A proteinogenic amino acid derivative resulting from reaction of L-proline at the amino group or the carboxy group, or from the replacement of any hydrogen of L-proline by a heteroatom.
ChEBI ID: 84186
| Member | Definition | Role |
|---|---|---|
| 4-ketoproline | The L-enantiomer of 4-oxoproline. | 4-oxo-L-proline zwitterion; 4-oxo-L-proline |
| captopril | A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug. | captopril |
| domoic acid | An L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is produced by the diatomic algal Pseudo-nitzschia. It is an analogue of kainic acid and a neurotoxin which causes amnesic shellfish poisoning (ASP). | domoic acid |
| fosinoprilat | A phosphinic acid-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. An inhibitor of angiotensin converting enzyme (ACE), it is used as the phosphinate ester pro-drug fosinopril for treatment of hypertension and chronic heart failure. | fosinoprilat |
| kainic acid | kainic acid | |
| lincomycin | A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis. | lincomycin |
| n-acetylproline | N-acetyl-L-proline | |
| n-methylproline | An L-proline derivative obtained by replacement of the amino hydrogen by a methyl group. | N-methylproline zwitterion; N-methylproline |
| n-nitroso-4-hydroxyproline | N-Nitrosohydroxyproline | |
| prolinamide | The carboxamide derivative of L-proline. | L-prolinamide |
| pyrrolidonecarboxylic acid | An optically active form of 5-oxoproline having L-configuration. | 5-oxo-L-proline |
| zofenopril | A proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-3-(benzoylsulfanyl)-2-methylpropanoyl group. A prodrug for zofenoprilat. | zofenopril |
| zofenoprilate | A proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-2-methyl-3-sulfanylpropanoyl group. The active metabolite of zofenopril. | zofenoprilat |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 7,810 (32.59) | 18.7374 |
| 1990's | 7,520 (31.38) | 18.2507 |
| 2000's | 4,624 (19.30) | 29.6817 |
| 2010's | 3,173 (13.24) | 24.3611 |
| 2020's | 835 (3.48) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,773 (6.78%) | 5.53% |
| Reviews | 1,101 (4.21%) | 6.00% |
| Case Studies | 1,083 (4.14%) | 4.05% |
| Observational | 8 (0.03%) | 0.25% |
| Other | 22,181 (84.84%) | 84.16% |