ascorbic-acid and Anemia--Macrocytic

Topics: Adult; Anemia, Macrocytic; Ascorbic Acid; Chemical Phenomena; Chemistry; Child, Preschool; Digestive System; Erythropoiesis; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Intestinal Absorption; Iron; Male; Pregnancy; Riboflavin; Vitamin B 12

Topics: Adult; Anemia, Hemolytic; Anemia, Macrocytic; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Cell Count; Bone Marrow Cells; Erythrocytes; Erythropoiesis; FIGLU Test; Folic Acid; Folic Acid Deficiency; Hemolysis; Hemorrhagic Disorders; Humans; Iron; Leukocytes; Liver; Reticulocytes; Scurvy; Tissue Extracts; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Abetalipoproteinemia; Adult; Anemia; Anemia, Macrocytic; Animals; Ascorbic Acid; Bone Marrow; Deficiency Diseases; Dietary Fats; DNA Replication; Erythropoiesis; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Iron; Kwashiorkor; RNA; Salmonidae; Selenium; Swine; Vitamin B 12; Vitamin E; Vitamin E Deficiency

Topics: Altitude; Anemia; Anemia, Macrocytic; Anemia, Sickle Cell; Ascorbic Acid; Celiac Disease; Climate; Deficiency Diseases; Female; Folic Acid; Hematology; Humans; Infant; Metabolism; Nutrition Disorders; Parasitic Diseases; Pharmaceutical Preparations; Poisons; Polycythemia; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Radiation Effects; Seasons; Sprue, Tropical; Vitamin B 12

A diet restricted to rice and boiled fruit and vegetables leads to vitamin C deficiency. We describe the third case, to our knowledge, of retinal hemorrhages related to scurvy. Reduced bilateral visual acuity in a 50-year-old patient was associated with macrocytic anemia, denutrition, and cutaneous ecchymoses. Oral vitamin C treatment provided subjective clinical improvement and regression of the retinal hemorrhages on fundus examination, with no side effects. Vitamin C plays an important role in collagen stability in vascular and bone walls.

Topics: Anemia, Macrocytic; Ascorbic Acid; Collagen; Cooking; Diet, Vegetarian; Ecchymosis; Emergencies; Gastritis, Atrophic; Humans; Male; Middle Aged; Retinal Hemorrhage; Scurvy; Vitamin B 12 Deficiency

Topics: Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Pernicious; Ascorbic Acid; Bone Marrow Diseases; Female; Humans; Iron; Male; Pyridoxine; Vitamin B 12

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Ascorbic Acid; Folic Acid; Formates; Humans; Leucovorin; Male; Middle Aged; Scurvy; Tetrahydrofolates

Topics: Anemia, Macrocytic; Ascorbic Acid; Ascorbic Acid Deficiency; Contraceptives, Oral; Depression; Female; Folic Acid Deficiency; Glutathione Reductase; Humans; Pyridoxine; Riboflavin Deficiency; Vitamin A; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency; Vitamins

Topics: Aged; Anemia, Macrocytic; Ascorbic Acid; Blood Cell Count; Blood Proteins; Bone Marrow Cells; Cell Nucleus; Erythrocytes, Abnormal; Female; Folic Acid; Hemoglobinometry; Humans; Iodine; Iron; Leukocytes; Male; Neutrophils; Protein Binding; Vitamin B 12

Topics: Aged; Anemia, Macrocytic; Animals; Ascorbic Acid; Blood Cells; Bone Marrow; Bone Marrow Cells; Female; Guinea Pigs; Haplorhini; Humans; Male; Middle Aged

The platelet ascorbic acid concentration was measured in 26 normal subjects and found to be 20 times as high as in plasma. This is in agreement with previous reports in the literature. The platelets of patients with uraemia, leukaemia, and megaloblastic anaemia had a lower than normal platelet ascorbic acid content. In uraemia and megaloblastic anaemia the plasma ascorbic acid concentration was normal suggesting that a platelet defect may be responsible for the low platelet ascorbic acid content. In leukaemia the low platelet ascorbic acid content is probably secondary to a low plasma level.

Topics: Acute Disease; Adolescent; Adult; Anemia, Macrocytic; Ascorbic Acid; Blood Platelet Disorders; Blood Platelets; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Plasma; Uremia

Topics: Adrenal Cortex Hormones; Androstanes; Anemia, Aplastic; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Pernicious; Ascorbic Acid; Blood Transfusion; Humans; Iron; Iron-Dextran Complex; Ketones; Splenectomy; Vitamin B 12

Topics: Adult; Anemia, Macrocytic; Ascorbic Acid; Deferoxamine; Humans; Iron; Male

Topics: Anemia, Macrocytic; Ascorbic Acid; Drug Stability; Erythropoiesis; Female; Folic Acid; Humans; Malaria; Nigeria; Plasmodium falciparum; Postpartum Period; Pregnancy; Pregnancy Complications, Hematologic; Temperature

Topics: Anemia, Macrocytic; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Dietary Fats; Folic Acid; Hominidae; Nutritional Requirements; Reticulocytes; Vitamin B 12

Topics: Aged; Anemia, Macrocytic; Ascorbic Acid; Erythropoiesis; Folic Acid; Hemoglobinometry; Humans; Male; Reticulocytes; Scurvy

Topics: Anemia, Macrocytic; Ascorbic Acid; Child, Preschool; Female; Folic Acid; Humans; Infant; Iron; Male; Protein-Energy Malnutrition; Vitamin B 12; Vitamin E

Topics: Adult; Anemia, Macrocytic; Ascorbic Acid; Female; Folic Acid; Humans; Lactobacillus; Pregnancy; Pregnancy Complications, Hematologic

Topics: Aged; Anemia, Macrocytic; Ascorbic Acid; Blood; Diet Therapy; England; Female; FIGLU Test; Folic Acid; Folic Acid Deficiency; Hemoglobins; Humans; Male; Middle Aged; Nutrition Surveys; Vitamin B 12; Vitamins

Topics: Anemia, Macrocytic; Ascorbic Acid; Blood; Folic Acid; Folic Acid Deficiency; Hemoglobins; Humans; Iron; Lactobacillus; Leuconostoc; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Ascorbic Acid; Blood Cell Count; Bone Marrow Examination; Erythropoiesis; Folic Acid; Geriatrics; Glutamates; Hematocrit; Hemoglobinometry; Humans; Iron; Liver Diseases; Liver Extracts; Phosphatidylethanolamines; Pyridoxine; Reticulocytes; Sulfobromophthalein; Urine; Vitamin B 12

Topics: Alcoholism; Anemia; Anemia, Macrocytic; Anorexia Nervosa; Ascorbic Acid; Avitaminosis; Celiac Disease; Deficiency Diseases; Diet; Diet Therapy; Female; Folic Acid; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Pregnancy Complications; Sprue, Tropical; United Kingdom; Vitamin A; Vitamin B 12; Vitamin B Complex; Vitamin D; Vitamin K; Vitamins; Vomiting

Measurement of the serum Lactobacillus casei (;folic-acid') activity is widely used as an index of folic-acid deficiency. Present methods of assay result in recovery of about half the active material in normal serum. A modified method of assay is described which gives higher L. casei values and a clearer distinction between the sera of normal subjects and of patients with folic-acid deficiency.

Topics: Anemia; Anemia, Macrocytic; Ascorbic Acid; Biological Assay; Blood; Folic Acid; Folic Acid Deficiency; Humans; Lactobacillus; Vitamin B 12 Deficiency

Topics: Anemia; Anemia, Macrocytic; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Cell Count; Blood Chemical Analysis; Blood Coagulation Tests; Blood Proteins; Bone Marrow Examination; Folic Acid; Gastric Acidity Determination; Geriatrics; Hemoglobins; Hemolysis; Hemorrhagic Disorders; Humans; Scurvy; Urine; Urobilin

Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Ascorbic Acid; Folic Acid; Humans; Metabolism; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Anemia, Sideroblastic; Ascorbic Acid; Child; Folic Acid; Humans; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Ascorbic Acid; Humans; Osteoporosis; Scurvy

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Ascorbic Acid; Ascorbic Acid Deficiency; Folic Acid; Humans; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Ascorbic Acid; Folic Acid; Geriatrics; Hemoglobinometry; Humans; Reticulocytes; Vitamin B 12; Vitamin B Deficiency

Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Ascorbic Acid; Blood Transfusion; Child; Diarrhea; Folic Acid; Humans; Infant; Infections; Nutrition Disorders

Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Ascorbic Acid; Asian People; Blood Chemical Analysis; Bone Marrow Examination; Dietary Carbohydrates; Dietary Proteins; Folic Acid; Folic Acid Deficiency; Leucovorin; Lipids; Myanmar; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Ascorbic Acid; Female; Folic Acid; Humans; Postpartum Period; Puerperal Disorders

Topics: Acetates; Anemia; Anemia, Macrocytic; Ascorbic Acid; Chromatography; Phenylacetates; Scurvy; Steatorrhea; Urine

Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Animals; Ascorbic Acid; Folic Acid; Folic Acid Deficiency; Scurvy; Tracheophyta

Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Ascorbic Acid; Humans; Pregnancy; Vitamin B 12