Roles > EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor
Page last updated: 2024-08-05 15:33:16
EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor
An EC 1.14.16.* (oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen) inhibitor that interferes with the action of tyrosine 3-monooxygenase (EC 1.14.16.2).
ChEBI ID: 63932
Members (3)
| Member | Definition | Class |
|---|
| bulbocapnine | An aporphine alkaloid that has been isolated from Corydalis and exhibits inhibitory activity against enzymes such as tyrosine 3-monooxygenase and diamine oxidase. | bulbocapnine |
| metyrosine | An L-tyrosine derivative that consists of L-tyrosine bearing an additional methyl substituent at position 2. An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. | alpha-methyl-L-tyrosine |
| monoiodotyrosine | The monoiodotyrosine that is L-tyrosine carrying an iodo-substituent at position C-3 of the benzyl group. | 3-iodo-L-tyrosine zwitterion; 3-iodo-L-tyrosine |
Research
Studies (730)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 552 (75.62) | 18.7374 |
| 1990's | 62 (8.49) | 18.2507 |
| 2000's | 47 (6.44) | 29.6817 |
| 2010's | 55 (7.53) | 24.3611 |
| 2020's | 14 (1.92) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 3 (0.38%) | 5.53% |
| Reviews | 25 (3.15%) | 6.00% |
| Case Studies | 8 (1.01%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 758 (95.47%) | 84.16% |
Protein Targets (19)
Potency Measurements
Inhibition Measurements
Activation Measurements