011
Histone-lysine N-methyltransferase EZH2Homo sapiens (human)IC5024.840055
Histone-lysine N-methyltransferase KMT5CHomo sapiens (human)IC5010.000011
Histone-lysine N-methyltransferase NSD2Homo sapiens (human)IC5039.100011
Histone-lysine N-methyltransferase SETD7Homo sapiens (human)IC5038.500022
Histone-lysine N-methyltransferase SETDB1Homo sapiens (human)IC502.200011
Histone-lysine N-methyltransferase SUV39H1Homo sapiens (human)IC501.200011
Histone-lysine N-methyltransferase SUV39H1Homo sapiens (human)Ki4.900011
Histone-lysine N-methyltransferase SUV39H2Homo sapiens (human)IC5027.000022
Histone-lysine N-methyltransferase, H3 lysine-79 specificHomo sapiens (human)IC500.390044
Histone-lysine N-methyltransferase, H3 lysine-79 specificHomo sapiens (human)Ki0.196733
Indolethylamine N-methyltransferaseHomo sapiens (human)Ki2.000012
Induced myeloid leukemia cell differentiation protein Mcl-1Homo sapiens (human)IC501,425.000011
Induced myeloid leukemia cell differentiation protein Mcl-1Homo sapiens (human)Ki57.000011
Killer cell lectin-like receptor subfamily B member 1ARattus norvegicus (Norway rat)IC502.253622
L-lactate dehydrogenase A chainHomo sapiens (human)Ki14.000011
Liver carboxylesterase 1Homo sapiens (human)Ki0.646635
Lysophosphatidylserine lipase ABHD12Homo sapiens (human)IC5011.600011
Methylosome protein 50Homo sapiens (human)IC500.580022
Monoacylglycerol lipase ABHD6Homo sapiens (human)IC5048.200011
Monoglyceride lipaseHomo sapiens (human)IC50100.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000012
Muscarinic acetylcholine receptor M2Homo sapiens (human)IC502.790022
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)IC503.593323
Muscarinic acetylcholine receptor M2Homo sapiens (human)Ki0.059011
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)Ki0.059011
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)IC500.700011
Muscarinic acetylcholine receptor M4Homo sapiens (human)Ki1.600011
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)Ki1.600011
N-lysine methyltransferase SMYD2Homo sapiens (human)IC500.180011
N6-adenosine-methyltransferase catalytic subunitHomo sapiens (human)IC500.590011
NeuraminidaseInfluenza A virus (A/Puerto Rico/8/1934(H1N1))IC501,000.000011
NeuraminidaseInfluenza B virus (B/Lee/1940)IC501,000.000011
Nicotinamide N-methyltransferaseHomo sapiens (human)IC5035.300011
Non-structural protein 1 Dengue virusIC500.490011
Nuclear receptor ROR-gammaHomo sapiens (human)IC5016.64191010
Phenylethanolamine N-methyltransferaseBos taurus (cattle)Ki45.650012
Phenylethanolamine N-methyltransferaseHomo sapiens (human)Ki14.000011
Protease Human immunodeficiency virus 1Ki0.010111
Protein arginine N-methyltransferase 1Homo sapiens (human)IC500.430044
Protein arginine N-methyltransferase 1Homo sapiens (human)Ki0.400011
Protein arginine N-methyltransferase 3Homo sapiens (human)IC500.956733
Protein arginine N-methyltransferase 5Homo sapiens (human)IC5012.840044
Protein arginine N-methyltransferase 7Homo sapiens (human)IC5025.055022
Protein dpy-30 homologHomo sapiens (human)IC500.724011
Protein-arginine deiminase type-4Homo sapiens (human)IC5010,000.000011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC500.190011
Retinoblastoma-binding protein 5Homo sapiens (human)IC500.724011
rRNA adenine N-6-methyltransferaseStreptococcus pneumoniaeKi40.000022
Set1/Ash2 histone methyltransferase complex subunit ASH2Homo sapiens (human)IC500.724011
Sialic acid-binding Ig-like lectin 7Homo sapiens (human)IC5036,900.000011
Sialidase-1Homo sapiens (human)IC50500.000011
Sialidase-2Homo sapiens (human)IC50500.000011
Sialidase-3Homo sapiens (human)IC50500.000011
Sialidase-4Homo sapiens (human)IC50500.000011
signal transducer and activator of transcription 1-alpha/beta isoform alphaHomo sapiens (human)IC5055.700011
Sodium-dependent noradrenaline transporter Homo sapiens (human)IC508.595011
Sodium-dependent noradrenaline transporter Homo sapiens (human)Ki8.524011
Sodium-dependent serotonin transporterHomo sapiens (human)IC506.053011
Sodium-dependent serotonin transporterHomo sapiens (human)Ki3.216011
Sodium/potassium-transporting ATPase subunit alpha-1Canis lupus familiaris (dog)IC500.500022
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)IC500.320033
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)Ki0.122012
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)IC500.335022
Sodium/potassium-transporting ATPase subunit alpha-2Rattus norvegicus (Norway rat)IC500.220011
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)Ki0.122012
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)IC500.335022
Sodium/potassium-transporting ATPase subunit alpha-3 Rattus norvegicus (Norway rat)IC500.220011
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)IC500.335022
Sodium/potassium-transporting ATPase subunit alpha-4Rattus norvegicus (Norway rat)IC500.005511
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)IC500.335022
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)Ki0.122012
Sodium/potassium-transporting ATPase subunit beta-1 Rattus norvegicus (Norway rat)IC500.005511
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)IC500.335022
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)IC500.335022
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)IC500.335022
Solute carrier family 15 member 1Homo sapiens (human)Ki30,000.000022
Solute carrier family 15 member 2Homo sapiens (human)Ki10,982.400012
Solute carrier family 15 member 2Rattus norvegicus (Norway rat)Ki11,100.000011
Solute carrier family 22 member 6Rattus norvegicus (Norway rat)Ki1,049.000022
Solute carrier family 22 member 8Mus musculus (house mouse)IC5089.400011
Solute carrier family 22 member 8Homo sapiens (human)Ki97.600011
Solute carrier family 22 member 8Rattus norvegicus (Norway rat)Ki52.800011
Solute carrier organic anion transporter family member 1A4Rattus norvegicus (Norway rat)Ki0.308522
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)IC503.235911
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)IC5013.182611
STAT3, partialHomo sapiens (human)IC501.862011
tRNA (cytosine(38)-C(5))-methyltransferaseHomo sapiens (human)IC5015.800011
WD repeat-containing protein 5Homo sapiens (human)IC500.724011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Asialoglycoprotein receptor 1Homo sapiens (human)Kd5,730.000012
Butyrophilin subfamily 3 member A1Homo sapiens (human)EC509.1256812
Butyrophilin subfamily 3 member A1Homo sapiens (human)Kd2.905022
Cannabinoid receptor 1Homo sapiens (human)EC500.045833
Cannabinoid receptor 1Rattus norvegicus (Norway rat)EC500.073823
Cannabinoid receptor 2Mus musculus (house mouse)EC500.007311
Cannabinoid receptor 2 Homo sapiens (human)EC500.008633
Chain 1, MANNOSE-BINDING PROTEIN-ARattus norvegicus (Norway rat)Kd200.000011
Chain A, ADENINE-N6-DNA-METHYLTRANSFERASE TAQIThermus aquaticusKd2.400012
Chain A, Agglutinin alpha chainArtocarpus integerKd820.000013
Chain A, Antigen-presenting glycoprotein CD1d1Mus musculus (house mouse)Kd0.234015
Chain A, cellulasePhanerodontia chrysosporiumKd115.000012
Chain A, Cellulose 1,4-beta-cellobiosidaseMelanocarpus albomycesKd6.000011
Chain A, Discoidin-2Dictyostelium discoideum AX2Kd1,150.000012
Chain A, Galacto-N-biose/lacto-N-biose I transporter substrate-binding proteinBifidobacterium longumKd0.010011
Chain A, GLUCOSE/GALACTOSE-BINDING PROTEINSalmonella enterica subsp. enterica serovar TyphimuriumKd0.200011
Chain A, L-ARABINOSE-BINDING PROTEINEscherichia coliKd0.010013
Chain A, LectinErythrina corallodendronKd662.555619
Chain A, Modification Methylase RsriCereibacter sphaeroidesKd8.100012
Chain A, Pea LectinPisum sativum (garden pea)Kd700.000011
Chain A, PROBABLE SUGAR ABC TRANSPORTER, SUGAR-BINDING PROTEINStreptococcus pneumoniae SP3-BS71Kd0.830011
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenasePisum sativum (garden pea)Kd21.200011
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferasePisum sativum (garden pea)Kd21.200013
Chain A, T-cell surface glycoprotein CD1d1Mus musculus (house mouse)Kd0.006811
Chain A, Undecaprenyl pyrophosphate synthetaseEscherichia coliKd520.000011
Chain B, ADENINE-N6-DNA-METHYLTRANSFERASE TAQIThermus aquaticusKd2.400011
Chain B, Agglutinin beta-3 chainArtocarpus integerKd820.000011
Chain B, Pea LectinPisum sativum (garden pea)Kd700.000011
Chain C, Agglutinin alpha chainArtocarpus integerKd820.000011
Chain C, NKT Valpha14-Jalpha18,NKT Valpha14-Jalpha18Mus musculus (house mouse)Kd0.234015
Chain D, Agglutinin beta-3 chainArtocarpus integerKd820.000011
Chain H, Protein (antibody M3c65 (heavy Chain))Mus musculus (house mouse)Kd0.320011
Chain L, Protein (antibody M3c65 (light Chain))Mus musculus (house mouse)Kd0.320011
D(3) dopamine receptorHomo sapiens (human)EC500.010211
G-protein coupled receptor 55Homo sapiens (human)EC5010.000011
Galectin-8Homo sapiens (human)Kd2.300011
Glutamate receptor 1Rattus norvegicus (Norway rat)EC500.199511
Glutamate receptor 2Rattus norvegicus (Norway rat)EC500.199511
Glutamate receptor 3Rattus norvegicus (Norway rat)EC500.199511
Glutamate receptor 4Rattus norvegicus (Norway rat)EC500.199511
Glycine receptor subunit alpha-1Homo sapiens (human)EC501.300011
Histone-lysine N-methyltransferase, H3 lysine-79 specificHomo sapiens (human)Kd0.255022
Induced myeloid leukemia cell differentiation protein Mcl-1Homo sapiens (human)Kd324.142012
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)EC500.400011
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)EC500.120011
N-arachidonyl glycine receptorHomo sapiens (human)EC504.610011
NPYLR7BAedes aegypti (yellow fever mosquito)EC5020.000011
Nuclear receptor ROR-gammaHomo sapiens (human)Kd0.109011
Nuclear receptor subfamily 1 group I member 2Homo sapiens (human)EC5018.933333
Protease Human immunodeficiency virus 1Kd0.577011
Sialic acid-binding Ig-like lectin 7Homo sapiens (human)Kd680.000011
streptokinase A precursorStreptococcus pyogenes M1 GASEC500.060011
Transient receptor potential cation channel subfamily A member 1Rattus norvegicus (Norway rat)EC500.230011
tRNA (cytosine(38)-C(5))-methyltransferaseHomo sapiens (human)Kd13.600011
tRNA (guanine-N(1)-)-methyltransferaseMycobacterium tuberculosis H37RvKd10.100011
tRNA (guanine-N(1)-)-methyltransferasePseudomonas aeruginosa PAO1Kd5.900011
tRNA (guanine-N(1)-)-methyltransferaseStaphylococcus aureus subsp. aureus NCTC 8325Kd3.300011
Type 1 fimbrin D-mannose specific adhesinEscherichia coli K-12Kd2.300011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-methylthioadenosine/S-adenosylhomocysteine deaminaseThermotoga maritima MSB8Km210.000011
AdenosylhomocysteinaseRattus norvegicus (Norway rat)Km9.700011
AdenosylhomocysteinaseThermotoga maritima MSB8Km21.000011
ATP-dependent translocase ABCB1Homo sapiens (human)Km25.900011
B2 metallo-beta-lactamase Chryseobacterium indologenesKm20.000011
Beta-lactamaseEnterobacter cloacaeKm5.925044
Beta-lactamaseMorganella morganiiKm7.900011
Beta-lactamaseProvidencia stuartiiKm14.000011
Beta-lactamasePseudomonas aeruginosa PAO1Km18.483366
Beta-lactamaseSerratia marcescensKm2.100011
Beta-lactamaseStaphylococcus aureusKm7.700022
Beta-lactamase Acinetobacter baumanniiKm13.750044
Beta-lactamase Aeromonas allosaccharophilaKm200.000011
Beta-lactamase Aeromonas caviaeKm206.000011
Beta-lactamase Burkholderia cenocepaciaKm25.000011
Beta-lactamase Citrobacter freundiiKm16.000011
Beta-lactamase Citrobacter gilleniiKm51.000011
Beta-lactamase Escherichia coliKm12.233366
Beta-lactamase Klebsiella oxytocaKm40.000011
Beta-lactamase Klebsiella pneumoniaeKm122.983366
Beta-lactamase Pseudomonas aeruginosaKm49.500044
Beta-lactamase Pseudomonas luteolaKm8.000011
Beta-lactamase Salmonella enterica subsp. enterica serovar WesthamptonKm10.000011
Beta-lactamase Serratia marcescensKm2.200022
Beta-lactamase Shouchella clausiiKm12.000011
Beta-lactamase 1Bacillus cereusKm65.000011
Beta-lactamase class B VIM-2 Pseudomonas aeruginosaKm130.000044
Beta-lactamase IMP-1 Pseudomonas aeruginosaKm550.000011
Beta-lactamase OXA-10Pseudomonas aeruginosaKm7.900011
Beta-lactamase SHV-1Escherichia coliKm23.000011
Beta-lactamase SHV-1Klebsiella pneumoniaeKm19.500044
Beta-lactamase TEMEscherichia coliKm33.000033
Beta-lactamase Toho-1Escherichia coliKm18.000011
Beta-lactamase VIM-1 Pseudomonas aeruginosaKm1,303.000011
BlaVIM-1 Escherichia coliKm850.000011
Butyrophilin subfamily 3 member A1Homo sapiens (human)ED50100.000011
Cannabinoid receptor 1Homo sapiens (human)Log Ki0.001611
Cannabinoid receptor 2 Homo sapiens (human)Log Ki0.001611
Carbapenem-hydrolyzing beta-lactamase KPCKlebsiella pneumoniaeKm30.000011
Catechol O-methyltransferaseRattus norvegicus (Norway rat)Kis36.300011
Class D beta-lactamaseBrachyspira pilosicoliKm19.000011
Efflux transporter Salmonella enterica subsp. enterica serovar NewportKm0.300011
Histamine N-methyltransferaseCavia porcellus (domestic guinea pig)Kis18.100011
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)Km51.000011
Metallo-b-lactamase Pseudomonas aeruginosaKm17.000011
Metallo-beta-lactamaseStutzerimonas stutzeriKm90.000011
Metallo-beta-lactamase type 2Klebsiella pneumoniaeKm16.000011
Metallo-beta-lactamase VIM-11 Pseudomonas aeruginosaKm15.300011
Metallo-beta-lactamase VIM-13Pseudomonas aeruginosaKm1,127.000011
Metallo-beta-lactamase VIM-19 Escherichia coliKm300.000011
Metallo-beta-lactamase VIM-2Klebsiella pneumoniaeKm49.000011
Metallo-beta-lactamase VIM-2Pseudomonas aeruginosaKm19.100011
PAX8Homo sapiens (human)AC500.414011
Putative glycosyltransferase WbgOEscherichia coli O55:H7Km325.000012
Solute carrier family 22 member 8Mus musculus (house mouse)Km40.000011
Solute carrier family 22 member 8Rattus norvegicus (Norway rat)Km82.600011
Solute carrier organic anion transporter family member 1A4Mus musculus (house mouse)Km5.700011
Solute carrier organic anion transporter family member 1A4Rattus norvegicus (Norway rat)Km0.529733
Solute carrier organic anion transporter family member 4C1Homo sapiens (human)Km7.800011
Solute carrier organic anion transporter family member 4C1Rattus norvegicus (Norway rat)Km8.000011
Transient receptor potential cation channel subfamily A member 1Homo sapiens (human)Activity10.000011
Tryptophan dimethylallyltransferaseAspergillus fumigatus Af293Km140.000011