Hyperchylomicronemia Late Onset

A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma CHYLOMICRONS and TRIGLYCERIDES contained in VERY-LOW-DENSITY LIPOPROTEINS. Type V hyperlipoproteinemia is often associated with DIABETES MELLITUS and is not caused by reduced LIPOPROTEIN LIPASE activity as in HYPERLIPOPROTEINEMIA TYPE I

Synonym
Hyperchylomicronemia, Late-Onset
Hyperlipoproteinemia Type 5
Hyperlipidemia, Type V
Hyperlipemia, Mixed
Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial
Hyperlipoproteinemia, Type V
Hyperlipoproteinemia Type V
Hyperlipemia, Combined Fat And Carbohydrate-Induced
Hyperchylomicronemia Late Onset

Excerpt	Reference
"Thirteen patients with phenotypic type V hyperlipidemia were treated with either gemfibrozil (Lopid) or a placebo in a randomized, double-blind, crossover study for two 8-week periods."	( Bacon, SP; Connor, WE; Illingworth, DR; Leaf, DA; Sexton, G, 1989)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	67 (58.77)	23.3326
1990's	21 (18.42)	12.5806
2000's	19 (16.67)	18.1394
2010's	7 (6.14)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
1-butanol	medium	1	1
carnitine	medium	1	1
salicylic acid	low	1	0
inositol	low	2	0
niacin	low	3	0
uric acid	medium	1	1
1-anilino-8-naphthalenesulfonate	medium	9	1
theophylline	low	1	0
azathioprine	low	1	0
ciprofibrate	medium	4	3
clofibrate	low	7	0
clofibric acid	medium	6	3
fenofibrate	medium	15	9
gemfibrozil	medium	8	3
inositol niacinate	low	1	0
metformin	low	1	0
miconazole	low	1	0
probucol	low	3	0
thyroxine	low	1	0
prednisone	low	1	0
oxandrolone	low	1	0
triiodothyronine	low	1	0
adenosine diphosphate	low	2	0
arginine	low	1	0
allylamine	medium	1	1
pyrroles	medium	5	5
framycetin	low	1	0
dextrothyroxine	low	1	0
pyrazines	medium	1	1
xanthinol niacinate	low	2	0
fluorobenzenes	low	1	0
cyanogen bromide	low	1	0
d-alpha tocopherol	low	1	0
tocopherols	low	1	0
bezafibrate	medium	10	5
ng-nitroarginine methyl ester	low	1	0
etofylline clofibrate	low	1	0
lovastatin	medium	1	1
simvastatin	medium	6	6
pravastatin	medium	5	3
lifibrol	medium	1	1
atorvastatin	medium	5	5
colestipol	low	2	0
coenzyme a	medium	1	1
fibrinogen	medium	3	2
homocysteine	medium	1	1
cysteinylglycine	medium	1	1
retinol	low	1	0
cerivastatin	medium	1	1
eicosapentaenoic acid	medium	4	1
melphalan	low	1	0
glycosides	low	1	0
linoleic acid	low	1	0
6-ketoprostaglandin f1 alpha	low	1	0
acipimox	medium	1	1
cysteine	medium	2	1
(3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid	medium	1	1
glucuronyl glucosamine glycan sulfate	medium	2	2
bms201038	low	1	0
ascorbic acid	low	1	0
carboxyethyl-hydroxychroman	low	1	0
promega	medium	1	1
cholestyramine resin	medium	3	1
leptin	medium	1	1

Protein Targets (707)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Cytochrome P450 2C9	0	4	2	6
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	1	0	0	1
thioredoxin reductase	12	0	0	12
USP1 protein, partial	15	0	0	15
TDP1 protein	18	0	0	18
vitamin D3 receptor isoform VDRA	8	0	0	8
importin subunit beta-1 isoform 1	4	0	0	4
flap endonuclease 1	4	0	0	4
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	6	0	0	6
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	16	0	0	16
DNA polymerase kappa isoform 1	5	0	0	5
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	2	0	2
Transthyretin	0	2	2	6
Fatty acid-binding protein, intestinal	0	4	2	6
Fatty acid-binding protein, adipocyte	0	3	1	4
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	2	0	2
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Fatty acid-binding protein 5	0	1	1	2
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	11	0	0	11
glucocorticoid receptor [Homo sapiens]	15	0	0	15
farnesoid X nuclear receptor	9	0	0	9
estrogen nuclear receptor alpha	25	0	0	25
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Cellular tumor antigen p53	16	0	0	16
Glutamate receptor 2	6	0	0	6
Choline O-acetyltransferase	0	1	0	2
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Fumarate hydratase	5	0	0	5
AR protein	22	0	0	22
EWS/FLI fusion protein	16	0	0	16
polyprotein	5	0	0	5
histone acetyltransferase KAT2A isoform 1	7	0	0	7
ATP-binding cassette sub-family C member 3	0	11	0	11
Multidrug resistance-associated protein 4	0	11	0	11
Bile salt export pump	0	18	0	18
Hydroxycarboxylic acid receptor 2	0	2	2	4
Canalicular multispecific organic anion transporter 1	0	9	0	9
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	6	0	0	6
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	2	1	3
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	1	3
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	3	0	0	3
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	11	0	0	11
NFKB1 protein, partial	1	0	0	1
GLS protein	4	0	0	4
thyroid stimulating hormone receptor	7	0	0	7
alpha-galactosidase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
cytochrome P450 2C19 precursor	4	0	0	4
chromobox protein homolog 1	8	0	0	8
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	5	0	0	5
Cytochrome P450 3A4	0	1	0	2
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	5	0	0	5
RAR-related orphan receptor gamma	13	0	0	13
GLI family zinc finger 3	12	0	0	12
thioredoxin glutathione reductase	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
estrogen-related nuclear receptor alpha	18	0	0	18
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
IDH1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
thyroid hormone receptor beta isoform 2	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lamin isoform A-delta10	14	0	0	14
Polyphenol oxidase 2	0	3	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	3
Spike glycoprotein	7	0	0	7
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Cruzipain	3	0	0	3
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
caspase 7, apoptosis-related cysteine protease	4	0	0	4
estrogen receptor 2 (ER beta)	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
retinoid X nuclear receptor alpha	12	0	0	12
pregnane X nuclear receptor	14	0	0	14
peroxisome proliferator-activated receptor delta	12	0	0	12
peroxisome proliferator activated receptor gamma	12	0	0	12
caspase-3	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	14	0	0	14
Caspase-7	2	0	0	2
thyroid hormone receptor beta isoform a	5	0	0	5
caspase-3	2	0	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	4
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	7	0	7
ATP-dependent translocase ABCB1	0	5	0	5
Insulin receptor	0	5	0	5
Dipeptidyl peptidase 4	0	1	0	1
Prostaglandin G/H synthase 2	0	7	0	7
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	5	0	5
Histone deacetylase 1	0	2	0	2
Histone deacetylase 2	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	3	0	5
Histone deacetylase 6	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	6	0	10
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Ferritin light chain	6	0	0	6
interleukin 8	3	0	0	3
ATAD5 protein, partial	2	0	0	2
Microtubule-associated protein tau	7	0	0	7
G	10	0	0	10
P53	1	0	0	1
arylsulfatase A	5	0	0	5
aryl hydrocarbon receptor	8	0	0	8
thyroid stimulating hormone receptor	4	0	0	4
activating transcription factor 6	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	4	0	0	4
Bloom syndrome protein isoform 1	3	0	0	3
peripheral myelin protein 22 isoform 1	3	0	0	3
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
heat shock protein beta-1	7	0	0	7
peripheral myelin protein 22	8	0	0	8
survival motor neuron protein isoform d	7	0	0	7
cytochrome P450 3A4 isoform 1	9	0	0	9
M-phase phosphoprotein 8	4	0	0	4
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	9	0	1	10
Bile salt export pump	0	4	0	4
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
Gamma-aminobutyric acid receptor subunit beta-1	9	0	1	10
Gamma-aminobutyric acid receptor subunit delta	9	0	1	10
Gamma-aminobutyric acid receptor subunit gamma-2	9	0	1	10
Gamma-aminobutyric acid receptor subunit alpha-5	9	0	1	10
Gamma-aminobutyric acid receptor subunit alpha-3	9	0	1	10
Gamma-aminobutyric acid receptor subunit gamma-1	9	0	1	10
Gamma-aminobutyric acid receptor subunit alpha-2	9	0	1	10
Gamma-aminobutyric acid receptor subunit alpha-4	9	0	1	10
Gamma-aminobutyric acid receptor subunit gamma-3	9	0	1	10
Gamma-aminobutyric acid receptor subunit alpha-6	9	0	1	10
Nuclear receptor ROR-gamma	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	9	0	1	10
Gamma-aminobutyric acid receptor subunit beta-3	9	0	1	10
Gamma-aminobutyric acid receptor subunit beta-2	9	0	1	10
GABA theta subunit	9	0	1	10
Inositol hexakisphosphate kinase 1	10	0	0	10
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit epsilon	9	0	1	10
Protein-arginine deiminase type-4	0	1	0	1
cytochrome P450 2C9, partial	10	0	0	10
Luciferase	4	0	0	4
D(1A) dopamine receptor	1	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	2	2
Glutamate receptor ionotropic, NMDA 3B	0	0	2	2
5-hydroxytryptamine receptor 4	0	4	3	7
Fatty acid-binding protein, liver	0	4	2	6
Muscarinic acetylcholine receptor M1	0	0	3	3
Muscarinic acetylcholine receptor M3	0	0	3	3
Muscarinic acetylcholine receptor M4	0	0	3	3
Muscarinic acetylcholine receptor M5	0	0	3	3
Muscarinic acetylcholine receptor M2	0	0	3	3
Peroxisome proliferator-activated receptor alpha	0	0	4	4
Peroxisome proliferator-activated receptor delta	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	10	11
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Peroxisome proliferator-activated receptor delta	0	0	2	2
Glutamate receptor ionotropic, NMDA 1	0	0	2	2
Peroxisome proliferator-activated receptor alpha	2	1	6	9
Glutamate receptor ionotropic, NMDA 2A	0	0	2	2
Glutamate receptor ionotropic, NMDA 2B	0	0	2	2
Glutamate receptor ionotropic, NMDA 2C	0	0	2	2
Glutamate receptor ionotropic, NMDA 3A	0	0	2	2
cytochrome P450 2D6	5	0	0	5
Delta-type opioid receptor	0	1	0	1
Microsomal triglyceride transfer protein large subunit	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, Beta-lactamase	6	0	0	6
Peroxisome proliferator-activated receptor alpha	0	0	2	2
GALC protein	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
cytochrome P450 2D6 isoform 1	2	0	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	0	1	1
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
N-alpha-acetyltransferase 50	0	0	1	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
Rap guanine nucleotide exchange factor 3	2	0	0	2
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
cytochrome P450 2C9 precursor	4	0	0	4
Thyroid hormone receptor beta	0	3	0	3
Histamine H2 receptor	4	0	0	4
Solute carrier organic anion transporter family member 1C1	0	2	0	2
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Trypsin	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Coagulation factor VII	0	2	0	2
Aromatase	0	3	0	3
Tissue factor	0	2	0	2
Retinoic acid receptor RXR-alpha	0	1	2	3
Prostaglandin G/H synthase 2	0	2	0	2
Oxoeicosanoid receptor 1	0	1	0	1
Endothelin-1 receptor	0	1	0	1
nuclear receptor ROR-gamma isoform 1	7	0	0	7
endonuclease IV	1	0	0	1
progesterone receptor	6	0	0	6
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
serine-protein kinase ATM isoform a	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
Fatty acid-binding protein, liver	0	1	0	1
Aldo-keto reductase family 1 member B1	0	6	0	6
Adenosine receptor A3	0	5	0	5
Beta-3 adrenergic receptor	0	4	0	4
Alpha-1B adrenergic receptor	0	4	0	4
Acetylcholinesterase	0	3	0	3
Sodium-dependent noradrenaline transporter	0	6	0	6
Cruzipain	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
D(3) dopamine receptor	0	4	0	4
Alpha-1A adrenergic receptor	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Sodium-dependent dopamine transporter	0	6	0	6
Sigma non-opioid intracellular receptor 1	0	0	1	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Smad3	5	0	0	5
histone deacetylase 9 isoform 3	1	0	0	1
Cytochrome P450 2C8	0	1	0	1
Cannabinoid receptor 2	0	0	1	1
Guanylate cyclase soluble subunit alpha-1	0	0	1	1
Guanylate cyclase soluble subunit beta-1	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	3
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	3
Glutamate receptor ionotropic, NMDA 2B	0	2	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	1	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	1	3
Proton-coupled amino acid transporter 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	1	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	3
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Amyloid-beta precursor protein	0	3	0	3
Sodium/myo-inositol cotransporter 2	0	1	0	1
15-lipoxygenase, partial	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
Free fatty acid receptor 1	0	0	1	1
Sterol O-acyltransferase 1	0	1	0	1
Fatty acid-binding protein, heart	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	3	0	4
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Dual specificity protein phosphatase 3	0	1	0	1
Free fatty acid receptor 4	0	0	1	1
Chain A, Antigen Cd11a (p180)	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
pregnane X receptor	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
PINK1	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
Parkin	2	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
bcl-2-related protein A1	0	1	0	1
Integrin beta-2	0	1	0	1
Intercellular adhesion molecule 1	0	1	0	1
Neutrophil elastase	0	2	0	2
Androgen receptor	0	4	0	4
Integrin alpha-L	0	1	1	2
Substance-K receptor	0	4	0	4
Adenosine receptor A1	0	8	1	11
Lanosterol 14-alpha demethylase	0	2	0	2
Rap guanine nucleotide exchange factor 4	2	0	0	2
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
glp-1 receptor, partial	4	0	0	4
glucocerebrosidase	2	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Solute carrier family 22 member 1	0	0	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
PPM1D protein	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Vpr	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Metabotropic glutamate receptor 6	0	1	0	1
Acetylcholinesterase	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Cannabinoid receptor 1	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Aromatase	0	0	1	1
Heme oxygenase 2	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A2a	0	4	2	7
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Cytochrome P450 2C19	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Beta-lactamase TEM	0	1	0	1
Cholinesterase	0	2	0	2
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Calcium release-activated calcium channel protein 1	0	1	0	1
heat shock protein 90, putative	0	0	0	1
methionyl-tRNA synthetase, putative	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Cholesteryl ester transfer protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Androgen receptor	0	3	0	3
Solute carrier organic anion transporter family member 1A4	0	1	0	4
Solute carrier family 22 member 6	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 7	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Solute carrier family 22 member 8	0	3	0	3
Solute carrier family 22 member 11	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 7	0	1	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Vascular cell adhesion protein 1	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Alpha-synuclein	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	1	3
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Renin	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
D(3) dopamine receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2a	0	1	0	3
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Endochitinase B1	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
apical membrane antigen 1, AMA1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Prothrombin	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Hyperchylomicronemia Late Onset

Synonyms(9)

Research Excerpts

Treatment

Research

Studies (114)

Protein Targets (707)

Hyperchylomicronemia Late Onset

Synonyms(9)

Research Excerpts

Treatment

Research

Studies (114)

Drugs Studied (76)

Protein Targets (707)