Page last updated: 2024-09-27

Geographic Atrophy

A form of MACULAR DEGENERATION also known as dry macular degeneration marked by occurrence of a well-defined progressive lesion or atrophy in the central part of the RETINA called the MACULA LUTEA. It is distinguishable from WET MACULAR DEGENERATION in that the latter involves neovascular exudates.

Synonyms(1)

Synonym
Geographic Atrophy

Research Excerpts

Overview

ExcerptReference
"As geographic atrophy is an increasingly common condition with no effective intervention, many treatments are under investigation, one of which is visual cycle modulators."( Colquitt, JL; Lois, N; Loveman, E; Royle, P; Waugh, N; Yeong, JL, 2020)

Context

ExcerptReference
"Geographic atrophy has a slow disease progression and patients tend to have preserved central vision until the final stages."( Colquitt, JL; Lois, N; Loveman, E; Royle, P; Waugh, N; Yeong, JL, 2020)

Research

Studies (121)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's82 (67.77)28.8240
2020's39 (32.23)9.53
DrugIndicatedRelationship StrengthStudiesTrials
thioctic acid0medium11
nitrates0low10
thiamine0medium11
3,4-methylenedioxyamphetamine0low10
aspirin0medium21
glyburide0low10
hydroxychloroquine0low10
ketotifen0low10
mebendazole0low10
propranolol0low10
perflutren0low10
triamcinolone acetonide0low10
phencyclidine0low10
pyrroles0low10
copper gluconate0medium11
durapatite0low10
zinc oxide0medium21
d-alpha tocopherol0medium43
sulfur hexafluoride0low10
Brilliant Blue0low10
cerium0low20
tricalcium phosphate0low10
ozone0low10
trolamine salicylate0low10
calcium dobesilate0low10
fludrocortisone0medium11
4-methoxyamphetamine0low10
zidovudine0low10
flubendazole0low10
ceric oxide0low20
sdds0low20
fibrinogen0low10
tandospirone0medium11
xaliproden0low10
fludrocortisone acetate0medium11
glucosamine0low10
elastin0low10
retinol0medium61
eicosapentaenoic acid0medium43
iridoids0low10
riboflavin0medium11
retinaldehyde0low10
vitamin k semiquinone radical0low10
beta carotene0medium32
alprostadil0medium11
zeaxanthin0medium137
lutein0medium147
4-hydroxy-2-nonenal0low10
sirolimus0medium22
fenretinide0medium31
lysophosphatidylcholines0low10
bay 11-70820low10
pregabalin0low10
tafamidis0low10
brimonidine tartrate0medium31
indocyanine green0low190
24-hydroxycholesterol0low10
3'-azido-3'-deoxy-5'-o-beta-glucopyranuronosylthymidine0low10
chitosan0low10
sodium iodate0low80
olaparib0low10
piperidines0medium11
interleukin-80low20
ascorbic acid0medium33
ferric ammonium citrate0low10
folic acid0medium11
sildenafil citrate0medium11
eye0low90
metallothionein0low10
leptin0low10

Protein Targets (859)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0224
5-hydroxytryptamine receptor 2A0224
5-hydroxytryptamine receptor 1A07311
Sodium-dependent noradrenaline transporter 0404
Sodium-dependent dopamine transporter0011
5-hydroxytryptamine receptor 1B0527
5-hydroxytryptamine receptor 1D0123
5-hydroxytryptamine receptor 1F0123
5-hydroxytryptamine receptor 2B0224
5-hydroxytryptamine receptor 60022
Sodium-dependent serotonin transporter0426
Sodium-dependent serotonin transporter0314
5-hydroxytryptamine receptor 7 0022
5-hydroxytryptamine receptor 5A0022
5-hydroxytryptamine receptor 5B0022
5-hydroxytryptamine receptor 3A0022
Sodium-dependent dopamine transporter 0202
5-hydroxytryptamine receptor 4 0022
5-hydroxytryptamine receptor 3B0022
Microtubule-associated protein tau6006
vitamin D3 receptor isoform VDRA5005
Transient receptor potential cation channel subfamily A member 10011
TDP1 protein160016
AR protein200020
glucocorticoid receptor [Homo sapiens]140014
estrogen nuclear receptor alpha210021
peroxisome proliferator activated receptor gamma110011
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010012
Bile salt export pump017017
Cellular tumor antigen p53120012
Thromboxane-A synthase 0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP1 subtype0101
Prostacyclin receptor0112
Nuclear receptor subfamily 4 group A member 20011
Solute carrier organic anion transporter family member 2A10001
Nuclear receptor subfamily 4 group A member 20011
Nuclear receptor subfamily 4 group A member 20011
Prostaglandin E2 receptor EP2 subtype0112
Canalicular multispecific organic anion transporter 10909
Solute carrier organic anion transporter family member 2A10001
Solute carrier organic anion transporter family member 2B10101
Solute carrier organic anion transporter family member 3A10001
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase7007
RAR-related orphan receptor gamma110011
GLI family zinc finger 3120012
thioredoxin glutathione reductase2002
cytochrome P450 family 3 subfamily A polypeptide 4100010
retinoic acid nuclear receptor alpha variant 1130013
estrogen-related nuclear receptor alpha140014
vitamin D (1,25- dihydroxyvitamin D3) receptor100010
IDH14004
euchromatic histone-lysine N-methyltransferase 2110011
chromobox protein homolog 17007
nuclear factor erythroid 2-related factor 2 isoform 25005
thyroid hormone receptor beta isoform 2110011
nuclear factor erythroid 2-related factor 2 isoform 1100010
lethal(3)malignant brain tumor-like protein 1 isoform I2002
geminin110011
lethal factor (plasmid)7007
lamin isoform A-delta10110011
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0326
Spike glycoprotein7018
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, 2-oxoglutarate Oxygenase3003
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 84004
thioredoxin reductase7007
GLS protein6006
aldehyde dehydrogenase 1 family, member A1120012
thyroid stimulating hormone receptor6006
hypothetical protein, conserved2002
EWS/FLI fusion protein8008
cytochrome P450 2D67007
glucocerebrosidase3003
peroxisome proliferator-activated receptor delta8008
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 14004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
DNA polymerase iota isoform a (long)4004
DNA polymerase kappa isoform 13003
muscarinic acetylcholine receptor M13003
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60203
Prostaglandin G/H synthase 1 0202
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0112
Carbonic anhydrase 10405
Carbonic anhydrase 20405
Fatty acid-binding protein, liver0101
Integrin beta-32103
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb2103
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma5005
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-16219
Prostaglandin G/H synthase 20202
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10213
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
phosphopantetheinyl transferase5005
ATAD5 protein, partial3003
Fumarate hydratase4004
regulator of G-protein signaling 45005
polyprotein4004
Parkin3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)4004
Replicase polyprotein 1ab0112
NPC intracellular cholesterol transporter 1 precursor1001
D(1A) dopamine receptor4004
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 13003
nuclear receptor ROR-gamma isoform 18008
histone acetyltransferase KAT2A isoform 15005
Amyloid-beta precursor protein1203
Replicase polyprotein 1ab0213
Nuclear factor NF-kappa-B p105 subunit0101
Alpha-synuclein3205
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
NACHT, LRR and PYD domains-containing protein 3 0202
Ataxin-29009
Class A sortase SrtA 0101
ATP-dependent phosphofructokinase5005
core protein, partial0101
peripheral myelin protein 228008
Solute carrier organic anion transporter family member 1B30202
Solute carrier organic anion transporter family member 1B10404
Luciferase4004
caspase 7, apoptosis-related cysteine protease4004
nuclear receptor subfamily 1, group I, member 39009
retinoid X nuclear receptor alpha120012
pregnane X nuclear receptor110011
caspase-34004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a100010
thyroid stimulating hormone receptor5005
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x3003
histone deacetylase 9 isoform 33003
Voltage-dependent calcium channel gamma-2 subunit3003
Glutamate receptor 24004
ATPase family AAA domain-containing protein 56006
Pannexin-10101
USP1 protein, partial9009
activating transcription factor 65005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
heat shock protein beta-16006
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
Rap guanine nucleotide exchange factor 33003
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))0101
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Trypsin0101
Cytochrome P450 1A20303
Coagulation factor VII0101
Aromatase0101
Tissue factor0101
Retinoic acid receptor RXR-alpha0202
Peroxisome proliferator-activated receptor gamma0112
Oxoeicosanoid receptor 10101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, Ferritin light chain4004
Chain A, Cruzipain2002
acid sphingomyelinase2002
glp-1 receptor, partial2002
BRCA11001
15-lipoxygenase, partial4004
pregnane X receptor3003
hypoxia-inducible factor 1 alpha subunit4004
SMAD family member 29009
NFKB1 protein, partial1001
PPM1D protein4004
SMAD family member 39009
Thrombopoietin1001
Smad32002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
estrogen receptor 2 (ER beta)5005
progesterone receptor7007
nonstructural protein 12002
farnesoid X nuclear receptor5005
G4004
67.9K protein2002
P531001
nuclear receptor subfamily 1, group I, member 27007
Caspase-73003
peripheral myelin protein 22 isoform 12002
cellular tumor antigen p53 isoform a2002
thyroid hormone receptor beta isoform a3003
potassium voltage-gated channel subfamily H member 2 isoform d6006
caspase-33003
huntingtin isoform 22002
mitogen-activated protein kinase 14004
nuclear factor NF-kappa-B p105 subunit isoform 12002
flap endonuclease 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
survival motor neuron protein isoform d1001
cytochrome P450 3A4 isoform 16006
M-phase phosphoprotein 81001
Gamma-aminobutyric acid receptor subunit pi6118
Glycoprotein hormones alpha chain1001
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 4004
Retinol-binding protein 40134
Prosaposin0011
Retinoic acid receptor gamma 0101
Gamma-aminobutyric acid receptor subunit beta-16118
Alpha-1B adrenergic receptor0213
Alpha-1A adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit delta6118
Gamma-aminobutyric acid receptor subunit gamma-26118
Gamma-aminobutyric acid receptor subunit alpha-56118
Gamma-aminobutyric acid receptor subunit alpha-36118
Gamma-aminobutyric acid receptor subunit gamma-16118
Gamma-aminobutyric acid receptor subunit alpha-26118
Alpha-1D adrenergic receptor0213
Gamma-aminobutyric acid receptor subunit alpha-46118
Gamma-aminobutyric acid receptor subunit gamma-36118
Retinoic acid receptor RXR-beta0101
Indoleamine 2,3-dioxygenase 10101
Gamma-aminobutyric acid receptor subunit alpha-66118
Alpha-1A adrenergic receptor0213
Retinoic acid receptor RXR-gamma0101
D(1A) dopamine receptor1001
Gamma-aminobutyric acid receptor subunit beta-36118
Guanine nucleotide-binding protein G2002
Gamma-aminobutyric acid receptor subunit beta-26118
Indoleamine 2,3-dioxygenase 20101
GABA theta subunit6118
Inositol hexakisphosphate kinase 14004
Gamma-aminobutyric acid receptor subunit epsilon6118
cytochrome P450 2C9, partial4004
relaxin receptor 1 isoform 11001
GALC protein2002
aryl hydrocarbon receptor5005
Glucocorticoid receptor0404
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Chain A, Dihydrofolate reductase0011
alpha-galactosidase1001
lysosomal alpha-glucosidase preproprotein1001
DNA polymerase beta2002
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10203
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30102
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
cytochrome P450 2D6 isoform 12002
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
ATP-binding cassette sub-family C member 90101
Bile salt export pump0404
Solute carrier organic anion transporter family member 2B1 0001
Potassium channel subfamily K member 20011
Chymotrypsinogen A0101
Beta-lactamase0101
ATP synthase subunit beta, mitochondrial0101
ATP synthase subunit delta, mitochondrial0101
ATP synthase subunit gamma, mitochondrial0101
ATP synthase subunit epsilon, mitochondrial0101
Cytochrome P450 2C9 0303
Cystic fibrosis transmembrane conductance regulator0101
Cholesteryl ester transfer protein0101
Malate dehydrogenase, cytoplasmic0101
Histamine H2 receptor3003
Solute carrier family 15 member 10101
Inositol monophosphatase 14004
ATP-binding cassette sub-family C member 80101
Potassium voltage-gated channel subfamily H member 20303
ATP-sensitive inward rectifier potassium channel 110101
Solute carrier family 22 member 70102
Solute carrier family 15 member 20101
NACHT, LRR and PYD domains-containing protein 3 0101
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20202
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Genome polyprotein 0101
Spike glycoprotein0011
Transmembrane protease serine 20011
Procathepsin L0011
Muscarinic acetylcholine receptor M20516
Muscarinic acetylcholine receptor M40303
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0427
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Muscarinic acetylcholine receptor M10415
Alpha-2C adrenergic receptor0225
Muscarinic acetylcholine receptor M30415
Alpha-1D adrenergic receptor0416
Sigma intracellular receptor 20101
Cyclic GMP-AMP synthase0101
Angiotensin-converting enzyme 2 0011
Toll-like receptor 90101
Toll-like receptor 70101
arylsulfatase A2002
hepatocyte nuclear factor 4-alpha isoform 20101
perilipin-50101
perilipin-10101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
5-hydroxytryptamine receptor 40404
Glutathione reductase, mitochondrial0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Glucose-6-phosphate 1-dehydrogenase0101
D(1A) dopamine receptor0314
UDP-glucuronosyltransferase 1A40001
Histamine H2 receptor0202
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 2C0415
Histamine H1 receptor0202
D(3) dopamine receptor0202
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 2B0415
5-hydroxytryptamine receptor 60415
6-phosphogluconate dehydrogenase, decarboxylating0101
retinoic acid receptor alpha isoform 10101
retinoic acid receptor RXR-alpha isoform a0101
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Tyrosine-protein kinase ABL10213
Methionine aminopeptidase0101
Proto-oncogene tyrosine-protein kinase Src0213
Vascular endothelial growth factor receptor 20101
Disintegrin and metalloproteinase domain-containing protein 172002
Fatty-acid amide hydrolase 10101
Calmodulin-domain protein kinase 10101
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0304
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Solute carrier family 22 member 10102
Multidrug and toxin extrusion protein 10101
Carbonic anhydrase 40102
Carbonic anhydrase0101
Sodium/iodide cotransporter0101
Carbonic anhydrase 150101
Poly [ADP-ribose] polymerase tankyrase-10101
Cholinesterase0202
Poly [ADP-ribose] polymerase 10224
Cytochrome P450 2D60202
Protein mono-ADP-ribosyltransferase PARP60101
Protein mono-ADP-ribosyltransferase PARP150101
Protein mono-ADP-ribosyltransferase PARP100112
Protein mono-ADP-ribosyltransferase PARP80011
Protein mono-ADP-ribosyltransferase PARP160112
Protein mono-ADP-ribosyltransferase PARP120101
Poly [ADP-ribose] polymerase tankyrase-20101
Histamine H3 receptor0101
Poly [ADP-ribose] polymerase 20123
Protein mono-ADP-ribosyltransferase PARP40112
Protein mono-ADP-ribosyltransferase PARP30123
Chain A, Immunoglobulin0011
Chain B, Immunoglobulin0011
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor M30011
Muscarinic acetylcholine receptor M40011
Muscarinic acetylcholine receptor M50011
Muscarinic acetylcholine receptor M20011
Muscarinic acetylcholine receptor M10012
Cytochrome P450 2B60101
Muscarinic acetylcholine receptor M40012
Delta-type opioid receptor0001
Kappa-type opioid receptor0001
Glutamate receptor ionotropic, NMDA 1 0202
Lysosomal Pro-X carboxypeptidase0101
Mu-type opioid receptor0001
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0203
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Muscarinic acetylcholine receptor M50012
Muscarinic acetylcholine receptor M30012
Muscarinic acetylcholine receptor M20012
Glutamate receptor ionotropic, NMDA 3A0202
Voltage-dependent calcium channel subunit alpha-2/delta-10102
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Beta-1 adrenergic receptor 0113
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Albumin0034
Beta-2 adrenergic receptor0213
ATP-dependent translocase ABCB10303
Beta-1 adrenergic receptor0213
Cytochrome P450 3A40202
5-hydroxytryptamine receptor 1A0202
Adenosine receptor A30112
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
Beta-3 adrenergic receptor0213
D(2) dopamine receptor0213
Beta-1 adrenergic receptor0214
D(3) dopamine receptor0101
Alpha-2B adrenergic receptor0011
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Cytochrome P450 2C190202
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Mu-type opioid receptor0112
Vasopressin V1a receptor0112
Delta-type opioid receptor0112
Kappa-type opioid receptor0112
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
Beta-2 adrenergic receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
Nuclear receptor subfamily 2 group E member 10022
Chain A, Cellular retinoic acid-binding protein 20011
Chain A, Cellular retinoic acid-binding protein 20011
Aldo-keto reductase family 1 member B100002
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Beta-lactoglobulin0011
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain A, Breast cancer type 1 susceptibility protein1001
Chain H, Immunoglobulin Igg1 Heavy chain0011
Chain L, Immunoglobulin Igg1 Lambda Light Chain0011
Chain A, DODECIN0011
Chain A, DODECIN0011
Chain C, DODECIN0011
Chain E, DODECIN0011
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
NPYLR7B0011
thyrotropin-releasing hormone receptor1001
tumor necrosis factor1001
caspase-1 isoform alpha precursor1001
Riboflavin-binding protein0112
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Caspase-71001
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Carbonic anhydrase 120001
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Carbonic anhydrase 30001
Carbonic anhydrase 60102
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase 70001
Carbonic anhydrase 90001
Carbonic anhydrase 130001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Bone morphogenetic protein receptor type-1B0011
Cell division cycle 7-related protein kinase0011
Serine/threonine-protein kinase PLK40011
ATP-dependent RNA helicase DDX3X0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase Chk10011
Aurora kinase A0011
Cyclin-G-associated kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Receptor-interacting serine/threonine-protein kinase 20011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
Dynamin-like 120 kDa protein, mitochondrial0011
Tyrosine-protein kinase JAK20011
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Nuclear receptor subfamily 1 group I member 20011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30011
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
High affinity nerve growth factor receptor0011
ADP/ATP translocase 20011
Protein kinase C beta type0112
Insulin receptor0011
Tyrosine-protein kinase Lck0011
Tyrosine-protein kinase Fyn0011
Cyclin-dependent kinase 10011
Eukaryotic translation initiation factor 4E0011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0011
Tyrosine-protein kinase Lyn0011
Proto-oncogene tyrosine-protein kinase receptor Ret0011
Insulin-like growth factor 1 receptor0011
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0011
Tyrosine-protein kinase HCK0011
Platelet-derived growth factor receptor beta0011
Tyrosine-protein kinase Fgr0011
Serine/threonine-protein kinase A-Raf0011
Glycogen phosphorylase, brain form0011
Breakpoint cluster region protein0011
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10011
DNA topoisomerase 2-alpha0011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Ribosyldihydronicotinamide dehydrogenase [quinone]0011
Tyrosine-protein kinase Fer0011
Protein kinase C alpha type0011
cAMP-dependent protein kinase catalytic subunit alpha0011
General transcription and DNA repair factor IIH helicase subunit XPD0011
Casein kinase II subunit alpha'0011
Ras-related protein Rab-6A0011
Ephrin type-A receptor 10011
Multifunctional protein ADE20011
cAMP-dependent protein kinase catalytic subunit beta0011
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Cyclin-dependent kinase 20011
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Mitogen-activated protein kinase 3 0011
MAP/microtubule affinity-regulating kinase 30011
Deoxycytidine kinase0011
Mitogen-activated protein kinase 10011
Ephrin type-A receptor 20011
Ephrin type-B receptor 20011
Non-receptor tyrosine-protein kinase TYK20011
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0011
RAC-beta serine/threonine-protein kinase0011
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40011
Myosin-100011
Dual specificity mitogen-activated protein kinase kinase 20011
Receptor-type tyrosine-protein kinase FLT30011
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0011
Glycine--tRNA ligase0011
Protein kinase C iota type0011
Exosome RNA helicase MTR40011
Serine/threonine-protein kinase mTOR0112
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0011
26S proteasome regulatory subunit 6B0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0011
Casein kinase I isoform delta0011
MAP kinase-activated protein kinase 20011
Elongation factor Tu, mitochondrial0011
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Interleukin-1 receptor-associated kinase 10011
Ribosomal protein S6 kinase alpha-30011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10011
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
5'-AMP-activated protein kinase subunit gamma-10011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Adenosine kinase0011
Ras-related protein Rab-100011
Actin-related protein 30011
Actin-related protein 20011
GTP-binding nuclear protein Ran0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Casein kinase I isoform gamma-20011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
ATP-dependent 6-phosphofructokinase, platelet type0011
Dual specificity mitogen-activated protein kinase kinase 10011
DNA topoisomerase 2-beta0011
Protein kinase C theta type0011
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10011
Protein kinase C zeta type0011
Protein kinase C delta type0011
Tyrosine-protein kinase BTK0011
Cyclin-dependent kinase 180011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Mitogen-activated protein kinase kinase kinase kinase 20011
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase 40011
5'-AMP-activated protein kinase catalytic subunit alpha-10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
Integrin-linked protein kinase0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10011
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Mitogen-activated protein kinase 140011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
Discoidin domain-containing receptor 20011
AP2-associated protein kinase 10011
Myosin light chain kinase 30011
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
Putative heat shock protein HSP 90-beta 20011
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
Mitogen-activated protein kinase kinase kinase kinase 30011
MAP kinase-activated protein kinase 50011
Regulatory-associated protein of mTOR0101
Misshapen-like kinase 10011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
ATP-dependent RNA helicase DDX10011
Mitogen-activated protein kinase kinase kinase kinase 10011
Aurora kinase B0011
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10011
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
Dual specificity testis-specific protein kinase 20011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0011
Mitogen-activated protein kinase kinase kinase 50011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Target of rapamycin complex subunit LST80101
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
dCTP pyrophosphatase 10011
Dual specificity protein kinase CLK40011
Casein kinase I isoform gamma-10011
Serine/threonine-protein kinase mTOR 0101
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Obg-like ATPase 10011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
Serine/threonine-protein kinase 260011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
5'-AMP-activated protein kinase subunit gamma-20011
Serine/threonine-protein kinase TBK10011
Septin-90011
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase TAO20011
Serine/threonine-protein kinase ICK0011
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
Transthyretin0112
D(4) dopamine receptor0101
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 20101
Chain A, Beta-lactamase3003
Ubiquitin-like modifier activating enzyme 20101
SUMO1 activating enzyme subunit 10101
bromodomain adjacent to zinc finger domain 2B1001
hexokinase0101
SUMO-conjugating enzyme UBC90101
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
eukaryotic translation initiation factor 4E isoform 10101
Vif0101
Tat0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Acetylcholinesterase0101
TAR DNA-binding protein 432002
pyruvate kinase PKM isoform a1001
serine/threonine-protein kinase PLK11001
tyrosine-protein kinase Yes1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Ectonucleoside triphosphate diphosphohydrolase 10001
Thymidine kinase, cytosolic0203
DNA polymerase beta0101
UDP-glucuronosyltransferase 2B70001
Thymidine kinase, cytosolic 0001
Thymidylate kinase0101
Protein kinase C epsilon type0101
Thymidine kinase 0102
Solute carrier family 22 member 60001
Reverse transcriptase/RNaseH 0126
Protease 0112
Solute carrier family 22 member 80001
Solute carrier family 22 member 110001
Thymidine kinase0102
Solute carrier family 22 member 70001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]