A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
| Member | Definition | Class |
|---|
| a 195773 | A macrolide antibiotic which displays in vitro activity against both gram-positive and gram-negative bacteria and is currently under investigation for the treatment of community-acquired pneumonia. The US Food and Drug Administration (FDA) have also granted orphan drug designation to cethromycin for the treatment of anthrax prophylaxis, tularemia, and plague (PDB entry: 1NWX). | cethromycin |
| acetopyrrothine | A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and acetamido groups, respectively. It is a potent inhibitor of RNA polymerases, inhibits the angiogenesis of human umbilical vein endothelial cells, and also inhibits JAMM metalloproteases. | thiolutin |
| althiomycin | A peptide antibiotic isolated from soil and enteric bacteria. It is a protein synthesis inhibitor which exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria. | althiomycin |
| anisomycin | An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. | (-)-anisomycin |
| arbekacin | A kanamycin that is kanamycin B bearing an N-(2S)-4-amino-2-hydroxybutyryl group on the aminocyclitol ring. | arbekacin |
| chloramphenicol | An organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions. | chloramphenicol |
| clarithromycin | The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis. | clarithromycin |
| cryptopleurine | An organic heteropentacyclic compound that is (14aR)-11,12,13,14,14a,15-hexahydro-9H-dibenzo[f,h]pyrido[1,2-b]isoquinoline substituted at positions 2, 3 and 6 by methoxy groups. | cryptopleurine |
| cycloheximide | A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus. | cycloheximide |
| dibekacin | A kanamycin that is kanamycin B lacking the 3- and 4-hydroxy groups on the 2,6-diaminosugar ring. | dibekacin |
| emetine | A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties. | emetine |
| emetine dihydrochloride | The dihydrochloride salt of emetine. | emetine dihydrochloride |
| fusidic acid | A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum. | fusidic acid |
| gamithromycin | A macrolide antibiotic with formula C40H76N2O12. It is used for the treatment of of bovine respiratory disease caused by Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis in beef and non-lactating dairy cattle. The compound is also licensed in Europe for the treatment of footrot in sheep caused by Dichelobacter nodosus and Fusobacterium nodosus. | gamithromycin |
| homoharringtonine | A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia. | omacetaxine mepesuccinate |
| linezolid | An organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex. | linezolid |
| lycorine | An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity. | lycorine |
| mupirocin | An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections. | mupirocin |
| nucleocidin | A nucleoside antibiotic that is 5'-O-sulfamoyladenosine in which the hydrogen atom at position 4' is replaced by a fluorine atom. It is a natural product synthesized by several Streptomyces species. It exhibits broad spectrum antibacterial activity, and also has a strong effect against Trypanosoma brucei, the protozoan parasite responsible for the African sleeping sickness. | nucleocidin |
| puromycin | An aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome. | puromycin |
| rifampin | A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei). | rifampicin zwitterion; rifampicin |
| s-2-aminoethyl cysteine | A cysteine derivative that is the S-(2-aminoethyl) analogue of L-cysteine; reported to have cytotoxic effects. | L-thialysine |
| streptomycin | A amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. The parent of the streptomycin class | streptomycin |
| tavaborole | A member of the class of benzoxaboroles that is 1,3-dihydro-1-hydroxy-2,1-benzoxaborole substituted at position 5 by a fluoro group. A topical antifungal agent used for the treatment of onychomycosis (fungal infection of the toenails and fingernails). | tavaborole |
| tedizolid | A member of the class of pyridines that is pyridine which is substituted by a 2-methyl-2H-tetrazol-5-yl group at position 2 and by a 2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl group at position 5. It is used as its phosphate pro-drug used for the treatment of acute bacterial skin and skin structure infections caused by certain susceptible bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis. | tedizolid |
| tedizolid phosphate | A phosphate monoester resulting from the formal condensation of equimolar amounts of phosphoric acid with the hydroxy group of tedizolid . It is a prodrug of tedizolid, used for the treatment of acute bacterial skin infections caused by certain susceptible bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis. | tedizolid phosphate |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 0.4840 | 2 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 13.0083 | 2 | 6 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 31.3424 | 1 | 4 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 14.8844 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 6.0322 | 11 | 40 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 38.8135 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 0.2241 | 9 | 9 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.2551 | 2 | 6 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 0.3209 | 2 | 9 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 17.7828 | 2 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 68.7989 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 30.7314 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 68.7989 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 30.7314 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 6.5684 | 2 | 6 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 0.2512 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 12.5893 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 23.3810 | 2 | 6 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 43.1256 | 1 | 4 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 89.3584 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 14.5451 | 2 | 5 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 6.8191 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 0.4036 | 1 | 4 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 8.1121 | 9 | 42 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 2.2161 | 1 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 1.8938 | 9 | 37 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 20.9279 | 1 | 5 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 3.2501 | 4 | 9 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 22.4910 | 2 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 29.9349 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 0.0935 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 43.1256 | 1 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 14.7624 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 4.3542 | 4 | 11 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 1.1137 | 3 | 15 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 9.8863 | 2 | 9 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.3482 | 1 | 5 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 0.5174 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 27.7799 | 1 | 2 |
| hepatitis C virus polyprotein | | Potency | 7.0456 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 13.4045 | 2 | 5 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 6.9854 | 2 | 4 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 43.1256 | 1 | 4 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 0.1585 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 2.9020 | 1 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 1.7959 | 1 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 0.5174 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 43.1256 | 1 | 8 |
| Interferon beta | Homo sapiens (human) | Potency | 11.7454 | 3 | 15 |
| interleukin 8 | Homo sapiens (human) | Potency | 69.5421 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 12.0985 | 2 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 8.0020 | 1 | 4 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 21.7515 | 2 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 9.9150 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 29.2473 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 31.0666 | 4 | 16 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 3.4522 | 2 | 4 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 0.2951 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.3090 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 0.1934 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 1.7829 | 2 | 10 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 0.1000 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 5.8698 | 3 | 12 |
| P53 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 9.2000 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 4.2251 | 2 | 3 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 0.0757 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 28.1713 | 5 | 10 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 14.0791 | 3 | 7 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 17.7828 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 3.0623 | 1 | 2 |
| polyprotein | Zika virus | Potency | 0.0935 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 22.7406 | 1 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.3378 | 1 | 6 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 18.8457 | 2 | 5 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 59.6649 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 8.8617 | 2 | 6 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.2993 | 2 | 10 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 9.3363 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 4.7444 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 3.5948 | 3 | 16 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 0.8824 | 4 | 10 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 3.5306 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 0.3092 | 4 | 5 |
| snurportin-1 | Homo sapiens (human) | Potency | 0.5174 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 2.3430 | 2 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.1149 | 1 | 7 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 18.7139 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 5.4764 | 2 | 23 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 50.1187 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 14.8502 | 1 | 3 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 3.7467 | 3 | 11 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0447 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 33.9432 | 3 | 3 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 26.9724 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 3.0623 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 3.0623 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 3.3808 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 9.6146 | 3 | 6 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 57.9003 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 0.3482 | 1 | 5 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 100.0000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 30S ribosomal protein S1 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S10 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S11 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S12 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S13 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S14 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S15 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S16 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S17 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S18 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S19 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S2 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S20 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S21 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S3 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S4 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S5 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S6 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S7 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S8 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 30S ribosomal protein S9 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L1 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L10 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L11 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L13 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L14 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L15 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L16 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L17 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L18 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L19 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L2 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L20 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L21 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L22 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L23 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L24 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L25 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L27 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L28 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L29 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L3 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L30 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L31 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L31 type B | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L32 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L33 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L34 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L35 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L36 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L36 2 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L4 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L5 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L6 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 50S ribosomal protein L7/L12 | Escherichia coli K-12 | IC50 | 575.3325 | 2 | 4 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 100.0000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 200.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 177.5000 | 2 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0380 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0140 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.1820 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0260 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 26.6500 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 27.3500 | 1 | 2 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 27.5800 | 4 | 5 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 8.2667 | 2 | 3 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 17.0000 | 1 | 2 |
| Aminopeptidase N | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| Aminopeptidase N | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| Arylacetamide deacetylase | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 123.8571 | 1 | 7 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 53.7286 | 7 | 14 |
| Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 | 49.7510 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 278.0667 | 6 | 18 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 350.7000 | 1 | 3 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | Ki | 7.0500 | 2 | 2 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 54.0000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 119.6667 | 1 | 6 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 8.7000 | 3 | 3 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | Ki | 0.0890 | 1 | 1 |
| Carbonic anhydrase | Nakaseomyces glabratus CBS 138 | Ki | 0.0720 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 2.0150 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.4620 | 2 | 2 |
| caspase recruitment domain family, member 15 | Homo sapiens (human) | IC50 | 49.7510 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | IC50 | 8.3190 | 1 | 1 |
| Chain A, Isoleucyl-tRNA synthetase | Thermus thermophilus | Ki | 0.2500 | 1 | 1 |
| Chain A, Type Iii Chloramphenicol Acetyltransferase | Shigella flexneri | Ki | 5.4000 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 200.0000 | 1 | 1 |
| COUP transcription factor 2 isoform a | Homo sapiens (human) | IC50 | 1.3150 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 20.0000 | 2 | 2 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 53.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 20.0000 | 2 | 2 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 20.0000 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 14.2333 | 3 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 8.0450 | 2 | 2 |
| Dihydroorotate dehydrogenase | Leishmania major | IC50 | 1,037.0000 | 1 | 2 |
| DNA gyrase subunit A | Escherichia coli K-12 | IC50 | 32.0000 | 1 | 1 |
| DNA gyrase subunit A | Mycobacterium tuberculosis H37Rv | IC50 | 50.0000 | 1 | 1 |
| DNA gyrase subunit B | Escherichia coli K-12 | IC50 | 32.0000 | 1 | 1 |
| DNA gyrase subunit B | Mycobacterium tuberculosis H37Rv | IC50 | 50.0000 | 1 | 1 |
| DNA-directed RNA polymerase subunit beta | Escherichia coli O127:H6 str. E2348/69 | IC50 | 511.3333 | 3 | 3 |
| DNA-directed RNA polymerase subunit beta | Mycobacterium tuberculosis H37Rv | IC50 | 0.0100 | 1 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Mus musculus (house mouse) | IC50 | 20.0000 | 1 | 1 |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | IC50 | 0.0594 | 3 | 4 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Mycobacterium tuberculosis H37Rv | IC50 | 0.0300 | 1 | 1 |
| Eukaryotic initiation factor 4A-I | Homo sapiens (human) | IC50 | 0.1390 | 4 | 4 |
| Glucose transporter | Leishmania mexicana | IC50 | 0.1827 | 1 | 3 |
| Glutathione S-transferase omega-1 | Homo sapiens (human) | IC50 | 75.0000 | 1 | 1 |
| Hexose transporter 1 | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.2420 | 1 | 3 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 | 0.0594 | 3 | 4 |
| Isoleucine--tRNA ligase | Escherichia coli K-12 | Ki | 0.0025 | 1 | 1 |
| Kinesin-like protein KIF11 | Homo sapiens (human) | IC50 | 63.0000 | 1 | 1 |
| L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase | Mycobacterium tuberculosis H37Rv | IC50 | 5,000.0000 | 1 | 1 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 20.4200 | 1 | 1 |
| Leucine--tRNA ligase, cytoplasmic | Saccharomyces cerevisiae S288C | IC50 | 2.1000 | 1 | 1 |
| Leucine--tRNA ligase, cytoplasmic | Saccharomyces cerevisiae S288C | Ki | 16.6250 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 119.9857 | 1 | 7 |
| NH(3)-dependent NAD(+) synthetase | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 1.0000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP14 | Homo sapiens (human) | Ki | 76.2000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Homo sapiens (human) | Ki | 3.4000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP3 | Homo sapiens (human) | Ki | 124.0000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP4 | Homo sapiens (human) | Ki | 24.2000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 | Homo sapiens (human) | Ki | 187.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | Ki | 24.2000 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.9490 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 51.1533 | 5 | 5 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 8.1900 | 1 | 1 |
| Protein-arginine deiminase type-4 | Homo sapiens (human) | IC50 | 1,800.0000 | 1 | 1 |
| Protein-arginine deiminase type-4 | Homo sapiens (human) | Ki | 560.0000 | 1 | 1 |
| Puromycin-sensitive aminopeptidase | Homo sapiens (human) | IC50 | 6.0750 | 2 | 2 |
| receptor-interacting serine/threonine-protein kinase 2 isoform 1 | Homo sapiens (human) | IC50 | 49.7510 | 1 | 1 |
| Renin | Callithrix jacchus (white-tufted-ear marmoset) | IC50 | 17.0000 | 1 | 1 |
| Serine hydrolase RBBP9 | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 1 | Homo sapiens (human) | IC50 | 0.2190 | 1 | 3 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 18.2000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A2 | Homo sapiens (human) | Ki | 51.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A4 | Rattus norvegicus (Norway rat) | Ki | 1.4300 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 1.8181 | 5 | 5 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 9.0500 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 2.4057 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 3.2000 | 2 | 2 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | IC50 | 65.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 63.0000 | 1 | 1 |
| Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | Homo sapiens (human) | IC50 | 8.1900 | 1 | 1 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| transactivating tegument protein VP16 [Human herpesvirus 1] | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | IC50 | 85.4210 | 1 | 1 |
| Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (human) | IC50 | 18,000.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 105.4000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 105.4000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 105.4000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 105.4000 | 1 | 1 |