Roles > EC 3.1.1.1 (carboxylesterase) inhibitor
Page last updated: 2024-08-05 15:18:37

EC 3.1.1.1 (carboxylesterase) inhibitor

Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of carboxylesterase (EC 3.1.1.1 ).

ChEBI ID: 78444

Members (7)

MemberDefinitionClass
arachidonic acidA long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.arachidonic acid
benzoinA ketone that consists of acetophenone bearing hydroxy and phenyl substituents at the alpha-position. The parent of the class of benzoins.benzoin
cholest-5-ene-3 beta,26-diolAn oxysterol that is cholesterol substituted at position 26 by a hydroxy group.26-hydroxycholesterol
disulfiramAn organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.disulfiram
myristic acidA straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.tetradecanoic acid
oleic acidAn octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.oleic acid
palmitoleic acidA hexadec-9-enoic acid in which the double bond at position C-9 has cis configuration.palmitoleic acid

Research

Studies (32,478)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19909,033 (27.81)18.7374
1990's8,671 (26.70)18.2507
2000's6,684 (20.58)29.6817
2010's6,183 (19.04)24.3611
2020's1,907 (5.87)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials957 (2.78%)5.53%
Reviews2,315 (6.72%)6.00%
Case Studies409 (1.19%)4.05%
Observational52 (0.15%)0.25%
Other30,712 (89.16%)84.16%

Protein Targets (289)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency7.348217
15-lipoxygenase, partialHomo sapiens (human)Potency0.271615
acetylcholinesteraseHomo sapiens (human)Potency65.439847
acid sphingomyelinaseHomo sapiens (human)Potency223.872011
activating transcription factor 6Homo sapiens (human)Potency0.627013
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency1.658617
Alpha-synucleinHomo sapiens (human)Potency5.173511
Amyloid-beta precursor proteinHomo sapiens (human)Potency5.173511
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency14.125411
AR proteinHomo sapiens (human)Potency6.3798928
aryl hydrocarbon receptorHomo sapiens (human)Potency51.028233
ATAD5 protein, partialHomo sapiens (human)Potency16.419534
Ataxin-2Homo sapiens (human)Potency30.545124
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency12.304422
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency33.335826
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency2.393411
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency5.211911
beta-2 adrenergic receptorHomo sapiens (human)Potency0.651311
Bloom syndrome protein isoform 1Homo sapiens (human)Potency30.300112
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency11.426413
caspase-1 isoform alpha precursorHomo sapiens (human)Potency31.622811
caspase-3Cricetulus griseus (Chinese hamster)Potency10.559012
caspase-3Homo sapiens (human)Potency11.426413
Caspase-7Cricetulus griseus (Chinese hamster)Potency10.559012
Cellular tumor antigen p53Homo sapiens (human)Potency35.450226
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency25.564823
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency26.651412
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency23.453612
Chain A, Beta-lactamaseEscherichia coli K-12Potency55.701423
Chain A, CruzipainTrypanosoma cruziPotency17.7159210
Chain A, Ferritin light chainEquus caballus (horse)Potency30.300122
Chain A, HADH2 proteinHomo sapiens (human)Potency12.354628
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency84.279012
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency5.515313
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency18.823112
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency12.046212
Chain B, HADH2 proteinHomo sapiens (human)Potency12.354628
chromobox protein homolog 1Homo sapiens (human)Potency53.631124
core-binding factor subunit beta isoform 2Homo sapiens (human)Potency0.538022
cytochrome P450 2C19 precursorHomo sapiens (human)Potency2.903112
cytochrome P450 2C9 precursorHomo sapiens (human)Potency1.455012
cytochrome P450 2C9, partialHomo sapiens (human)Potency5.221413
cytochrome P450 2D6Homo sapiens (human)Potency16.280111
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency15.8979210
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency22.323913
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency0.090613
D(1A) dopamine receptorHomo sapiens (human)Potency3.264111
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency3.162311
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency33.498311
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.125111
DNA polymerase kappa isoform 1Homo sapiens (human)Potency17.405413
estrogen nuclear receptor alphaHomo sapiens (human)Potency17.4302832
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency17.628627
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency5.26901030
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency4.576915
EWS/FLI fusion proteinHomo sapiens (human)Potency0.038944
farnesoid X nuclear receptorHomo sapiens (human)Potency4.598347
flap endonuclease 1Homo sapiens (human)Potency92.750113
Fumarate hydrataseHomo sapiens (human)Potency19.487214
GVesicular stomatitis virusPotency5.221413
GABA theta subunitRattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency15.897915
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency15.897915
gemininHomo sapiens (human)Potency11.0388412
GLI family zinc finger 3Homo sapiens (human)Potency5.540939
glp-1 receptor, partialHomo sapiens (human)Potency14.125411
GLS proteinHomo sapiens (human)Potency21.098124
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency36.216425
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency0.225613
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency50.118711
heat shock protein beta-1Homo sapiens (human)Potency23.5033211
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency11.4617218
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency26.475017
histone deacetylase 9 isoform 3Homo sapiens (human)Potency11.125511
Histone H2A.xCricetulus griseus (Chinese hamster)Potency18.920527
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency27.829812
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency5.221413
huntingtin isoform 2Homo sapiens (human)Potency0.794311
hypothetical protein, conservedTrypanosoma bruceiPotency9.942924
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency29.100628
IDH1Homo sapiens (human)Potency0.013011
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency5.221416
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency15.848911
Integrin alpha-IIbHomo sapiens (human)Potency25.118911
Integrin beta-3Homo sapiens (human)Potency25.118911
Interferon betaHomo sapiens (human)Potency9.980826
lamin isoform A-delta10Homo sapiens (human)Potency5.284026
lethal factor (plasmid)Bacillus anthracis str. A2012Potency17.802012
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency39.810711
LuciferasePhotinus pyralis (common eastern firefly)Potency39.0405313
M-phase phosphoprotein 8Homo sapiens (human)Potency10.000011
Microtubule-associated protein tauHomo sapiens (human)Potency12.6237213
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency12.589311
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency39.810711
neuropeptide S receptor isoform AHomo sapiens (human)Potency19.783012
NFKB1 protein, partialHomo sapiens (human)Potency7.079522
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency3.311712
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency13.431447
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency15.765914
Nuclear receptor ROR-gammaHomo sapiens (human)Potency37.578011
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency8.2960213
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency16.6316318
Ornithine decarboxylaseRattus norvegicus (Norway rat)Potency25.118911
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency5.623411
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency20.614923
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency11.995511
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency19.9941414
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)Potency34.504514
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency15.484437
phosphopantetheinyl transferaseBacillus subtilisPotency16.334216
plasminogen precursorMus musculus (house mouse)Potency12.589312
polyproteinZika virusPotency19.487214
polypyrimidine tract-binding protein 1 isoform aHomo sapiens (human)Potency14.550022
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency2.901913
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency16.465016
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency2.818411
PPM1D proteinHomo sapiens (human)Potency14.740312
pregnane X nuclear receptorHomo sapiens (human)Potency27.746526
progesterone receptorHomo sapiens (human)Potency1.707324
pyruvate kinaseLeishmania mexicana mexicanaPotency15.848922
pyruvate kinase PKM isoform bHomo sapiens (human)Potency25.118922
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency30.623012
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency19.952611
RAR-related orphan receptor gammaMus musculus (house mouse)Potency6.997429
regulator of G-protein signaling 4Homo sapiens (human)Potency1.062111
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency7.2742312
retinoid X nuclear receptor alphaHomo sapiens (human)Potency26.8443311
runt-related transcription factor 1 isoform AML1bHomo sapiens (human)Potency0.538022
serine-protein kinase ATM isoform aHomo sapiens (human)Potency15.848911
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency0.736033
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency13.800013
SMAD family member 2Homo sapiens (human)Potency0.199511
SMAD family member 3Homo sapiens (human)Potency0.199511
Smad3Homo sapiens (human)Potency0.100011
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency0.794311
TAR DNA-binding protein 43Homo sapiens (human)Potency7.490613
TDP1 proteinHomo sapiens (human)Potency6.0024215
thioredoxin glutathione reductaseSchistosoma mansoniPotency17.782811
thioredoxin reductaseRattus norvegicus (Norway rat)Potency36.450724
ThrombopoietinHomo sapiens (human)Potency0.398122
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency22.4908311
thyroid stimulating hormone receptorHomo sapiens (human)Potency41.807749
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency23.526723
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency3.162311
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency12.589312
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency12.589312
USP1 protein, partialHomo sapiens (human)Potency42.365028
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency8.886427
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency21.3700513
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency5.703316
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency0.225613
VprHuman immunodeficiency virus 1Potency12.589311

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)IC504.290522
10 kDa chaperonin Escherichia coliIC5012.650022
10 kDa heat shock protein, mitochondrialHomo sapiens (human)IC504.500011
5-hydroxytryptamine receptor 2BHomo sapiens (human)IC5034.547011
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki21.984011
5-hydroxytryptamine receptor 6Homo sapiens (human)IC5016.001011
5-hydroxytryptamine receptor 6Homo sapiens (human)Ki7.429011
60 kDa chaperoninEscherichia coli K-12IC50250.000011
60 kDa chaperonin Escherichia coliIC5012.650022
60 kDa heat shock protein, mitochondrialHomo sapiens (human)IC504.500011
AcetylcholinesteraseHomo sapiens (human)Ki76.183848
Adenosine receptor A3Homo sapiens (human)IC500.356011
Adenosine receptor A3Homo sapiens (human)Ki0.201011
Aldehyde dehydrogenase, mitochondrialHomo sapiens (human)IC503.400011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC5070.370011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)Ki69.812011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC500.356011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Ki0.201011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC500.356011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Ki0.201011
Alpha-2A adrenergic receptorHomo sapiens (human)IC504.904011
Alpha-2A adrenergic receptorHomo sapiens (human)Ki1.839011
Alpha-2B adrenergic receptorHomo sapiens (human)IC503.218011
Alpha-2B adrenergic receptorHomo sapiens (human)Ki1.469011
Amine oxidase [flavin-containing] AHomo sapiens (human)IC5013.734011
Angiotensin-converting enzyme 2 Homo sapiens (human)IC509.350011
apelin receptorHomo sapiens (human)IC502.630011
AromataseHomo sapiens (human)IC5030.450012
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferaseMycobacterium tuberculosis H37RvIC5085.030011
Bile salt export pumpHomo sapiens (human)IC5071.500022
C-C chemokine receptor type 2Homo sapiens (human)IC502.468011
C-C chemokine receptor type 2Homo sapiens (human)Ki0.954011
C-C chemokine receptor type 4Homo sapiens (human)IC508.395011
C-C chemokine receptor type 4Homo sapiens (human)Ki4.397011
C-C chemokine receptor type 5Homo sapiens (human)IC5023.661011
C-C chemokine receptor type 5Homo sapiens (human)Ki18.284011
C-X-C chemokine receptor type 2Homo sapiens (human)IC506.013011
C-X-C chemokine receptor type 2Homo sapiens (human)Ki4.209011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Carbamate kinaseGiardia intestinalisIC500.600011
Caspase-1Homo sapiens (human)IC501.800011
CholinesteraseHomo sapiens (human)Ki72.781437
Coagulation factor VIIHomo sapiens (human)IC50101.666713
Coagulation factor XIIHomo sapiens (human)Ki61.894015
Cocaine esteraseHomo sapiens (human)Ki2.370033
Cytochrome P450 1A2Homo sapiens (human)IC504.000011
Cytosolic phospholipase A2 gammaHomo sapiens (human)IC50100.000011
D(1A) dopamine receptorHomo sapiens (human)IC502.158011
D(1A) dopamine receptorHomo sapiens (human)Ki1.079011
D(2) dopamine receptorHomo sapiens (human)IC5023.018011
D(2) dopamine receptorHomo sapiens (human)Ki7.673011
D(3) dopamine receptorHomo sapiens (human)IC501.084011
D(3) dopamine receptorHomo sapiens (human)Ki0.368011
D(4) dopamine receptorHomo sapiens (human)IC503.150011
D(4) dopamine receptorHomo sapiens (human)Ki1.105011
DNA topoisomerase 1Homo sapiens (human)IC5031.000011
Dynamin-1Homo sapiens (human)IC50100.000011
Fatty acid-binding protein 5Homo sapiens (human)Ki3.142627
Fatty acid-binding protein, adipocyteHomo sapiens (human)IC5014.425022
Fatty acid-binding protein, adipocyteHomo sapiens (human)Ki0.842522
Fatty acid-binding protein, liverRattus norvegicus (Norway rat)Ki1.540022
Fatty-acid amide hydrolase 1Homo sapiens (human)IC50231.539022
Fatty-acid amide hydrolase 1Homo sapiens (human)Ki6.000011
Fructose-1,6-bisphosphatase 1Homo sapiens (human)IC50101.23801010
G-protein coupled receptor 84Homo sapiens (human)Ki2.640011
Gasdermin-DHomo sapiens (human)IC500.400011
Gasdermin-DMus musculus (house mouse)IC500.400011
glucose-6-phosphate 1-dehydrogenase isoform bHomo sapiens (human)IC5080.000011
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonasePlasmodium bergheiIC5056.700033
Histone-lysine N-methyltransferase EHMT1Homo sapiens (human)IC501.600011
Histone-lysine N-methyltransferase EHMT2Homo sapiens (human)IC500.600011
Kappa-type opioid receptorHomo sapiens (human)IC506.103011
Kappa-type opioid receptorHomo sapiens (human)Ki2.441011
Lanosterol 14-alpha demethylaseHomo sapiens (human)IC50200.000011
large T antigenBetapolyomavirus macacaeIC5010.730011
Liver carboxylesterase 1Homo sapiens (human)Ki47.908949
Liver carboxylesterase 1Oryctolagus cuniculus (rabbit)Ki68.245026
Lysine-specific demethylase 5AHomo sapiens (human)IC5010.000011
Lysyl oxidase homolog 2Homo sapiens (human)IC500.150011
Lysyl oxidase homolog 3Homo sapiens (human)IC500.093011
Lysyl oxidase homolog 4Homo sapiens (human)IC500.059011
Mitogen-activated protein kinase 3 Homo sapiens (human)IC501.510011
Monoglyceride lipaseHomo sapiens (human)IC500.809522
Mu-type opioid receptorHomo sapiens (human)IC503.511011
Mu-type opioid receptorHomo sapiens (human)Ki1.425011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
NACHT, LRR and PYD domains-containing protein 3 Mus musculus (house mouse)IC503.000011
perilipin-1Homo sapiens (human)IC506.959011
perilipin-5Homo sapiens (human)IC501.622011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)IC502,120.000022
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)IC5016.066011
Procathepsin LHomo sapiens (human)IC509.350011
Prostaglandin G/H synthase 1 Bos taurus (cattle)IC50500.000012
Prostaglandin G/H synthase 2Ovis aries (sheep)IC50500.000012
Protein-lysine 6-oxidaseHomo sapiens (human)IC500.320011
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusIC509.350011
Replicase polyprotein 1abBetacoronavirus England 1IC5018.075022
Replicase polyprotein 1abHuman coronavirus 229EIC509.350011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC506.917199
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusIC509.350022
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2Ki3.710011
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusKi3.710011
Retinal dehydrogenase 1Homo sapiens (human)IC500.130011
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)Ki22.000011
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)Ki7.210011
Sodium-dependent dopamine transporter Homo sapiens (human)IC504.637011
Sodium-dependent dopamine transporter Homo sapiens (human)Ki3.684011
Sodium-dependent noradrenaline transporter Homo sapiens (human)IC5070.370011
Sodium-dependent noradrenaline transporter Homo sapiens (human)Ki69.812011
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)IC500.602611
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)Ki0.330011
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)IC501.071511
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)Ki0.820011
Spike glycoproteinBetacoronavirus England 1IC509.350011
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusIC509.350011
Sterol O-acyltransferase 1Homo sapiens (human)IC501,000.000022
Sterol O-acyltransferase 1Rattus norvegicus (Norway rat)IC501,000.000011
Thiosulfate sulfurtransferaseHomo sapiens (human)IC50100.000011
Tissue factorHomo sapiens (human)IC50101.666713
Toll-like receptor 2Homo sapiens (human)IC505.000011
Transient receptor potential cation channel subfamily V member 2Rattus norvegicus (Norway rat)IC5010.000024
Transmembrane protease serine 2Homo sapiens (human)IC509.350011
TrypsinSus scrofa (pig)IC50200.000013
type-1 angiotensin II receptorHomo sapiens (human)IC506.637011
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC506.300012

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
bcl-2-like protein 11 isoform 1Homo sapiens (human)EC50350.000011
Chain A, Adipocyte Lipid-binding ProteinMus musculus (house mouse)Kd2.350012
Chain A, BCL-2-RELATED PROTEIN A1Homo sapiens (human)EC50350.000011
Chain A, MUSCLE FATTY ACID BINDING PROTEINHomo sapiens (human)Kd0.430013
Chain A, SERUM ALBUMINHomo sapiens (human)Kd0.049814
Fatty acid-binding protein 5Mus musculus (house mouse)Kd0.042111
Fatty acid-binding protein, adipocyteHomo sapiens (human)Kd0.180011
Fatty acid-binding protein, liverHomo sapiens (human)Kd0.550022
G-protein coupled receptor 84Homo sapiens (human)EC5010.936733
LacZ protein (plasmid)Escherichia coliEC5040.000011
Nuclear receptor subfamily 4 group A member 2Homo sapiens (human)Kd50.000012
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)EC5024.500012
Prostaglandin G/H synthase 2Homo sapiens (human)Kd8.070011
putative potassium channel subunitHomo sapiens (human)EC5010.410011
Transient receptor potential cation channel subfamily A member 1Homo sapiens (human)EC503.000011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Calmodulin Bos taurus (cattle)Km9.700011
H3 histone acetyltransferaseCandida albicans SC5314AC503.260011
heat shock protein 90, putativePlasmodium falciparum 3D7AC504.554011
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)AC505.178011
hypothetical protein CAALFM_CR05890CACandida albicans SC5314AC503.260011
Peroxisome proliferator-activated receptor deltaHomo sapiens (human)Emax49.000012
Prostaglandin G/H synthase 1 Bos taurus (cattle)Km8.800011
Prostaglandin G/H synthase 2Homo sapiens (human)Km105.500022
Prostaglandin G/H synthase 2Ovis aries (sheep)Km9.700011
Protein kinase C alpha typeHomo sapiens (human)Km102.000011
Solute carrier organic anion transporter family member 2A1Rattus norvegicus (Norway rat)Km96.000011