An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of fatty acid synthase (EC 2.3.1.85), a multi-enzyme protein involved in fatty acid synthesis.
ChEBI ID: 71476
| Member | Definition | Class |
|---|---|---|
| luteolin | A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers. | luteolin |
| orlistat | A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. | orlistat |
| platencin | A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the polycyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase. | platencin |
| platensimycin | A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the oxatetracyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase. | platensimycin |
| rhapontin | A rhaponticin in which the double bond adopts a trans-configuration. It possesses a range of pharmacological activities including antitumour, antiinflammatory, antilipemic and neuroprotective activities. | trans-rhaponticin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 43 (1.11) | 18.7374 |
| 1990's | 216 (5.57) | 18.2507 |
| 2000's | 1,174 (30.25) | 29.6817 |
| 2010's | 1,679 (43.26) | 24.3611 |
| 2020's | 769 (19.81) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 289 (7.09%) | 5.53% |
| Reviews | 472 (11.58%) | 6.00% |
| Case Studies | 72 (1.77%) | 4.05% |
| Observational | 3 (0.07%) | 0.25% |
| Other | 3,239 (79.48%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 2.0484 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 10.0664 | 2 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 2.5701 | 3 | 3 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 3.3780 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 14.4326 | 1 | 2 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 5.0544 | 3 | 3 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 8.2505 | 2 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 16.0281 | 3 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 18.7775 | 2 | 4 |
| BRCA1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 23.7101 | 1 | 1 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 6.9212 | 2 | 3 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 10.1381 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 13.1213 | 3 | 6 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 50.1187 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 11.9496 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 4.7708 | 1 | 4 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 29.8816 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 11.9496 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 2.7540 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 10.4304 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.9497 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 49.7801 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 5.1021 | 1 | 6 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 1.6930 | 2 | 2 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 1.6785 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 33.1734 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 13.5346 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 2.7540 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| galactokinase | Homo sapiens (human) | Potency | 47.2690 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 1.6602 | 2 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 20.3866 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.3011 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 9.4384 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 20.9380 | 2 | 7 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 39.0762 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 2.7540 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 0.3981 | 2 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 47.3936 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 2.7540 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 8.8006 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 8.8006 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 14.6062 | 2 | 4 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 13.0594 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 23.9341 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 15.8553 | 1 | 3 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 13.3322 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 9.5205 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 22.7464 | 2 | 6 |
| P53 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 11.8823 | 1 | 1 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 28.1838 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 63.0957 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 9.1804 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 12.9244 | 1 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 18.5569 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 1.8834 | 1 | 1 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 66.8968 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 18.3676 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 47.3936 | 2 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 24.8258 | 2 | 7 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 45.4613 | 2 | 3 |
| WRN | Homo sapiens (human) | Potency | 6.5201 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli K-12 | IC50 | 3.4000 | 1 | 1 |
| 3-oxoacyl-[acyl-carrier-protein] synthase 2 | Staphylococcus aureus | IC50 | 4.5800 | 1 | 1 |
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 4.0000 | 1 | 1 |
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 1.3000 | 2 | 2 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 3.6100 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 65.8000 | 1 | 1 |
| Acyl-protein thioesterase 2 | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | IC50 | 5.1620 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 1.9000 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 1.5400 | 1 | 1 |
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | IC50 | 58.5000 | 2 | 2 |
| Alpha-amylase 1A | Homo sapiens (human) | IC50 | 18.4000 | 2 | 2 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 4.9000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 59.7000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 6.4000 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 290.0000 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 19.6000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 3.8800 | 1 | 1 |
| Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 5.0000 | 1 | 1 |
| Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 11.5000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 8.9000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 2.5000 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 4.5480 | 2 | 5 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.0603 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 3.2863 | 2 | 5 |
| Carbonic anhydrase 3 | Bos taurus (cattle) | Ki | 3.1850 | 1 | 4 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 2.6066 | 2 | 5 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 0.0047 | 1 | 1 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 0.7500 | 2 | 2 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 0.8333 | 3 | 3 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 0.8333 | 3 | 3 |
| Cationic trypsin | Bos taurus (cattle) | IC50 | 35.3000 | 1 | 1 |
| Chain A, Casein kinase II subunit alpha | Zea mays | IC50 | 0.3500 | 1 | 3 |
| Chemotaxis protein CheA | Escherichia coli K-12 | IC50 | 111.0000 | 1 | 1 |
| Collagenase 3 | Homo sapiens (human) | IC50 | 10.0500 | 1 | 1 |
| Cruzipain | Trypanosoma cruzi | IC50 | 91.5000 | 2 | 2 |
| Cyclin homolog | Herpesvirus saimiri (strain 11) | IC50 | 77.7000 | 1 | 4 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 6.2000 | 1 | 1 |
| Cyclin-dependent kinase 1 | Oryzias latipes (Japanese medaka) | IC50 | 77.7000 | 1 | 4 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | IC50 | 62.9200 | 2 | 5 |
| Cyclin-dependent kinase 6 | Homo sapiens (human) | IC50 | 122.1600 | 2 | 5 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | IC50 | 62.9200 | 2 | 5 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 1.2490 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 1.8967 | 2 | 3 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 3.3700 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 0.2195 | 2 | 2 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 1.2280 | 2 | 2 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.4200 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.4200 | 1 | 1 |
| Cytosol aminopeptidase | Sus scrofa (pig) | IC50 | 49.6000 | 1 | 1 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 21.0000 | 1 | 1 |
| Diacylglycerol lipase-alpha | Homo sapiens (human) | IC50 | 0.2678 | 4 | 4 |
| Diacylglycerol lipase-alpha | Mus musculus (house mouse) | IC50 | 0.0200 | 1 | 1 |
| Diacylglycerol lipase-beta | Homo sapiens (human) | IC50 | 0.2400 | 2 | 2 |
| Dipeptidyl peptidase 3 | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 0.1200 | 1 | 1 |
| DNA topoisomerase 1 | Rattus norvegicus (Norway rat) | IC50 | 2.8300 | 2 | 2 |
| Endothelial lipase | Homo sapiens (human) | IC50 | 0.0060 | 1 | 1 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] FabI | Escherichia coli K-12 | Ki | 7.0500 | 1 | 1 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 2.0000 | 2 | 2 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 2.1000 | 1 | 1 |
| Fatty acid synthase | Gallus gallus (chicken) | IC50 | 62.5000 | 1 | 1 |
| Fatty acid synthase | Homo sapiens (human) | IC50 | 67.8700 | 4 | 4 |
| Fatty acid synthase | Homo sapiens (human) | Ki | 0.2800 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0100 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 18.6000 | 1 | 1 |
| G2/mitotic-specific cyclin-B | Marthasterias glacialis (spiny starfish) | IC50 | 77.7000 | 1 | 4 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 | 6.2000 | 1 | 1 |
| G2/mitotic-specific cyclin-B2 | Homo sapiens (human) | IC50 | 6.2000 | 1 | 1 |
| G2/mitotic-specific cyclin-B3 | Homo sapiens (human) | IC50 | 6.2000 | 1 | 1 |
| Genome polyprotein | Zika virus | IC50 | 53.0000 | 1 | 1 |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Rattus norvegicus (Norway rat) | IC50 | 77.7000 | 1 | 4 |
| Hepatic triacylglycerol lipase | Homo sapiens (human) | IC50 | 0.0030 | 1 | 1 |
| histidine kinase | Streptococcus pneumoniae TIGR4 | IC50 | 216.0000 | 1 | 1 |
| Histone-lysine N-methyltransferase SETD7 | Homo sapiens (human) | IC50 | 6.0800 | 1 | 1 |
| Homeobox protein Nkx-2.5 | Mus musculus (house mouse) | IC50 | 22.0000 | 1 | 1 |
| Inositol hexakisphosphate kinase 2 | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| Inositol polyphosphate multikinase | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 17.4500 | 5 | 5 |
| integrase, partial | Human immunodeficiency virus 1 | IC50 | 7.8945 | 2 | 2 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 3.0300 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.6600 | 1 | 1 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | IC50 | 0.1903 | 1 | 2 |
| Lactoylglutathione lyase | Homo sapiens (human) | IC50 | 7.7000 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 11.9000 | 1 | 1 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 7.8945 | 2 | 2 |
| Lipoprotein lipase | Homo sapiens (human) | IC50 | 0.0660 | 1 | 1 |
| Lysophosphatidylserine lipase ABHD12 | Homo sapiens (human) | IC50 | 0.1682 | 3 | 5 |
| M1-family alanyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 22.8600 | 1 | 1 |
| Macrophage metalloelastase | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| MAP kinase-interacting serine/threonine-protein kinase 1 | Homo sapiens (human) | IC50 | 0.1790 | 1 | 1 |
| MAP kinase-interacting serine/threonine-protein kinase 2 | Homo sapiens (human) | IC50 | 0.5790 | 1 | 1 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 5.6200 | 1 | 1 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 10.1500 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 10.1500 | 1 | 2 |
| Monoacylglycerol lipase ABHD6 | Homo sapiens (human) | IC50 | 0.0300 | 5 | 6 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| NADPH oxidase 4 | Homo sapiens (human) | IC50 | 0.8500 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 32.6500 | 4 | 4 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | Ki | 19.6000 | 1 | 1 |
| Neutral cholesterol ester hydrolase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Neutrophil elastase | Homo sapiens (human) | IC50 | 12.7000 | 1 | 1 |
| Neutrophil elastase | Homo sapiens (human) | Ki | 10.1000 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Homo sapiens (human) | IC50 | 0.3253 | 3 | 3 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 0.4214 | 14 | 14 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | Ki | 5.0300 | 2 | 2 |
| Phosphatidylserine lipase ABHD16A | Homo sapiens (human) | IC50 | 0.1000 | 2 | 2 |
| Platelet-activating factor acetylhydrolase | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Poly [ADP-ribose] polymerase 1 | Homo sapiens (human) | IC50 | 4.2329 | 1 | 2 |
| Poly [ADP-ribose] polymerase tankyrase-1 | Homo sapiens (human) | IC50 | 2.3994 | 1 | 2 |
| Poly [ADP-ribose] polymerase tankyrase-2 | Homo sapiens (human) | IC50 | 1.0858 | 1 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 3.2000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| Proteasome subunit beta type-1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Proteasome subunit beta type-2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 34.2667 | 3 | 3 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 0.8300 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 20.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 20.0000 | 2 | 2 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 3.2000 | 3 | 3 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | Ki | 121.7000 | 1 | 1 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| Short transient receptor potential channel 5 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Sialidase | Clostridium perfringens | IC50 | 4.3000 | 1 | 1 |
| Sialidase-2 | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| Stromelysin-1 | Homo sapiens (human) | IC50 | 16.2000 | 1 | 1 |
| Substance-K receptor | Cavia porcellus (domestic guinea pig) | IC50 | 33.7000 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 33.7000 | 1 | 1 |
| Transcription factor GATA-4 | Mus musculus (house mouse) | IC50 | 22.0000 | 1 | 1 |
| Translocator protein | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Transthyretin | Homo sapiens (human) | IC50 | 6.4000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| Tyrosine-protein kinase SYK | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| Tyrosine-protein kinase Yes | Homo sapiens (human) | Ki | 2.3800 | 1 | 1 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 35.4000 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 35.4000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 10.2000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 6.6300 | 3 | 3 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | Ki | 1.9000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | Ki | 2.9000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 10.6000 | 1 | 1 |
| Chain A, Transthyretin | Homo sapiens (human) | Kd | 0.1000 | 1 | 5 |
| Chain B, Transthyretin | Homo sapiens (human) | Kd | 0.1000 | 1 | 2 |
| G-protein coupled receptor 35 | Homo sapiens (human) | EC50 | 5.2200 | 2 | 2 |
| glycogen synthase kinase-3 beta isoform 1 | Homo sapiens (human) | EC50 | 3.8120 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | EC50 | 47.9300 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 14.9000 | 2 | 2 |
| Peroxisome proliferator-activated receptor gamma | Mus musculus (house mouse) | EC50 | 2.3000 | 1 | 1 |
| POsterior Segregation | Caenorhabditis elegans | EC50 | 60.3740 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | EC50 | 10.6000 | 1 | 1 |
| Protein polybromo-1 | Homo sapiens (human) | Kd | 12.9000 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 10.6000 | 2 | 2 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 10.6000 | 1 | 1 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 10.6000 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 10.6000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 10.6000 | 2 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | EC50 | 1.4500 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | EC50 | 31.0000 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 10.6000 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 10.6000 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 10.6000 | 1 | 1 |
| Transthyretin | Homo sapiens (human) | Kd | 0.0700 | 1 | 1 |
| Tyrosine-protein kinase SYK | Homo sapiens (human) | EC50 | 4.5000 | 1 | 1 |
| Zinc finger protein mex-5 | Caenorhabditis elegans | EC50 | 31.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | EC150 | 18.0000 | 1 | 1 |
| cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7 | Homo sapiens (human) | AC50 | 29.2700 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | EC150 | 18.0000 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | Km | 225.8400 | 3 | 3 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | Km | 169.0500 | 2 | 2 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | Vmax | 0.0105 | 2 | 2 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | Km | 32.3500 | 4 | 4 |