An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of histamine N-methyltransferase (EC 2.1.1.8).
ChEBI ID: 110725
| Member | Definition | Class |
|---|---|---|
| amodiaquine | A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position. | amodiaquine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 398 (29.07) | 18.7374 |
| 1990's | 114 (8.33) | 18.2507 |
| 2000's | 351 (25.64) | 29.6817 |
| 2010's | 385 (28.12) | 24.3611 |
| 2020's | 121 (8.84) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 315 (21.65%) | 5.53% |
| Reviews | 84 (5.77%) | 6.00% |
| Case Studies | 40 (2.75%) | 4.05% |
| Observational | 4 (0.27%) | 0.25% |
| Other | 1,012 (69.55%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 7.5637 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 16.9330 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 0.4467 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 9.2842 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 4.7000 | 2 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 77.7600 | 1 | 1 |
| Chain A, Histamine N-methyltransferase | Homo sapiens (human) | Ki | 0.0186 | 1 | 4 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 0.9900 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 0.9900 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 5.1500 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 3.1933 | 1 | 3 |
| Nuclear receptor subfamily 4 group A member 2 | Homo sapiens (human) | EC50 | 44.7500 | 4 | 4 |
| Procathepsin L | Homo sapiens (human) | EC50 | 3.1933 | 1 | 3 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 3.1933 | 1 | 3 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 3.1933 | 1 | 3 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 3.1933 | 1 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 3.1933 | 1 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 3.1933 | 1 | 3 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 3.1933 | 1 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 3.1933 | 1 | 3 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 3.1933 | 1 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 2C8 | Homo sapiens (human) | Km | 1.9000 | 1 | 1 |