Any carboxylic acid containing two carboxy groups.
| Member | Definition | Role |
|---|
| (6R,7R)-7-[[(2R)-2-carboxy-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-7-methoxy-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | | (6R,7R)-7-[[(2R)-2-carboxy-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-7-methoxy-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| 1,4-thiomorpholine-3,5-dicarboxylic acid | | thiomorpholine-3,5-dicarboxylic acid |
| 2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid | | 2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid |
| 2-succinylbenzoate | | 2-succinylbenzoic acid |
| 2,2-dimethylmalonate | A dicarboxylic acid that is malonic acid in which both methylene hydrogens have been replaced by methyl groups. | dimethylmalonic acid |
| 2,2'-(3-methylcyclohexane-1,1-diyl)diacetic acid | | 2,2'-(3-methylcyclohexane-1,1-diyl)diacetic acid |
| 2,5-furandicarboxylic acid | A member of the class of furans carrying two carboxy substituents at positions 2 and 5. | furan-2,5-dicarboxylic acid |
| 2,6-naphthalenedicarboxylic acid | | naphthalene-2,6-dicarboxylic acid |
| 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid | A furoic acid that is furan-3-carboxylic acid substituted by a methyl group at position 4, a propyl group at position 5 and a 2-carboxyethyl group at position 2. It is a potent uremic toxin that has been found to accumulate in human serum of patients with chronic kidney diseases. | 2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid |
| 3-methylglutaconic acid | A dicarboxylic acid comprising (E)-glutaconic acid carrying a 3-methyl substituent. | (E)-3-methylglutaconic acid |
| 4-aminobenzoylglutamic acid | A dipeptide resulting from the formal condensation of the carboxylic acid group of 4-aminobenzoic acid with the amino group of L-glutamic acid. | N-(4-aminobenzoyl)-L-glutamic acid |
| 7432 s | A third-generation cephalosporin antibiotic with a [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino substituent at the 7 position of the cephem skeleton. An orally-administered agent, ceftibuten is used as the dihydrate to treat urinary-tract and respiratory-tract infections. | ceftibuten |
| alpha-isopropylmalate | A dicarboxylic acid that is malic acid (2-hydroxysuccinic acid) in which the hydrogen at position 2 is substituted by an isopropyl group. | 2-isopropylmalic acid |
| alpha-methylene glutarate | A dicarboxylic acid comprising a glutaric acid core with a methylene group at the 2-position. | 2-methylideneglutaric acid |
| aminopterin | | 4-aminofolic acid |
| bay 58-2667 | A benzoic acid that is 4-(aminomethyl)benzoic acid in which the amino group is substituted by 4-carboxybutyl and 2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl groups. It is a soluble guanylate cyclase activator, used for the treatment of acute decompensated heart failure. | cinaciguat |
| bay u9773 | A dicarboxylic acid that is that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 4S and a (4-carboxyphenyl)sulfanediyl group at 5R. It is a dual cysteinyl leukotriene receptor antagonist that acts at the CysLT1 and CysLT2 receptors (IC50 = 0.44 and 0.30 muM, respectively). | BAYu9773 |
| benazeprilat | A benzazepine that is 1,3,4,5-tetrahydro-2H-1-benzazepin-2-one in which the hydrogen attached to the nitrogen is replaced by a carboxy methyl group and in which the 3-pro-S hydrogen is replaced by the amino group of (2S)-2-amino-4-phenylbutanoic acid. An angiotensin-converting enzyme inhibitor, it is used as its monoester prodrug benazepril in the treatment of hypertension and heart failure. | benazeprilat |
| benzylsuccinic acid | A dicarboxylic acid consisting of succinic acid carrying a 2-benzyl substituent. | 2-benzylsuccinic acid |
| beta-aminoglutaric acid | A 1,5-dicarboxylic acid compound having a 3-amino substituent. It has been isolated from the extracts of the algae, Chondria armata. | isoglutamic acid |
| betalamic acid | | betalamic acid |
| bilirubin | A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin. | bilirubin IXalpha |
| bromosuccinic acid | A dicarboxylic acid that is succinic acid substituted at position 2 by a bromine atom. | bromosuccinic acid |
| calcium propionate | | Calcium propionate |
| carboxyibuprofen | A dicarboxylic acid that is ibuprofen in which one of the methyl groups in the isobutyl portion has been converted to the corresponding carboxylic acid. | carboxyibuprofen |
| chlorendic acid | A bridged organochlorine compound resulting from the Diels-Alder reaction of hexachlorocyclopentadiene with maleic anhydride followed by hydrolysis of the resulting anhydride. A chemical intermediate used in the preparation of fire-retardant polyester resins and plasticisers. | chlorendic acid |
| citraconic acid | A dicarboxylic acid consisting of maleic acid having a methyl substituent at the 2-position. | citraconic acid |
| cromolyn | A dicarboxylic acid that is the bis-chromone derivative of glycerol. It is effective as a mast cell stabilizer. | cromoglycic acid |
| Diethyl 2-(2-furyl)-4-hydroxy-4-methyl-6-oxo-1,3-cyclohexanedicarboxylate | | Diethyl 2-(2-furyl)-4-hydroxy-4-methyl-6-oxo-1,3-cyclohexanedicarboxylate |
| diethyl malonate | | Ethyl malonate |
| diglycolic acid | | Diglycolic acid |
| dihydrokainate | | dihydrokainic acid |
| diphenic acid | | diphenic acid |
| enalaprilat anhydrous | Enalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor and is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is given by intravenous injection, usually as the dihydrate. | enalaprilat (anhydrous) |
| eprosartan | A member of the class of imidazoles and thiophenes that is an angiotensin II receptor antagonist used for the treatment of high blood pressure. | eprosartan |
| ethylmalonic acid | A dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group. | ethylmalonic acid |
| ferrous fumarate | | Ferrous fumarate |
| fertaric acid | A cinnamate ester obtained by formal condensation of the carboxy group of ferulic acid with one of the hydroxy groups of tartaric acid. | fertaric acid |
| formiminoglutamic acid | The N-formimidoyl derivative of L-glutamic acid | N-formimidoyl-L-glutamic acid |
| gamma-glutamyltyrosine | A dipeptide composed of L-glutamic acid and L-tyrosine joined by a peptide linkage. | gamma-Glu-Tyr |
| gibberellin a12 | A C20-gibberellin, initially identified in Gibberella fujikuroi, in which the gibbane skeleton carries 1beta- and 4aalpha-methyl groups, 1alpha- and 10beta-carboxy substituents, and a methylene group at C-8 (all gibbane numberings). | gibberellin A12 |
| hawkinsin | A cysteine derivative that is cysteine in which the thiol group is substituted by a [2-(carboxymethyl)-2,5-dihydroxycyclohex-3-en-1-yl]sulfanediyl group. Hawkinsinuria is an inherited disorder which is characterized by the inability to break down the amino acid tyrosine. This results in the finding of certain metabolites in the urine, such as hawkinsin. | hawkinsin |
| imidaprilat | A member of the class of imidazolidines that is imidapril in which the ethyl ester group has been hydrolysed to the corresponding acid group. It is the active metabolite of imidapril used to treat hypertension. | imidaprilat |
| itaconic acid | A dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group. | itaconic acid |
| kainic acid | | kainic acid |
| lanthionine ketimine | A member of the class of 1,4-thiazines that is 3,6-dihydro-2H-1,4-thiazine substituted by carboxy groups at positions 3 and 5. It is a natural but non-proteogenic amino acid found in human urine and brain. | lanthionine ketimine |
| lauroyl peroxide | | Lauroyl peroxide |
| ly 404039 | An organic heterobicyclic compound that is (1S,5R)-2-thiabicyclo[3.1.0]hexane carrying oxo, oxo, amino, carboxy, and carboxy groups at positions 2, 2, 4S, 4S, and 6S, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 mGluR3 (Ki = 149 nM and 92 nM, respectively) and exhibits antipsychotic and anxiolytic efficacy in animal models. | LY404039 |
| meglutol | A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura. | 3-hydroxy-3-methylglutaric acid |
| methotrexate | | methotrexate |
| monomethyl succinate | A dicarboxylic acid that is butanedioic acid substituted at position 2 by a methyl group. | 2-methylbutanedioic acid |
| n-(2-acetamido)iminodiacetic acid | A tricarboxylic acid amide that is a Good's buffer substance, pKa = 6.6 at 20 degreeC. | 2,2'-[(2-amino-2-oxoethyl)imino]diacetic acid |
| nedocromil | | nedocromil |
| nigranoic acid | A tetracyclic triterpenoid that is 3,4-secocycloarta-4(28),24-(Z)-diene substituted by carboxy groups at positions 3 and 26. Isolated from Schisandra henryi and Schisandra propinqua, it exhibits cytotoxic and anti-HIV activities. | nigranoic acid |
| olsalazine | An azobenzene that consists of two molecules of 4-aminosalicylic acid joined by an azo linkage. A prodrug for mesalazine, an anti-inflammatory drug, it is used (as the disodium salt) in the treatment of inflammatory bowel disease. | olsalazine |
| pamoic acid | | pamoic acid |
| perindoprilat | A dipeptide obtained by formal condensation of one of the carboxy groups of N-[(1S)-1-carboxyethyl]-L-norvaline with the amino group of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid. The major active metabolite of perindopril. | perindoprilat |
| poricoic acid a | A tricyclic triterpenoid isolated from Poria cocos. | poricoic acid A |
| poricoic acid g | A tricyclic triterpenoid isolated from Poria cocos. | poricoic acid G |
| porphobilinogen | A dicarboxylic acid that is pyrole bearing aminomethyl, carboxymethyl and 2-carboxyethyl substituents at positions 2, 3 and 4 respectively. | porphobilinogen |
| quinaprilat | A dicarboxylic acid resulting from the hydrolysis of the ethyl ester group of quinapril to give the corresponding dicarboxylic acid. The active angiotensin-converting enzyme inhibitor (ACE inhibitor) of the prodrug quinapril. | quinaprilat |
| ramiprilat | A dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. | ramiprilat |
| salvianolic acid B | A member of the class of 1-benzofurans that is an antioxidant and free radical scavenging compound extracted from S. miltiorrhiza | salvianolic acid B |
| spiraprilat | An azaspiro compound that is spirapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid group. It is the active metabolite of the angiotensin-converting enzyme (ACE) inhibitor spirapril. | spiraprilat |
| succimer | A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning. | succimer |
| tartronic acid | A dicarboxylic acid that is malonic acid substituted by a hydroxy group at position 2. | hydroxymalonic acid |
| thiodiacetic acid | | thiodiacetic acid |
| thiodipropionic acid | | 3,3'-Thiobispropanoic acid |
| trandolaprilat | A heterobicyclic compound that is trandolapril in which the ethyl ester group has been hydrolysed to the corresponding acid group. It is the active metabolite of the prodrug trandolapril. | trandolaprilat |
| traumatic acid | A monounsaturated straight-chain dicarboxylic acid with the double bond at C-2; a plant wound-healing hormone. | traumatic acid |