An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
ChEBI ID: 35530
| Member | Definition | Class |
|---|---|---|
| 1-0-octadecyl 2-0-acetyl sn-glycero-3-phosphorylcholine | A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has octadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis. | 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine |
| 1-hexadecyl-2-acetyl-glycero-3-phosphocholine | A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis. | 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine |
| acebutolol | An ether that is the 2-acetyl-4-(butanoylamino)phenyl ether of the primary hydroxy group of 3-(propan-2-ylamino)propane-1,2-diol. | acebutolol |
| acebutolol hydrochloride | The hydrochloride salt of acebutolol, prepared using equimolar amounts of acebutolol and hydrogen chloride. | acebutolol hydrochloride |
| ag 1879 | A member of the class of pyrazolopyrimidine that is pyrazolo[3,4-d]pyrimidin-4-amine bearing additional tert-butyl and 4-chlorophenyl substituents at positions 1 and 3 respectively. It is a potent ATP-competitive inhibitor of the Src family of protein tyrosine kinases. | PP2 |
| alprenolol | A secondary alcohol that is propan-2-ol substituted by a 2-allylphenoxy group at position 1 and an isopropylamino group at position 3. It is a beta-adrenergic antagonist used as a antihypertensive, anti-arrhythmia and a sympatholytic agent. | alprenolol |
| asl 8052 | The hydrochloride salt of esmolol. A cardioselective and short-acting beta1 receptor blocker with rapid onset but lacking intrinsic sympathomimetic and membrane-stabilising properties, it is used in the management of supraventricular arrhythmias, and for the control of hypertension and tachycardia during surgery. | esmolol hydrochloride |
| atenolol | An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent. | atenolol |
| betaxolol | A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment of glaucoma as well as hypertension, arrhythmias, and coronary heart disease. It is also used to reduce non-fatal cardiac events in patients with heart failure. | betaxolol |
| betaxolol hydrochloride | The hydrochloride salt of betaxolol. | betaxolol hydrochloride |
| bevantolol | A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by 3-methylphenyl and one of the hydrogens attached to the nitrogen is substituted by 2-(3,4-dimethoxyphenyl)ethyl. A beta1 adrenoceptor antagonist, it has been shown to be as effective as other beta-blockers for the treatment of angina pectoris and hypertension. | bevantolol |
| bisoprolol | bisoprolol | |
| carteolol | carteolol | |
| carteolol hydrochloride | carteolol hydrochloride | |
| carvedilol | A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure. | carvedilol |
| cgp 12177 | A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group. | CGP 12177 |
| esatenolol | The (S)-enantiomer of atenolol. | esatenolol |
| icatibant | A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acute attacks of hereditary angioedema in adult patients. | icatibant |
| ici 118551 | An indane substituted at position 7 by a methyl group and at position 4 by a 3-(isopropylamino)-2-hydroxybutoxy group (the 2R,3S-diastereomer). | ICI 118551 |
| levobunolol | A cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. | levobunolol |
| levobunolol hydrochloride | A hydrochloride obtained by combining equimolar amounts of levobunolol and hydrochloric acid. A non-selective beta-adrenergic antagonist used for treatment of glaucoma. | levobunolol hydrochloride |
| metipranolol | 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angle glaucoma. | metipranolol |
| metoprolol | A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1. | metoprolol |
| pindolol | A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol. | pindolol |
| practolol | N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias. | practolol |
| propranolol | A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3. | propranolol |
| sotalol | A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias. | sotalol |
| sotalol hydrochloride | A hydrochloride salt that is the monohydrochloride of sotalol. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias. | sotalol hydrochloride |
| timolol | The (S)-(-) (more active) enantiomer of timolol. A beta-adrenergic antagonist, both the hemihydrate and the maleate salt are used in the mangement of glaucoma, hypertension, angina pectoris and myocardial infarction, and for the prevention of migraine. | (S)-timolol (anhydrous) |
| timolol maleate | The maleic acid salt of the active (S)-enantiomer of timolol, comprising equimolar amounts of (S)-timolol and maleic acid. | (S)-timolol maleate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 30,224 (48.15) | 18.7374 |
| 1990's | 14,306 (22.79) | 18.2507 |
| 2000's | 9,122 (14.53) | 29.6817 |
| 2010's | 7,262 (11.57) | 24.3611 |
| 2020's | 1,859 (2.96) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 11,648 (15.49%) | 5.53% |
| Reviews | 4,072 (5.42%) | 6.00% |
| Case Studies | 4,063 (5.40%) | 4.05% |
| Observational | 121 (0.16%) | 0.25% |
| Other | 55,269 (73.52%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 4.1707 | 1 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 41.9936 | 2 | 2 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 4.5753 | 1 | 3 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 2.3753 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 28.6237 | 6 | 7 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 29.8493 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 6.5146 | 1 | 8 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 21.7994 | 2 | 5 |
| Ataxin-2 | Homo sapiens (human) | Potency | 23.8875 | 2 | 4 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 19.5259 | 1 | 5 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 124.4242 | 2 | 8 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 44.9647 | 1 | 2 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 17.5594 | 1 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 25.3606 | 1 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 21.3145 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 6.4238 | 1 | 4 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 23.1288 | 1 | 5 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 48.5745 | 2 | 7 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 16.7678 | 1 | 6 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 17.0011 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 21.5102 | 2 | 10 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 27.5957 | 1 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 13.3332 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 5.0925 | 3 | 6 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 14.6892 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.4208 | 1 | 4 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 44.0596 | 1 | 3 |
| endonuclease IV | Escherichia coli | Potency | 14.1254 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 12.2612 | 4 | 7 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 43.2771 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 41.1312 | 4 | 4 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.0965 | 1 | 10 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 17.6540 | 4 | 8 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 19.7802 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 21.5102 | 1 | 5 |
| geminin | Homo sapiens (human) | Potency | 9.7887 | 2 | 11 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 8.6282 | 2 | 3 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 21.9511 | 2 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 16.6344 | 2 | 3 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 5.0119 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 61.9315 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 2.2387 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.0672 | 1 | 11 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 22.1060 | 1 | 2 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 26.2248 | 3 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 22.3872 | 1 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 19.9554 | 2 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 4.0648 | 2 | 5 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 4.2617 | 2 | 8 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 4.2800 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 26.6011 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 6.0070 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 17.0448 | 2 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 17.3246 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 44.9647 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 13.5120 | 1 | 5 |
| progesterone receptor | Homo sapiens (human) | Potency | 61.7528 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.4724 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 5.6714 | 1 | 7 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 49.2911 | 2 | 2 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 14.6892 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 2.0585 | 1 | 3 |
| snurportin-1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 29.9503 | 1 | 5 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 11.6902 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 23.4334 | 1 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 16.0644 | 2 | 14 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 13.0490 | 2 | 7 |
| Thrombopoietin | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 31.2530 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 19.1116 | 2 | 5 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 22.1060 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 1.4926 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 37.6460 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 2.3055 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.6003 | 5 | 10 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.0518 | 5 | 5 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 2.6336 | 3 | 13 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 1.1820 | 1 | 5 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Ki | 7.5333 | 1 | 3 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.4509 | 4 | 8 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.1000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.1000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 2.2960 | 2 | 3 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.2680 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 114.7500 | 2 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 1.7923 | 2 | 3 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.1165 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 114.7500 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 2.4736 | 2 | 3 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 18.4207 | 2 | 3 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 114.7500 | 2 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 1.2045 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.6310 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 3.1986 | 2 | 3 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 1.0640 | 1 | 2 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 63.2000 | 1 | 2 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Albumin | Homo sapiens (human) | Ki | 354,813,000.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.5380 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 0.5330 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | IC50 | 2.6209 | 2 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | IC50 | 0.2300 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.1159 | 2 | 2 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0009 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 2.5589 | 2 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0400 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.0940 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.0430 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 2.5509 | 2 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0130 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 4.1193 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 3.3749 | 1 | 1 |
| Angiotensin-converting enzyme | Rattus norvegicus (Norway rat) | Ki | 0.0240 | 1 | 4 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 8 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 378.0400 | 4 | 5 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 124.0000 | 1 | 2 |
| B2 bradykinin receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0025 | 2 | 3 |
| B2 bradykinin receptor | Homo sapiens (human) | IC50 | 0.0019 | 4 | 4 |
| B2 bradykinin receptor | Homo sapiens (human) | Ki | 0.0001 | 4 | 4 |
| B2 bradykinin receptor | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 1.7235 | 19 | 29 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 2 | 3 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 0.2127 | 9 | 21 |
| Beta-1 adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0189 | 1 | 3 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.8031 | 7 | 17 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0347 | 1 | 1 |
| Beta-2 adrenergic receptor | Canis lupus familiaris (dog) | IC50 | 3.8042 | 3 | 4 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0288 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | IC50 | 1.6062 | 12 | 20 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 2 | 3 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 1.0074 | 10 | 22 |
| Beta-2 adrenergic receptor | Mus musculus (house mouse) | Ki | 13.5000 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | IC50 | 1.5434 | 5 | 10 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 2 | 3 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Ki | 0.1524 | 1 | 5 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 393.7000 | 4 | 20 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 8 |
| Casein kinase I isoform delta | Homo sapiens (human) | IC50 | 0.0410 | 1 | 1 |
| Chain A, Lck Kinase | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| Chain A, Tyrosine-protein kinase Lyn | Mus musculus (house mouse) | IC50 | 0.0090 | 1 | 2 |
| Cholecystokinin receptor type A | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 7.0000 | 2 | 2 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 28.7175 | 2 | 4 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 18.3186 | 3 | 6 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 34.9567 | 1 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 3.2549 | 2 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.7490 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 2.5789 | 2 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.0490 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.5770 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.1960 | 1 | 1 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Endothelin-1 receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Ephrin type-B receptor 2 | Homo sapiens (human) | IC50 | 52.0000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 0.4800 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Fatty acid-binding protein, liver | Rattus norvegicus (Norway rat) | Ki | 717.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 4.2300 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 92.4000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 8 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 4.1193 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 3.3749 | 1 | 1 |
| Platelet-activating factor receptor | Homo sapiens (human) | IC50 | 0.0003 | 1 | 1 |
| Platelet-activating factor receptor | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| Potassium channel subfamily K member 10 | Homo sapiens (human) | IC50 | 15.8000 | 2 | 2 |
| Potassium channel subfamily K member 2 | Homo sapiens (human) | IC50 | 10.9500 | 2 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 7.3286 | 7 | 7 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 3.3749 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase LCK | Mus musculus (house mouse) | IC50 | 0.0310 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Gallus gallus (chicken) | IC50 | 0.0360 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 1.1814 | 8 | 8 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | Ki | 0.5000 | 2 | 2 |
| Receptor-interacting serine/threonine-protein kinase 2 | Homo sapiens (human) | IC50 | 0.0190 | 1 | 1 |
| Renin | Rattus norvegicus (Norway rat) | Ki | 13.5000 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 1.8215 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.7655 | 1 | 2 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 2.1000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.8450 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.6710 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 0.5380 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.5330 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 1.8330 | 1 | 3 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.9740 | 1 | 3 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 7.0000 | 1 | 1 |
| Sodium/bile acid cotransporter | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 33.3000 | 2 | 2 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Ki | 95.8000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 7.5000 | 1 | 1 |
| Squalene synthase | Rattus norvegicus (Norway rat) | IC50 | 4.2000 | 1 | 1 |
| Toll-like receptor 4 | Homo sapiens (human) | IC50 | 32.2200 | 1 | 1 |
| Type-1 angiotensin II receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| Tyrosine-protein kinase CSK | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 0.0052 | 2 | 2 |
| Tyrosine-protein kinase HCK | Homo sapiens (human) | IC50 | 0.0050 | 1 | 1 |
| Tyrosine-protein kinase JAK2 | Homo sapiens (human) | IC50 | 50,000.0000 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 0.0040 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Tyrosine-protein kinase Lyn | Homo sapiens (human) | IC50 | 0.0005 | 1 | 1 |
| Tyrosine-protein kinase ZAP-70 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 19.5000 | 2 | 2 |
| Urease | Canavalia ensiformis (jack bean) | IC50 | 64.3600 | 1 | 1 |
| Vasopressin V1a receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Cavia porcellus (domestic guinea pig) | IC50 | 21.0000 | 1 | 4 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 412.4333 | 3 | 3 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Rattus norvegicus (Norway rat) | IC50 | 21.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 193.3000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 193.3000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 193.3000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | EC50 | 0.0270 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Kd | 0.0631 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Kd | 0.9098 | 2 | 13 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Albumin | Homo sapiens (human) | Kd | 520.3425 | 6 | 6 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0270 | 1 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0270 | 1 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0270 | 1 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| amino acid transporter AGP1 | Saccharomyces cerevisiae S288C | EC50 | 10.8000 | 1 | 1 |
| B2 bradykinin receptor | Homo sapiens (human) | Kd | 0.0003 | 1 | 1 |
| bcl-2-like protein 11 isoform 1 | Homo sapiens (human) | EC50 | 350.0000 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | EC50 | 0.0123 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Kd | 5.2652 | 10 | 50 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0551 | 4 | 10 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.6372 | 17 | 29 |
| Beta-2 adrenergic receptor | Canis lupus familiaris (dog) | Kd | 0.1862 | 1 | 1 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.6115 | 6 | 22 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Kd | 5.0512 | 13 | 60 |
| Beta-2 adrenergic receptor | Bos taurus (cattle) | Kd | 69.0690 | 1 | 3 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Kd | 5.7821 | 7 | 44 |
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | EC50 | 350.0000 | 1 | 1 |
| Cholecystokinin receptor type A | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Endothelin-1 receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Ephrin type-A receptor 3 | Homo sapiens (human) | Kd | 200.0000 | 1 | 1 |
| Ephrin type-B receptor 2 | Homo sapiens (human) | Kd | 36.5000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Kd | 0.9853 | 1 | 6 |
| Kappa-type opioid receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| LAP4 | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 4.8230 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Neuromedin-K receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.0024 | 1 | 1 |
| Nuclear receptor subfamily 2 group E member 1 | Homo sapiens (human) | EC50 | 33.6667 | 3 | 3 |
| Nuclear receptor subfamily 2 group E member 1 | Homo sapiens (human) | Kd | 0.5000 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Gallus gallus (chicken) | Kd | 0.2960 | 1 | 1 |
| RPL19A | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 0.8525 | 2 | 2 |
| short transient receptor potential channel 6 isoform 1 | Mus musculus (house mouse) | EC50 | 44.6700 | 1 | 1 |
| Type-1 angiotensin II receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Vasopressin V1a receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Affinity constant | 0.0130 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Kapp | 78.2828 | 1 | 4 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Kapp | 78.2828 | 1 | 4 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Kapp | 78.2827 | 1 | 4 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Kapp | 78.2827 | 1 | 4 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Kapp | 78.2827 | 1 | 4 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Kapp | 78.2828 | 1 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki1 | 200.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki2 | 1,750.0000 | 1 | 1 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Kapp | 4.5082 | 1 | 4 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Affinity constant | 0.0130 | 1 | 1 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Affinity constant | 0.0006 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Kapp | 78.2827 | 1 | 4 |
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | AC50 | 697.4500 | 2 | 2 |
| HSP40, subfamily A [Plasmodium falciparum 3D7] | Plasmodium falciparum 3D7 | AbsAC1000_uM | 1.5580 | 1 | 1 |
| POU domain, class 2, transcription factor 1 | Homo sapiens (human) | Km | 195.9000 | 1 | 1 |
| Skn7p | Saccharomyces cerevisiae (brewer's yeast) | AbsAC40_uM | 12.6100 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Activity | 9.7000 | 1 | 1 |